LOCUS       NM_012577                769 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus glutathione S-transferase pi 1 (Gstp1), mRNA.
ACCESSION   NM_012577 NM_138974 XM_346578
VERSION     NM_012577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 769)
  AUTHORS   Lei,J., Zheng,F., Chen,L., Zhang,R., Yang,Y., Yin,Z. and Luo,L.
  TITLE     Gstp1 negatively regulates blood pressure in hypertensive rat via
            promoting APLNR ubiquitination degradation mediated by Nedd4
  JOURNAL   Clin Sci (Lond) 138 (14), 883-900 (2024)
   PUBMED   38959295
  REMARK    GeneRIF: Gstp1 negatively regulates blood pressure in hypertensive
            rat via promoting APLNR ubiquitination degradation mediated by
            Nedd4.
REFERENCE   2  (bases 1 to 769)
  AUTHORS   Oliveira de Araujo Melo,C., Cidalia Vieira,T., Duarte
            Gigonzac,M.A., Soares Fortes,J., Moreira Duarte,S.S., da Cruz,A.D.
            and Silva,D.M.E.
  TITLE     Evaluation of polymorphisms in repair and detoxification genes in
            alcohol drinkers and non-drinkers using capillary electrophoresis
  JOURNAL   Electrophoresis 41 (3-4), 254-258 (2020)
   PUBMED   31886888
REFERENCE   3  (bases 1 to 769)
  AUTHORS   Yang,Y., Kimura-Ohba,S., Thompson,J.F., Salayandia,V.M., Cosse,M.,
            Raz,L., Jalal,F.Y. and Rosenberg,G.A.
  TITLE     Vascular tight junction disruption and angiogenesis in
            spontaneously hypertensive rat with neuroinflammatory white matter
            injury
  JOURNAL   Neurobiol Dis 114, 95-110 (2018)
   PUBMED   29486300
REFERENCE   4  (bases 1 to 769)
  AUTHORS   Satoh,K.
  TITLE     Strong carcinogenic stress response induction of preneoplastic
            cells positive for GST-P in the rat liver: Physiological mechanism
            for initiation
  JOURNAL   Life Sci 200, 42-48 (2018)
   PUBMED   29501922
  REMARK    GeneRIF: The cytotoxic action of 2-acetylaminofluorene that give
            rise to the GST-P(+) single hepatocytes was suggested to be an
            injury to the excretory pump(s) and the duct of hepatocytes. A new
            physiological mechanism was hypothesized for the induction of
            preneoplastic cell populations in the rat liver instead of a
            genetic mechanism.
REFERENCE   5  (bases 1 to 769)
  AUTHORS   Oz,O., Aras Ates,N., Tamer,L., Yildirim,O. and Adiguzel,U.
  TITLE     Glutathione s-transferase m1, t1, and p1 gene polymorphism in
            exudative age-related macular degeneration: a preliminary report
  JOURNAL   Eur J Ophthalmol 16 (1), 105-110 (2006)
   PUBMED   28221473
REFERENCE   6  (bases 1 to 769)
  AUTHORS   Kong,K.H., Nishida,M., Inoue,H. and Takahashi,K.
  TITLE     Tyrosine-7 is an essential residue for the catalytic activity of
            human class PI glutathione S-transferase: chemical modification and
            site-directed mutagenesis studies
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1122-1129 (1992)
   PUBMED   1540159
REFERENCE   7  (bases 1 to 769)
  AUTHORS   Hatayama,I., Yamada,Y., Tanaka,K., Ichihara,A. and Sato,K.
  TITLE     Induction of glutathione S-transferase P-form in primary cultured
            rat hepatocytes by epidermal growth factor and insulin
  JOURNAL   Jpn J Cancer Res 82 (7), 807-814 (1991)
   PUBMED   1908848
REFERENCE   8  (bases 1 to 769)
  AUTHORS   Cho,K.J., Myong,N.H. and Jang,J.J.
