LOCUS       NM_001007602             907 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus glutathione S-transferase omega 1 (Gsto1), mRNA.
ACCESSION   NM_001007602 XM_342062
VERSION     NM_001007602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 907)
  AUTHORS   Wang,L., Lei,L., Xu,T. and Wang,Y.
  TITLE     GSTO1 regulates insulin biosynthesis in pancreatic beta cells
  JOURNAL   Biochem Biophys Res Commun 524 (4), 936-942 (2020)
   PUBMED   32057363
  REMARK    GeneRIF: GSTO1 regulates insulin biosynthesis in pancreatic beta
            cells.
REFERENCE   2  (bases 1 to 907)
  AUTHORS   Bluggel,M., Spertini,F., Lutter,P., Wassenberg,J., Audran,R.,
            Corthesy,B., Mullner,S., Blum,S., Wattenberg,A., Mercenier,A.,
            Affolter,M. and Kussmann,M.
  TITLE     Toward protein biomarkers for allergy: CD4+ T cell proteomics in
            allergic and nonallergic subjects sampled in and out of pollen
            season
  JOURNAL   J Proteome Res 10 (4), 1558-1570 (2011)
   PUBMED   21410266
REFERENCE   3  (bases 1 to 907)
  AUTHORS   Capurso,C., Panza,F., Seripa,D., Frisardi,V., Imbimbo,B.P.,
            Verdile,G., Vendemiale,G., Pilotto,A. and Solfrizzi,V.
  TITLE     Polymorphisms in glutathione S-transferase omega-1 gene and
            increased risk of sporadic Alzheimer disease
  JOURNAL   Rejuvenation Res 13 (6), 645-652 (2010)
   PUBMED   20818931
REFERENCE   4  (bases 1 to 907)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 907)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 907)
  AUTHORS   Dulhunty,A., Gage,P., Curtis,S., Chelvanayagam,G. and Board,P.
  TITLE     The glutathione transferase structural family includes a nuclear
            chloride channel and a ryanodine receptor calcium release channel
            modulator
  JOURNAL   J Biol Chem 276 (5), 3319-3323 (2001)
   PUBMED   11035031
REFERENCE   7  (bases 1 to 907)
  AUTHORS   Fornai,F., Piaggi,S., Gesi,M., Saviozzi,M., Lenzi,P., Paparelli,A.
            and Casini,A.F.
  TITLE     Subcellular localization of a glutathione-dependent
            dehydroascorbate reductase within specific rat brain regions
  JOURNAL   Neuroscience 104 (1), 15-31 (2001)
   PUBMED   11311527
REFERENCE   8  (bases 1 to 907)
  AUTHORS   Strange,R.C., Jones,P.W. and Fryer,A.A.
  TITLE     Glutathione S-transferase: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 357-363 (2000)
   PUBMED   10720752
  REMARK    Review article
REFERENCE   9  (bases 1 to 907)
  AUTHORS   Ishikawa,T., Casini,A.F. and Nishikimi,M.
  TITLE     Molecular cloning and functional expression of rat liver
            glutathione-dependent dehydroascorbate reductase
  JOURNAL   J Biol Chem 273 (44), 28708-28712 (1998)
   PUBMED   9786866
REFERENCE   10 (bases 1 to 907)
  AUTHORS   Maellaro,E., Del Bello,B., Sugherini,L., Santucci,A., Comporti,M.
            and Casini,A.F.
  TITLE     Purification and characterization of glutathione-dependent
            dehydroascorbate reductase from rat liver
  JOURNAL   Biochem J 301 (Pt 2) (Pt 2), 471-476 (1994)
   PUBMED   8042991
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079363.1.
            
            On Nov 29, 2004 this sequence version replaced XM_342062.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079363.1, FQ218105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..907
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /note="glutathione S-transferase omega 1"
                     /db_xref="GeneID:114846"
                     /db_xref="RGD:70952"
     exon            1..116
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..808
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /EC_number="2.5.1.18"
                     /EC_number="1.8.5.1"
                     /EC_number="1.20.4.2"
                     /note="GSTO 1-1; glutathione-dependent dehydroascorbate
                     reductase; GSTO-1; MMA(V) reductase; monomethylarsonic
                     acid reductase; S-(Phenacyl)glutathione reductase;
                     glutathione S-transferase omega 1-1"
                     /codon_start=1
                     /product="glutathione S-transferase omega-1"
                     /protein_id="NP_001007603.1"
                     /db_xref="GeneID:114846"
                     /db_xref="RGD:70952"
                     /translation="MSGASARSLGKGSAPPGPVPEGQIRVYSMRFCPFAQRTLMVLKA
                     KGIRHEIININLKNKPEWFFEKNPFGLVPVLENTQGHLITESVITCEYLDEAYPEKKL
                     FPDDPYEKACQKMTFELFSKVPSLVTSFIRAKRKEDHPGIKEELKKEFSKLEEAMAKK
                     RTAFFGGNSLSMIDYLIWPWFQRLEALELNECIDHTPKLKLWMATMQEDPVASSHFID
                     AKTYRDYLSLYLQDSPEACDYGL"
     exon            117..225
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            226..448
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            449..547
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            548..654
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            655..878
                     /gene="Gsto1"
                     /gene_synonym="SPG-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagactt ggccacgtgc ttcctgagtc acccgcaaac gagagcagga ccctcttggc
       61 tctccgtctg ctcggcgcag cgatgtccgg ggcgtccgcc aggagcctgg ggaagggaag
      121 cgcgccccct ggcccggtcc cggagggcca gatccgagtc tacagcatga ggttctgtcc
      181 ctttgctcag aggacgctga tggtcctgaa ggccaaggga atccggcatg aaatcatcaa
      241 catcaacctg aagaataagc ccgagtggtt ctttgagaag aatccctttg ggctggtgcc
      301 ggttctggag aacactcagg gtcacttgat cactgaatct gtcatcactt gcgagtacct
      361 ggatgaagca tacccggaga agaagttatt cccagatgac ccgtacgaga aagcttgcca
      421 gaagatgacc tttgagttat tctcaaaggt gccgtctctg gttacgagtt ttattagggc
      481 gaagagaaag gaagaccatc cgggcataaa ggaagaactg aagaaagagt tcagcaagct
      541 agaagaggct atggctaaaa agaggacagc cttcttcggt gggaattcgc tctcaatgat
      601 cgattatctt atttggccgt ggtttcagcg actggaagca ctggagctca atgagtgtat
      661 agaccacacc ccaaaactca agctctggat ggcaaccatg caggaagacc ccgtggcatc
      721 atcccacttc attgatgcca agacctaccg tgattactta agtctctacc tacaggacag
      781 ccccgaggcc tgtgattatg ggctctgagg ggcaagagcc ctcagcgaat gatgttttcc
      841 ttcatcgatt gaatagcatg cttttatttt acccattaaa aaaaaaaaaa aaaaaaaaaa
      901 aaaaaaa
//
