LOCUS       NM_012796               1381 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase theta 2 (Gstt2), mRNA.
ACCESSION   NM_012796
VERSION     NM_012796.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1381)
  AUTHORS   Weh,K.M., Turgeon,D.K., Rubenstein,J.H., Clarke,J.L., Howell,A.B.,
            Chang,A.C. and Kresty,L.A.
  TITLE     Proanthocyanidins mitigate bile acid-induced changes in GSTT2
            levels in a panel of racially diverse patient-derived primary
            esophageal cell cultures
  JOURNAL   Mol Carcinog 61 (3), 281-287 (2022)
   PUBMED   34758158
  REMARK    GeneRIF: Proanthocyanidins mitigate bile acid-induced changes in
            GSTT2 levels in a panel of racially diverse patient-derived primary
            esophageal cell cultures.
REFERENCE   2  (bases 1 to 1381)
  AUTHORS   Fledrich,R., Schlotter-Weigel,B., Schnizer,T.J., Wichert,S.P.,
            Stassart,R.M., Meyer zu Horste,G., Klink,A., Weiss,B.G., Haag,U.,
            Walter,M.C., Rautenstrauss,B., Paulus,W., Rossner,M.J. and
            Sereda,M.W.
  TITLE     A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease
            variability and supplies biomarkers of axonal loss in patients
  JOURNAL   Brain 135 (Pt 1), 72-87 (2012)
   PUBMED   22189569
REFERENCE   3  (bases 1 to 1381)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 1381)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   5  (bases 1 to 1381)
  AUTHORS   Coggan,M., Flanagan,J.U., Parker,M.W., Vichai,V., Pearson,W.R. and
            Board,P.G.
  TITLE     Identification and characterization of GSTT3, a third murine Theta
            class glutathione transferase
  JOURNAL   Biochem J 366 (Pt 1), 323-332 (2002)
   PUBMED   12038961
REFERENCE   6  (bases 1 to 1381)
  AUTHORS   Mainwaring,G.W., Williams,S.M., Foster,J.R., Tugwood,J. and
            Green,T.
  TITLE     The distribution of theta-class glutathione S-transferases in the
            liver and lung of mouse, rat and human
  JOURNAL   Biochem J 318 (Pt 1) (Pt 1), 297-303 (1996)
   PUBMED   8761485
REFERENCE   7  (bases 1 to 1381)
  AUTHORS   Ogura,K., Nishiyama,T., Hiratsuka,A., Watabe,T. and Watabe,T.
  TITLE     Isolation and characterization of the gene encoding rat class theta
            glutathione S-transferase subunit yrs
  JOURNAL   Biochem Biophys Res Commun 205 (2), 1250-1256 (1994)
   PUBMED   7802657
REFERENCE   8  (bases 1 to 1381)
  AUTHORS   Ogura,K., Nishiyama,T., Okada,T., Kajital,J., Narihata,H.,
            Watabe,T., Hiratsuka,A. and Watabe,T.
  TITLE     Molecular cloning and amino acid sequencing of rat liver class
            theta glutathione S-transferase Yrs-Yrs inactivating reactive
            sulfate esters of carcinogenic arylmethanols
  JOURNAL   Biochem Biophys Res Commun 181 (3), 1294-1300 (1991)
   PUBMED   1764080
REFERENCE   9  (bases 1 to 1381)
  AUTHORS   Meyer,D.J., Coles,B., Pemble,S.E., Gilmore,K.S., Fraser,G.M. and
            Ketterer,B.
  TITLE     Theta, a new class of glutathione transferases purified from rat
            and man
  JOURNAL   Biochem J 274 (Pt 2) (Pt 2), 409-414 (1991)
   PUBMED   1848757
REFERENCE   10 (bases 1 to 1381)
  AUTHORS   Hiratsuka,A., Sebata,N., Kawashima,K., Okuda,H., Ogura,K.,
            Watabe,T., Satoh,K., Hatayama,I., Tsuchida,S., Ishikawa,T. et al.
  TITLE     A new class of rat glutathione S-transferase Yrs-Yrs inactivating
            reactive sulfate esters as metabolites of carcinogenic
            arylmethanols
  JOURNAL   J Biol Chem 265 (20), 11973-11981 (1990)
   PUBMED   2114406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK473092.1 and JAXUCZ010000020.1.
