LOCUS       NM_053293               1090 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase theta 1 (Gstt1), mRNA.
ACCESSION   NM_053293
VERSION     NM_053293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1090)
  AUTHORS   Pei,J., Tian,X., Yu,C., Luo,J., Zhang,J., Hua,Y. and Wei,G.
  TITLE     GPX3 and GSTT1 as biomarkers related to oxidative stress during
            renal ischemia reperfusion injuries and their relationship with
            immune infiltration
  JOURNAL   Front Immunol 14, 1136146 (2023)
   PUBMED   37033969
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1090)
  AUTHORS   DeMarini,D.M., Warren,S.H., Smith,W.J., Richardson,S.D. and
            Liberatore,H.K.
  TITLE     Inability of GSTT1 to activate iodinated halomethanes to mutagens
            in Salmonella
  JOURNAL   Environ Mol Mutagen 62 (3), 168-176 (2021)
   PUBMED   33484035
  REMARK    GeneRIF: Inability of GSTT1 to activate iodinated halomethanes to
            mutagens in Salmonella.
REFERENCE   3  (bases 1 to 1090)
  AUTHORS   Saadat,M.
  TITLE     An evidence for correlation between the glutathione S-transferase
            T1 (GSTT1) polymorphism and outcome of COVID-19
  JOURNAL   Clin Chim Acta 508, 213-216 (2020)
   PUBMED   32454047
REFERENCE   4  (bases 1 to 1090)
  AUTHORS   Decharatchakul,N., Settasatian,C., Settasatian,N., Komanasin,N.,
            Kukongviriyapan,U., Intharapetch,P., Senthong,V. and
            Sawanyawisuth,K.
  TITLE     Association of combined genetic variations in SOD3, GPX3, PON1, and
            GSTT1 with hypertension and severity of coronary artery disease
  JOURNAL   Heart Vessels 35 (7), 918-929 (2020)
   PUBMED   32034489
REFERENCE   5  (bases 1 to 1090)
  AUTHORS   Zhang,L., Xu,P., Cheng,Y., Wang,P., Ma,X., Liu,M., Wang,X. and
            Xu,F.
  TITLE     Diet-induced obese alters the expression and function of hepatic
            drug-metabolizing enzymes and transporters in rats
  JOURNAL   Biochem Pharmacol 164, 368-376 (2019)
   PUBMED   31063713
REFERENCE   6  (bases 1 to 1090)
  AUTHORS   Chen,H., Sandler,D.P., Taylor,J.A., Shore,D.L., Liu,E.,
            Bloomfield,C.D. and Bell,D.A.
  TITLE     Increased risk for myelodysplastic syndromes in individuals with
            glutathione transferase theta 1 (GSTT1) gene defect
  JOURNAL   Lancet 347 (8997), 295-297 (1996)
   PUBMED   8569364
REFERENCE   7  (bases 1 to 1090)
  AUTHORS   Ogura,K., Nishiyama,T., Hiratsuka,A., Watabe,T. and Watabe,T.
  TITLE     Isolation and characterization of the gene encoding rat class theta
            glutathione S-transferase subunit yrs
  JOURNAL   Biochem Biophys Res Commun 205 (2), 1250-1256 (1994)
   PUBMED   7802657
REFERENCE   8  (bases 1 to 1090)
  AUTHORS   Pemble,S.E. and Taylor,J.B.
  TITLE     An evolutionary perspective on glutathione transferases inferred
            from class-theta glutathione transferase cDNA sequences
  JOURNAL   Biochem J 287 (Pt 3) (Pt 3), 957-963 (1992)
   PUBMED   1445253
REFERENCE   9  (bases 1 to 1090)
  AUTHORS   Ogura,K., Nishiyama,T., Okada,T., Kajital,J., Narihata,H.,
            Watabe,T., Hiratsuka,A. and Watabe,T.
