LOCUS       NM_001004080            2612 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus gelsolin (Gsn), mRNA.
ACCESSION   NM_001004080 XM_216043
VERSION     NM_001004080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2612)
  AUTHORS   Benavente-Fernandez,I., Ramos-Rodriguez,J.J., Infante-Garcia,C.,
            Jimenez-Gomez,G., Lechuga-Sancho,A., Lubian-Lopez,S. and
            Garcia-Alloza,M.
  TITLE     Altered plasma-type gelsolin and amyloid-beta in neonates with
            hypoxic-ischaemic encephalopathy under therapeutic hypothermia
  JOURNAL   J Cereb Blood Flow Metab 39 (7), 1349-1354 (2019)
   PUBMED   29466895
REFERENCE   2  (bases 1 to 2612)
  AUTHORS   Gupta,A.K., Chopra,B.S., Vaid,B., Sagar,A., Raut,S., Badmalia,M.D.,
            Ashish and Khatri,N.
  TITLE     Protective effects of gelsolin in acute pulmonary thromboembolism
            and thrombosis in the carotid artery of mice
  JOURNAL   PLoS One 14 (4), e0215717 (2019)
   PUBMED   31002695
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2612)
  AUTHORS   Hu,W.S., Ting,W.J., Tamilselvi,S., Day,C.H., Wang,T., Chiang,W.D.,
            Viswanadha,V.P., Yeh,Y.L., Lin,W.T. and Huang,C.Y.
  TITLE     Oral administration of alcalase potato protein hydrolysate-APPH
            attenuates high fat diet-induced cardiac complications via
            TGF-beta/GSN axis in aging rats
  JOURNAL   Environ Toxicol 34 (1), 5-12 (2019)
   PUBMED   30240538
REFERENCE   4  (bases 1 to 2612)
  AUTHORS   Gertz,K., Uhlemann,R., Foryst-Ludwig,A., Barrientos,R.M.,
            Kappert,K., Thone-Reineke,C., Djoufack,P., Kirschbaum,C.,
            Fink,K.B., Heinz,A., Kintscher,U., Endres,M. and Kronenberg,G.
  TITLE     The cytoskeleton in 'couch potato-ism': Insights from a murine
            model of impaired actin dynamics
  JOURNAL   Exp Neurol 306, 34-44 (2018)
   PUBMED   29684438
REFERENCE   5  (bases 1 to 2612)
  AUTHORS   Segado-Arenas,A., Infante-Garcia,C., Benavente-Fernandez,I.,
            Sanchez-Sotano,D., Ramos-Rodriguez,J.J., Alonso-Ojembarrena,A.,
            Lubian-Lopez,S. and Garcia-Alloza,M.
  TITLE     Cognitive Impairment and Brain and Peripheral Alterations in a
            Murine Model of Intraventricular Hemorrhage in the Preterm Newborn
  JOURNAL   Mol Neurobiol 55 (6), 4896-4910 (2018)
   PUBMED   28755273
REFERENCE   6  (bases 1 to 2612)
  AUTHORS   Levy,E., Haltia,M., Fernandez-Madrid,I., Koivunen,O., Ghiso,J.,
            Prelli,F. and Frangione,B.
  TITLE     Mutation in gelsolin gene in Finnish hereditary amyloidosis
  JOURNAL   J Exp Med 172 (6), 1865-1867 (1990)
   PUBMED   2175344
REFERENCE   7  (bases 1 to 2612)
  AUTHORS   Chaponnier,C., Kocher,O. and Gabbiani,G.
  TITLE     Modulation of gelsolin content in rat aortic smooth muscle cells
            during development, experimental intimal thickening and culture. An
            immunohistochemical and biochemical study
  JOURNAL   Eur J Biochem 190 (3), 559-565 (1990)
   PUBMED   2164930
REFERENCE   8  (bases 1 to 2612)
  AUTHORS   Rabie,A., Ferraz,C., Clavel,M.C. and Legrand,C.
