LOCUS       NM_017344               2157 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), mRNA.
ACCESSION   NM_017344 XM_346536
VERSION     NM_017344.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Oh,J., Kim,Y., Che,L., Kim,J.B., Chang,G.E., Cheong,E., Kang,S.G.
            and Ha,Y.
  TITLE     Regulation of cAMP and GSK3 signaling pathways contributes to the
            neuronal conversion of glioma
  JOURNAL   PLoS One 12 (11), e0178881 (2017)
   PUBMED   29161257
  REMARK    GeneRIF: he combined action of CHIR99021 and forskolin markedly
            delayed neurological deficits and significantly reduced the tumor
            volume. We suggest that reprogramming technology may be a potential
            treatment strategy replacing the therapeutic paradigm of
            traditional treatment of malignant glioma, and a combination
            molecule comprising a GSK3 inhibitor and a cAMP inducer could be
            the next generation of anticancer drugs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Xiao,H., Deng,M., Yang,B., Tang,J. and Hu,Z.
  TITLE     Role of glycogen synthase kinase 3 in ischemia-induced blood-brain
            barrier disruption in aged female rats
  JOURNAL   J Neurochem 142 (2), 194-203 (2017)
   PUBMED   28440874
  REMARK    GeneRIF: found that ovariectomized female rats exhibited increased
            mRNA levels of estrogen receptor alpha (ERalpha) and estrogen
            receptor beta (ERbeta), and increased protein levels of GSK3beta
            but not GSK3alpha in brain cortical area
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Cuadrado,A.
  TITLE     Structural and functional characterization of Nrf2 degradation by
            glycogen synthase kinase 3/beta-TrCP
  JOURNAL   Free Radic Biol Med 88 (Pt B), 147-157 (2015)
   PUBMED   25937177
  REMARK    Review article
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2157)
  AUTHORS   Kobayashi,S., Nakamura,T.Y. and Wakabayashi,S.
  TITLE     Calcineurin B homologous protein 3 negatively regulates
            cardiomyocyte hypertrophy via inhibition of glycogen synthase
            kinase 3 phosphorylation
  JOURNAL   J Mol Cell Cardiol 84, 133-142 (2015)
   PUBMED   25935310
  REMARK    GeneRIF: CHP3 functions as a novel negative regulator of
            cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta
            phosphorylation.
REFERENCE   6  (bases 1 to 2157)
  AUTHORS   Cross,D.A., Alessi,D.R., Cohen,P., Andjelkovich,M. and
            Hemmings,B.A.
  TITLE     Inhibition of glycogen synthase kinase-3 by insulin mediated by
            protein kinase B
  JOURNAL   Nature 378 (6559), 785-789 (1995)
   PUBMED   8524413
REFERENCE   7  (bases 1 to 2157)
  AUTHORS   Rao,P.V., Pugazhenthi,S. and Khandelwal,R.L.
  TITLE     Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels
            by altering its stability in streptozotocin-induced diabetic rat
            liver
  JOURNAL   Biochem Biophys Res Commun 217 (1), 250-256 (1995)
   PUBMED   8526919
REFERENCE   8  (bases 1 to 2157)
  AUTHORS   Hoshi,M., Sato,M., Kondo,S., Takashima,A., Noguchi,K.,
            Takahashi,M., Ishiguro,K. and Imahori,K.
  TITLE     Different localization of tau protein kinase I/glycogen synthase
            kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum
            mitochondria
  JOURNAL   J Biochem 118 (4), 683-685 (1995)
   PUBMED   8576078
REFERENCE   9  (bases 1 to 2157)
  AUTHORS   Hughes,K., Nikolakaki,E., Plyte,S.E., Totty,N.F. and Woodgett,J.R.
  TITLE     Modulation of the glycogen synthase kinase-3 family by tyrosine
            phosphorylation
  JOURNAL   EMBO J 12 (2), 803-808 (1993)
   PUBMED   8382613
REFERENCE   10 (bases 1 to 2157)
  AUTHORS   Woodgett,J.R.
  TITLE     Molecular cloning and expression of glycogen synthase
            kinase-3/factor A
  JOURNAL   EMBO J 9 (8), 2431-2438 (1990)
   PUBMED   2164470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000033.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_017344.3.
