LOCUS       NM_020540               1110 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase mu 3 (Gstm3), mRNA.
ACCESSION   NM_020540
VERSION     NM_020540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Seymour,E.M., Bennink,M.R. and Bolling,S.F.
  TITLE     Diet-relevant phytochemical intake affects the cardiac AhR and nrf2
            transcriptome and reduces heart failure in hypertensive rats
  JOURNAL   J Nutr Biochem 24 (9), 1580-1586 (2013)
   PUBMED   23528973
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Salinas-Souza,C., Petrilli,A.S. and de Toledo,S.R.
  TITLE     Glutathione S-transferase polymorphisms in osteosarcoma patients
  JOURNAL   Pharmacogenet Genomics 20 (8), 507-515 (2010)
   PUBMED   20577141
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Maes,O.C., Schipper,H.M., Chong,G., Chertkow,H.M. and Wang,E.
  TITLE     A GSTM3 polymorphism associated with an etiopathogenetic mechanism
            in Alzheimer disease
  JOURNAL   Neurobiol Aging 31 (1), 34-45 (2010)
   PUBMED   18423940
REFERENCE   4  (bases 1 to 1110)
  AUTHORS   Francis,S.M., Larsen,J.E., Pavey,S.J., Bowman,R.V., Hayward,N.K.,
            Fong,K.M. and Yang,I.A.
  TITLE     Expression profiling identifies genes involved in emphysema
            severity
  JOURNAL   Respir Res 10 (1), 81 (2009)
   PUBMED   19723343
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1110)
  AUTHORS   Jeong,H.C., Lee,S.Y., Lee,E.J., Jung,K.H., Kang,E.H., Lee,S.Y.,
            Kim,J.H., Park,E.K., Lee,S.H., Uhm,C.S., Cho,Y., Shin,C.,
            Shim,J.J., Kim,H.K., In,K.H., Kang,K.H. and Yoo,S.H.
  TITLE     Proteomic analysis of peripheral T-lymphocytes in patients with
            asthma
  JOURNAL   Chest 132 (2), 489-496 (2007)
   PUBMED   17550934
REFERENCE   6  (bases 1 to 1110)
  AUTHORS   Mann,C.L., Davies,M.B., Boggild,M.D., Alldersea,J., Fryer,A.A.,
            Jones,P.W., Ko Ko,C., Young,C., Strange,R.C. and Hawkins,C.P.
  TITLE     Glutathione S-transferase polymorphisms in MS: their relationship
            to disability
  JOURNAL   Neurology 54 (3), 552-557 (2000)
   PUBMED   10680782
REFERENCE   7  (bases 1 to 1110)
  AUTHORS   Patskovsky,Y.V., Patskovska,L.N. and Listowsky,I.
  TITLE     An asparagine-phenylalanine substitution accounts for catalytic
            differences between hGSTM3-3 and other human class mu glutathione
            S-transferases
  JOURNAL   Biochemistry 38 (49), 16187-16194 (1999)
   PUBMED   10587441
REFERENCE   8  (bases 1 to 1110)
  AUTHORS   Jourenkova-Mironova,N., Voho,A., Bouchardy,C., Wikman,H., Dayer,P.,
            Benhamou,S. and Hirvonen,A.
  TITLE     Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx
            cancer risk
  JOURNAL   Cancer Epidemiol Biomarkers Prev 8 (2), 185-188 (1999)
   PUBMED   10067818
REFERENCE   9  (bases 1 to 1110)
  AUTHORS   Rowe,J.D., Patskovsky,Y.V., Patskovska,L.N., Novikova,E. and
            Listowsky,I.
  TITLE     Rationale for reclassification of a distinctive subdivision of
            mammalian class Mu glutathione S-transferases that are primarily
            expressed in testis
  JOURNAL   J Biol Chem 273 (16), 9593-9601 (1998)
   PUBMED   9545290
REFERENCE   10 (bases 1 to 1110)
  AUTHORS   Lai,H.C., Qian,B., Grove,G. and Tu,C.P.