  TITLE     Gelsolin immunoreactivity and development of the tectorial membrane
            in the cochlea of normal and hypothyroid rats
  JOURNAL   Cell Tissue Res 254 (1), 241-245 (1988)
   PUBMED   2848627
REFERENCE   9  (bases 1 to 2612)
  AUTHORS   Smith,D.B., Janmey,P.A. and Lind,S.E.
  TITLE     Circulating actin-gelsolin complexes following oleic acid-induced
            lung injury
  JOURNAL   Am J Pathol 130 (2), 261-267 (1988)
   PUBMED   2829631
REFERENCE   10 (bases 1 to 2612)
  AUTHORS   Kwiatkowski,D.J., Stossel,T.P., Orkin,S.H., Mole,J.E., Colten,H.R.
            and Yin,H.L.
  TITLE     Plasma and cytoplasmic gelsolins are encoded by a single gene and
            contain a duplicated actin-binding domain
  JOURNAL   Nature 323 (6087), 455-458 (1986)
   PUBMED   3020431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079472.1.
            
            On Sep 3, 2004 this sequence version replaced XM_216043.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132271, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2612
                     /gene="Gsn"
                     /note="gelsolin"
                     /db_xref="GeneID:296654"
                     /db_xref="RGD:1303089"
     exon            1..148
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2353
                     /gene="Gsn"
                     /note="ADF; brevin; actin-depolymerizing factor"
                     /codon_start=1
                     /product="gelsolin precursor"
                     /protein_id="NP_001004080.1"
                     /db_xref="GeneID:296654"
                     /db_xref="RGD:1303089"
                     /translation="MAPYCSSLRSALLVLALCALSPSHAATASRGRAQERAPQSRVSE
                     TRPSTMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLR
                     NGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESSTFQGYFK
                     SGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCFILDL
                     GNNIYQWCGSGSNKFERLKATQVSKGIRDNERSGRAQVHVSEEGSEPEAMLQVLGPKP
                     DLPQGTEDTAKEDAANRRLAKLYKVSNSGGSMSVSLVADENPFAQSALRSEDCFILDH
                     GRDGKIFVWKGKQANMDERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFK
                     NWRDPDQTDGPGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRI
                     EGSNKVLVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILT
                     AQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTTPASTRLFQV
                     RASSSGATRAVEVMPKAGALNSNDAFVLKTPSAAYLWVGTGASDAEKTGALELLKVLR
                     AQHVQVEEGSEPDGFWEALGGKTAYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEV
                     PGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRT
                     PITVVRQGFEPPSFVGWFLGWDDDYWSVDPLDRALAELAA"
     exon            149..353
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            354..508
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            509..670
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            671..820
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            821..910
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1043
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1132
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1348
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1482
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1573
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1744
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1919
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2044
