LOCUS       NM_001191749            2381 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus gasdermin E (Gsdme), mRNA.
ACCESSION   NM_001191749 XM_231759
VERSION     NM_001191749.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Li,C., Zhang,H., Mo,J., Zuo,J. and Ye,L.
  TITLE     Caspase-3/GSDME dependent pyroptosis contributes to offspring lung
            injury induced by gestational PFOS exposure via PERK/ATF4 signaling
  JOURNAL   Arch Toxicol 98 (1), 207-221 (2024)
   PUBMED   37955688
  REMARK    GeneRIF: Caspase-3/GSDME dependent pyroptosis contributes to
            offspring lung injury induced by gestational PFOS exposure via
            PERK/ATF4 signaling.
REFERENCE   2  (bases 1 to 2381)
  AUTHORS   Zhang,Y., Cai,X., Wang,B., Zhang,B. and Xu,Y.
  TITLE     Exploring the molecular mechanisms of the involvement of
            GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid
            arthritis
  JOURNAL   Mol Immunol 161, 82-90 (2023)
   PUBMED   37531918
  REMARK    GeneRIF: Exploring the molecular mechanisms of the involvement of
            GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid
            arthritis.
REFERENCE   3  (bases 1 to 2381)
  AUTHORS   Wang,Y., Gao,W., Shi,X., Ding,J., Liu,W., He,H., Wang,K. and
            Shao,F.
  TITLE     Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of
            a gasdermin
  JOURNAL   Nature 547 (7661), 99-103 (2017)
   PUBMED   28459430
REFERENCE   4  (bases 1 to 2381)
  AUTHORS   Rogers,C., Fernandes-Alnemri,T., Mayes,L., Alnemri,D., Cingolani,G.
            and Alnemri,E.S.
  TITLE     Cleavage of DFNA5 by caspase-3 during apoptosis mediates
            progression to secondary necrotic/pyroptotic cell death
  JOURNAL   Nat Commun 8, 14128 (2017)
   PUBMED   28045099
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2381)
  AUTHORS   Van Rossom,S., Op de Beeck,K., Hristovska,V., Winderickx,J. and Van
            Camp,G.
  TITLE     The deafness gene DFNA5 induces programmed cell death through
            mitochondria and MAPK-related pathways
  JOURNAL   Front Cell Neurosci 9, 231 (2015)
   PUBMED   26236191
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2381)
  AUTHORS   Op de Beeck,K., Van Camp,G., Thys,S., Cools,N., Callebaut,I.,
            Vrijens,K., Van Nassauw,L., Van Tendeloo,V.F., Timmermans,J.P. and
            Van Laer,L.
  TITLE     The DFNA5 gene, responsible for hearing loss and involved in
            cancer, encodes a novel apoptosis-inducing protein
  JOURNAL   Eur J Hum Genet 19 (9), 965-973 (2011)
   PUBMED   21522185
REFERENCE   7  (bases 1 to 2381)
  AUTHORS   Kim,M.S., Chang,X., Yamashita,K., Nagpal,J.K., Baek,J.H., Wu,G.,
            Trink,B., Ratovitski,E.A., Mori,M. and Sidransky,D.
  TITLE     Aberrant promoter methylation and tumor suppressive activity of the
            DFNA5 gene in colorectal carcinoma
  JOURNAL   Oncogene 27 (25), 3624-3634 (2008)
   PUBMED   18223688
REFERENCE   8  (bases 1 to 2381)
  AUTHORS   Van Laer,L., Pfister,M., Thys,S., Vrijens,K., Mueller,M., Umans,L.,
            Serneels,L., Van Nassauw,L., Kooy,F., Smith,R.J., Timmermans,J.P.,
            Van Leuven,F. and Van Camp,G.
  TITLE     Mice lacking Dfna5 show a diverging number of cochlear fourth row
            outer hair cells
  JOURNAL   Neurobiol Dis 19 (3), 386-399 (2005)
   PUBMED   16023581
REFERENCE   9  (bases 1 to 2381)
  AUTHORS   Gregan,J., Van Laer,L., Lieto,L.D., Van Camp,G. and Kearsey,S.E.
  TITLE     A yeast model for the study of human DFNA5, a gene mutated in
            nonsyndromic hearing impairment
  JOURNAL   Biochim Biophys Acta 1638 (2), 179-186 (2003)
   PUBMED   12853124
REFERENCE   10 (bases 1 to 2381)
  AUTHORS   Van Laer,L., Huizing,E.H., Verstreken,M., van Zuijlen,D.,
            Wauters,J.G., Bossuyt,P.J., Van de Heyning,P., McGuirt,W.T.,
            Smith,R.J., Willems,P.J., Legan,P.K., Richardson,G.P. and Van
            Camp,G.
