LOCUS       NM_053906               1850 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus glutathione-disulfide reductase (Gsr), mRNA.
ACCESSION   NM_053906 XM_344528
VERSION     NM_053906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Bessieres,B., Cruz,E. and Alberini,C.M.
  TITLE     Metabolomic profiling reveals a differential role for hippocampal
            glutathione reductase in infantile memory formation
  JOURNAL   Elife 10, e68590 (2021)
   PUBMED   34825649
  REMARK    GeneRIF: Metabolomic profiling reveals a differential role for
            hippocampal glutathione reductase in infantile memory formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Kim,J.S., Kwon,W.Y., Suh,G.J., Kim,K.S., Jung,Y.S., Kim,S.H. and
            Lee,S.E.
  TITLE     Plasma glutathione reductase activity and prognosis of septic shock
  JOURNAL   J Surg Res 200 (1), 298-307 (2016)
   PUBMED   26316444
  REMARK    GeneRIF: Plasma glutathione reductase (GR) activity was correlated
            with erythrocyte GR activity and the erythrocyte reduced
            glutathione/glutathione disulfide ratio. A decrease in plasma GR
            activity was associated with an increase in mortality in septic
            shock.
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Nidhi,B., Sharavana,G., Ramaprasad,T.R. and Vallikannan,B.
  TITLE     Lutein derived fragments exhibit higher antioxidant and
            anti-inflammatory properties than lutein in lipopolysaccharide
            induced inflammation in rats
  JOURNAL   Food Funct 6 (2), 450-460 (2015)
   PUBMED   25469663
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Abd El Tawab,A.M., Shahin,N.N. and AbdelMohsen,M.M.
  TITLE     Protective effect of Satureja montana extract on
            cyclophosphamide-induced testicular injury in rats
  JOURNAL   Chem Biol Interact 224, 196-205 (2014)
   PUBMED   25446862
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Yeung,J.H.
  TITLE     Effects of glycerol-induced acute renal failure on tissue
            glutathione and glutathione-dependent enzymes in the rat
  JOURNAL   Methods Find Exp Clin Pharmacol 13 (1), 23-28 (1991)
   PUBMED   1870354
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Loos,H., Roos,D., Weening,R. and Houwerzijl,J.
  TITLE     Familial deficiency of glutathione reductase in human blood cells
  JOURNAL   Blood 48 (1), 53-62 (1976)
   PUBMED   947404
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Carlberg,I. and Mannervik,B.
  TITLE     Purification and characterization of the flavoenzyme glutathione
            reductase from rat liver
  JOURNAL   J Biol Chem 250 (14), 5475-5480 (1975)
   PUBMED   237922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM035154.1, CK357934.1 and JAXUCZ010000016.1.
            
            On Oct 20, 2010 this sequence version replaced NM_053906.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32873.1,
                                           SRR26643291.38408.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               FM035154.1         1-556
            557-1219            CK357934.1         20-682
            1220-1850           JAXUCZ010000016.1  65185574-65186204   c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..1850
                     /gene="Gsr"
                     /note="glutathione-disulfide reductase"
                     /db_xref="GeneID:116686"
                     /db_xref="RGD:621747"
     exon            1..26
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            27..53
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            54..142
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1289
                     /gene="Gsr"
                     /EC_number="1.8.1.7"
                     /note="GR; GRase; glutathione reductase, mitochondrial"
                     /codon_start=1