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2122
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2183
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2582
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccgtcacc atggctccgt attgctcctc gctgcgctct gcgctgctcg tcctggcgct
       61 gtgcgcactg tcgccgtccc atgcagccac cgcatcgcgg ggcagggccc aagagagggc
      121 gccccaaagt cgggtgtctg agacgcggcc cagcaccatg gtggtggagc accccgaatt
      181 cctgaaggca gggaaggagc ctggcctgca gatctggcgt gtggagaagt ttgacctggt
      241 gcctgtgccc cccaacctct atggagactt cttcacgggt gacgcctatg tcatcctaaa
      301 gacggtgcag ctgaggaatg ggaatctgca gtatgacctc cactattggc tgggcaacga
      361 gtgcagccag gacgagagcg gggctgccgc catctttacc gtgcagctgg atgactacct
      421 gaatggccgg gctgtacagc accgtgaggt tcagggcttt gagtcgtcca cattccaagg
      481 ctacttcaag tctggactta agtacaagaa aggaggcgtg gcatctggat tcaaacacgt
      541 ggtacccaac gaggtggtgg tgcagaggct cttccaggtc aagggacgcc gtgtagtccg
      601 tgccactgaa gtacctgtgt cctgggacag tttcaacaac ggtgactgct tcattctgga
      661 cctgggaaat aatatctatc agtggtgtgg ctccggcagc aacaagtttg aaagactgaa
      721 ggccacgcag gtgtccaagg gcatccggga caacgagagg agtggacgcg cccaagtaca
      781 tgtgtctgaa gagggtagcg agccggaagc catgctccag gtgctgggcc ccaagccgga
      841 tctgcctcag ggcaccgagg acacagccaa ggaagatgct gccaaccgaa ggctggccaa
      901 gctctacaag gtctccaaca gtggaggcag catgtcagtc tccctcgtgg ctgacgagaa
      961 ccccttcgcc cagtccgccc tgagatccga ggactgtttc atcctggacc acggcagaga
     1021 tgggaaaatc tttgtttgga aaggcaagca ggccaacatg gatgagcgga aggctgccct
     1081 caaaacagcc tctgacttca tctccaagat gcagtacccc aggcagaccc aggtttcagt
     1141 cctcccggag ggcggcgaga ctcctctctt taagcagttc ttcaagaact ggcgggaccc
     1201 agaccagaca gacggccctg gcctgagcta cctctccagc cacattgcca acgtggagcg
     1261 cgtgcctttc gatgctgcta cactgcacac ctccactgcc atggctgccc agcacggcat
     1321 ggatgatgac ggaactggcc agaaacagat ctggagaatt gaaggttcca acaaggtact
     1381 ggtggacccc gccacatatg gccagttcta tggaggtgac agctacatca ttctgtacaa
     1441 ctaccgccat ggtggccgcc agggacagat catctacaac tggcagggtg cccagtctac
     1501 ccaggatgag gtcgctgctt cagccatcct gactgcccag ctggatgagg aactgggagg
     1561 aactcctgtc cagagccgag tggtccaagg caaagagcct gcacacctca tgagcttgtt
     1621 tggtgggaag cccatgatca tctacaaggg cggcacctcc cgagatggtg ggcagacaac
     1681 ccctgccagt acccgcctct tccaagtccg ggccagcagc tctggagcca ccagggctgt
     1741 tgaggtaatg cctaaggctg gcgctctcaa ctccaatgat gcctttgtgc tgaaaacccc
     1801 ctccgccgcc tacctgtggg tgggtacagg agccagtgat gcggagaaga ccggcgccct
     1861 ggagctgctg aaggtgctga gggcccagca cgtgcaggtg gaggaaggca gtgaaccaga
     1921 tggcttctgg gaggctctgg gcgggaagac tgcctaccgc acatccccca ggcttaagga
     1981 caagaagatg gatgctcatc ctcctcgcct cttcgcctgc tccaacagga tcgggcgctt
     2041 tgtgatcgaa gaggttcctg gcgagcttat gcaggaagac ctggctactg atgacgtcat
     2101 gctcctggac acctgggacc aggtctttgt ctgggttgga aaggactctc aggaagagga
     2161 aaagacagaa gccttgacct ctgctaagcg gtacatcgag acggacccag cgaatcggga
     2221 caggcggacc cccatcactg tcgttaggca aggctttgag cctccttcct ttgtgggctg
     2281 gttcctcggc tgggatgatg actactggtc ggtggatccc ttggaccggg ccttggctga
     2341 gctggctgcc tgagtaagga ccagagctac caatgtcacc aatcagtgcc tttgagggtt
     2401 gtccatctcc cagagagatc ctatgacaag caggaaaact atagtgtgtg tgcacgtgtt
     2461 tttgtttgtt tgtttttttt tacgatagcc aaaacaagcc ctgtgaaaac tcagggtctt
     2521 tgcagaattg cttcaagtat ctgtactttg gaaataaaac ccaataaaag cttttcgaag
     2581 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
