LOCUS       NM_001010921             792 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase alpha 5 (Gsta5), mRNA.
ACCESSION   NM_001010921
VERSION     NM_001010921.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 792)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 792)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   3  (bases 1 to 792)
  AUTHORS   Koen,Y.M., Yue,W., Galeva,N.A., Williams,T.D. and Hanzlik,R.P.
  TITLE     Site-specific arylation of rat glutathione s-transferase A1 and A2
            by bromobenzene metabolites in vivo
  JOURNAL   Chem Res Toxicol 19 (11), 1426-1434 (2006)
   PUBMED   17112229
REFERENCE   4  (bases 1 to 792)
  AUTHORS   Klinga-Levan,K., Andersson,A., Hanson,C., Ridderstrom,M.,
            Stenberg,G., Mannervik,B., Vajdy,M., Szpirer,J., Szpirer,C. and
            Levan,G.
  TITLE     Mapping of glutathione transferase (GST) genes in the rat
  JOURNAL   Hereditas 119 (3), 285-296 (1993)
   PUBMED   8144363
REFERENCE   5  (bases 1 to 792)
  AUTHORS   Wang,R.W., Pickett,C.B. and Lu,A.Y.
  TITLE     Expression of a cDNA encoding a rat liver glutathione S-transferase
            Ya subunit in Escherichia coli
  JOURNAL   Arch Biochem Biophys 269 (2), 536-543 (1989)
   PUBMED   2645828
REFERENCE   6  (bases 1 to 792)
  AUTHORS   Telakowski-Hopkins,C.A., Rothkopf,G.S. and Pickett,C.B.
  TITLE     Structural analysis of a rat liver glutathione S-transferase Ya
            gene
  JOURNAL   Proc Natl Acad Sci U S A 83 (24), 9393-9397 (1986)
   PUBMED   3025841
REFERENCE   7  (bases 1 to 792)
  AUTHORS   Pickett,C.B., Telakowski-Hopkins,C.A., Ding,G.J. and Ding,V.D.
  TITLE     Expression and sequence analysis of rat liver glutathione
            S-transferase genes
  JOURNAL   Adv Exp Med Biol 197, 185-193 (1986)
   PUBMED   3766257
REFERENCE   8  (bases 1 to 792)
  AUTHORS   Pickett,C.B., Telakowski-Hopkins,C.A., Ding,G.J., Argenbright,L.
            and Lu,A.Y.
  TITLE     Rat liver glutathione S-transferases. Complete nucleotide sequence
            of a glutathione S-transferase mRNA and the regulation of the Ya,
            Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital
  JOURNAL   J Biol Chem 259 (8), 5182-5188 (1984)
   PUBMED   6325423
REFERENCE   9  (bases 1 to 792)
  AUTHORS   Taylor,J.B., Craig,R.K., Beale,D. and Ketterer,B.
  TITLE     Construction and characterization of a plasmid containing
            complementary DNA to mRNA encoding the N-terminal amino acid
            sequence of the rat glutathione transferase Ya subunit
  JOURNAL   Biochem J 219 (1), 223-231 (1984)
   PUBMED   6547043
REFERENCE   10 (bases 1 to 792)
  AUTHORS   Tu,C.P., Weiss,M.J., Karakawa,W.W. and Reddy,C.C.
  TITLE     Cloning and sequence analysis of a cDNA plasmid for one of the rat
            liver glutathione S-transferase subunits
  JOURNAL   Nucleic Acids Res 10 (18), 5407-5419 (1982)
   PUBMED   6292839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001010921.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ094052.1, BQ200925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000008.1  87988354-87988466
            114-165             JAXUCZ010000008.1  87991875-87991926
            166-298             JAXUCZ010000008.1  87992734-87992866
            299-440             JAXUCZ010000008.1  87995044-87995185
            441-572             JAXUCZ010000008.1  87996643-87996774
            573-792             JAXUCZ010000008.1  87997546-87997765
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..792
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /note="glutathione S-transferase alpha 5"
                     /db_xref="GeneID:494499"
                     /db_xref="RGD:1593189"
     exon            1..113
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..695
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /EC_number="2.5.1.18"
                     /note="glutathione transferase YA subunit; GHS
                     transferase; glutathione S-transferase Ya subunit; GST
                     Ya2; GST A2-2; GST 1b-1b; glutathione S-transferase Ya-2"
                     /codon_start=1
                     /product="glutathione S-transferase alpha-2"
                     /protein_id="NP_001010921.1"
                     /db_xref="GeneID:494499"
                     /db_xref="RGD:1593189"
                     /translation="MSGKPVLHYFNARGRMECIRWLLAAAGVEFEEKLIQSPEDLEKL
                     KKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDL
                     TEMIIQLVICPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHL
                     LELLLYVEEFDASLLTPFPLLKAFKSRISSLPNVKKFLQPGSQRKPAMDAKQIEEARK
                     VFKF"
     exon            114..165
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..298
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..440
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..572
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..792
                     /gene="Gsta5"
                     /gene_synonym="Gsta2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagacagtg aagcacagtt gctgctatgt ctgggaagcc agtgcttcac tacttcaatg
       61 cccggggcag aatggagtgc atccggtggc tcctggctgc agcaggagtg gagtttgaag
      121 agaagcttat acagagtcca gaagacttgg aaaagctaaa gaaagacggg aatttgatgt
      181 ttgaccaagt gcccatggtg gagattgacg ggatgaagct ggcacagacc agagccattc
      241 tcaactacat cgccaccaaa tatgacctct atgggaagga catgaaggag agagccctga
      301 ttgacatgta ttcagagggt attttagatc tgactgaaat gattatccaa ttggtaatat
      361 gtcccccaga ccaaagagaa gccaagaccg ccttggcaaa agacaggacc aaaaaccggt
      421 acttgcctgc ctttgaaaag gtgttgaaga gccatggcca agactacctt gtaggcaaca
      481 ggctgacccg ggtagacatc cacctgctgg aacttctcct ctatgttgaa gagtttgatg
      541 ccagccttct gacccctttc cctctgctga aggccttcaa gagcagaatc agcagcctcc
      601 ccaatgtgaa gaagttcctg cagcctggca gtcagagaaa gccagccatg gatgcaaaac
      661 aaatcgaaga agcaaggaag gttttcaagt tttagcggag ctgcactgtc caatttcttt
      721 atgttttgca aaaaatgaga agcaattgtt gatcctggct attttgcaat aataaaaaaa
      781 tgaacaaatg gt
//
