LOCUS       NM_012962               1882 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus glutathione synthetase (Gss), mRNA.
ACCESSION   NM_012962
VERSION     NM_012962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Jobgen,W., Fu,W.J., Gao,H., Li,P., Meininger,C.J., Smith,S.B.,
            Spencer,T.E. and Wu,G.
  TITLE     High fat feeding and dietary L-arginine supplementation
            differentially regulate gene expression in rat white adipose tissue
  JOURNAL   Amino Acids 37 (1), 187-198 (2009)
   PUBMED   19212806
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Lee,J.S., Ward,W.O., Wolf,D.C., Allen,J.W., Mills,C., DeVito,M.J.
            and Corton,J.C.
  TITLE     Coordinated changes in xenobiotic metabolizing enzyme gene
            expression in aging male rats
  JOURNAL   Toxicol Sci 106 (1), 263-283 (2008)
   PUBMED   18653662
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Dahl,N., Pigg,M., Ristoff,E., Gali,R., Carlsson,B., Mannervik,B.,
            Larsson,A. and Board,P.
  TITLE     Missense mutations in the human glutathione synthetase gene result
            in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and
            neurological dysfunction
  JOURNAL   Hum Mol Genet 6 (7), 1147-1152 (1997)
   PUBMED   9215686
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Shi,Z.Z., Habib,G.M., Rhead,W.J., Gahl,W.A., He,X., Sazer,S. and
            Lieberman,M.W.
  TITLE     Mutations in the glutathione synthetase gene cause 5-oxoprolinuria
  JOURNAL   Nat Genet 14 (3), 361-365 (1996)
   PUBMED   8896573
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Shi,Z.Z., Carter,B.Z., Habib,G.M., He,X., Sazer,S., Lebovitz,R.M.
            and Lieberman,M.W.
  TITLE     A single mouse glutathione synthetase gene encodes six mRNAs with
            different 5' ends
  JOURNAL   Arch Biochem Biophys 331 (2), 215-224 (1996)
   PUBMED   8660701
REFERENCE   9  (bases 1 to 1882)
  AUTHORS   Huang,C.S., He,W., Meister,A. and Anderson,M.E.
  TITLE     Amino acid sequence of rat kidney glutathione synthetase
  JOURNAL   Proc Natl Acad Sci U S A 92 (4), 1232-1236 (1995)
   PUBMED   7862666
REFERENCE   10 (bases 1 to 1882)
  AUTHORS   Biocca,M.E., Canuto,R.A., Muzio,G., Rossi,M.A. and Dianzani,M.U.
  TITLE     Glutathione synthesis in normal liver and in Yoshida AH-130
            hepatoma
  JOURNAL   Toxicol Pathol 14 (4), 415-416 (1986)
   PUBMED   3809895
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L38615.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38615.1, SRR8487231.39633.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1882
                     /gene="Gss"
                     /note="glutathione synthetase"
                     /db_xref="GeneID:25458"
                     /db_xref="RGD:2752"
     exon            1..38
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            39..173
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1469
                     /gene="Gss"
                     /EC_number="6.3.2.3"
                     /function="catalyzes the second step in glutathione
                     synthetase"
                     /note="GSH-S; GSH synthetase; glutathione synthase"
                     /codon_start=1
                     /product="glutathione synthetase"
                     /protein_id="NP_037094.1"
                     /db_xref="GeneID:25458"
                     /db_xref="RGD:2752"
                     /translation="MATSWGSILQDEKQLEELAQQAIDRALAEGVLLRSAKNPSSSDV
                     VTYAPFTLFPSPVPSTLLEQAYAVQMDFNILVDAVSQNSAFLEQTLSSTIKKDEYTAR
                     LFDIYKQVLKEGIAQTVFLGLNRSDYMFQCSADGSKALKQIEINTISASFGGLASRTP
