LOCUS       NM_172038                846 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase, mu 5 (Gstm5), mRNA.
ACCESSION   NM_172038
VERSION     NM_172038.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 846)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 846)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 846)
  AUTHORS   Hunter,A., Spechler,P.A., Cwanger,A., Song,Y., Zhang,Z., Ying,G.S.,
            Hunter,A.K., Dezoeten,E. and Dunaief,J.L.
  TITLE     DNA methylation is associated with altered gene expression in AMD
  JOURNAL   Invest Ophthalmol Vis Sci 53 (4), 2089-2105 (2012)
   PUBMED   22410570
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 846)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 846)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (bases 1 to 846)
  AUTHORS   Yang,G.P., Ross,D.T., Kuang,W.W., Brown,P.O. and Weigel,R.J.
  TITLE     Combining SSH and cDNA microarrays for rapid identification of
            differentially expressed genes
  JOURNAL   Nucleic Acids Res 27 (6), 1517-1523 (1999)
   PUBMED   10037815
REFERENCE   7  (bases 1 to 846)
  AUTHORS   Rowe,J.D., Patskovsky,Y.V., Patskovska,L.N., Novikova,E. and
            Listowsky,I.
  TITLE     Rationale for reclassification of a distinctive subdivision of
            mammalian class Mu glutathione S-transferases that are primarily
            expressed in testis
  JOURNAL   J Biol Chem 273 (16), 9593-9601 (1998)
   PUBMED   9545290
REFERENCE   8  (bases 1 to 846)
  AUTHORS   Ross,V.L. and Board,P.G.
  TITLE     Molecular cloning and heterologous expression of an alternatively
            spliced human Mu class glutathione S-transferase transcript
  JOURNAL   Biochem J 294 (Pt 2) (Pt 2), 373-380 (1993)
   PUBMED   8373352
REFERENCE   9  (bases 1 to 846)
  AUTHORS   Reinhart,J. and Pearson,W.R.
  TITLE     The structure of two murine class-mu glutathione transferase genes
            coordinately induced by butylated hydroxyanisole
  JOURNAL   Arch Biochem Biophys 303 (2), 383-393 (1993)
   PUBMED   8512323
REFERENCE   10 (bases 1 to 846)
  AUTHORS   Pearson,W.R., Windle,J.J., Morrow,J.F., Benson,A.M. and Talalay,P.
  TITLE     Increased synthesis of glutathione S-transferases in response to
            anticarcinogenic antioxidants. Cloning and measurement of messenger
            RNA
  JOURNAL   J Biol Chem 258 (3), 2052-2062 (1983)
   PUBMED   6822548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_172038.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CV463517.1, U86635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000002.1  198219769-198219844
            77-152              JAXUCZ010000002.1  198220140-198220215
            153-217             JAXUCZ010000002.1  198220499-198220563
            218-299             JAXUCZ010000002.1  198221168-198221249
            300-400             JAXUCZ010000002.1  198221341-198221441
            401-496             JAXUCZ010000002.1  198221867-198221962
            497-607             JAXUCZ010000002.1  198222132-198222242
            608-846             JAXUCZ010000002.1  198222494-198222732
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..846
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /note="glutathione S-transferase, mu 5"
                     /db_xref="GeneID:64352"
                     /db_xref="RGD:61964"
     exon            1..76
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..706
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /EC_number="2.5.1.18"
                     /function="conjugation of electrophiles with glutathione"
                     /note="GST class-mu 5; glutathione S-transferase mu 3"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 5"
                     /protein_id="NP_742035.1"
                     /db_xref="GeneID:64352"
                     /db_xref="RGD:61964"
                     /translation="MSCSKSMVLGYWDIRGLAHAIRMLLEFTDTSYEEKQYTCGEAPD
                     YDRSQWLDVKFKLDLDFPNLPYLMDGKNKITQSNAILRYIARKHNMCGDTEEEKIRVD
                     IMENQIMDFRMQLVRLCYNSNHESLKPQYLEQLPAQLKQFSLFLGKFTWFAGEKLTFV
                     DFLTYDVLDQNRMFEPKCLDEFPNLKAFMCRFEALEKIAAFLQSDRCFKMPINNKMAK
                     WGNKSIC"
     exon            77..152
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            153..217
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            218..299
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            300..400
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            401..496
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..607
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            608..846
                     /gene="Gstm5"
                     /gene_synonym="Gstm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcccagaag gggctaagat ctcccaaaat gtcgtgctcc aagtctatgg ttctgggtta
       61 ctgggatatc cgcgggctgg ctcatgccat ccgtatgctc ctggagttta ctgataccag
      121 ctatgaagag aaacagtaca cgtgtgggga agctcctgac tatgatagaa gccaatggct
      181 ggacgtgaaa ttcaagctag atctggattt tcctaacctg ccctacctta tggacgggaa
      241 gaacaagatc acccagagta acgccatctt gcggtacatc gcacgcaagc acaacatgtg
      301 tggtgacacc gaagaagaaa agattcgagt ggacatcatg gagaaccaga taatggactt
      361 ccgcatgcag ctggttcggc tctgctacaa ttctaaccac gaaagcctga agcctcagta
      421 tttggaacaa ctgcctgcac agctgaaaca gttctcgttg ttcctgggga aattcacatg
      481 gtttgcagga gaaaagctga ccttcgtgga ttttctcact tatgacgtct tggaccagaa
      541 tcgtatgttt gagcccaagt gcctggatga gttcccaaat ctgaaggctt tcatgtgccg
      601 ttttgaggct ttggagaaga ttgctgcatt cctgcagtct gaccgctgct tcaagatgcc
      661 aatcaacaac aagatggcca agtggggtaa caagagcata tgctgagctg gagctcgctg
      721 ctgctgagcc atctttccct caagggaccc accctctgta agcttcctgc cagccttgtc
      781 ccatccgatc tggaggggcc cgcactctgt ctcctctgct ccttccaata aacagcagtt
      841 aaatta
//