                     /product="glutathione reductase"
                     /protein_id="NP_446358.2"
                     /db_xref="GeneID:116686"
                     /db_xref="RGD:621747"
                     /translation="MWNTAVHSEFIHDHVDYGFQNCKSKFNWHVIKEKRDAYVSRLNN
                     IYQNNLTKSHIEVIHGYATFADGPQPTVEVNGKKFTAPHILIATGGVPTVPHENQIPG
                     ASLGITSDGFFQLEDLPSRSVIVGAGYIAVEIAGILSALGSKTSLMIRHDKVLRSFDS
                     LISSNCTEELENAGVEVLKFSQVKEVKKTPSGLELHVVTALPGRKPTVTTIPDVDCLL
                     WAIGRDPNSKGLNLNKLGIQTDDKGHILVDEFQNTNVKGVYAVGDVCGKALLTPVAIA
                     AGRKLAHRLFEGKEDSRLDYDNIPTVVFSHPPIGTVGLTEDEAVHKYGKDNVKIYSTA
                     FTPMYHAVTTRKTKCVMKMVCANKEEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADF
                     DNTVAIHPTSSEELVTLR"
     exon            143..212
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            213..360
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            361..415
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            416..515
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            516..602
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            603..761
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            762..873
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1005
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1139
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1850
                     /gene="Gsr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtcacaa gctgggcggc acttgcgtga acgttggatg tgtacccaaa aaggtaatgt
       61 ggaacacagc cgtgcactcg gaattcatac atgatcacgt ggattacggc tttcaaaact
      121 gcaagagtaa attcaattgg catgtcatca aggagaagcg ggatgcttac gtgagccgcc
      181 tgaacaacat ctaccaaaac aatttaacca agtcccacat cgaagtcatc cacggctacg
      241 caacatttgc agatggtccc cagcccacag tggaagtcaa cgggaaaaag ttcactgctc
      301 cacacatcct gatcgccacg ggtggtgtgc ccacggttcc tcatgagaac cagatcccag
      361 gtgccagcct ggggataacc agtgatgggt tctttcagct ggaagacttg cccagccgca
      421 gcgttattgt gggtgccggt tacattgccg tggagattgc gggcatcctc tccgccctgg
      481 gctccaagac gtctcttatg atcaggcatg ataaggtgct tagaagcttt gattcactca
      541 tcagttccaa ctgcaccgag gagctggaga acgctggcgt ggaggtgttg aagttctcac
      601 aggttaagga agtaaagaag accccatcgg gcttggaact ccatgtggtt actgcacttc
      661 ccggtaggaa acccaccgtg accacgattc cagatgtcga ttgcctgctc tgggccattg
      721 gacgggaccc aaattctaag ggcctgaatc taaataaact ggggattcag actgatgaca
      781 aaggccatat cctagtggac gagttccaga ataccaatgt caaaggcgtc tatgccgtgg
      841 gcgatgtctg tgggaaagca cttctcaccc cagttgcgat cgctgctggc cggaaactcg
      901 cccatagact ttttgagggc aaagaagatt ccaggttgga ctatgacaac atccctaccg
      961 tggtcttcag ccacccgcct atcgggacag tggggctcac tgaagatgaa gccgtccata
     1021 agtatggcaa agacaatgtg aaaatctact cgaccgcctt caccccgatg tatcacgctg
     1081 tgaccacgag gaagacgaaa tgcgtgatga agatggtttg tgccaacaaa gaggagaagg
     1141 tggttggcat ccatatgcag gggattggct gcgatgagat gcttcagggc ttcgctgtag
     1201 cagtgaaaat gggggccacc aaggccgact tcgacaatac ggtcgccatt catcctacct
     1261 cttcagaaga gctggtcaca ctgcgctgag agccccggga ctcgtggcta gcggtccgac
     1321 cagtgggcct ctgggaggaa ccaatcaagt ttacgtcctg cgccagcttt atagatttct
     1381 gtattttaat caggaacttc tggtggtgta aatttctagt taagcaaaaa atcgaggtct
     1441 taagtgtcta atcataaggt tgttttgtta atccggggtt ggttttcatg tgataatatt
     1501 tacactagtt agcattttga tttttttttt taattaacag cctgtgttct ttgtgttttt
     1561 cttgctttgg cctcattcca agtttaaata tatgaagtac acggaagtta gcacacctga
     1621 cggatgacta tagcagctaa tttttttttt tttttttctg tgcagcccag ggtaagctca
     1681 aacaactcaa aatcctccag ctacagcctc atgagcgctg cagttctggg catgcgtggc
     1741 ctctcccggc ctagcttgct agttttatat gatggtaagt ctccatctat aaatatgcaa
     1801 gtgtacagaa tacatgtgtg cttttcgacc tggtgtttct gtatgggaaa
//
