LOCUS       NM_001024236            1878 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus general transcription factor IIH subunit 3
            (Gtf2h3), mRNA.
ACCESSION   NM_001024236 XM_213778
VERSION     NM_001024236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   He,Y., Yan,C., Fang,J., Inouye,C., Tjian,R., Ivanov,I. and
            Nogales,E.
  TITLE     Near-atomic resolution visualization of human transcription
            promoter opening
  JOURNAL   Nature 533 (7603), 359-365 (2016)
   PUBMED   27193682
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Egly,J.M. and Coin,F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Kershnar,E., Wu,S.Y. and Chiang,C.M.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Iyer,N., Reagan,M.S., Wu,K.J., Canagarajah,B. and Friedberg,E.C.
  TITLE     Interactions involving the human RNA polymerase II
            transcription/nucleotide excision repair complex TFIIH, the
            nucleotide excision repair protein XPG, and Cockayne syndrome group
            B (CSB) protein
  JOURNAL   Biochemistry 35 (7), 2157-2167 (1996)
   PUBMED   8652557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC093380.1.
            
            On May 27, 2005 this sequence version replaced XM_213778.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093380.1, SRR8487230.117016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1878
                     /gene="Gtf2h3"
                     /note="general transcription factor IIH subunit 3"
                     /db_xref="GeneID:288651"
                     /db_xref="RGD:1305494"
     exon            1..37
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..954
                     /gene="Gtf2h3"
                     /note="general transcription factor IIH, polypeptide 3"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 3"
                     /protein_id="NP_001019407.1"
                     /db_xref="GeneID:288651"
                     /db_xref="RGD:1305494"
                     /translation="MAADEDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVL
                     ANAHLFMNRSNQLAVIASHIQESRFLYPGKNGRLGDFFGDPGNALPDCNPSGSKDGKY
                     ELLTAANEVIAEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRASKAVKDNQEMKS
                     RILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKV
                     PQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDYRAACFCHRSLIEIGYVCSVCLSIF
                     CNFSPICTTCETAFKISLPPVLKAKKKKQKVSL"
     exon            38..117
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            118..224
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            225..391
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..454
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..484
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..513
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..588
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..642
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..711
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..847
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..884
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1842
                     /gene="Gtf2h3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttcaccg aggcataggg agccatggcc gcggacgaag atgagttgaa tcttctggtt
       61 atcatagttg acaccaaccc gatttggtgg ggaaagcaag cgttaaagga atctcagttc
      121 actctgtcca agtgcatgga tgctgtgatg gtgctggcaa acgcccacct gttcatgaac
      181 cgctccaacc agctagcggt catcgccagc cacattcagg aaagtcgatt cttatacccg
      241 gggaagaacg gccgactcgg agacttcttc ggagatcctg gcaacgccct tcctgactgt
      301 aatccctctg ggagtaagga cgggaaatat gagctgttga cagcggcaaa cgaggtgatc
      361 gccgaggaga tcaaggatct gatgaccaag agtgacatca agggccagca cacggagacc
      421 ctactggcag gatccctcgc caaggccctc tgctacattc acagagcgag caaggcagtg
      481 aaagataatc aggagatgaa atcaaggatt ttggtcatca aggctgcaga ggacagtgca
      541 ctgcagtaca tgaacttcat gaacgtcatc tttgctgctc agaagcagaa tatcctcatc
      601 gatgcctgcg tcctggactc ggattcaggg ctcctccagc aggcttgtga catcactggg
      661 ggactgtacc tgaaggtgcc tcagatgcct tctctcctgc agtacttact gtgggttttt
      721 cttccggatc aagaccagcg atctcagcta atcctcccac ctccgatcca cgtggactat
      781 agggctgcct gcttctgcca tcgaagtctc attgagattg gctatgtctg ctctgtgtgt
      841 ctgtctattt tctgcaactt cagccccatc tgcaccacgt gcgagacagc ttttaagatc
      901 tccctccctc ctgtgctgaa ggccaagaaa aagaaacaga aggtgtccct gtgatgagtg
      961 atacaaactt ccccatctct tcccaccggc tgcctctctg tagggagcac ggaagacttt
     1021 gaagcaccgc ctttgttctg tacttttagg gtgtgaggct ggagagtacg cacccctctg
     1081 attcatctgg aagggggacg gctttgtagg ttgttgtggg gtagcaggtg cctgtcggat
     1141 gctaatctgt ggctgttttg ttagttgttg cttggatgct tggtgctggg gtttgaaccc
     1201 tagccttgca cgagctagcc ctacagccca cctcagaact gcagtgggcc cctgggattt
     1261 tgttttcaca tgatcctctg tcaaagctta tgtggtgggt gctgggtctt ctgtacttca
     1321 gaagtgtgtg aggttgggac gtcgtctggg agggtgaccg gcaccgggtc actgtgggcc
     1381 gtgacagaat atcttagttg ctcaggtgat gcacgcctgg aaccttgaac ttaggaggct
     1441 gagacaggaa ggtttggggt tcggatcctg cttgggatat gtatgaagtg ccggcttttt
     1501 ttctttcttt ctttttttct ttttttaaca gaagaacatt ttacttcaaa taaattgttt
     1561 ccttcaactg ttttcaaata taaccagaca taaaggcaca gccttccatc tcagcactca
     1621 gggagcccag acaagtgcat cactgcgttt gaggccagcc aggtctacat agtgagttca
     1681 gaccacacca accagggttg catcttgcca ccttgtttac aaaaaataaa accccaaacc
     1741 agtcacgttc acagggagaa ccgctgacca ttagaaatgt aaatgagttc aggagaaacg
     1801 tttgtactct caacaataaa gtcctatttt tgtatttact aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaa
//
