LOCUS       NM_001393689            2517 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus glycosyltransferase-like domain containing 1
            (Gtdc1), transcript variant 1, mRNA.
ACCESSION   NM_001393689
VERSION     NM_001393689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.13082.1,
                                           SRR26643285.11540.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000003.1  49571036-49571115   c
            81-116              JAXUCZ010000003.1  49473727-49473762   c
            117-309             JAXUCZ010000003.1  49426805-49426997   c
            310-477             JAXUCZ010000003.1  49364058-49364225   c
            478-651             JAXUCZ010000003.1  49356899-49357072   c
            652-966             JAXUCZ010000003.1  49236574-49236888   c
            967-1076            JAXUCZ010000003.1  49201226-49201335   c
            1077-1221           JAXUCZ010000003.1  49187111-49187255   c
            1222-1292           JAXUCZ010000003.1  49182934-49183004   c
            1293-1384           JAXUCZ010000003.1  49182142-49182233   c
            1385-2517           JAXUCZ010000003.1  49176110-49177242   c
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2517
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /note="glycosyltransferase-like domain containing 1"
                     /db_xref="GeneID:362129"
                     /db_xref="RGD:1563393"
     exon            1..80
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            81..116
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            117..309
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1468
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like protein; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     1"
                     /protein_id="NP_001380618.1"
                     /db_xref="GeneID:362129"
                     /db_xref="RGD:1563393"
                     /translation="MSILIIEAFYGGSHRQLVELLREEVDDCVLYTLPAKKWHWRART
                     AALYFSQSVPSSEHYRVLFASSVLNLAELSALRPDLGKLKKILYFHENQLVYPVKKYQ
                     ERDFQYGYNQILSCLVADVVVFNSNFNMESFLTSIGKFLKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKIAHLRRMLSLIGNDAAALSVTLPPQPEQRLSKKSLENF
                     ESKSDEHPGLDTEQETLDTPTILKSVSLPVSEENPALGHSTFLCGAEDQQRPLHITWP
                     HRWEHDKDPETFLKVLMHLKELRLNFYVSVLGETFTDVPDIFSEAKKALGSSVLHWGY
                     LPSKEDYFRVLCTADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDLVYPEIFPAEYLY
                     STPEQLSKRLKSFCERPDIIRKHLYKGEVAPFSWAALHGKFRSLLTTEPREDL"
     exon            310..477
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            478..651
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            652..966
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1076
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1221
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1292
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1384
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..2517
                     /gene="Gtdc1"
                     /gene_synonym="QTMAN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagcgcgt cgccagctgg gctgtcggtg gcctggaggg agccgtggag gaggaggagg
       61 aggaggagaa ggaggaggag gtaccagatc ggatatcagt acatccggat cataaggttt
      121 gatcaagcca atgagtattc ttatcattga ggcattttat ggaggctccc atcgacagct
      181 ggtagagctg ctccgagaag aagtggatga ctgtgtgctg tacacccttc ctgcaaagaa
      241 atggcattgg cgagcacgca cagcagcgct gtacttctca cagagtgtgc ccagcagtga
      301 gcactacagg gtcctctttg caagctcagt actcaacctg gctgaactga gtgcacttcg
      361 gcctgatctg ggaaaattga agaagatact gtacttccat gaaaaccagt tggtatatcc
      421 tgtcaagaag tatcaggaga gggattttca atatggatat aaccaaattc tctcatgttt
      481 ggtggctgat gttgtggtat tcaattccaa ttttaatatg gaatcatttc ttacttctat
      541 tggaaaattc ctgaagctga ttcctgatca caggcctaag gatctggaaa gcattatcag
      601 acccaagtgt caagtaattt actttcccat cagatttcct gatgtgagca gattcatgcc
      661 caagcacaaa atagcccact taaggaggat gctcagcctt attggaaatg atgctgcagc
      721 gctgtctgtg acgcttcctc cccaaccaga gcagaggctt tctaagaagt cactggagaa
      781 ttttgaatca aagtctgatg aacaccctgg ccttgatact gaacaagaaa ccctggacac
      841 cccaacaatc ctcaaatcag tctcccttcc tgtgagcgaa gaaaacccgg ctcttggtca
      901 cagcaccttt ttgtgtggag ctgaagatca gcagagaccg ctgcacatta catggccgca
      961 caggtgggag catgacaaag atccagagac gtttttaaag gtcttaatgc atctaaaaga
     1021 gttaaggctc aatttctacg tctctgtcct tggagagact tttacagatg taccagatat
     1081 attttcagaa gccaaaaagg cactgggctc ttcagtcttg cactggggct acttacccag
     1141 taaagaagac tatttccgag tactgtgcac ggctgatgtt gtcatctcaa cagccaagca
     1201 tgaattcttt ggagtagcaa tgttggaagc tgtgtactgt ggctgttacc cactctgtcc
     1261 caaagacttg gtttatcctg aaatctttcc agctgagtat ctgtattcca cacctgaaca
     1321 gctttcaaaa aggctcaaga gtttctgtga gagaccagac attataagaa aacatcttta
     1381 taagggtgaa gtggctccat tttcttgggc agccctacat ggtaaattca ggtctctgct
     1441 cacaacagaa cccagggaag atttgtgaca gatggggcta agtcgcaaac ttgcagccta
     1501 aggcagaatc tgaagaactt tccagagtgt gcccatattt acctgatcag agagaaaaga
     1561 aaatctgcag aggaagccga gcctggctgc ttgtcatagc tgacacagag ccatctgcca
     1621 caaacctgtg gcagcttcag atctccaatc cctgccacca ccccaacgca aattaaatac
     1681 agattcctag agacgctatg atggttacac atgtcctcgg catcacatgt aggagactgt
     1741 tcaaaaaaaa atatgtggcc tgttgtataa ccgcactcat gtatcccata tgtggtgcca
     1801 cattgaattt ccggttgaat ccgtttttat cctttgtact ggatgacatg gtgcctgaat
     1861 tctttctctc tgccgacacg atggcagcca aactgcagct tcaaacactc acacttggcc
     1921 gagtttctac ctgggttgcc aggttatcat cggagccttc ttgtgtcctc aaagggccac
     1981 ggggcctaga aagaggatca gaatgctacc gaactaattg ggtagccatc tcaaagctgc
     2041 tgtaggcaaa ggactgcttt agcacttttc ttttagcaaa ttaatgactc tctggcaaag
     2101 gaggtttaag tgaaggtatt aataaggggt ctggcaggta ttcccatgat tcacagggtt
     2161 tcatttgcat ttaattaatc ttaaagaaac ttgcaagata aacagctgta attcggacaa
     2221 acatggcaga ttcagtgagt gaagtcctct catccataaa atgaacacga gatacttgtt
     2281 ttaaaatttt tccctgtggg taaaaagaga aaaatcaaaa tgctcataac aaaacataat
     2341 ttggtacaaa attcctcaaa aatacttgca tccaactata aatatattcc ttttaagata
     2401 agtcacttat gattcttgga gtcaggctgc tctgtttgtt ggtgtaaaga tgttttaaat
     2461 ggctggattg taaaataaat ttttaataaa ctgcccgctg caattttaat tagcata
//