  TITLE     Molecular cloning and amino acid sequencing of rat liver class
            theta glutathione S-transferase Yrs-Yrs inactivating reactive
            sulfate esters of carcinogenic arylmethanols
  JOURNAL   Biochem Biophys Res Commun 181 (3), 1294-1300 (1991)
   PUBMED   1764080
REFERENCE   10 (bases 1 to 1090)
  AUTHORS   Meyer,D.J., Coles,B., Pemble,S.E., Gilmore,K.S., Fraser,G.M. and
            Ketterer,B.
  TITLE     Theta, a new class of glutathione transferases purified from rat
            and man
  JOURNAL   Biochem J 274 (Pt 2) (Pt 2), 409-414 (1991)
   PUBMED   1848757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086426.1.
            
            On Nov 22, 2004 this sequence version replaced NM_053293.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086426.1, X67654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1090
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /note="glutathione S-transferase theta 1"
                     /db_xref="GeneID:25260"
                     /db_xref="RGD:2765"
     exon            1..142
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..753
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /EC_number="2.5.1.18"
                     /note="GST 5-5; GST class-theta-1; glutathione
                     S-transferase 5; Glutathione S-transferase 1 (theta)"
                     /codon_start=1
                     /product="glutathione S-transferase theta-1"
                     /protein_id="NP_445745.1"
                     /db_xref="GeneID:25260"
                     /db_xref="RGD:2765"
                     /translation="MVLELYLDLLSQPCRAIYIFAKKNNIPFQMHTVELRKGEHLSDA
                     FAQVNPMKKVPAMKDGGFTLCESVAILLYLAHKYKVPDHWYPQDLQARARVDEYLAWQ
                     HTTLRRSCLRTLWHKVMFPVFLGEQIRPEMLAATLADLDVNVQVLEDQFLQDKDFLVG
                     PHISLADVVAITELMHPVGGGCPVFEGRPRLAAWYRRVEAAVGKDLFLEAHEVILKVR
                     DCPPADPVIKQKLMPRVLTMIQ"
     exon            143..230
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /inference="alignment:Splign:2.1.0"
     exon            231..381
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /inference="alignment:Splign:2.1.0"
     exon            382..558
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /inference="alignment:Splign:2.1.0"
     exon            559..949
                     /gene="Gstt1"
                     /gene_synonym="GSTYRS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttacggaag tagttcccgc tgcttatgcc atggtcctgg aactgtacct ggatctgctg
       61 tcgcagccct gtcgcgctat ttatatcttc gccaagaaga acaatatccc gttccagatg
      121 catactgtgg agctgcgcaa gggtgagcac ctcagcgatg cctttgccca ggtgaacccc
      181 atgaagaagg taccagccat gaaggatggt ggcttcacct tgtgtgagag tgtggccatc
      241 ctgctctacc tggcgcacaa gtataaggtt cctgaccact ggtaccccca agacctgcag
      301 gcccgtgctc gtgtggatga gtacctggca tggcagcata cgacccttcg gagaagctgt
      361 ctccggaccc tgtggcataa ggtgatgttc cccgttttcc tgggtgagca gatacgcccg
      421 gagatgctgg cagccacatt ggcagatctg gatgttaacg tacaggtgct ggaagaccag
      481 ttcctccagg acaaagactt ccttgtcgga ccgcacatct ccctggctga cgtggtagct
      541 atcacagagc tgatgcatcc tgtaggtggt ggctgcccag tctttgaagg gcgtcccagg
      601 ctggctgcat ggtacaggag agtggaggca gctgtgggga aggacctctt cctggaggcc
      661 catgaggtca tcctgaaggt gagagactgt ccacctgctg accccgtcat aaagcaaaag
      721 ctgatgccca gagtgctgac catgatccag tgacgtcaga agcttcatcc ctgcaccagc
      781 caggccactc gcattacacg actgtgcgcc ccagccctca cggcatgatg gtttctgggc
      841 gagggtccct cttcaccctt ttcccatgct agccacccat ggtcacaact acaaccacta
      901 cttttccctt tgagtttggg caataaaccg aggctcgatt cgagctttaa aaaaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1021 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa
//
