LOCUS       NM_032080               1525 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), mRNA.
ACCESSION   NM_032080
VERSION     NM_032080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1525)
  AUTHORS   Zhu,D., Shi,C., Sun,S., Chen,X., Xu,Y., Wang,B., Xu,Z., Zhang,P.
            and Sun,M.
  TITLE     The SIRT3/GSK-3beta/GLUT4 axis might be involved in maternal
            hypoxia-induced skeletal muscle insulin resistance in old male rat
            offspring
  JOURNAL   Toxicol Appl Pharmacol 489, 117019 (2024)
   PUBMED   38950736
  REMARK    GeneRIF: The SIRT3/GSK-3beta/GLUT4 axis might be involved in
            maternal hypoxia-induced skeletal muscle insulin resistance in old
            male rat offspring.
REFERENCE   2  (bases 1 to 1525)
  AUTHORS   Velazquez Toledano,J., Bello,M., Correa Basurto,J., Guerrero
            Gonzalez,I., Pacheco-Yepez,J. and Rosales Hernandez,M.C.
  TITLE     Determining Structural Changes for Ligand Recognition between Human
            and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by
            GSK3beta at Thr252 by in Vitro Studies
  JOURNAL   ACS Chem Neurosci 15 (3), 629-644 (2024)
   PUBMED   38227464
  REMARK    GeneRIF: Determining Structural Changes for Ligand Recognition
            between Human and Rat Phosphorylated BACE1 in Silico and Its
            Phosphorylation by GSK3beta at Thr252 by in Vitro Studies.
REFERENCE   3  (bases 1 to 1525)
  AUTHORS   Yang,Z., Sun,X., Deng,X., Jiang,W., Zhang,Z., Liu,H., Zhong,M.,
            Xie,Y., Ruan,Y. and Lu,H.
  TITLE     A novel lncRNA TCONS_00071187 upregulated by activated GSK3beta
            promotes high glucose-induced mesangial cell proliferation in the
            diabetic nephropathy
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 219-225 (2024)
   PUBMED   38372092
  REMARK    GeneRIF: A novel lncRNA TCONS_00071187 upregulated by activated
            GSK3beta promotes high glucose-induced mesangial cell proliferation
            in the diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1525)
  AUTHORS   Liu,C., Wang,C., Zhang,H., Gao,X., Xiao,P., Yu,M., Wang,X., Wang,X.
            and Wang,X.
  TITLE     Hypoxia ischemia results in blood brain barrier damage via
            AKT/GSK-3beta/CREB pathway in neonatal rats
  JOURNAL   Brain Res 1822, 148640 (2024)
   PUBMED   37863169
  REMARK    GeneRIF: Hypoxia ischemia results in blood brain barrier damage via
            AKT/GSK-3beta/CREB pathway in neonatal rats.
REFERENCE   5  (bases 1 to 1525)
  AUTHORS   Li,T., Tao,X., Sun,R., Han,C., Li,X., Zhu,Z., Li,W., Huang,P. and
            Gong,W.
  TITLE     Cognitive-exercise dual-task intervention ameliorates cognitive
            decline in natural aging rats via inhibiting the promotion of
            LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3beta Pathway
  JOURNAL   Brain Res Bull 202, 110761 (2023)
   PUBMED   37714275
  REMARK    GeneRIF: Cognitive-exercise dual-task intervention ameliorates
            cognitive decline in natural aging rats via inhibiting the
            promotion of LncRNA NEAT1/miR-124-3p on
            caveolin-1-PI3K/Akt/GSK3beta Pathway.
REFERENCE   6  (bases 1 to 1525)
  AUTHORS   Kobayashi,S., Ishiguro,K., Omori,A., Takamatsu,M., Arioka,M.,
            Imahori,K. and Uchida,T.
  TITLE     A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa
            subunit of tau protein kinase II, a proline-directed protein kinase
            associated with microtubule
  JOURNAL   FEBS Lett 335 (2), 171-175 (1993)
   PUBMED   8253190
REFERENCE   7  (bases 1 to 1525)
  AUTHORS   Ishiguro,K., Shiratsuchi,A., Sato,S., Omori,A., Arioka,M.,
            Kobayashi,S., Uchida,T. and Imahori,K.
  TITLE     Glycogen synthase kinase 3 beta is identical to tau protein kinase
            I generating several epitopes of paired helical filaments
  JOURNAL   FEBS Lett 325 (3), 167-172 (1993)
   PUBMED   7686508
REFERENCE   8  (bases 1 to 1525)
  AUTHORS   Hughes,K., Nikolakaki,E., Plyte,S.E., Totty,N.F. and Woodgett,J.R.
