LOCUS       NM_017013                831 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), mRNA.
ACCESSION   NM_017013 XM_003750543
VERSION     NM_017013.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Swain,A., Turton,J., Scudamore,C., Maguire,D., Pereira,I.,
            Freitas,S., Smyth,R., Munday,M., Stamp,C., Gandhi,M., Sondh,S.,
            Ashall,H., Francis,I., Woodfine,J., Bowles,J. and York,M.
  TITLE     Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover
            Wistar rat; correlation of minimal histopathological changes with
            biomarkers of renal injury
  JOURNAL   J Appl Toxicol 32 (6), 417-428 (2012)
   PUBMED   21905055
  REMARK    GeneRIF: The most sensitive, noninvasive biomarkers of HCBD-induced
            renal toxicity in Hanover Wistar rats were urinary alpha-GST and
            KIM-1.
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Stella,L., Pallottini,V., Moreno,S., Leoni,S., De Maria,F.,
            Turella,P., Federici,G., Fabrini,R., Dawood,K.F., Bello,M.L.,
            Pedersen,J.Z. and Ricci,G.
  TITLE     Electrostatic association of glutathione transferase to the nuclear
            membrane. Evidence of an enzyme defense barrier at the nuclear
            envelope
  JOURNAL   J Biol Chem 282 (9), 6372-6379 (2007)
   PUBMED   17197701
  REMARK    GeneRIF: a considerable amount of GSTs, in particular GSTA1-1,
            GSTA2-2, and GSTA3-3, corresponding to 10% of the cytosolic pool is
            electrostatically associated with the outer nuclear membrane, and a
            similar quantity is compartmentalized inside the nucleus
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Falkner,K.C. and Prough,R.A.
  TITLE     Regulation of the rat glutathione S-transferase A2 gene by
            glucocorticoids: crosstalk through C/EBPs
  JOURNAL   Drug Metab Rev 39 (2-3), 401-418 (2007)
   PUBMED   17786629
  REMARK    GeneRIF: C/EBP alpha and beta are involved in
            glucocorticoid-dependent repression of GSTA2 gene expression
REFERENCE   6  (bases 1 to 831)
  AUTHORS   Wang,R.W., Pickett,C.B. and Lu,A.Y.
  TITLE     Expression of a cDNA encoding a rat liver glutathione S-transferase
            Ya subunit in Escherichia coli
  JOURNAL   Arch Biochem Biophys 269 (2), 536-543 (1989)
   PUBMED   2645828
REFERENCE   7  (bases 1 to 831)
  AUTHORS   Telakowski-Hopkins,C.A., Rothkopf,G.S. and Pickett,C.B.
  TITLE     Structural analysis of a rat liver glutathione S-transferase Ya
            gene
  JOURNAL   Proc Natl Acad Sci U S A 83 (24), 9393-9397 (1986)
   PUBMED   3025841
REFERENCE   8  (bases 1 to 831)
  AUTHORS   Rothkopf,G.S., Telakowski-Hopkins,C.A., Stotish,R.L. and
            Pickett,C.B.
  TITLE     Multiplicity of glutathione S-transferase genes in the rat and
            association with a type 2 Alu repetitive element
  JOURNAL   Biochemistry 25 (5), 993-1002 (1986)
   PUBMED   2421763
REFERENCE   9  (bases 1 to 831)
  AUTHORS   Pickett,C.B., Telakowski-Hopkins,C.A., Ding,G.J. and Ding,V.D.
  TITLE     Expression and sequence analysis of rat liver glutathione
            S-transferase genes
  JOURNAL   Adv Exp Med Biol 197, 185-193 (1986)
   PUBMED   3766257
REFERENCE   10 (bases 1 to 831)
  AUTHORS   Telakowski-Hopkins,C.A., Rodkey,J.A., Bennett,C.D., Lu,A.Y. and
            Pickett,C.B.
  TITLE     Rat liver glutathione S-transferases. Construction of a cDNA clone
            complementary to a Yc mRNA and prediction of the complete amino
            acid sequence of a Yc subunit
  JOURNAL   J Biol Chem 260 (9), 5820-5825 (1985)
   PUBMED   2985614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            K01931.1 and BC078706.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003750543.1, NM_017013.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: K01931.1, FQ217939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               K01931.1           1-131
            132-831             BC078706.1         124-823
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..831
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /note="glutathione S-transferase alpha 2"
                     /db_xref="GeneID:24422"
                     /db_xref="RGD:2754"
     exon            1..41
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..150
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..732
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase Ya subunit; glutathione
                     S-transferase A2; Glutathione-S-transferase alpha type
                     (Yc?); GST B; GST 1-1; GST Ya1; GST A1-1; ligandin; GST
                     1a-1a; glutathione S-transferase Ya-1;
                     glutathione-S-transferase, alpha type2;
                     androst-5-ene-3,17-dione isomerase;
                     13-hydroperoxyoctadecadienoate peroxidase"
                     /codon_start=1
                     /product="glutathione S-transferase alpha-1"
                     /protein_id="NP_058709.2"
                     /db_xref="GeneID:24422"
                     /db_xref="RGD:2754"
                     /translation="MSGKPVLHYFNARGRMECIRWLLAAAGVEFDEKFIQSPEDLEKL
                     KKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDL
                     TEMIMQLVICPPDQKEAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHL
                     LELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKLPVDAKQIEEARK
                     IFKF"
     exon            151..202
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..335
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..477
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..609
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..831
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      809..814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
     polyA_site      831
                     /gene="Gsta2"
                     /gene_synonym="Gsta1"
ORIGIN      
        1 agttgggagc tgagtggaga agaagccacg attctcgcta gacagtgaag cacagttgct
       61 gctatgtctg ggaagccagt gcttcactac ttcaatgccc ggggcagaat ggagtgcatc
      121 cggtggctcc tggctgcagc aggagtggag tttgatgaga agtttataca gagtccagaa
      181 gacttggaaa agctaaagaa agacgggaat ttgatgtttg accaagtgcc catggtggag
      241 attgacggga tgaagctggc acagaccaga gccattctca actacatcgc caccaaatat
      301 gacctctatg ggaaggacat gaaggagaga gccctgattg acatgtacac cgaaggcatt
      361 ttagatctga ctgaaatgat tatgcaattg gtaatatgtc ccccagacca aaaagaagcc
      421 aagaccgcct tggcaaaaga caggaccaaa aaccggtact tgcctgcctt tgaaaaggtg
      481 ttgaagagcc atggccaaga ctaccttgta ggtaacaggc tgacccgggt agacatccac
      541 ctgctggaac ttctcctcta tgttgaagag tttgatgcca gccttctgac ctctttccct
      601 ctgctgaagg ccttcaagag cagaatcagc agcctcccca atgtgaagaa gttcctgcag
      661 cctggcagtc agagaaagct tcccgtggat gcaaaacaaa tcgaagaagc aaggaagatt
      721 ttcaagtttt agcggagctg cactgtccaa tttctttatg ttttgcaaaa aatgagaagc
      781 aattgttgat cctaggtatt tttgaaataa taaacacgaa aaaatactct a
//