  TITLE     Gene expression of rat glutathione S-transferases. Evidence for
            gene conversion in the evolution of the Yb multigene family
  JOURNAL   J Biol Chem 263 (23), 11389-11395 (1988)
   PUBMED   3403534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_020540.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.8513.1,
                                           SRR26643288.11252.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000002.1  198300604-198300667 c
            65-140              JAXUCZ010000002.1  198300277-198300352 c
            141-205             JAXUCZ010000002.1  198299703-198299767 c
            206-287             JAXUCZ010000002.1  198299334-198299415 c
            288-388             JAXUCZ010000002.1  198299134-198299234 c
            389-484             JAXUCZ010000002.1  198297849-198297944 c
            485-595             JAXUCZ010000002.1  198297656-198297766 c
            596-1110            JAXUCZ010000002.1  198295442-198295956 c
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1110
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /note="glutathione S-transferase mu 3"
                     /db_xref="GeneID:57298"
                     /db_xref="RGD:620381"
     exon            1..64
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..685
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase M4; glutathione
                     S-transferase M3; glutathione S-transferase Yb4;
                     glutathione S-transferase mu 3-like 1"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 3"
                     /protein_id="NP_065415.2"
                     /db_xref="GeneID:57298"
                     /db_xref="RGD:620381"
                     /translation="MAMILGYWNVRGLTHPIRLLLEYTDSNYEEKRYVMGDAPNFDRS
                     QWLSEKFNLGLDIPNLPYLIDGSHKVTQSNAILRYLGRKHNLCGETEEERIRVDTLEN
                     QVMDTRIHLMIVCCSPDFEKQKPEFLKSIPEKMKIYSEFLGKRPWFAGDKVTYVDFLA
                     YDILDQYRMFEPECLDAFPNLKDFLARFEGLKKISAYMKSSSFLPRPVFTKIAQWGTD
                     "
     exon            65..140
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     exon            141..205
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     exon            206..287
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..388
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     exon            389..484
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     exon            485..595
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
     exon            596..1110
                     /gene="Gstm3"
                     /gene_synonym="Gstm3l; Gstm3l1; Gstm4; GstYb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgagaa gaccacagca ccagagccat ggctatgata ctgggatatt ggaacgttcg
       61 cggacttact caccccatcc gcctgctcct ggaatacaca gattcaaact atgaggagaa
      121 gagatacgtc atgggggatg cccccaactt tgacagaagc cagtggctga gtgagaaatt
      181 caatcttggc ctggacattc ccaatttgcc ctacttaatt gatgggtcac acaaggtcac
      241 ccagagcaat gccatcctgc gctaccttgg ccggaagcac aacctgtgtg gggagacaga
      301 ggaggagagg attcgtgtgg acactttgga gaaccaggtc atggacaccc gcatacatct
      361 catgatagtt tgctgcagtc ctgactttga gaagcagaag ccagagttct tgaagtccat
      421 cccggagaag atgaaaatct attcagagtt cctgggcaag cgaccatggt ttgcagggga
      481 caaggtcacc tatgtggatt tccttgctta tgacattctt gaccagtacc gtatgtttga
      541 gcccgagtgc ctggacgcct tcccaaacct gaaggacttc ctggcccgct tcgagggcct
      601 gaagaagatc tctgcttaca tgaagagtag cagctttctc ccaagacctg tgtttactaa
      661 gatagcccag tggggcactg attaggcccc tgccatgctg gcactcacag gaaggacctg
      721 tccacactgg atcctgcagg ccctgggcag gaacagcact tttgcactgt ggctcctggt
      781 tctctctcct tccctatccc ttctccagct ttctcagcct catctcctcg ccctcacccc
      841 agtcaagtcc acacagtcct cattcttccc actttctttc attatgatcc ccttcttctt
      901 atggcaccct aacccatcct cacagacctt ttctgtgatt tgaggtctgc cctgaactca
      961 ggctccctag aattaaccca aaggtcaatg ctgtctcagt gccagccctc cttagaatta
     1021 ccccgaagct caacactgtc tcagtgccag cctgttctcc tggaggagct tccctcagcc
     1081 tgtctcatct ctaataaagc ctgaaacaca
//
