LOCUS       NM_001137563            1677 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus GS homeobox 2 (Gsx2), mRNA.
ACCESSION   NM_001137563 XM_001076578 XM_344233
VERSION     NM_001137563.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1677)
  AUTHORS   De Mori,R., Severino,M., Mancardi,M.M., Anello,D., Tardivo,S.,
            Biagini,T., Capra,V., Casella,A., Cereda,C., Copeland,B.R.,
            Gagliardi,S., Gamucci,A., Ginevrino,M., Illi,B., Lorefice,E.,
            Musaev,D., Stanley,V., Micalizzi,A., Gleeson,J.G., Mazza,T.,
            Rossi,A. and Valente,E.M.
  TITLE     Agenesis of the putamen and globus pallidus caused by recessive
            mutations in the homeobox gene GSX2
  JOURNAL   Brain 142 (10), 2965-2978 (2019)
   PUBMED   31412107
REFERENCE   2  (bases 1 to 1677)
  AUTHORS   Wang,B., Long,J.E., Flandin,P., Pla,R., Waclaw,R.R., Campbell,K.
            and Rubenstein,J.L.
  TITLE     Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in
            Dlx1/2 mutants
  JOURNAL   J Comp Neurol 521 (7), 1561-1584 (2013)
   PUBMED   23042297
  REMARK    Erratum:[J Comp Neurol. 2024 Feb;532(2):e25592. PMID: 38362770]
REFERENCE   3  (bases 1 to 1677)
  AUTHORS   Carney,R.S., Cocas,L.A., Hirata,T., Mansfield,K. and Corbin,J.G.
  TITLE     Differential regulation of telencephalic pallial-subpallial
            boundary patterning by Pax6 and Gsh2
  JOURNAL   Cereb Cortex 19 (4), 745-759 (2009)
   PUBMED   18701439
REFERENCE   4  (bases 1 to 1677)
  AUTHORS   Mizuguchi,R., Kriks,S., Cordes,R., Gossler,A., Ma,Q. and
            Goulding,M.
  TITLE     Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in
            spinal sensory interneurons
  JOURNAL   Nat Neurosci 9 (6), 770-778 (2006)
   PUBMED   16715081
REFERENCE   5  (bases 1 to 1677)
  AUTHORS   Kriks,S., Lanuza,G.M., Mizuguchi,R., Nakafuku,M. and Goulding,M.
  TITLE     Gsh2 is required for the repression of Ngn1 and specification of
            dorsal interneuron fate in the spinal cord
  JOURNAL   Development 132 (13), 2991-3002 (2005)
   PUBMED   15930101
REFERENCE   6  (bases 1 to 1677)
  AUTHORS   Toresson,H. and Campbell,K.
  TITLE     A role for Gsh1 in the developing striatum and olfactory bulb of
            Gsh2 mutant mice
  JOURNAL   Development 128 (23), 4769-4780 (2001)
   PUBMED   11731457
REFERENCE   7  (bases 1 to 1677)
  AUTHORS   Yun,K., Potter,S. and Rubenstein,J.L.
  TITLE     Gsh2 and Pax6 play complementary roles in dorsoventral patterning
            of the mammalian telencephalon
  JOURNAL   Development 128 (2), 193-205 (2001)
   PUBMED   11124115
REFERENCE   8  (bases 1 to 1677)
  AUTHORS   Corbin,J.G., Gaiano,N., Machold,R.P., Langston,A. and Fishell,G.
  TITLE     The Gsh2 homeodomain gene controls multiple aspects of
            telencephalic development
  JOURNAL   Development 127 (23), 5007-5020 (2000)
   PUBMED   11060228
REFERENCE   9  (bases 1 to 1677)
  AUTHORS   Szucsik,J.C., Witte,D.P., Li,H., Pixley,S.K., Small,K.M. and
            Potter,S.S.
  TITLE     Altered forebrain and hindbrain development in mice mutant for the
            Gsh-2 homeobox gene
  JOURNAL   Dev Biol 191 (2), 230-242 (1997)
   PUBMED   9398437
REFERENCE   10 (bases 1 to 1677)
  AUTHORS   Hsieh-Li,H.M., Witte,D.P., Szucsik,J.C., Weinstein,M., Li,H. and
            Potter,S.S.
