LOCUS       NM_001419662            3862 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus GSG1-like (Gsg1l), mRNA.
ACCESSION   NM_001419662 XM_008759923
VERSION     NM_001419662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Mao,X., Gu,X. and Lu,W.
  TITLE     GSG1L regulates the strength of AMPA receptor-mediated synaptic
            transmission but not AMPA receptor kinetics in hippocampal dentate
            granule neurons
  JOURNAL   J Neurophysiol 117 (1), 28-35 (2017)
   PUBMED   27707810
  REMARK    GeneRIF: The current work reveals that GSG1L regulates strength of
            AMPAR-mediated synaptic transmission but not the receptor kinetic
            properties in hippocampal dentate granule neurons.
REFERENCE   2  (bases 1 to 3862)
  AUTHORS   Gu,X., Mao,X., Lussier,M.P., Hutchison,M.A., Zhou,L., Hamra,F.K.,
            Roche,K.W. and Lu,W.
  TITLE     GSG1L suppresses AMPA receptor-mediated synaptic transmission and
            uniquely modulates AMPA receptor kinetics in hippocampal neurons
  JOURNAL   Nat Commun 7, 10873 (2016)
   PUBMED   26932439
  REMARK    GeneRIF: These data demonstrate that GSG1L represents a new class
            of auxiliary subunit with distinct functional properties for AMPA
            receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3862)
  AUTHORS   McGee,T.P., Bats,C., Farrant,M. and Cull-Candy,S.G.
  TITLE     Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA
            Receptor Function
  JOURNAL   J Neurosci 35 (49), 16171-16179 (2015)
   PUBMED   26658868
REFERENCE   4  (bases 1 to 3862)
  AUTHORS   Shanks,N.F., Savas,J.N., Maruo,T., Cais,O., Hirao,A., Oe,S.,
            Ghosh,A., Noda,Y., Greger,I.H., Yates,J.R. 3rd and Nakagawa,T.
  TITLE     Differences in AMPA and kainate receptor interactomes facilitate
            identification of AMPA receptor auxiliary subunit GSG1L
  JOURNAL   Cell Rep 1 (6), 590-598 (2012)
   PUBMED   22813734
  REMARK    GeneRIF: The interactomes of native AMPA-Rs and KA-Rs were compared
            and identified an AMPA-R auxiliary subunit, GSG1L.
REFERENCE   5  (bases 1 to 3862)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 13, 2023 this sequence version replaced XM_008759923.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.3964.1,
                                           SRR26643298.5125.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JAXUCZ010000001.1  190084421-190084947 c
            528-575             JAXUCZ010000001.1  190018798-190018845 c
            576-728             JAXUCZ010000001.1  189948299-189948451 c
            729-840             JAXUCZ010000001.1  189910641-189910752 c
            841-1008            JAXUCZ010000001.1  189897878-189898045 c
            1009-1079           JAXUCZ010000001.1  189885484-189885554 c
            1080-3862           JAXUCZ010000001.1  189871034-189873816 c
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3862
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /note="GSG1-like"
                     /db_xref="GeneID:499263"
                     /db_xref="RGD:1562278"
     exon            1..527
