LOCUS       NM_001399644            2715 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus general transcription factor IIH subunit 1
            (Gtf2h1), mRNA.
ACCESSION   NM_001399644 XM_006229235
VERSION     NM_001399644.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Compe,E. and Egly,J.M.
  TITLE     TFIIH: when transcription met DNA repair
  JOURNAL   Nat Rev Mol Cell Biol 13 (6), 343-354 (2012)
   PUBMED   22572993
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2012 Jul;13(7):476]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Egly,J.M. and Coin,F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Cowling,V.H. and Cole,M.D.
  TITLE     The Myc transactivation domain promotes global phosphorylation of
            the RNA polymerase II carboxy-terminal domain independently of
            direct DNA binding
  JOURNAL   Mol Cell Biol 27 (6), 2059-2073 (2007)
   PUBMED   17242204
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Ng,J.M., Vermeulen,W., van der Horst,G.T., Bergink,S., Sugasawa,K.,
            Vrieling,H. and Hoeijmakers,J.H.
  TITLE     A novel regulation mechanism of DNA repair by damage-induced and
            RAD23-dependent stabilization of xeroderma pigmentosum group C
            protein
  JOURNAL   Genes Dev 17 (13), 1630-1645 (2003)
   PUBMED   12815074
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Yanagi,S., Shimbara,N. and Tamura,Ta.
  TITLE     Tissue and cell distribution of a mammalian proteasomal ATPase,
            MSS1, and its complex formation with the basal transcription
            factors
  JOURNAL   Biochem Biophys Res Commun 279 (2), 568-573 (2000)
   PUBMED   11118327
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Kershnar,E., Wu,S.Y. and Chiang,C.M.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   Reardon,J.T., Ge,H., Gibbs,E., Sancar,A., Hurwitz,J. and Pan,Z.Q.
  TITLE     Isolation and characterization of two human transcription factor
            IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6482-6487 (1996)
   PUBMED   8692841
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538]
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Ossipow,V., Tassan,J.P., Nigg,E.A. and Schibler,U.
  TITLE     A mammalian RNA polymerase II holoenzyme containing all components
            required for promoter-specific transcription initiation
  JOURNAL   Cell 83 (1), 137-146 (1995)
   PUBMED   7553866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006229235.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.2529.1,
                                           SRR26643289.1748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000001.1  106457692-106457866
            176-344             JAXUCZ010000001.1  106465040-106465208
            345-537             JAXUCZ010000001.1  106466667-106466859
            538-700             JAXUCZ010000001.1  106467917-106468079
            701-794             JAXUCZ010000001.1  106470259-106470352
            795-944             JAXUCZ010000001.1  106471710-106471859
            945-1024            JAXUCZ010000001.1  106471984-106472063
            1025-1152           JAXUCZ010000001.1  106475076-106475203
            1153-1240           JAXUCZ010000001.1  106475309-106475396
            1241-1329           JAXUCZ010000001.1  106476826-106476914
            1330-1447           JAXUCZ010000001.1  106478248-106478365
            1448-1538           JAXUCZ010000001.1  106479306-106479396
            1539-1654           JAXUCZ010000001.1  106479838-106479953
            1655-1747           JAXUCZ010000001.1  106482570-106482662
            1748-2715           JAXUCZ010000001.1  106484762-106485729
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2715
                     /gene="Gtf2h1"
                     /note="general transcription factor IIH subunit 1"
                     /db_xref="GeneID:361580"
                     /db_xref="RGD:1308225"
     exon            1..175
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            176..344
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1834
                     /gene="Gtf2h1"
                     /note="general transcription factor IIH, polypeptide 1"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 1"
                     /protein_id="NP_001386573.1"
                     /db_xref="GeneID:361580"
                     /db_xref="RGD:1308225"
                     /translation="MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTIS
                     HMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPK
                     FKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATESSTSSHK
                     QDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKE
                     FWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTALEDKPL
                     DEGYGISSVPSTSNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSV
                     DGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQ
                     YATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAVNQ
                     MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQ
                     EKIRRQYLSTNLVTHIEEMLQTAYNKLHSWQSRRLMKKT"
     exon            345..537
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..700
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..794
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..944
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1024
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1152
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1240
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1329
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1447
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1538
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1654
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1747
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..2715
                     /gene="Gtf2h1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccctcg cagccagcga tggaggcgag accccccggc aacagaggcg gtggcgacgg
       61 ctgcggccgc agggtttcac cctcctccgt gcagcggctg tgagaagctc ggcggagcca
      121 gatccgacag gacgcggttc acgcacccca ggccggagac agtagctccc acctgcacct
      181 tatagccatc atggcaactt catcagaaga agtattgctg attgtgaaga aggttcgtca
      241 gaagaagcag gatggagcac tatacctcat ggcagaaaga attgcttggg cacctgaagg
      301 caaagacaga tttacaatca gccatatgta tgcagatatt aaatgccaga aaataagtcc
      361 agaaggaaaa gctaagatac aacttcagct ggtcctgcat gcaggggaca caacaaactt
      421 ccatttttcc aacgaaagca cagccgtgaa agagcgggat gcagtgaagg acctccttca
      481 gcagctgctg cccaagttca agcggaaagc caacaaagaa ctggaggaga agaacagaat
      541 gctccaagaa gatcctgttt tattccagct ctataaagac cttgttgtga gccaagtgat
      601 cagtgctgag gagttctggg ccaaccgttt aaatgtgaat gcaacagaga gctctacatc
      661 cagtcacaag caggatgttg gcatttctgc agcatttctg gctgatgtcc gtcctcaaac
      721 agatggctgt aatggtctga gatataattt aacttctgat atcattgaat ctatatttag
      781 gacctatcca gcagtaaaaa tgaaatatgc agaaactgta ccacataaca tgacagaaaa
      841 ggagttctgg acacgatttt tccagtccca ttattttcac agggaccgac taaatacagg
      901 atcaaaggac ctctttgcag aatgtgccaa aatagatgaa aagggattaa aaacaatggt
      961 ttcattagga gtaaaaaacc caatgctaga tttgacagcg ttggaagata aaccattaga
     1021 cgagggctat ggcatttcct ccgtgccatc tacttccaat tccaaatcca taaaggagaa
     1081 tagtaatgct gccatcatca aaaggtttaa ccaccacagt gccatggtcc tggctgctgg
     1141 tctcagaaaa caacaagcac aaaatggaca gaatggtgag cccagcagcg tggatggaaa
     1201 ttctggagat acagactgct ttcagccagc agtcaagagg gcaaagttac aggaatccat
     1261 tgaatatgaa gacttgggaa acaacaattc tgtgaaaacg attgcactga atctcaagaa
     1321 gtcagacagg tattatcatg gtcctactcc aattcagtca ctacagtatg caacaagtca
     1381 ggacattatt aattcttttc aaagtattag acaagaaatg gaagcttata cacccaagtt
     1441 aactcaggtt ctctcaagca gcgctgctag tagcaccatc acagccctgt cacctggagg
     1501 agcacttatg cagggaggga cacagcaagc agtaaaccag atggtgccaa acgatattca
     1561 gtctgaattg aaacacttgt atgtggctgt tggggagctt ctgcggcatt tctggtcttg
     1621 ctttcctgtt aatacaccat tcctagaaga aaaggtggtg aaaatgaaga gtaatttgga
     1681 acggttccaa gttacaaagc tctgcccatt ccaagaaaag atccggaggc agtatttaag
     1741 cacaaacctg gtgactcaca tagaggagat gctacagacg gcctacaaca agctgcactc
     1801 gtggcaatcc cggcgcctga tgaagaagac gtgaagtgtt tgtggtgctt acaggttttg
     1861 tgggttaaaa aaaactgacc tgcagtgact ctggaaacct ggctgaggac aagcagatgc
     1921 tcacaccagg gaaacatctg cagcttgccg actcccggag ctgacgctgt tgtacttgca
     1981 catgataact gagaggagga agggacggga ttcacctaac tctggggagg taaactaagg
     2041 cagaaccaaa tgagctaagt tgcagatata tacatatgta tgtgtacatg tatatgtatt
     2101 taaagactgt ttactgcagt tactcaggaa ctgcttttca ttcacgttaa gctgctttca
     2161 aaatttaaaa aaaaaaaatt aaaagaaaaa atacttaaaa cggtgcattg ataaaatcta
     2221 agagtttttt cagttttgtt ttctaggtaa atttttgcgt aagttttgtg gcacagggta
     2281 gccctaagta tccctcctcg gtcccgcact gggatcctca aatgctcctg aattctagtt
     2341 gtttctttca tcggcacggg ggagagtgct ttaaggcaga tggaggctgt gctcagccat
     2401 tgggaaacag ttgtcagaag acgccactgg gcctgtgttt cctacggaaa taagtgttgc
     2461 actgaagcct gtgttctgag tccccaagta gaacgcacat gtgcaggagt cggtgggtta
     2521 gtgcaggaca ttgtcagacg gcagtgatgc tgcatgtatt tcttgggtgc aaatgtatat
     2581 tgctgagaat tttttaaaga tggcatgtgc tttgaaaaga aaattgcatt tttaagaatt
     2641 taaaaatctt acaagtgaga aatataagaa ttgcttattt tcacctgttt agaagaataa
     2701 aggaagtttc tcata
//
