LOCUS       NM_031509               1178 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus glutathione S-transferase alpha 1 (Gsta1), mRNA.
ACCESSION   NM_031509 XM_343435
VERSION     NM_031509.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Korashy,H.M., Maayah,Z.H., Al Anazi,F.E., Alsaad,A.M.,
            Alanazi,I.O., Belali,O.M., Al-Atawi,F.O. and Alshamsan,A.
  TITLE     Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing
            Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting
            NF-kappaB Signaling Pathways
  JOURNAL   Anticancer Res 37 (9), 4899-4909 (2017)
   PUBMED   28870911
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Polimanti,R., Piacentini,S., Moscatelli,B., Pellicciotti,L.,
            Manfellotto,D. and Fuciarelli,M.
  TITLE     GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma
            patients
  JOURNAL   Clin Exp Pharmacol Physiol 37 (8), 870-872 (2010)
   PUBMED   20374258
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Achilonu,I., Gildenhuys,S., Fisher,L., Burke,J., Fanucchi,S.,
            Sewell,B.T., Fernandes,M. and Dirr,H.W.
  TITLE     The role of a topologically conserved isoleucine in glutathione
            transferase structure, stability and function
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 66 (Pt 7), 776-780
            (2010)
   PUBMED   20606271
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Khrunin,A.V., Moisseev,A., Gorbunova,V. and Limborska,S.
  TITLE     Genetic polymorphisms and the efficacy and toxicity of
            cisplatin-based chemotherapy in ovarian cancer patients
  JOURNAL   Pharmacogenomics J 10 (1), 54-61 (2010)
   PUBMED   19786980
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Hayes,J.D., Judah,D.J., McLellan,L.I., Kerr,L.A., Peacock,S.D. and
            Neal,G.E.
  TITLE     Ethoxyquin-induced resistance to aflatoxin B1 in the rat is
            associated with the expression of a novel alpha-class glutathione
            S-transferase subunit, Yc2, which possesses high catalytic activity
            for aflatoxin B1-8,9-epoxide
  JOURNAL   Biochem J 279 (Pt 2) (Pt 2), 385-398 (1991)
   PUBMED   1953636
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Huskey,S.E., Wang,R.W., Linemeyer,D.L., Pickett,C.B. and Lu,A.Y.
  TITLE     Expression in Escherichia coli of rat liver cytosolic glutathione
            S-transferase Yc cDNA
  JOURNAL   Arch Biochem Biophys 279 (1), 116-121 (1990)
   PUBMED   2186703
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Telakowski-Hopkins,C.A., Rodkey,J.A., Bennett,C.D., Lu,A.Y. and
            Pickett,C.B.
  TITLE     Rat liver glutathione S-transferases. Construction of a cDNA clone
            complementary to a Yc mRNA and prediction of the complete amino
            acid sequence of a Yc subunit
  JOURNAL   J Biol Chem 260 (9), 5820-5825 (1985)
   PUBMED   2985614
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Tu,C.P., Lai,H.C., Li,N.Q., Weiss,M.J. and Reddy,C.C.
  TITLE     The Yc and Ya subunits of rat liver glutathione S-transferases are
            the products of separate genes
  JOURNAL   J Biol Chem 259 (15), 9434-9439 (1984)
   PUBMED   6204982
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Pickett,C.B., Telakowski-Hopkins,C.A., Ding,G.J., Argenbright,L.
            and Lu,A.Y.
  TITLE     Rat liver glutathione S-transferases. Complete nucleotide sequence
            of a glutathione S-transferase mRNA and the regulation of the Ya,
            Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital
  JOURNAL   J Biol Chem 259 (8), 5182-5188 (1984)
   PUBMED   6325423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF111160.1.
            
            On Jan 29, 2005 this sequence version replaced NM_031509.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213952.1, X78848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1178
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /note="glutathione S-transferase alpha 1"
                     /db_xref="GeneID:24421"
                     /db_xref="RGD:2753"
     exon            1..218
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..326
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..905
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase A3 subunit; glutathione
                     S-transferase Yc1 subunit; glutathione S-transferase A5;
                     Glutathione-S-transferase alpha type (Ya); glutathione
                     S-transferase A1"
                     /codon_start=1
                     /product="glutathione S-transferase alpha-3"
                     /protein_id="NP_113697.1"
                     /db_xref="GeneID:24421"
                     /db_xref="RGD:2753"
                     /translation="MPGKPVLHYFDGRGRMEPIRWLLAAAGVEFEEQFLKTRDDLARL
                     RNDGSLMFQQVPMVEIDGMKLVQTRAILNYIATKYNLYGKDMKERALIDMYAEGVADL
                     DEIVLHYPYIPPGEKEASLAKIKDKARNRYFPAFEKVLKSHGQDYLVGNRLSRADVYL
                     VQVLYHVEELDPSALANFPLLKALRTRVSNLPTVKKFLQPGSQRKPLEDEKCVESAVK
                     IFS"
     exon            327..378
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..511
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..653
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..785
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1158
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
     polyA_site      1157
                     /gene="Gsta1"
                     /gene_synonym="GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3;
                     Gsta5; Yc1"
ORIGIN      
        1 acattaacca actgtttagc aactcaggca tgactttgca tttttcttct aatctttcat
       61 agaaatttct ggccactgga cactgtggga gcagctttta ccttattgga ctatctcccc
      121 ttaagtggga agggcttagt caaatgcagt aaagagctat aaaacaccga gaactcttga
      181 tgtgttgtga aacttagagg gagcagcttt ttaacaagag aactcaagca attgctgcca
      241 tgccggggaa gccagtcctt cactacttcg atggcagggg gagaatggag cccatccggt
      301 ggctcctggc tgcagctgga gtagagtttg aagaacaatt tctgaaaact cgggatgacc
      361 tggccaggct aaggaatgat gggagtttga tgttccagca agtgcccatg gtggagattg
      421 atgggatgaa gctggtgcag accagagcca ttctcaacta cattgccacc aaatacaacc
      481 tctatgggaa ggacatgaag gagagagccc tcatcgacat gtatgcagaa ggagtggcgg
      541 atctggatga aatagttctc cattaccctt acattccccc tggggagaaa gaggcaagtc
      601 ttgccaaaat caaggacaaa gcaaggaacc gttactttcc tgcctttgaa aaggtgttga
      661 agagccatgg acaagattat ctcgttggca ataggctgag cagggctgat gtttacctag
      721 ttcaagttct ctaccatgtg gaagagctgg accccagcgc tttggccaac ttccctctgc
      781 tgaaggccct gagaaccaga gtcagcaacc tccccacagt gaagaagttt cttcagcctg
      841 gcagccagag gaagccatta gaggatgaga aatgtgtaga atctgcagtt aagatcttca
      901 gttaattcag gcatctatgg atacactgta cccacaaagc cagccttcga aagctttgca
      961 acaatcgcat attttgacta aatgttgacc ctacttattg ggaggccaac acgttttcta
     1021 atgcttctgt gttaattcat atagacatga ctgatgagga attgctggga tgctatttgg
     1081 ttgtagttaa aatttgaaat catgatcact tcctcagata ttactttgaa tctcaataaa
     1141 aacttcgcaa gcttcttaaa aaaaaaaaaa aaaaaaaa
//