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1177
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /note="GSG1-like protein"
                     /codon_start=1
                     /product="germ cell-specific gene 1-like protein"
                     /protein_id="NP_001406591.1"
                     /db_xref="GeneID:499263"
                     /db_xref="RGD:1562278"
                     /translation="MKTSRRGRALLAVALNLLALLFATTAFLTTYWCQGTQRVPKPGC
                     GQGGGANCPNSGANATANSTAAPVAASPAGAPYSWEAGDERFQLRRFHTGIWYSCEEE
                     LGGPGEKCRSFIDLAPASEKGVLWLSVVSEVLYILLLVVGFSLMCLELLHSSSVIDGL
                     KLNAFAAVFTVLSGLLGMVAHMMYTQVFQVTVSLGPEDWRPHSWDYGWSFCLAWGSFT
                     CCMAASVTTLNSYTKTVIEFRHKRKVFEQGYREEPTFIDPEAIKYFRERIEKGDVSEE
                     EDFRLACRHERYPTRHQPHMGDSWPRSSAHEAAELNRQCWVLGHWV"
     exon            528..575
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
     exon            576..728
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
     exon            729..840
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1008
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1079
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..3862
                     /gene="Gsg1l"
                     /gene_synonym="RGD1562278"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactcgcgc tccgggcttc gggtgcgctg gtcggctcca ctctgcggcc ccggccactc
       61 cgcgtcctcg tcgtcccgcg tccccgccgg gggccatggg cccgtgtcgc gagagccgtc
      121 gccgaccgca ggcaccagag ccccggggcg ggcgctgacg cgggcattgc tgccaacttc
      181 gcgcagagct gcgggcggcg cgggcggcat gaagacgagc cgccgcggcc gagcgctcct
      241 ggccgtggcc ttgaacctgc tggcgttgct cttcgccacg accgccttcc tcaccacgta
      301 ctggtgccag ggcacgcaac gggtgcccaa gcctggctgc ggccagggcg gcggcgccaa
      361 ctgccccaac tcgggcgcca acgccacagc caacagcaca gccgcccccg ttgctgcgag
      421 cccggccggc gcgccctaca gctgggaggc gggcgacgag cgcttccagc tgcgccgttt
      481 ccatactggc atctggtact cgtgcgagga agagctcggt ggcccgggtg agaaatgtcg
      541 cagcttcatt gacctggccc cagcttcaga gaaaggggtg ctgtggctgt cggtggtctc
      601 cgaggtgctc tacatccttc tgctggtggt cggcttcagc ctcatgtgtc ttgagctcct
      661 ccactccagc agcgtcatag atgggctcaa gctcaatgcc tttgctgcag tcttcacggt
      721 gctctcaggt ctcctgggaa tggtcgcaca catgatgtac acacaagtgt tccaggtcac
      781 tgtgagcctc ggtcctgaag actggagacc tcattcctgg gactatgggt ggtccttctg
      841 cttggcctgg ggttcattta cctgctgcat ggcggcgtcc gtcactacgc tcaactccta
      901 taccaagaca gtcattgagt tccggcacaa gcgcaaggtc tttgagcagg gataccggga
      961 agagccgacc ttcatagacc ccgaggccat caaatacttc cgggagagga ttgagaaggg
     1021 ggacgtgagt gaagaggaag acttccgcct tgcctgccgc cacgagagat accccacccg
     1081 gcaccagcca cacatgggag actcctggcc acggagctca gctcatgaag cagcagagct
     1141 aaaccgtcag tgctgggtcc tggggcactg ggtgtgatgt ggcccaagcg cccctgcctt
     1201 cctgccatca ctggcacacc cctcccacag gacatggaag cctggtctct gtgctgtgga
     1261 ctcagctctc ctgtcatgga gacaccaggc ctagactgcc accgctgcct gggtctcagg
     1321 gccccagaaa tgggtcaagt gggcctgagg gactgtccag gtggcacaga gactcagaga