            
            On Nov 27, 2020 this sequence version replaced NM_017344.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               JACYVU010000033.1  4702243-4702645     c
            404-591             JACYVU010000033.1  4700418-4700605     c
            592-675             JACYVU010000033.1  4698727-4698810     c
            676-786             JACYVU010000033.1  4698459-4698569     c
            787-917             JACYVU010000033.1  4696512-4696642     c
            918-1024            JACYVU010000033.1  4696313-4696419     c
            1025-1122           JACYVU010000033.1  4695425-4695522     c
            1123-1218           JACYVU010000033.1  4695242-4695337     c
            1219-1405           JACYVU010000033.1  4694379-4694565     c
            1406-1498           JACYVU010000033.1  4693997-4694089     c
            1499-2157           JACYVU010000033.1  4692801-4693459     c
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2157
                     /gene="Gsk3a"
                     /note="glycogen synthase kinase 3 alpha"
                     /db_xref="GeneID:50686"
                     /db_xref="RGD:620351"
     exon            1..403
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1572
                     /gene="Gsk3a"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="FA; factor A; GSK-3 alpha; serine/threonine-protein
                     kinase GSK3A"
                     /codon_start=1
                     /product="glycogen synthase kinase-3 alpha"
                     /protein_id="NP_059040.1"
                     /db_xref="GeneID:50686"
                     /db_xref="RGD:620351"
                     /translation="MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPG
                     GTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTT
                     VVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRE
                     LQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLIIPI
                     IYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN
                     VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK
                     VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRL
                     SPLEACAHSFFDELRSLGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPSG
                     PATLTSSSQALTETQTGQDWQAPDATPTLTNSS"
     exon            404..591
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            592..675
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            676..786
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            787..917
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1024
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1122
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1218
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1405
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1498
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..2157
                     /gene="Gsk3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggagccc gaacggcgcg gcctggaaga ggccggagcc caagggaggc ggcggtagag
       61 gcagcggcgg gggcagccca ggcagcccga gccccgcggc ctgggcctgc gctcggcgcc
      121 atgagcggcg gcgggccttc gggaggtggc cctgggggct cgggccgggc gcggaccagc
      181 tcgttcgcgg agccaggcgg cggaggcgga ggcggtggcg gcggccccgg gggctcggcc
      241 tccggcccag gaggcactgg cggcgggaag gcgtcagtcg gggctatggg tgggggcgtg
      301 ggagcctcga gctctggggg tggccccagc ggcagcggcg gaggaggcag cggtggcccc
      361 ggcgcgggca ctagcttccc gccgcccgga gtgaagctgg gccgtgacag cgggaaggtg
      421 accacagtgg tagccactct aggccaaggc ccagagcgtt cccaagaggt ggcttacacc
      481 gacatcaaag tgattggcaa tggctcattc ggagtagtgt accaggcacg gctggcagaa
      541 acgagggaac tggtggccat caagaaggtt cttcaggaca aaaggttcaa gaaccgagag
      601 ctgcagatta tgcgtaagct ggaccactgc aatatcgtga ggctacggta ctttttctac
      661 tccagtgggg agaagaaaga tgagctgtat ttaaatctgg tgctggaata tgtgcccgag
      721 acggtgtacc gagtggcccg tcactttacc aaggccaagt tgatcatccc tatcatctat
      781 gtcaaggtgt acatgtacca gctcttccgg agcttggcct acatccactc ccaaggtgtg
      841 tgtcaccgtg acatcaagcc ccagaatttg cttgtggacc ctgacactgc tgtcctcaag
      901 ctctgcgact ttggcagtgc aaagcagttg gttcgggggg agcccaacgt gtcctacatc
      961 tgttctcggt actaccgtgc tccggagctc atctttggag ccacagatta cacctcgtcc
     1021 atcgatgtgt ggtcagctgg ctgtgtactg gctgagctgc ttcttggcca gcccatcttc
     1081 cctggggaca gtggggtaga ccagcttgtg gagatcatca aggtactagg gacgccaacc
     1141 agggagcaaa tccgagagat gaaccctaac tacacagaat tcaagttccc ccagatcaaa
     1201 gctcacccct ggacaaaggt gttcaaatct cggacaccac ctgaggccat cgcactctgc
     1261 tctagcctgc tggagtacac tccatcctca aggctctccc cactagaggc ctgtgcccac
     1321 agtttctttg atgaactgcg gagtctcgga acccagctcc ccaacaaccg cccgcttccc
     1381 cccctcttca acttcagtcc tggtgaactt tccatccaac cgtctctcaa tgccattctc
     1441 atccctcctc acttgaggtc cccatcaggc cctgctaccc tcacctcgtc ctcacaagct
     1501 ttaactgaga ctcagactgg ccaagactgg caggcacctg atgccacacc taccctcact
     1561 aactcttcct gagggcccta ccgactaccc ctccacgtcc atctgggaag gctcaagtgg
     1621 ggctgggaag ggggccatag cccatccagc tcctgccctg gctgggcccc tagactgagg
     1681 gcagaggtaa atgaactacc cagcatctag gcctccctca ccagcctcac ctttgtggtg
     1741 ggctttttaa agaggatttt aactgtttgt gggggaggga agggaagaga aggacggacg
     1801 gggtttgggg gtatgaggac cttctacccc cgtggtcccc tcccctcccc caggctacca
     1861 ctcctccccc ccccccctcc catgtccctt gtaaatagaa ccagcccagc ccgtatcctc
     1921 ttcctggccc cttgggtgta aatagattgt tataattttt ttcttaaaga aaacgtcgat
     1981 tcacaccatc caacctgccc tccccctcag ctgtaccccc ctcttgtcct ctgctcccaa
     2041 ggcttcctcc ctctccccat cccaaggagg ggagtaggga gagcccctgg tgtcttagtt
     2101 tccacagtaa ggtttgcctg tgtacagacc tccgttcaat aaattattgg catgaaa
//