            
            On Oct 24, 2007 this sequence version replaced NM_012796.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK473092.1, FJ179409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-700               CK473092.1         1-700
            701-1381            JAXUCZ010000020.1  12822044-12822724
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1381
                     /gene="Gstt2"
                     /note="glutathione S-transferase theta 2"
                     /db_xref="GeneID:29487"
                     /db_xref="RGD:69362"
     exon            1..246
                     /gene="Gstt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..869
                     /gene="Gstt2"
                     /EC_number="2.5.1.18"
                     /note="GST 12-12; GST class-theta-2; glutathione
                     S-transferase 12; glutathione S-transferase Yrs-Yrs;
                     glutathione S-transferase theta-2-like"
                     /codon_start=1
                     /product="glutathione S-transferase theta-2"
                     /protein_id="NP_036928.1"
                     /db_xref="GeneID:29487"
                     /db_xref="RGD:69362"
                     /translation="MGLELYLDLLSQPSRAVYIFAKKNGIPFQLRTVDLLKGQHLSEQ
                     FSQVNCLKKVPVLKDGSFVLTESTAILIYLSSKYQVADHWYPADLQARAQVHEYLGWH
                     ADNIRGTFGVLLWTKVLGPLIGVQVPEEKVERNRNSMVLALQRLEDKFLRDRAFIAGQ
                     QVTLADLMSLEELIQPVALGCNLFEGRPQLTAWRERVEAFLGAELCQEAHNPIMSVLG
                     QAAKKTLPVPPPEAHASMMLRIARIP"
     exon            247..334
                     /gene="Gstt2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..485
                     /gene="Gstt2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..659
                     /gene="Gstt2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..1381
                     /gene="Gstt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgtccag aagggggaac gcgtcagact tggccaactg aggctgggct ggacccctat
       61 tgtggaatcg cggacacttc ctacagttgt cgaacgcaat ccgtctacac caccttgtgt
      121 cactacctac caccatgggt ttggagctct acctggacct gctgtcgcag cccagccgcg
      181 cggtctacat cttcgccaag aagaatggca tcccctttca gttgcgtacc gtggatttac
      241 tcaaagggca gcacttgagc gagcaattct cccaggtgaa ctgcttaaag aaagtgcctg
      301 tcctcaaaga cggaagcttc gtgttgaccg aaagcactgc catcttgatt tacctgagtt
      361 ccaagtacca ggtggcagac cactggtacc cggccgacct acaggcccgt gcccaagtcc
      421 acgaatacct gggttggcat gccgacaaca tccgtggcac ctttggagta ctcctgtgga
      481 ccaaggtgtt ggggccactc attggggtcc aggttcccga ggaaaaggtg gaacggaaca
      541 gaaatagtat ggtcttggct ctgcaacgtc tggaggacaa gttcctcagg gacagggcct
      601 tcattgctgg ccagcaggtg acgctagcgg atctcatgtc tctagaggag ttgatacagc
      661 cggtggctct tggctgtaat ctgtttgagg ggcggcctca actgacagcg tggcgagaga
      721 gggtggaggc gttcttgggt gctgagctat gtcaggaggc gcacaacccc atcatgagcg
      781 tcctgggaca ggcagccaag aaaacattac cagtaccccc tccggaggcc catgccagca
      841 tgatgcttcg aattgccagg attccctgag tggttttttt tccctgagta tttttattgc
      901 tataaagact cattttgtat tttgcctctt tgttttgttt tgtttttgtt tcttcttgtc
      961 ccaacctttt tttttttttt tttttttttt cggagctggg gaccgaaccc agggccttgc
     1021 gcttcctagg caagcgctct accactgagc taaatcccca acccccccct tttttttttt
     1081 ctggctcctt ttctggctct gggaggagct ttgctcaaaa gggacaccac ctatccttag
     1141 catgcttctc ttgaggtaca gtatgcacaa ccaataggag acccaagtca ataatatata
     1201 aaaggtgctt aaaaaaaaaa aaaaagcaaa cagtaacaca cacgaagaaa tcaaccaaaa
     1261 gttggtgaac atctgttttt tattataata tagattctga atattttaag gaataaagag
     1321 ttattgtttt attacattgc cctctaatct gtatggaata aaattatgac tttgtaaaac
     1381 a
//
