LOCUS       NM_177426               1037 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase mu 2 (Gstm2), mRNA.
ACCESSION   NM_177426
VERSION     NM_177426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1037)
  AUTHORS   Hewawasam,R.P., Liu,D., Casarotto,M.G., Board,P.G. and
            Dulhunty,A.F.
  TITLE     The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+
            Transients in Neonatal Rat Ventricular Cardiomyocytes
  JOURNAL   PLoS One 11 (9), e0162415 (2016)
   PUBMED   27612301
  REMARK    GeneRIF: GSTM2C is translocated into the cytoplasm of neonatal
            cardiomyocytes and is effective in reducing spontaneous
            contractility and that its actions on field stimulated Ca2+ release
            and contraction is very similar to that reported for adult
            cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1037)
  AUTHORS   Seymour,E.M., Bennink,M.R. and Bolling,S.F.
  TITLE     Diet-relevant phytochemical intake affects the cardiac AhR and nrf2
            transcriptome and reduces heart failure in hypertensive rats
  JOURNAL   J Nutr Biochem 24 (9), 1580-1586 (2013)
   PUBMED   23528973
REFERENCE   3  (bases 1 to 1037)
  AUTHORS   Stanley,J.A., Sivakumar,K.K., Nithy,T.K., Arosh,J.A., Hoyer,P.B.,
            Burghardt,R.C. and Banu,S.K.
  TITLE     Postnatal exposure to chromium through mother's milk accelerates
            follicular atresia in F1 offspring through increased oxidative
            stress and depletion of antioxidant enzymes
  JOURNAL   Free Radic Biol Med 61, 179-196 (2013)
   PUBMED   23470461
REFERENCE   4  (bases 1 to 1037)
  AUTHORS   Liu,D., Hewawasam,R., Karunasekara,Y., Casarotto,M.G.,
            Dulhunty,A.F. and Board,P.G.
  TITLE     The inhibitory glutathione transferase M2-2 binding site is located
            in divergent region 3 of the cardiac ryanodine receptor
  JOURNAL   Biochem Pharmacol 83 (11), 1523-1529 (2012)
   PUBMED   22406107
REFERENCE   5  (bases 1 to 1037)
  AUTHORS   Guven,M., Gorgun,E., Unal,M., Yenerel,M., Batar,B., Kucumen,B.,
            Dinc,U.A., Guven,G.S., Ulus,T. and Yuksel,A.
  TITLE     Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms
            and the risk of age-related macular degeneration
  JOURNAL   Ophthalmic Res 46 (1), 31-37 (2011)
   PUBMED   21212706
REFERENCE   6  (bases 1 to 1037)
  AUTHORS   Harada,S., Misawa,S., Nakamura,T., Tanaka,N., Ueno,E. and Nozoe,M.
  TITLE     Detection of GST1 gene deletion by the polymerase chain reaction
            and its possible correlation with stomach cancer in Japanese
  JOURNAL   Hum Genet 90 (1-2), 62-64 (1992)
   PUBMED   1427788
REFERENCE   7  (bases 1 to 1037)
  AUTHORS   Vorachek,W.R., Pearson,W.R. and Rule,G.S.
  TITLE     Cloning, expression, and characterization of a class-mu glutathione
            transferase from human muscle, the product of the GST4 locus
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4443-4447 (1991)
   PUBMED   2034681
REFERENCE   8  (bases 1 to 1037)
  AUTHORS   Strange,R.C., Matharoo,B., Faulder,G.C., Jones,P., Cotton,W.,
            Elder,J.B. and Deakin,M.
  TITLE     The human glutathione S-transferases: a case-control study of the
            incidence of the GST1 0 phenotype in patients with adenocarcinoma
  JOURNAL   Carcinogenesis 12 (1), 25-28 (1991)
   PUBMED   1988177
REFERENCE   9  (bases 1 to 1037)
  AUTHORS   Chang,L.H., Hsieh,J.C., Chen,W.L. and Tam,M.F.
  TITLE     Identification of rat liver glutathione S-transferase Yb subunits
            by partial N-terminal sequencing after electroblotting of proteins
            onto a polyvinylidene difluoride membrane from an analytical
            isoelectric focusing gel
  JOURNAL   Electrophoresis 11 (7), 589-593 (1990)
   PUBMED   2226415
REFERENCE   10 (bases 1 to 1037)
  AUTHORS   Townsend,A.J., Goldsmith,M.E., Pickett,C.B. and Cowan,K.H.