     1381 cagcagccac caccacacct agagctccac ccagctggaa agccaggaag atcatgggca
     1441 ttgagcactg gatgctggac acccacagcc agccaccaag tcaagcgggt gcccagaggg
     1501 gcagggtcct gtggggacag ggagcagggc ttattgaggg agaggcagtg tctgcctctg
     1561 taggggccac acagcaggcg cacagtaggg gctcaataaa tgcttgttga ctctgttctc
     1621 ttgctatgta tgggctggct cccccatcat taacttaccc cagaggtgtg agccctggac
     1681 actgagatca gggccaaaca ttatggatga gctagagtcc ggcccagcct ggggaagatc
     1741 aagacagaga caggtgggca gagcaggaag gacaggccag gagctagacg cagagcatgt
     1801 gtccaggaac ttcagcaatg tgacaccacc ctgaccctgg agatgcttta ccctgtgtct
     1861 agggctactt tacatacaac ctctggctca gctgcgtggg gaagataaca attgccatct
     1921 tgactttgag agcttggggt ccagagaggg aaggttcttg cttgagatta gaggtgacat
     1981 gtgggacatt aaactagact cactcccaaa agcctaatcc tgccctgaag gattggcaga
     2041 cccaggcaga atgtggtctt ctccttcact catctaccca ttgcccatcc atgacccacc
     2101 atcccgccag ccagccattt agtcagcatt tagccactca tctgcccatc cattcatcca
     2161 tacaagatcc atccattcac catccactca cccatcatcc agcatttacc cacccgccca
     2221 tctatgtatc atgacccttt aatcaacatc cacccatcca ctcatatatg gttcatctat
     2281 ctaatcattc actcatttag cagcatgtag ccactcatca cctatccatc cctccatcta
     2341 cccatccatc catccatcca tccatccatc catccatcca tccaaccatc catccatcca
     2401 tccatccatc caaccatcca tccatccatc caacagtcca tccatccatc catccattca
     2461 tccatctaac catccatcca tccatacacc ctcaactatc cattcaccca tctattatcc
     2521 ctttgtcact ctcattcctc cctttgtcaa tcatccatcc acccatccat acctcagcca
     2581 tctttatcat ccagttatct attggtgcat ctgtctacat acaggcatca tctattgtgc
     2641 ccctactgtg tgccacacag tgtggtaggc ccctgagatg ggacactgaa gcttccagag
     2701 aagcagacaa ggggtggaat aggaggtgac agttcagtgt ttgagtgctg ggtgtggtac
     2761 ctgctctgga gtcagactgc ctagcatcag atcctgtctc ctcagccccg gtggccttac
     2821 cctgtagatg ggactcttca ctgtacctac ctcttatagc tgctgggggt ggggtgtggg
     2881 aatggcatag actggtgcct gtgagcacag ggagcagagt ctggaccatg gaaagcaccc
     2941 tgccatcatg tcaatgggga gagttgaggc catggacctg gggcggtgcc tgttggagac
     3001 tacctgaagg attggtgatc aaggaaatga tacccaagtc atcttgctga tgtcagattg
     3061 tggaaggaag gacaggacag gagaaggctt tcaaatggcc caaagacaag catggaggaa
     3121 aaggaggttt gtggggagtg gaaccaggct gcagagagga ttcaaagctt cctcggagga
     3181 cctgtagctt gggaacagct ctgggcaggg tgggaccggc taaggtgagg tatgtagaaa
     3241 gtcaccacag ctccaggcta gagatgatga tgagggcagg actcccgtgt gcttgcagcc
     3301 ctaagtggga ggagagtgct gtggttgagg aaagaggccc atggagggtc gggtggctga
     3361 ctcaggggcc atgaggaggg attggcatgg gaggagagga cttcaatgtc tgttctgggt
     3421 caggaggagc acctaggggc aaaggatgac tacatgcttc tgtgtgcagg taggcctgtg
     3481 ctcagaggac accagaaaac cagtatgggg agctgtggca cggacctttc acaagtggga
     3541 gccactgggc tgggtcctga gcatggtcac tggtctgaat ctgaccctgc caccaggaat
     3601 tctgtaggtc ttagtggtca tccacgggcc ttgtgaagtt ggccacgggc cccagaaggt
     3661 ccaagaaatg attttagttg caaaactgcc atctatttta atagctgtgt ttatgtaaat
     3721 gtgtattaga aaacagtgta tgggcgtgtc cacgctccag atgcaggcgc ttctgcgtag
     3781 agtgaaccac aataggcgtt tcagtaaaaa gagttggctt aaagaaaaat actaaataaa
     3841 taatcatgca agtggtctgt ga
//