                     AVHRHVLNVLNKTNEASKILSNNPSKGLALGIAKAWELYGSANAVVLLIAQEKERNIF
                     DQRAIENELLDRKIHVIRRRFEDVSERGSLDQNRRLFMEDQEVAVVYFRDGYMPSQYN
                     AQNWEARLLLERSCAAKCPDIATQLAGTKKVQQELSRVGLLEALLPGQPEAVARLRAT
                     FAGLYSLDMGEEGDQAVAEALAAPSHFVLKPQREGGGNNFYGEEMVHALEQLKDSEER
                     ASYILMEKIEPEPFRNCLLRPGSPAQVVQCISELGIFGVYVRQGTTLVMNKHVGHLLR
                     TKAIEHADGGVAAGVAVLDNPYPV"
     exon            174..319
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            320..395
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            396..535
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            536..652
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            653..733
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            734..811
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            812..878
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1073
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1155
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1345
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1882
                     /gene="Gss"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1882
                     /gene="Gss"
ORIGIN      
        1 tggagtttga gcttggcgag cagctggaca acgagcgagt tgggatggcc accagctggg
       61 gaagcatctt gcaggatgag aagcagctgg aagagttggc acagcaggcc atagaccggg
      121 ccctggctga gggggtgttg ctgaggtccg caaagaaccc cagctcctct gacgtggtga
      181 cgtatgcccc attcacgctc ttcccctcac cagtgcccag cactctgctg gagcaggcct
      241 atgctgtgca gatggacttc aacatcctgg tagatgctgt cagccagaac tccgccttcc
      301 tggagcaaac actgtctagc accatcaaaa aggatgagta tactgcccgt ctctttgata
      361 tctacaagca agtcctgaaa gagggcatag cccagactgt gttcctgggc ctcaatcgtt
      421 cagattacat gttccagtgc agcgcagacg gctccaaagc cctgaaacag attgagatca
      481 acactatctc tgccagcttt gggggcctgg cctcccggac tccggctgtg caccgacatg
      541 ttctcaatgt cctgaataag accaacgaag cttccaagat cctgtccaac aaccccagca
      601 agggactggc cctggggatc gccaaagcct gggagctcta tggctcagcc aatgccgtgg
      661 tgctactgat tgctcaggag aaggaaagga acatatttga ccagcgtgcc atagagaacg
      721 agctgctaga caggaagatc catgtaatcc gccgaagatt tgaagatgtc tctgaaaggg
      781 gttctctaga ccaaaaccga aggctgttta tggaggacca ggaagttgct gtggtttact
      841 tccgagatgg ctacatgccc agtcagtata acgcacagaa ctgggaagct cgcctgctgc
      901 tagagagatc atgtgctgcc aagtgtcccg acattgccac acagctggct ggcactaaga
      961 aggtgcagca ggaactgagc agggtgggcc tgctggaagc gctgctcccg ggccagcccg
     1021 aggctgtggc ccgcctccgt gccacctttg ctggcctcta ttcactggac atgggtgaag
     1081 aaggggacca ggctgtcgct gaggcccttg ctgcccctag ccactttgtg ctgaagcccc
     1141 aaagagaggg cggaggtaat aacttctatg gggaggaaat ggtacacgct ctggagcagc
     1201 tgaaagacag cgaggagaga gcctcctaca tcctcatgga gaagattgaa cctgagcctt
     1261 ttaggaattg cttactacgg cctggcagcc ctgcccaagt ggtccagtgc atctcggagc
     1321 tgggtatttt tggagtctat gtcagacagg gaacaacact tgtgatgaac aagcatgtgg
     1381 ggcatctgct tcgaaccaaa gccattgaac atgcagatgg aggtgtggca gcaggagtgg
     1441 cagtcctgga caacccctac cctgtgtgaa gacatgttct gggcttcact caagagacct
     1501 tctatcctct gtacttggca ctcctctcct gaggggctac ccctgtacct gtgttagggg
     1561 agggagcttg tctctttcat agacctccag gggctttagg gaagggaaaa tcccgggtcc
     1621 cttctctcag ccttccatcc aaggaccaga aaagctatga ttccattgga agagttctgg
     1681 agctccccag atttggagtg ggaatggaag ctcctttgag gcaaaggccc acaaacccca
     1741 cacatcttca ttgccctctc gccagccttt ccagcaggtt ctagtgcctt gacctggggt
     1801 aggaccaagt gacaggagga agagggtaga tgggcataga cttccccagc tctgccctaa
     1861 ataaaacaat gctgattcaa tg
//
