LOCUS       NM_001106840             898 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus glutathione S-transferase alpha 4 (Gsta4), mRNA.
ACCESSION   NM_001106840 XM_001059683 XM_217195
VERSION     NM_001106840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Carlstrom,K.E., Zhu,K., Ewing,E., Krabbendam,I.E., Harris,R.A.,
            Falcao,A.M., Jagodic,M., Castelo-Branco,G. and Piehl,F.
  TITLE     Gsta4 controls apoptosis of differentiating adult oligodendrocytes
            during homeostasis and remyelination via the
            mitochondria-associated Fas-Casp8-Bid-axis
  JOURNAL   Nat Commun 11 (1), 4071 (2020)
   PUBMED   32792491
  REMARK    GeneRIF: Gsta4 controls apoptosis of differentiating adult
            oligodendrocytes during homeostasis and remyelination via the
            mitochondria-associated Fas-Casp8-Bid-axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Ahmad,I., Shukla,S., Singh,D., Chauhan,A.K., Kumar,V., Singh,B.K.,
            Patel,D.K., Pandey,H.P. and Singh,C.
  TITLE     CYP2E1-mediated oxidative stress regulates HO-1 and GST expression
            in maneb- and paraquat-treated rat polymorphonuclear leukocytes
  JOURNAL   Mol Cell Biochem 393 (1-2), 209-222 (2014)
   PUBMED   24771067
  REMARK    GeneRIF: The results demonstrate that CYP2E1 induces
            iNOS-independent free radical generation and subsequently modulates
            the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb-
            and paraquat-treated PMNs.
            Erratum:[Mol Cell Biochem. 2019 Sep;459(1-2):215-217. doi:
            10.1007/s11010-019-03587-8.. PMID: 31325012]
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Ahmad,I., Shukla,S., Kumar,A., Singh,B.K., Kumar,V., Chauhan,A.K.,
            Singh,D., Pandey,H.P. and Singh,C.
  TITLE     Biochemical and molecular mechanisms of N-acetyl cysteine and
            silymarin-mediated protection against maneb- and paraquat-induced
            hepatotoxicity in rats
  JOURNAL   Chem Biol Interact 201 (1-3), 9-18 (2013)
   PUBMED   23159886
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Wang,H., Wu,G., Park,H.J., Jiang,P.P., Sit,W.H., van Griensven,L.J.
            and Wan,J.M.
  TITLE     Protective effect of Phellinus linteus polysaccharide extracts
            against thioacetamide-induced liver fibrosis in rats: a proteomics
            analysis
  JOURNAL   Chin Med 7 (1), 23 (2012)
   PUBMED   23075396
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Strom,M., Al Nimer,F., Lindblom,R., Nyengaard,J.R. and Piehl,F.
  TITLE     Naturally occurring genetic variability in expression of Gsta4 is
            associated with differential survival of axotomized rat motoneurons
  JOURNAL   Neuromolecular Med 14 (1), 15-29 (2012)
   PUBMED   22160604
  REMARK    GeneRIF: These results showed and mapped naturally occurring
            genetic differences in the expression of Gsta4 associated both with
            a highly significant increase in the survival of axotomized
            motoneurons and with a trans-regulation of several molecular
            pathways.
REFERENCE   6  (bases 1 to 898)
  AUTHORS   Strange,R.C., Jones,P.W. and Fryer,A.A.
  TITLE     Glutathione S-transferase: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 357-363 (2000)
   PUBMED   10720752
  REMARK    Review article
REFERENCE   7  (bases 1 to 898)
  AUTHORS   Bruns,C.M., Hubatsch,I., Ridderstrom,M., Mannervik,B. and
            Tainer,J.A.
  TITLE     Human glutathione transferase A4-4 crystal structures and
            mutagenesis reveal the basis of high catalytic efficiency with
            toxic lipid peroxidation products
  JOURNAL   J Mol Biol 288 (3), 427-439 (1999)
   PUBMED   10329152
REFERENCE   8  (bases 1 to 898)
  AUTHORS   Bhagwat,S.V., Vijayasarathy,C., Raza,H., Mullick,J. and
            Avadhani,N.G.
