LOCUS       NM_001012071            1415 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase omega 2 (Gsto2),
            transcript variant 1, mRNA.
ACCESSION   NM_001012071 XM_006231589 XM_219980
VERSION     NM_001012071.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Polimanti,R., Piacentini,S., Moscatelli,B., Pellicciotti,L.,
            Manfellotto,D. and Fuciarelli,M.
  TITLE     GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma
            patients
  JOURNAL   Clin Exp Pharmacol Physiol 37 (8), 870-872 (2010)
   PUBMED   20374258
REFERENCE   2  (bases 1 to 1415)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1415)
  AUTHORS   Wahner,A.D., Glatt,C.E., Bronstein,J.M. and Ritz,B.
  TITLE     Glutathione S-transferase mu, omega, pi, and theta class variants
            and smoking in Parkinson's disease
  JOURNAL   Neurosci Lett 413 (3), 274-278 (2007)
   PUBMED   17194543
REFERENCE   4  (bases 1 to 1415)
  AUTHORS   Ozturk,A., Desai,P.P., Minster,R.L., Dekosky,S.T. and Kamboh,M.I.
  TITLE     Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10
            are not associated with age-at-onset of Alzheimer's disease
  JOURNAL   Neurobiol Aging 26 (8), 1161-1165 (2005)
   PUBMED   15917099
REFERENCE   5  (bases 1 to 1415)
  AUTHORS   Schmuck,E.M., Board,P.G., Whitbread,A.K., Tetlow,N.,
            Cavanaugh,J.A., Blackburn,A.C. and Masoumi,A.
  TITLE     Characterization of the monomethylarsonate reductase and
            dehydroascorbate reductase activities of Omega class glutathione
            transferase variants: implications for arsenic metabolism and the
            age-at-onset of Alzheimer's and Parkinson's diseases
  JOURNAL   Pharmacogenet Genomics 15 (7), 493-501 (2005)
   PUBMED   15970797
REFERENCE   6  (bases 1 to 1415)
  AUTHORS   Li,Y.J., Oliveira,S.A., Xu,P., Martin,E.R., Stenger,J.E.,
            Scherzer,C.R., Hauser,M.A., Scott,W.K., Small,G.W., Nance,M.A.,
            Watts,R.L., Hubble,J.P., Koller,W.C., Pahwa,R., Stern,M.B.,
            Hiner,B.C., Jankovic,J., Goetz,C.G., Mastaglia,F., Middleton,L.T.,
            Roses,A.D., Saunders,A.M., Schmechel,D.E., Gullans,S.R.,
            Haines,J.L., Gilbert,J.R., Vance,J.M., Pericak-Vance,M.A.,
            Hulette,C. and Welsh-Bohmer,K.A.
  TITLE     Glutathione S-transferase omega-1 modifies age-at-onset of
            Alzheimer disease and Parkinson disease
  JOURNAL   Hum Mol Genet 12 (24), 3259-3267 (2003)
   PUBMED   14570706
  REMARK    Erratum:[Hum Mol Genet. 2004 Mar 1;13(5):573]
REFERENCE   7  (bases 1 to 1415)
  AUTHORS   Strange,R.C., Jones,P.W. and Fryer,A.A.
  TITLE     Glutathione S-transferase: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 357-363 (2000)
   PUBMED   10720752
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079295.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006231589.1, XM_219980.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1415
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /note="glutathione S-transferase omega 2"
                     /db_xref="GeneID:309465"
                     /db_xref="RGD:1310764"
     exon            1..230
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..367
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..532
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..1245
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /EC_number="2.5.1.18"
                     /EC_number="1.8.5.1"
                     /EC_number="1.20.4.2"
                     /note="GSTO-2; MMA(V) reductase; monomethylarsonic acid
                     reductase; glutathione S-transferase omega 2-2;
                     glutathione-dependent dehydroascorbate reductase"
                     /codon_start=1
                     /product="glutathione S-transferase omega-2"
                     /protein_id="NP_001012071.1"
                     /db_xref="GeneID:309465"
                     /db_xref="RGD:1310764"
                     /translation="MSGDLTRCLGKGSCPPGPVPEGVIRIYSMRFCPYSHRTRLVLKA
                     KSIRHEIININLKNKPDWYYTKHPFGQVPVLENSQCQLIYESVIACEYLDDVFPGRKL
                     FPYDPYERARQKMLLELFCKVPQLSKECLVALRCGRDCTDLKVALRQELCNLEEILEY
                     QNTTFFGGDSISMIDYLVWPWFERLDVYGLADCVNHTPMLRLWISSMKQDPAVCALHI
                     DKNIFLGFLNLYFQNNPCAFDFGLCGPIVR"
     exon            533..641
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..864
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..966
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1073
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1384
                     /gene="Gsto2"
                     /gene_synonym="GSTO 2-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgccggcc gctgggcggg ccctggcggt tcctcgcgga tttccagtag gatgtgagac
       61 cagcggctga gaggaacggc ctgctaccga cttcctcttg cggtagccct agatttccgg
      121 cctgactctc gtttctctag ctagctgctg taacgcggtc gcctattggt tcgttcttcc
      181 aaatgcgcca ggtattggct ggagctcagg actcggcggc caattgcggg ttttgccgtc
      241 gagcctgtcc atctgtcaga gttagttcca gggaagttag cagttgctga tcagacctgc
      301 atcctccaca gtgcaaagtg agaagctcct ccttcagcac cgcaaggcaa gaacccatca
      361 acaccagagt gctgtcaacc gtcgagaaat tgagtttgga tctggaggga gctcagctgt
      421 gcctggagcc agcagcagca gaggtccaca aggcagtgac tgtgagcttc cgggcactgc
      481 gtagacacct ggacattgat gtctggggat ttgacaagat gcttggggaa aggaagctgt
      541 cccccagggc cggtccctga gggtgtgatc cgaatctaca gcatgaggtt ctgcccctac
      601 tcgcacagga cacgcctggt cctcaaggcc aaaagcatca ggcatgaaat catcaacatt
      661 aacctgaaaa acaagcctga ttggtactat acaaaacacc cttttggcca ggttcctgtc
      721 ctggagaaca gccaatgtca gctgatctat gaatccgtca ttgcgtgtga gtacctggat
      781 gacgtcttcc caggaaggaa gctgtttcca tacgacccat atgaacgagc tcgccagaag
      841 atgttattgg agctattctg taaggtccca cagttaagca aggaatgtct ggtagcgctg
      901 agatgtggga gagactgtac ggatctgaag gttgccctgc gtcaggagtt gtgcaatctg
      961 gaagagattc ttgaatatca gaacactacc ttcttcggtg gagactctat atccatgatt
     1021 gattacctcg tctggccctg gtttgagcga ctggatgtat atggactggc tgactgtgtg
     1081 aatcacaccc caatgctgcg gctctggata tcctccatga agcaggaccc cgcagtgtgc
     1141 gctctgcaca ttgataagaa cattttcctg ggcttcttga atctctattt ccaaaacaac
     1201 ccttgtgcct ttgattttgg gctgtgtggc ccaatcgtac ggtaatccag tcattgccca
     1261 ggattctcct catatctgat tctgcatcac gggtcatctt ggagtcagtg tatttgtttt
     1321 tttgtttttt ttttgctttt ttgttttttt gaggtcccta ataaacatgg acgtgtaaaa
     1381 tataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
