LOCUS       NM_017014               1056 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase mu 1 (Gstm1), mRNA.
ACCESSION   NM_017014
VERSION     NM_017014.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Olson,E., Pravenec,M., Landa,V., Koh-Tan,H.H.C., Dominiczak,A.F.,
            McBride,M.W. and Graham,D.
  TITLE     Transgenic overexpression of glutathione S-transferase mu-type 1
            reduces hypertension and oxidative stress in the stroke-prone
            spontaneously hypertensive rat
  JOURNAL   J Hypertens 37 (5), 985-996 (2019)
   PUBMED   30308595
  REMARK    GeneRIF: These data support the hypothesis that reduced renal Gstm1
            plays a role in the development of hypertension.
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Xu,S., Hou,D., Liu,J. and Ji,L.
  TITLE     Age-associated changes in GSH S-transferase gene/proteins in livers
            of rats
  JOURNAL   Redox Rep 23 (1), 213-218 (2018)
   PUBMED   30444463
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Iorio,A., Ylli,D., Polimanti,R., Picconi,F., Maggio,P.,
            Francomano,D., Aversa,A., Manfellotto,D., Fuciarelli,M. and
            Frontoni,S.
  TITLE     Effect of the GSTM1 gene deletion on glycemic variability,
            sympatho-vagal balance and arterial stiffness in patients with
            metabolic syndrome, but without diabetes
  JOURNAL   Diabetes Res Clin Pract 138, 158-168 (2018)
   PUBMED   29452132
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Chbili,C., Hassine,A., Fathallah,N., Nouira,M., Naija,S., Ben
            Ammou,S. and Saguem,S.
  TITLE     Glutathione S-transferase M1 and T1 polymorphisms and the risk of
            mild hepatotoxicity induced by carbamazepine in a tunisian
            population study
  JOURNAL   BMC Neurol 18 (1), 24 (2018)
   PUBMED   29523098
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1056)
  AUTHORS   Yuan,X.P., Liu,L.S., Chen,C.B., Zhou,J., Zheng,Y.T., Wang,X.P.,
            Han,M. and Wang,C.X.
  TITLE     MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis
            in renal proximal tubular epithelial cells by targeting GSTM1 via
            endoplasmic reticulum stress
  JOURNAL   Oncotarget 8 (47), 82064-82077 (2017)
   PUBMED   29137244
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1056)
  AUTHORS   Katusz,R.M., Bono,B. and Colman,R.F.
  TITLE     Identification of Tyr115 labeled by
            S-(4-bromo-2,3-dioxobutyl)glutathione in the hydrophobic substrate
            binding site of glutathione S-transferase, isoenzyme 3-3
  JOURNAL   Arch Biochem Biophys 298 (2), 667-677 (1992)
   PUBMED   1416995
REFERENCE   7  (bases 1 to 1056)
  AUTHORS   Ji,X., Zhang,P., Armstrong,R.N. and Gilliland,G.L.
  TITLE     The three-dimensional structure of a glutathione S-transferase from
            the mu gene class. Structural analysis of the binary complex of
            isoenzyme 3-3 and glutathione at 2.2-A resolution
  JOURNAL   Biochemistry 31 (42), 10169-10184 (1992)
   PUBMED   1420139
REFERENCE   8  (bases 1 to 1056)
  AUTHORS   Harada,S., Misawa,S., Nakamura,T., Tanaka,N., Ueno,E. and Nozoe,M.
  TITLE     Detection of GST1 gene deletion by the polymerase chain reaction
            and its possible correlation with stomach cancer in Japanese
  JOURNAL   Hum Genet 90 (1-2), 62-64 (1992)
   PUBMED   1427788
REFERENCE   9  (bases 1 to 1056)
  AUTHORS   Hsieh,J.C., Huang,S.C., Chen,W.L., Lai,Y.C. and Tam,M.F.
  TITLE     Cysteine-86 is not needed for the enzymic activity of glutathione
            S-transferase 3-3
  JOURNAL   Biochem J 278 (Pt 1) (Pt 1), 293-297 (1991)
   PUBMED   1883338
REFERENCE   10 (bases 1 to 1056)
  AUTHORS   Strange,R.C., Matharoo,B., Faulder,G.C., Jones,P., Cotton,W.,
            Elder,J.B. and Deakin,M.