  TITLE     Modulation of the glycogen synthase kinase-3 family by tyrosine
            phosphorylation
  JOURNAL   EMBO J 12 (2), 803-808 (1993)
   PUBMED   8382613
REFERENCE   9  (bases 1 to 1525)
  AUTHORS   Hughes,K., Pulverer,B.J., Theocharous,P. and Woodgett,J.R.
  TITLE     Baculovirus-mediated expression and characterisation of rat
            glycogen synthase kinase-3 beta, the mammalian homologue of the
            Drosophila melanogaster zeste-white 3sgg homeotic gene product
  JOURNAL   Eur J Biochem 203 (1-2), 305-311 (1992)
   PUBMED   1346104
REFERENCE   10 (bases 1 to 1525)
  AUTHORS   Woodgett,J.R.
  TITLE     Molecular cloning and expression of glycogen synthase
            kinase-3/factor A
  JOURNAL   EMBO J 9 (8), 2431-2438 (1990)
   PUBMED   2164470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X73653.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X73653.1, X53428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1525
                     /gene="Gsk3b"
                     /note="glycogen synthase kinase 3 beta"
                     /db_xref="GeneID:84027"
                     /db_xref="RGD:70982"
     exon            1..227
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1402
                     /gene="Gsk3b"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="FA; factor A; GSK-3 beta; serine/threonine-protein
                     kinase GSK3B"
                     /codon_start=1
                     /product="glycogen synthase kinase-3 beta"
                     /protein_id="NP_114469.1"
                     /db_xref="GeneID:84027"
                     /db_xref="RGD:70982"
                     /translation="MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATP
                     GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR
                     KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL
                     YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC
                     SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP
                     TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA
                     CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA
                     NATAASDTNAGDRGQTNNAASASASNST"
     exon            228..421
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            422..505
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            506..616
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            617..747
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            748..854
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            855..952
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1048
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1235
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1334
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1525
                     /gene="Gsk3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccaagaga acgaagtctt tttttttttt ttcttgcggg agaacttaat gctgcattta
       61 ttattaacct agtaccctaa cataaaacaa aaggaagaaa aggattaagg aaggaaaagg
      121 tgaatcgaga agagccatca tgtcggggcg accgagaacc acctcctttg cggagagctg
      181 caagccagtg cagcagcctt cagcttttgg tagcatgaaa gttagcagag ataaagatgg
      241 cagcaaggta accacagtgg tggcaactcc tggacagggt cctgacaggc cacaggaagt
      301 cagttacaca gacactaaag tcattggaaa tgggtcattt ggtgtggtat atcaagccaa
      361 actttgtgac tcaggagaac tggtggccat caagaaagtt cttcaggaca agcgatttaa
      421 gaaccgagag ctccagatca tgagaaagct agatcactgt aacatagtcc gattgcggta
      481 tttcttctac tcgagtggcg agaagaaaga tgaggtctac cttaacctgg tgctggacta
      541 tgttccggaa acagtgtaca gagtcgccag acactatagt cgagccaagc agacactccc
      601 tgtgatctat gtcaagttgt atatgtacca gctgttcaga agtctagcct atatccattc
      661 ctttgggatc tgccatcgag acattaaacc acagaacctc ttgctggatc ctgatacagc
      721 tgtattaaaa ctctgcgact ttggaagtgc aaagcagctg gtccgaggag agcccaatgt
      781 ttcatatatc tgttctcggt actacagggc accagagctg atctttggag ccaccgatta
      841 cacgtctagt atagatgtat ggtctgcagg ctgtgtgttg gctgaattgt tgctaggaca
      901 accaatattt cctggggaca gtggtgtgga tcagttggtg gaaataataa aggtcctagg
      961 aacaccaaca agggagcaaa ttagagaaat gaacccaaat tatacagaat tcaaattccc
     1021 ccaaatcaag gcacatcctt ggacgaaggt ctttcggccc cgaactccac cagaggcaat
     1081 cgcactgtgt agccgtctcc tggagtacac gccgaccgcc cggctaacac cactggaagc
     1141 ttgtgcacat tcattttttg atgaattacg ggacccaaat gtcaaactac caaatgggcg
     1201 agacacacct gccctcttca actttaccac tcaagaactg tcaagtaacc cacctctggc
     1261 caccatcctt atccctcctc acgctcggat tcaggcagct gcttcaccgc ctgcaaacgc
     1321 cacagcagcc tcagatacta atgctggaga ccgtggacag accaataacg ccgcttctgc
     1381 atcagcctcc aactctacct gaacagcccc aagtagccag ctgcgcaggg aagaccagca
     1441 cttacttgag tgccactcag caacactggt cacgtttgga aagaaaatta aaaagaggaa
     1501 aacaaaaaca aaaacaaaaa acccc
//