  TITLE     The enhancing effect of ethanol on the development of glutatione
            S-transferase placental form-positive foci induced by
            diethylnitrosamine in F344 rat
  JOURNAL   J Korean Med Sci 5 (1), 13-17 (1990)
   PUBMED   2206462
REFERENCE   9  (bases 1 to 769)
  AUTHORS   Suguoka,Y., Kano,T., Okuda,A., Sakai,M., Kitagawa,T. and
            Muramatsu,M.
  TITLE     Cloning and the nucleotide sequence of rat glutathione
            S-transferase P cDNA
  JOURNAL   Nucleic Acids Res 13 (17), 6049-6057 (1985)
   PUBMED   2995915
REFERENCE   10 (bases 1 to 769)
  AUTHORS   Tanaka,S., Tamura,K. and Mizuno,Y.
  TITLE     [Clinical consideration with special reference to autopsy cases of
            malignant tumor in the oral cavity, treated with Bleomycin
            (author's transl)]
  JOURNAL   Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975)
   PUBMED   69641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058440.1 and JAXUCZ010000001.1.
            
            On or before Mar 7, 2008 this sequence version replaced
            NM_138974.1, NM_012577.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217279.1, BC058440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-764               BC058440.1         5-768
            765-769             JAXUCZ010000001.1  210767237-210767241 c
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..769
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /note="glutathione S-transferase pi 1"
                     /db_xref="GeneID:24426"
                     /db_xref="RGD:2758"
     exon            1..71
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..703
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /EC_number="2.5.1.18"
                     /note="Glutathione-S-transferase, placental enzyme pi
                     type; glutathione S-transferase, pi 2; GST 7-7; chain 7;
                     GST class-pi"
                     /codon_start=1
                     /product="glutathione S-transferase P"
                     /protein_id="NP_036709.1"
                     /db_xref="GeneID:24426"
                     /db_xref="RGD:2758"
                     /translation="MPPYTIVYFPVRGRCEATRMLLADQGQSWKEEVVTIDVWLQGSL
                     KSTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKDQKEAALVDMVNDGVEDLRC
                     KYGTLIYTNYENGKDDYVKALPGHLKPFETLLSQNQGGKAFIVGNQISFADYNLLDLL
                     LVHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPDHLNRPINGNGKQ"
     exon            72..107
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
     exon            108..214
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..302
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..406
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..514
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..769
                     /gene="Gstp1"
                     /gene_synonym="GST-P; Gst3; Gstp; Gstp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcgtctgc gtctgagata cttcatcgtc cacgcagctt tgagtccaca cctctgtcta
       61 cgcagcagct atgccaccgt acaccattgt gtacttccca gttcgagggc gctgtgaggc
      121 cacgcgcatg ctgctggctg accagggcca gagctggaag gaggaggtgg ttaccataga
      181 tgtctggctt caaggctcgc tcaagtccac ttgtctgtat gggcagctcc ccaagtttga
      241 agatggagac ctcacccttt accaatctaa tgccatcttg aggcacctgg gtcgctcttt
      301 agggctttat gggaaagacc agaaggaggc tgccttggtg gatatggtga atgatggggt
      361 ggaggacctt cgatgcaaat atggtaccct catctacact aactatgaga atggtaagga
      421 tgactatgtg aaggccctgc ctgggcatct gaaacctttt gagaccctgc tgtcccagaa
      481 ccagggaggc aaagctttca ttgtgggtaa ccagatttcc tttgcagatt acaacttgct
      541 ggacctgctg ctggtccacc aagtcctggc ccctggctgc ctggacaact tccccctgct
      601 ctctgcctat gtggctcgcc tcagtgcccg ccccaagatc aaggcctttc tgtcctcccc
      661 tgaccatttg aaccgtccca tcaacggcaa tggtaaacag tagtggacga agggacagga
      721 actccttgtc ccccttttcc cagactaata aagtttgtaa ggcagaggt
//