  TITLE     The human glutathione S-transferases: a case-control study of the
            incidence of the GST1 0 phenotype in patients with adenocarcinoma
  JOURNAL   Carcinogenesis 12 (1), 25-28 (1991)
   PUBMED   1988177
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02810.1, FQ214055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000002.1  198343311-198343383 c
            74-149              JAXUCZ010000002.1  198342941-198343016 c
            150-214             JAXUCZ010000002.1  198342491-198342555 c
            215-296             JAXUCZ010000002.1  198342163-198342244 c
            297-397             JAXUCZ010000002.1  198341973-198342073 c
            398-493             JAXUCZ010000002.1  198340709-198340804 c
            494-604             JAXUCZ010000002.1  198340516-198340626 c
            605-1056            JAXUCZ010000002.1  198338006-198338457 c
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1056
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /note="glutathione S-transferase mu 1"
                     /db_xref="GeneID:24423"
                     /db_xref="RGD:2755"
     exon            1..73
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..694
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase Yb-1 subunit;
                     glutathione-S-transferase, mu type 1 (Yb1); GST 3-3; GST
                     Yb1; GSTM1-1; glutathione S-transferase M1"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 1"
                     /protein_id="NP_058710.2"
                     /db_xref="GeneID:24423"
                     /db_xref="RGD:2755"
                     /translation="MPMILGYWNVRGLTHPIRLLLEYTDSSYEEKRYAMGDAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGSRKITQSNAIMRYLARKHHLCGETEEERIRADIVEN
                     QVMDNRMQLIMLCYNPDFEKQKPEFLKTIPEKMKLYSEFLGKRPWFAGDKVTYVDFLA
                     YDILDQYHIFEPKCLDAFPNLKDFLARFEGLKKISAYMKSSHYLSTPIFSKLAQWSNK
                     "
     exon            74..149
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            150..214
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            215..296
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..397
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            398..493
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..604
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            605..1056
                     /gene="Gstm1"
                     /gene_synonym="GSTA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaagcca aattgagaag accacagcgc cagaaccatg cctatgatac tgggatactg
       61 gaacgtccgc gggctgacac acccgatccg cctgctcctg gaatacacag actcaagcta
      121 tgaggagaag agatacgcca tgggcgacgc tcccgactat gacagaagcc agtggctgaa
      181 tgagaagttc aaactgggcc tggacttccc caatctgccc tacttaattg atggatcgcg
      241 caagattacc cagagcaatg ccataatgcg ctaccttgcc cgcaagcacc acctgtgtgg
      301 agagacagag gaggagcgga ttcgtgcaga cattgtggag aaccaggtca tggacaaccg
      361 catgcagctc atcatgcttt gttacaaccc cgactttgag aagcagaagc cagagttctt
      421 gaagaccatc cctgagaaga tgaagctcta ctctgagttc ctgggcaagc gaccatggtt
      481 tgcaggggac aaggtcacct atgtggattt ccttgcttat gacattcttg accagtacca
      541 catttttgag cccaagtgcc tggacgcctt cccaaacctg aaggacttcc tggcccgctt
      601 cgagggcctg aagaagatct ctgcctacat gaagagcagc cactacctct caacacctat
      661 attttcgaag ttggcccaat ggagtaacaa gtaggccctt gctacactgg cactcacagg
      721 gaggacctat ccacattgga tcctgcaggc accctggcct tctgcactgt ggttctctct
      781 ccttcctgct cccttctcca gctttgtcag ccccatctcc tcaacctcac cccagtcatg
      841 cccacatagt cttcattctc cccactttct ttcatagtgg tccccttctt tattgacacc
      901 ttaacacaac ctcacagtcc ttttctgtga tttgaggtct gccctgaact cagtctccct
      961 agacttaccc caaatgtaac actgtctcag tgccagcctg ttcctggtgg gggagctgcc
     1021 ccaggcctgt ctcatcttta ataaagcctg aaacac
//