  TITLE     Gsh-2, a murine homeobox gene expressed in the developing brain
  JOURNAL   Mech Dev 50 (2-3), 177-186 (1995)
   PUBMED   7619729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NM_001137563.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.46579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-754               JAXUCZ010000014.1  33479567-33480320   c
            755-1677            JAXUCZ010000014.1  33477968-33478890   c
FEATURES             Location/Qualifiers
     source          1..1677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1677
                     /gene="Gsx2"
                     /gene_synonym="Gsh2"
                     /note="GS homeobox 2"
                     /db_xref="GeneID:364140"
                     /db_xref="RGD:1308047"
     exon            1..754
                     /gene="Gsx2"
                     /gene_synonym="Gsh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1095
                     /gene="Gsx2"
                     /gene_synonym="Gsh2"
                     /note="genomic screened homeo box 2 protein"
                     /codon_start=1
                     /product="GS homeobox 2"
                     /protein_id="NP_001131035.2"
                     /db_xref="GeneID:364140"
                     /db_xref="RGD:1308047"
                     /translation="MSRSFYVDSLIIKDSSRPAPSLPESHPGPDFFIPLGMPSPLVMS
                     VSGPGCPSRKSGAFCVCPLCVTSHLHSSRPPAGAGGGATGTAGAAVAGGGVAGGTGAL
                     PLLKSQFSPGPGDAQFCPRVSHAHHHHHAPQHHHHHHQPQQPGSAAAAAAAAAAAAAA
                     AAALGHPQHHAPVCAATTYNVSDPRRFHCLTMGGSDTSQVPNGKRMRTAFTSTQLLEL
                     EREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGASRNNHASCKCV
                     GSQAHYARSEDEDSLSPASANEDKEISPL"
     exon            755..1677
                     /gene="Gsx2"
                     /gene_synonym="Gsh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggacgtg aggaccaacc ctctccaggg acccctttgt tcgaatccca gtacacctca
       61 gcatccccaa gggcttgacc gcccgcgtac gcacagctct ctggacagag ctcagatcac
      121 ggaaagagag gaggggacgc cgcggcccgc tggacaagcc atcgatcccc cgtcgaaatg
      181 tcgcgctcct tctacgtgga ctcactcatc atcaaggact cctcgcggcc cgcaccctcg
      241 ctgccggaat cgcacccagg tccggatttc ttcatcccgc tgggcatgcc gtccccgttg
      301 gtgatgtcag tgtccgggcc tggctgtccg tcccgcaaaa gcggcgcttt ttgcgtgtgc
      361 ccgctttgcg tcacctcgca cctgcactcc tctcgcccgc ccgctggagc gggtggcgga
      421 gctacgggga ccgcaggggc tgcggtggcg ggcggcgggg tggctggagg cacgggcgcc
      481 ctacctttgc ttaagagcca gttctctccc ggtcctgggg acgcgcagtt ttgcccacgg
      541 gtgagccacg cacaccatca ccaccacgct ccccaacatc accatcacca ccatcagccc
      601 cagcagcccg gctcggctgc agcggcggcg gctgcggcgg ctgcggcagc ggccgcagcg
      661 gcggccctgg gacacccgca gcaccacgca cctgtctgcg ccgccacaac ctacaacgtg
      721 tccgacccgc ggagattcca ctgcctcacc atgggaggct cagataccag ccaggtaccc
      781 aatggcaaaa ggatgaggac ggcatttacc agcacgcagc tcctggagct ggagcgagaa
      841 ttctcttcca atatgtacct gtcccgactc cggagaatcg agatcgcgac gtacctgaac
      901 ctgtcagaga agcaggtgaa aatctggttt cagaaccgtc gcgtgaagca caagaaggag
      961 gggaaaggcg cttcgaggaa caatcacgca agctgcaagt gcgtgggtag ccaggctcac
     1021 tatgcgcgct cagaggacga ggactccttg tccccagcct cggctaacga agacaaggag
     1081 atttccccct tgtaagggcg gaggctcctt ctccgggtac ctactctcgg taccccgctt
     1141 ccctcctccc tgtcagcaca gggaccaaag ttctagctca ttgccctcat cccacctgga
     1201 agagaaactc tgaaaagccc ggggagtcca gtgttgggcc cggctttgaa gctagttcct
     1261 ctatatctgg gactccactc agttacagat cggcttttta tctgttggct ttttaaaaaa
     1321 tttttttaaa tgtaaatact ctagaatctt aatctgtctc acataacagg aaaaaacagg
     1381 gttgatttaa atataacact atatgggggg gcgttggttg aagccgcatg tcattggcca
     1441 cccctatctt ttcagaattt gatgagaact tgtttttgtt gttgttttaa aatgaagtca
     1501 ttgaagttgc cattaatata gagttaaact ccgtaggtct tgttttctga catttttcat
     1561 gggggagagt tttaaacaca agcctctgga agtcccttcg tatgtgaata gttttatata
     1621 aaatacatat ttatatttat ttaaataaat gaaacgaaat aaatattttt aattcgt
//