  TITLE     Preferential effects of nicotine and
            4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on
            mitochondrial glutathione S-transferase A4-4 induction and
            increased oxidative stress in the rat brain
  JOURNAL   Biochem Pharmacol 56 (7), 831-839 (1998)
   PUBMED   9774145
REFERENCE   9  (bases 1 to 898)
  AUTHORS   Stenberg,G., Ridderstrom,M., Engstrom,A., Pemble,S.E. and
            Mannervik,B.
  TITLE     Cloning and heterologous expression of cDNA encoding class alpha
            rat glutathione transferase 8-8, an enzyme with high catalytic
            activity towards genotoxic alpha,beta-unsaturated carbonyl
            compounds
  JOURNAL   Biochem J 284 (Pt 2) (Pt 2), 313-319 (1992)
   PUBMED   1599415
REFERENCE   10 (bases 1 to 898)
  AUTHORS   Alin,P., Jensson,H., Cederlund,E., Jornvall,H. and Mannervik,B.
  TITLE     Cytosolic glutathione transferases from rat liver. Primary
            structure of class alpha glutathione transferase 8-8 and
            characterization of low-abundance class Mu glutathione transferases
  JOURNAL   Biochem J 261 (2), 531-539 (1989)
   PUBMED   2775231
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217195.3, XM_001059683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..898
                     /gene="Gsta4"
                     /note="glutathione S-transferase alpha 4"
                     /db_xref="GeneID:300850"
                     /db_xref="RGD:1309970"
     exon            1..47
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            48..154
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..736
                     /gene="Gsta4"
                     /EC_number="2.5.1.18"
                     /note="glutathione transferase; GST K; GST Yk; GST 8-8;
                     GST A4-4; glutathione S-transferase Yk; glutathione
                     S-transferase A4"
                     /codon_start=1
                     /product="glutathione S-transferase alpha-4"
                     /protein_id="NP_001100310.1"
                     /db_xref="GeneID:300850"
                     /db_xref="RGD:1309970"
                     /translation="MEVKPKLYYFQGRGRMESIRWLLATAGVEFEEEFLETREQYEKL
                     QKDGCLLFGQVPLVEIDGMLLTQTRAILSYLAAKYNLYGKDLKERVRIDMYADGTQDL
                     MMMIIGAPFKAPQEKEESLALAVKRAKNRYFPVFEKILKDHGEAFLVGNQLSWADIQL
                     LEAILMVEEVSAPVLSDFPLLQAFKTRISNIPTIKKFLQPGSQRKPPPDGHYVDVVRT
                     VLKF"
     exon            155..206
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            207..339
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            340..481
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            482..613
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
     exon            614..898
                     /gene="Gsta4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcaacagc ctttctctag ttcctgcaga caaaatccca gaataaggaa actctgaacc
       61 aggagtcatg gaagtcaaac ccaagctcta ctactttcaa ggcaggggaa ggatggagtc
      121 gatccgctgg ctgctggcta cagctggagt ggagtttgaa gaagaatttc ttgagacgag
      181 agaacaatat gagaagttgc aaaaggatgg atgcctgctt tttggccaag tcccattggt
      241 ggaaatagac gggatgctac tgacacagac cagagccatc ctcagctacc tggccgccaa
      301 gtacaacttg tatgggaagg acctgaagga gagagtcagg attgacatgt atgccgatgg
      361 cacccaggac ctgatgatga tgattatcgg ggctccattt aaagcccctc aggaaaaaga
      421 agagagccta gctttagcag tgaagagggc taaaaaccgt tacttcccag tgtttgaaaa
      481 gattttaaaa gaccatggag aggcatttct tgttggcaac caactcagtt gggcagacat
      541 acagctacta gaagccattt tgatggtgga agaagtcagt gctcctgtgt tgtctgactt
      601 ccctctgctg caggcattta agacaagaat cagcaacatt cctacaatta agaagttcct
      661 gcaacctgga agtcagagga agccacctcc ggatggccac tatgttgacg tggtcaggac
      721 cgtcctgaag ttctagtgac agcgtgcttt aaagtggcta ctgcaagggt ccaatcacag
      781 cagcagctac agagcattcc agaggcaaga tagagctctc aggagtaaag gtcttcaaag
      841 aacgaaacca ctctgtccac aatgacaaat gccaattaaa tagagtgaaa aactgttc
//
