LOCUS       NM_031041               1220 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus general transcription factor IIB (Gtf2b), mRNA.
ACCESSION   NM_031041
VERSION     NM_031041.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Bratkowski,M., Unarta,I.C., Zhu,L., Shubbar,M., Huang,X. and Liu,X.
  TITLE     Structural dissection of an interaction between transcription
            initiation and termination factors implicated in
            promoter-terminator cross-talk
  JOURNAL   J Biol Chem 293 (5), 1651-1665 (2018)
   PUBMED   29158257
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   He,Y., Yan,C., Fang,J., Inouye,C., Tjian,R., Ivanov,I. and
            Nogales,E.
  TITLE     Near-atomic resolution visualization of human transcription
            promoter opening
  JOURNAL   Nature 533 (7603), 359-365 (2016)
   PUBMED   27193682
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Gelev,V., Zabolotny,J.M., Lange,M., Hiromura,M., Yoo,S.W.,
            Orlando,J.S., Kushnir,A., Horikoshi,N., Paquet,E., Bachvarov,D.,
            Schaffer,P.A. and Usheva,A.
  TITLE     A new paradigm for transcription factor TFIIB functionality
  JOURNAL   Sci Rep 4, 3664 (2014)
   PUBMED   24441171
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Grunberg,S. and Hahn,S.
  TITLE     Structural insights into transcription initiation by RNA polymerase
            II
  JOURNAL   Trends Biochem Sci 38 (12), 603-611 (2013)
   PUBMED   24120742
  REMARK    Review article
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Sang,A., Xu,Y., Jin,N., Zhou,T., Wang,J., Zhu,J., Chen,C., Shi,J.,
            Shuai,J., Xu,G. and Gu,Z.
  TITLE     Involvement of transcription initiation factor IIB in the
            light-induced death of rat retinal ganglion cells in vivo
  JOURNAL   J Mol Histol 44 (1), 11-18 (2013)
   PUBMED   23264107
  REMARK    GeneRIF: Spatiotemporal changes of TFIIB expression suggest that
            this protein may play a role in the degenerative process of RGCs by
            light-induced damage in the retina.
REFERENCE   6  (bases 1 to 1220)
  AUTHORS   Zawel,L., Kumar,K.P. and Reinberg,D.
  TITLE     Recycling of the general transcription factors during RNA
            polymerase II transcription
  JOURNAL   Genes Dev 9 (12), 1479-1490 (1995)
   PUBMED   7601352
REFERENCE   7  (bases 1 to 1220)
  AUTHORS   Ing,N.H., Beekman,J.M., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Members of the steroid hormone receptor superfamily interact with
            TFIIB (S300-II)
  JOURNAL   J Biol Chem 267 (25), 17617-17623 (1992)
   PUBMED   1517211
REFERENCE   8  (bases 1 to 1220)
  AUTHORS   Tsuboi,A., Conger,K., Garrett,K.P., Conaway,R.C., Conaway,J.W. and
            Arai,N.
  TITLE     RNA polymerase II initiation factor alpha from rat liver is almost
            identical to human TFIIB
  JOURNAL   Nucleic Acids Res 20 (12), 3250 (1992)
   PUBMED   1620622
REFERENCE   9  (bases 1 to 1220)
  AUTHORS   Ha,I., Lane,W.S. and Reinberg,D.
  TITLE     Cloning of a human gene encoding the general transcription
            initiation factor IIB
  JOURNAL   Nature 352 (6337), 689-695 (1991)
   PUBMED   1876184
REFERENCE   10 (bases 1 to 1220)
  AUTHORS   Reinberg,D. and Roeder,R.G.
  TITLE     Factors involved in specific transcription by mammalian RNA
            polymerase II. Purification and functional analysis of initiation
            factors IIB and IIE
  JOURNAL   J Biol Chem 262 (7), 3310-3321 (1987)
   PUBMED   3029109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X65948.1, BC085345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000002.1  234427734-234427759
            27-133              JAXUCZ010000002.1  234433581-234433687
            134-267             JAXUCZ010000002.1  234441576-234441709
            268-414             JAXUCZ010000002.1  234442514-234442660
            415-544             JAXUCZ010000002.1  234442793-234442922
            545-826             JAXUCZ010000002.1  234443883-234444164
            827-1220            JAXUCZ010000002.1  234445650-234446043
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1220
                     /gene="Gtf2b"
                     /note="general transcription factor IIB"
                     /db_xref="GeneID:81673"
                     /db_xref="RGD:619735"
     exon            1..26
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..960
                     /gene="Gtf2b"
                     /EC_number="2.3.1.48"
                     /note="general transcription factor TFIIB; RNA polymerase
                     II alpha initiation factor"
                     /codon_start=1
                     /product="transcription initiation factor IIB"
                     /protein_id="NP_112303.1"
                     /db_xref="GeneID:81673"
                     /db_xref="RGD:619735"
                     /translation="MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDR
                     VIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQ
                     NRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIA
                     SACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRF
                     CSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGD
                     IAGVADVTIRQSYRLIYPRAPDLFPSDFKFDTPVDKLPQL"
     exon            27..133
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            134..267
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            268..414
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            415..544
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            545..826
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1220
                     /gene="Gtf2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttgaaga tggcgtcgac cagccgtttg gatgctctcc cacgagtcac atgtcccaat
       61 catccagatg cgattttagt tgaggactac agagctggcg acatgatctg tcccgaatgc
      121 ggcctagttg taggggaccg ggttattgat gtggggtctg aatggagaac tttcagcaat
      181 gacaaagcaa cgaaagaccc atctcgagtt ggagactctc agaatcctct tctgagtgat
      241 ggagatttgt ccaccatgat tggcaagggt acaggagcgg caagttttga tgaatttggc
      301 aattctaagt atcagaaccg gagaacaatg agcagctctg atagagctat gatgaacgca
      361 ttcaaggaga tcacgaccat ggcagacaga atcaacctcc cacgcaatat agttgatcga
      421 acaaataatt tattcaagca agtatatgag cagaagagcc tgaagggaag agctaatgat
      481 gcgatagctt ctgcttgtct gtacatcgct tgtagacaag aaggcgttcc caggacattt
      541 aaagaaatat gtgctgtgtc tcgaatctct aagaaagaaa ttggccgttg ttttaaactg
      601 attttgaaag ctttggagac gagcgtggat ctgatcacaa ctggggactt catgtccagg
      661 ttctgctcca acctttgcct ccccaagcaa gtgcagatgg cagctacaca catagcccgc
      721 aaggctgtgg agctggactt ggttcctggc aggagtccta tctctgtggc ggcagcagct
      781 atttacatgg cctcccaggc ttcagctgag aagcgaacac agaaagaaat cggggatatt
      841 gctggtgttg ctgatgttac aatccgacag tcctacagac tgatctaccc tcgggctcca
      901 gatctcttcc cttcagactt caagtttgac accccagtgg acaaattacc ccagctataa
      961 gctgaggcaa ctaagtgtca cactcttaat gtacatggaa ctttgtgcat agccacacag
     1021 tgctggttga gcctttaatg aggaaaaagg agatggtacg cattccacag ctaagtatta
     1081 ttgcttagtc ttctgtatgt atatagtagt gcgacatatt taatgactta aatttcttac
     1141 tgattctgct ttctttttta gtgatctagg aaacagtatt ttggaagata ttaaaatatg
     1201 taattctcaa ataaaatttt
//
