LOCUS       NM_001109445            1670 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus glutathione S-transferase zeta 1 (Gstz1), mRNA.
ACCESSION   NM_001109445 XM_001061450 XM_001061506 XM_001061560 XM_001061615
VERSION     NM_001109445.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Jahn,S.C., Smeltz,M.G., Hu,Z., Rowland-Faux,L., Zhong,G.,
            Lorenzo,R.J., Cisneros,K.V., Stacpoole,P.W. and James,M.O.
  TITLE     Regulation of dichloroacetate biotransformation in rat liver and
            extrahepatic tissues by GSTZ1 expression and chloride concentration
  JOURNAL   Biochem Pharmacol 152, 236-243 (2018)
   PUBMED   29626439
  REMARK    GeneRIF: This study evaluated the metabolism of dichloroacetic acid
            in liver, hear, brain, and kidney via GSTZ1.
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Li,W., James,M.O., McKenzie,S.C., Calcutt,N.A., Liu,C. and
            Stacpoole,P.W.
  TITLE     Mitochondrion as a novel site of dichloroacetate biotransformation
            by glutathione transferase zeta 1
  JOURNAL   J Pharmacol Exp Ther 336 (1), 87-94 (2011)
   PUBMED   20884751
  REMARK    GeneRIF: The mitochondrion is a second site of dichloroacetate
            biotransformation in a reaction catalyzed by GSTZ1, an enzyme
            colocalized in the mitochondrial matrix and cytosol.
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Polekhina,G., Board,P.G., Blackburn,A.C. and Parker,M.W.
  TITLE     Crystal structure of maleylacetoacetate isomerase/glutathione
            transferase zeta reveals the molecular basis for its remarkable
            catalytic promiscuity
  JOURNAL   Biochemistry 40 (6), 1567-1576 (2001)
   PUBMED   11327815
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Blackburn,A.C., Tzeng,H.F., Anders,M.W. and Board,P.G.
  TITLE     Discovery of a functional polymorphism in human glutathione
            transferase zeta by expressed sequence tag database analysis
  JOURNAL   Pharmacogenetics 10 (1), 49-57 (2000)
   PUBMED   10739172
REFERENCE   6  (bases 1 to 1670)
  AUTHORS   Tong,Z., Board,P.G. and Anders,M.W.
  TITLE     Glutathione transferase zeta catalyses the oxygenation of the
            carcinogen dichloroacetic acid to glyoxylic acid
  JOURNAL   Biochem J 331 (Pt 2) (Pt 2), 371-374 (1998)
   PUBMED   9531472
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061615.1, XM_001061450.1, XM_001061560.1, XM_001061506.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158833.1, FJ179410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132265, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1670
                     /gene="Gstz1"
                     /note="glutathione S-transferase zeta 1"
                     /db_xref="GeneID:681913"
                     /db_xref="RGD:1589363"
     exon            1..138
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..774
                     /gene="Gstz1"
                     /EC_number="2.5.1.18"
                     /EC_number="5.2.1.2"
                     /note="glutathione S-transferase alpha 3; glutathione
                     transferase zeta 1; MAAI; GSTZ1-1"
                     /codon_start=1
                     /product="maleylacetoacetate isomerase"
                     /protein_id="NP_001102915.1"
                     /db_xref="GeneID:681913"
                     /db_xref="RGD:1589363"
                     /translation="MQAGKPVLYSYFRSSCSWRVRIALALKGIDYEIVPINLIKDGGQ
                     QFSEEFQTLNPMKQVPALKIDGITIGQSLAILEYLEETRPIPRLLPQDPQKRAIVRMI
                     SDLIASGIQPLQNLSVLKQVGQENQMPWAQKAITSGFNALEKILQSTAGKYCVGDEVS
                     MADVCLAPQVANAERFKVDLSPYPTISHINKALLALEAFQVSHPCRQPDTPAELRT"
     exon            139..190
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..258
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..339
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..465
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..544
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..597
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..647
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1670
                     /gene="Gstz1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcgggg ccagcccgaa ggagggaacg ccatctagtc caaccttcgc tctctggacc
       61 ccgctaggcc tcagtcatct tctagtcctg agaactgact ttcttggctg gccgacgggc
      121 gagatgcaag ccgggaagcc tgttctctat tcctatttcc gaagctcctg ttcatggaga
      181 gttcgaattg ctctggcgtt aaaaggcatt gactatgaga tagtgcccat caacctcata
      241 aaggatggcg ggcaacagtt ctccgaggaa tttcagaccc tgaatcccat gaagcaagtg
      301 ccagcactga agattgatgg aatcaccatt ggccagtcac tggccatcct ggagtacctg
      361 gaagagactc gacccatccc acggctcctg ccccaggacc cacagaaaag agccatcgtg
      421 cgcatgattt ctgacctcat cgccagtggc atccagcccc ttcagaacct gtctgtcctg
      481 aagcaagtgg gacaggagaa ccagatgcct tgggcccaaa aggctattac ttccggcttt
      541 aatgctctgg agaagatcct gcaaagcaca gcagggaagt actgtgtagg agatgaggtg
      601 tccatggctg atgtgtgctt agcgccccaa gtggcaaatg ctgaaaggtt caaggtggac
      661 ctaagcccct accctaccat cagtcacatc aacaaggcac tgctggcctt agaggctttc
      721 caagtgtctc acccctgtcg acagccagat acaccggccg agctgaggac ttagctccca
      781 aaccatgcct cactggtaca gggaggggag tagggctcag atgttgggtg tcttagggtt
      841 ttactgctgt gaagagacac caagaccatg gcaactctaa aagaggaaaa catttaattg
      901 gggtgggctt acagtttcag aggttcagtc tattatcatc atggtgggag catggtagca
      961 tccaggcaca catggtgttg gagaggtaac tgagagttca catctggatc cgaaggcagc
     1021 aggaagaggg agtgacactg ggcctggcat gagcaacctg aaaccttaaa gccggttccc
     1081 aatgatactt ttcctccaaa aaggccacac ctgctattag tgccactacc aacgtacccg
     1141 atgggggtca tttttgttca aatccaagca ggcccagaaa tgaatgaatt gtagtagagg
     1201 atttgaactt tagctctttc ctcaagaagc agcagattcg tggagtccat gatatttctt
     1261 caaggtcccc atattaagag ttttctctag cgaaatgaag ccagtaggat atatcttcct
     1321 cctgcttgca ctgtagcccc tacattctgc cttcatcctc ttacctgtca tgtgttagga
     1381 ggggggaggc agagacatgg cctgctctgc taatgataat tgtcaacttg aaataaaatt
     1441 agagtcacta gggaaaaggg cctttatgaa tgtctgttga agtgggaaga ctcacccatc
     1501 acggatggca ccattccctg ggtagaggat cctgggacta gaagagtaga gaaagagtgg
     1561 agcaactgcc atgtgtgcat tctgattggt tctcacgcag atgccttgac tcccctgcca
     1621 ttaccgactg taacctgaga ctatgagcca aaataaacct cctctccttt
//
