LOCUS       NM_181371                897 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase kappa 1 (Gstk1), mRNA.
ACCESSION   NM_181371
VERSION     NM_181371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   2  (bases 1 to 897)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 897)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 897)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 897)
  AUTHORS   Morel,F., Rauch,C., Petit,E., Piton,A., Theret,N., Coles,B. and
            Guillouzo,A.
  TITLE     Gene and protein characterization of the human glutathione
            S-transferase kappa and evidence for a peroxisomal localization
  JOURNAL   J Biol Chem 279 (16), 16246-16253 (2004)
   PUBMED   14742434
REFERENCE   6  (bases 1 to 897)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 897)
  AUTHORS   Jowsey,I.R., Thomson,R.E., Orton,T.C., Elcombe,C.R. and Hayes,J.D.
  TITLE     Biochemical and genetic characterization of a murine class Kappa
            glutathione S-transferase
  JOURNAL   Biochem J 373 (Pt 2), 559-569 (2003)
   PUBMED   12720545
REFERENCE   8  (bases 1 to 897)
  AUTHORS   Strange,R.C., Jones,P.W. and Fryer,A.A.
  TITLE     Glutathione S-transferase: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 357-363 (2000)
   PUBMED   10720752
  REMARK    Review article
REFERENCE   9  (bases 1 to 897)
  AUTHORS   Pemble,S.E., Wardle,A.F. and Taylor,J.B.
  TITLE     Glutathione S-transferase class Kappa: characterization by the
            cloning of rat mitochondrial GST and identification of a human
            homologue
  JOURNAL   Biochem J 319 (Pt 3) (Pt 3), 749-754 (1996)
   PUBMED   8920976
REFERENCE   10 (bases 1 to 897)
  AUTHORS   Harris,J.M., Meyer,D.J., Coles,B. and Ketterer,B.
  TITLE     A novel glutathione transferase (13-13) isolated from the matrix of
            rat liver mitochondria having structural similarity to class theta
            enzymes
  JOURNAL   Biochem J 278 (Pt 1) (Pt 1), 137-141 (1991)
   PUBMED   1883325
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from S83436.1.
            
            On Jun 6, 2003 this sequence version replaced NM_181371.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214179.1, FQ220456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..897
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /note="glutathione S-transferase kappa 1"
                     /db_xref="GeneID:297029"
                     /db_xref="RGD:735188"
     exon            1..106
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..715
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase subunit 13; rGSTK1;
                     GSTK1-1; GST 13-13; GST class-kappa; glutathione
                     S-transferase, mitochondrial"
                     /codon_start=1
                     /product="glutathione S-transferase kappa 1"
                     /protein_id="NP_852036.1"
                     /db_xref="GeneID:297029"
                     /db_xref="RGD:735188"
                     /translation="MGPAPRVLELFYDVLSPYSWLGFEVLCRYQHLWNIKLKLRPALL
                     AGIMKDSGNQPPAMVPHKGQYILKEIPLLKQLFQVPMSVPKDFFGEHVKKGTVNAMRF
                     LTAVSMEQPEMLEKVSRELWMRIWSRDEDITESQNILSAAEKAGMATAQAQHLLNKIS
                     TELVKSKLRETTGAACKYGAFGLPTTVAHVDGKTYMLFGSDRMELLAYLLGEKWMGPV
                     PPTLNARL"
     exon            107..188
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            189..317
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            318..418
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            419..454
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            455..571
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            572..665
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            666..897
                     /gene="Gstk1"
                     /gene_synonym="GST13-13; GSTkappa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcttcac gttcgcttct ctctccacta cagtatgggg ccggcgccgc gcgtcctgga
       61 actgttctac gatgtgctgt ccccctactc ctggctgggc tttgaggtcc tatgcagata
      121 ccaacacctc tggaatatca agctgaagtt gcggcccgct ttactcgctg ggatcatgaa
      181 agacagtgga aaccaaccac cagctatggt tccccacaaa ggccagtaca tactcaaaga
      241 gattcctctc ctgaagcagc tcttccaggt tcccatgagc gtccccaagg atttctttgg
      301 tgaacatgtt aagaaaggaa ctgtaaatgc catgcgcttc ctcaccgcgg tgagcatgga
      361 gcaaccagag atgctggaga aggtgtccag agagctgtgg atgcgcattt ggtcccgaga
      421 tgaagatatc acggagtccc agaacatttt gtctgcagca gagaaggccg gaatggccac
      481 agcgcaagcc caacaccttc tgaataagat ctccaccgaa ctggtgaaga gcaagctcag
      541 ggagaccact ggggcagcct gcaaatatgg ggcctttggg ctgcccacca ctgttgccca
      601 cgtggatggt aaaacctaca tgctatttgg gtctgaccgc atggagttgc tagcttacct
      661 gctaggagag aagtggatgg gccctgtgcc cccaaccctg aatgccagac tttaagattg
      721 ccttagaaag taaactttga catctccatc tgatgaagct gtcttctgtg gccctggggg
      781 ttgaaacaag agtccacctt tagctgtggc tgcctttacg tctgtgcctc ccaagtgcct
      841 cttgaaaaac cttaagctct gcattcccat aaataaaccc gatgccacta gacaaca
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