LOCUS       NP_001004080             780 aa            linear   ROD 15-MAR-2025
DEFINITION  gelsolin precursor [Rattus norvegicus].
ACCESSION   NP_001004080 XP_216043
VERSION     NP_001004080.1
DBSOURCE    REFSEQ: accession NM_001004080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 780)
  AUTHORS   Benavente-Fernandez,I., Ramos-Rodriguez,J.J., Infante-Garcia,C.,
            Jimenez-Gomez,G., Lechuga-Sancho,A., Lubian-Lopez,S. and
            Garcia-Alloza,M.
  TITLE     Altered plasma-type gelsolin and amyloid-beta in neonates with
            hypoxic-ischaemic encephalopathy under therapeutic hypothermia
  JOURNAL   J Cereb Blood Flow Metab 39 (7), 1349-1354 (2019)
   PUBMED   29466895
REFERENCE   2  (residues 1 to 780)
  AUTHORS   Gupta,A.K., Chopra,B.S., Vaid,B., Sagar,A., Raut,S., Badmalia,M.D.,
            Ashish and Khatri,N.
  TITLE     Protective effects of gelsolin in acute pulmonary thromboembolism
            and thrombosis in the carotid artery of mice
  JOURNAL   PLoS One 14 (4), e0215717 (2019)
   PUBMED   31002695
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 780)
  AUTHORS   Hu,W.S., Ting,W.J., Tamilselvi,S., Day,C.H., Wang,T., Chiang,W.D.,
            Viswanadha,V.P., Yeh,Y.L., Lin,W.T. and Huang,C.Y.
  TITLE     Oral administration of alcalase potato protein hydrolysate-APPH
            attenuates high fat diet-induced cardiac complications via
            TGF-beta/GSN axis in aging rats
  JOURNAL   Environ Toxicol 34 (1), 5-12 (2019)
   PUBMED   30240538
REFERENCE   4  (residues 1 to 780)
  AUTHORS   Gertz,K., Uhlemann,R., Foryst-Ludwig,A., Barrientos,R.M.,
            Kappert,K., Thone-Reineke,C., Djoufack,P., Kirschbaum,C.,
            Fink,K.B., Heinz,A., Kintscher,U., Endres,M. and Kronenberg,G.
  TITLE     The cytoskeleton in 'couch potato-ism': Insights from a murine
            model of impaired actin dynamics
  JOURNAL   Exp Neurol 306, 34-44 (2018)
   PUBMED   29684438
REFERENCE   5  (residues 1 to 780)
  AUTHORS   Segado-Arenas,A., Infante-Garcia,C., Benavente-Fernandez,I.,
            Sanchez-Sotano,D., Ramos-Rodriguez,J.J., Alonso-Ojembarrena,A.,
            Lubian-Lopez,S. and Garcia-Alloza,M.
  TITLE     Cognitive Impairment and Brain and Peripheral Alterations in a
            Murine Model of Intraventricular Hemorrhage in the Preterm Newborn
  JOURNAL   Mol Neurobiol 55 (6), 4896-4910 (2018)
   PUBMED   28755273
REFERENCE   6  (residues 1 to 780)
  AUTHORS   Levy,E., Haltia,M., Fernandez-Madrid,I., Koivunen,O., Ghiso,J.,
            Prelli,F. and Frangione,B.
  TITLE     Mutation in gelsolin gene in Finnish hereditary amyloidosis
  JOURNAL   J Exp Med 172 (6), 1865-1867 (1990)
   PUBMED   2175344
REFERENCE   7  (residues 1 to 780)
  AUTHORS   Chaponnier,C., Kocher,O. and Gabbiani,G.
  TITLE     Modulation of gelsolin content in rat aortic smooth muscle cells
            during development, experimental intimal thickening and culture. An
            immunohistochemical and biochemical study
  JOURNAL   Eur J Biochem 190 (3), 559-565 (1990)
   PUBMED   2164930
REFERENCE   8  (residues 1 to 780)
  AUTHORS   Rabie,A., Ferraz,C., Clavel,M.C. and Legrand,C.