  TITLE     Isolation, characterization, and expression in Escherichia coli of
            two murine Mu class glutathione S-transferase cDNAs homologous to
            the rat subunits 3 (Yb1) and 4 (Yb2)
  JOURNAL   J Biol Chem 264 (36), 21582-21590 (1989)
   PUBMED   2689439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_177426.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218596.1, FQ214985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000002.1  198316849-198316917 c
            70-145              JAXUCZ010000002.1  198316505-198316580 c
            146-210             JAXUCZ010000002.1  198316120-198316184 c
            211-292             JAXUCZ010000002.1  198315751-198315832 c
            293-393             JAXUCZ010000002.1  198315553-198315653 c
            394-489             JAXUCZ010000002.1  198314591-198314686 c
            490-600             JAXUCZ010000002.1  198314399-198314509 c
            601-1037            JAXUCZ010000002.1  198312179-198312615 c
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1037
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /note="glutathione S-transferase mu 2"
                     /db_xref="GeneID:24424"
                     /db_xref="RGD:2756"
     exon            1..69
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..690
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase Yb2 subunit; GST 4-4; GST
                     Yb2; GSTM2-2; glutathione S-transferase Yb-2;
                     Glutathione-S-transferase, mu type 2 (Yb2); glutathione
                     S-transferase M2"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 2"
                     /protein_id="NP_803175.1"
                     /db_xref="GeneID:24424"
                     /db_xref="RGD:2756"
                     /translation="MPMTLGYWDIRGLAHAIRLFLEYTDTSYEDKKYSMGDAPDYDRS
                     QWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLGRKHNLCGETEEERIRVDVLEN
                     QAMDTRLQLAMVCYSPDFERKKPEYLEGLPEKMKLYSEFLGKQPWFAGNKITYVDFLV
                     YDVLDQHRIFEPKCLDAFPNLKDFVARFEGLKKISDYMKSGRFLSKPIFAKMAFWNPK
                     "
     exon            70..145
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     exon            146..210
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     exon            211..292
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     exon            293..393
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     exon            394..489
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..600
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1037
                     /gene="Gstm2"
                     /gene_synonym="GSTA4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtttgtct gctctgtaca ccctaccagc acgatgccta tgacactggg ttactgggac
       61 atccgtgggc tggctcacgc cattcgcctg ttcctggagt atacagacac aagctatgag
      121 gacaagaagt acagcatggg ggatgctccc gactatgaca gaagccagtg gctgagtgag
      181 aagttcaaac tgggcctgga cttccccaat ctgccctact taattgatgg gtcacacaag
      241 atcacccaga gcaatgccat cctgcgctac cttggccgga agcacaacct ttgtggggag
      301 acagaggagg agaggattcg tgtggacgtt ttggagaacc aggctatgga cacccgccta
      361 cagttggcca tggtctgcta cagccctgac tttgagagaa agaagccaga gtacttagag
      421 ggtctccctg agaagatgaa gctttactcc gaattcctgg gcaagcagcc atggtttgca
      481 gggaacaaga ttacgtatgt ggattttctt gtttacgatg tccttgatca acaccgtata
      541 tttgaaccca agtgcctgga cgccttccca aacctgaagg acttcgtggc tcggtttgag
      601 ggcctgaaga agatatctga ctacatgaag agcggccgct tcctctccaa gccaatcttt
      661 gcaaagatgg ccttttggaa cccaaagtag caccacaaag tccagacctg gggatactca
      721 tgagtgccct gctggctgtg ggcctagagc atggctctgg cgcccaccac atgcagcttt
      781 ctcctccttt ccattccctg ttcctccatc tcctcttccc agcccttgcc tcagtcaagc
      841 ctcagttccc tggtctctcc atttcttcat tagtcccctc ccttgtctct gccctgcatc
      901 caacccttcc ctcactgatt ttcggaggac tgtaccagac ccctgaatcc ccagcctggc
      961 ctgagagatt agatctcact gtgctgccct ggtccccagg aaggacccat ttgatttgca
     1021 ataaagtgtg aaccaca
//