  TITLE     Gelsolin immunoreactivity and development of the tectorial membrane
            in the cochlea of normal and hypothyroid rats
  JOURNAL   Cell Tissue Res 254 (1), 241-245 (1988)
   PUBMED   2848627
REFERENCE   9  (residues 1 to 780)
  AUTHORS   Smith,D.B., Janmey,P.A. and Lind,S.E.
  TITLE     Circulating actin-gelsolin complexes following oleic acid-induced
            lung injury
  JOURNAL   Am J Pathol 130 (2), 261-267 (1988)
   PUBMED   2829631
REFERENCE   10 (residues 1 to 780)
  AUTHORS   Kwiatkowski,D.J., Stossel,T.P., Orkin,S.H., Mole,J.E., Colten,H.R.
            and Yin,H.L.
  TITLE     Plasma and cytoplasmic gelsolins are encoded by a single gene and
            contain a duplicated actin-binding domain
  JOURNAL   Nature 323 (6087), 455-458 (1986)
   PUBMED   3020431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079472.1.
            
            On Sep 3, 2004 this sequence version replaced XP_216043.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132271, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     Protein         1..780
                     /product="gelsolin precursor"
                     /note="ADF; brevin; actin-depolymerizing factor"
                     /calculated_mol_wt=83511
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2575
     mat_peptide     26..780
                     /product="Gelsolin. /id=PRO_0000288477"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
                     /calculated_mol_wt=83511
     Region          28..48
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          51..174
                     /region_name="Actin-severing. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          57..169
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(74..75,114,120..121,123..125,127..129,131..132,143,
                     145)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Site            84
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          121..124
                     /region_name="Actin-actin interfilament contact point.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          184..273
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          196..268
                     /region_name="Gelsolin-like 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          244..286
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          296..393
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Region          315..387
                     /region_name="Gelsolin-like 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Site            order(388,393)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          432..780
                     /region_name="Actin-binding, Ca-sensitive.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          437..537
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(453..454,492,498..499,501..503,505..507,509..510,
                     521,523)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            463
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     Site            528
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          559..647
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            567
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Site            582
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P13020; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     Site            601
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     Region          664..762
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Site            740
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1)"
     CDS             1..780
                     /gene="Gsn"
                     /coded_by="NM_001004080.1:11..2353"
                     /db_xref="GeneID:296654"
                     /db_xref="RGD:1303089"
ORIGIN      
        1 mapycsslrs allvlalcal spshaatasr graqerapqs rvsetrpstm vvehpeflka
       61 gkepglqiwr vekfdlvpvp pnlygdfftg dayvilktvq lrngnlqydl hywlgnecsq
      121 desgaaaift vqlddylngr avqhrevqgf esstfqgyfk sglkykkggv asgfkhvvpn
      181 evvvqrlfqv kgrrvvrate vpvswdsfnn gdcfildlgn niyqwcgsgs nkferlkatq
      241 vskgirdner sgraqvhvse egsepeamlq vlgpkpdlpq gtedtakeda anrrlaklyk
      301 vsnsggsmsv slvadenpfa qsalrsedcf ildhgrdgki fvwkgkqanm derkaalkta
      361 sdfiskmqyp rqtqvsvlpe ggetplfkqf fknwrdpdqt dgpglsylss hianvervpf
      421 daatlhtsta maaqhgmddd gtgqkqiwri egsnkvlvdp atygqfyggd syiilynyrh
      481 ggrqgqiiyn wqgaqstqde vaasailtaq ldeelggtpv qsrvvqgkep ahlmslfggk
      541 pmiiykggts rdggqttpas trlfqvrass sgatravevm pkagalnsnd afvlktpsaa
      601 ylwvgtgasd aektgalell kvlraqhvqv eegsepdgfw ealggktayr tsprlkdkkm
      661 dahpprlfac snrigrfvie evpgelmqed latddvmlld twdqvfvwvg kdsqeeekte
      721 altsakryie tdpanrdrrt pitvvrqgfe ppsfvgwflg wdddywsvdp ldralaelaa
//