  TITLE     Nonsyndromic hearing impairment is associated with a mutation in
            DFNA5
  JOURNAL   Nat Genet 20 (2), 194-197 (1998)
   PUBMED   9771715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_231759.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000004.1  80651586-80651611   c
            27-256              JAXUCZ010000004.1  80641293-80641522   c
            257-449             JAXUCZ010000004.1  80636057-80636249   c
            450-656             JAXUCZ010000004.1  80615349-80615555   c
            657-724             JAXUCZ010000004.1  80614686-80614753   c
            725-889             JAXUCZ010000004.1  80607261-80607425   c
            890-1017            JAXUCZ010000004.1  80605524-80605651   c
            1018-1219           JAXUCZ010000004.1  80603748-80603949   c
            1220-1293           JAXUCZ010000004.1  80600859-80600932   c
            1294-2381           JAXUCZ010000004.1  80592322-80593409   c
FEATURES             Location/Qualifiers
     source          1..2381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2381
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /note="gasdermin E"
                     /db_xref="GeneID:353316"
                     /db_xref="RGD:727871"
     exon            1..26
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            27..256
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1569
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /note="deafness, autosomal dominant 5 homolog;
                     non-syndromic hearing impairment protein 5; DFNA5,
                     deafness associated tumor suppressor"
                     /codon_start=1
                     /product="gasdermin-E"
                     /protein_id="NP_001178678.1"
                     /db_xref="GeneID:353316"
                     /db_xref="RGD:727871"
                     /translation="MFAKATRNFLKEVDAGGDLISVSHLNDSDKLQLLSLVTKKKRYW
                     CWQRPKYQFLSATLGDVLTEGHCLSPVVVESDFVKYESKCENHKSGTIGTVMGKVKLN
                     VGGKGLVESQSSFGTLRKQEVDVQQLIQDAVGRTVNLDSLVLQQVLESRNEVLCVLTQ
                     KIVTTQKCVISEHVQSEETCGGMVGIQTKIVQVPHLSMEDVSHGRLRRAVFGSGLREA
                     WRKSTVMPEFCLLQGKHGGFEQERKVDSVYLDPLAYREFAFLDMPDGGQGISSQDGPL
                     RVLKQATLHLERSFRSFAVLPAQQQMALFCILQKILFDEELLRALEQVCDDVAGGLWS
                     SQAILAMEELTGSQQQDLTAFLKLVGYRVQGEHPGPQDEVSNQKLFATAYFLVSALAE
                     MPDNATVFLGTCCKLHVIPSLCHLLHALSDDSVCDFQDPTLAPLRDTERFGIVQRLFA
                     SADIALERMQFSAKATILKDSCMFPLILHITLSGLYTLSKEHEEHLFQSEVHATSQD"
     exon            257..449
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            450..656
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            657..724
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            725..889
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1017
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1219
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1293
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..2381
                     /gene="Gsdme"
                     /gene_synonym="Dfna5; Dfna5h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccggacg gagcggcagc gcgcgggtaa tctcaacccg acaaaatgtt tgccaaagcg
       61 actcggaatt tccttaaaga agttgatgct ggaggagacc tgatttcagt ctcacacttg
      121 aacgactctg acaagctgca acttctaagt ctggtgacca aaaagaagag atactggtgc
      181 tggcagagac ccaagtacca gttcttatcg gccaccctgg gagatgttct tacagaaggg
      241 cactgtctca gtccagtggt tgtggagtca gacttcgtaa aatacgaaag caagtgtgag
      301 aaccacaaga gcgggactat cgggaccgtc atggggaagg tcaagctgaa tgttggaggc
      361 aaaggcctgg tggagagtca gtcttcgttt ggaactctga ggaagcagga ggtagatgtg
      421 cagcaactca ttcaggatgc cgtcgggaga acagttaatc tggacagcct ggtgctccag
      481 caggtgctag agagcaggaa cgaggtcctg tgcgtgctga cgcagaagat cgtgacaaca
      541 cagaagtgtg tgatttctga gcacgtgcag tcggaggaga cgtgcggagg catggtgggg
      601 atccagacca agattgtgca ggtgccacac ctcagcatgg aggacgtttc tcacggaaga
      661 ctcaggaggg ctgtatttgg aagtggcctg cgtgaggcat ggcgtaagtc tacagtcatg
      721 ccagaattct gcctccttca agggaaacat ggtggcttcg agcaggagag gaaagtagat
      781 tctgtctact tggaccccct ggcctacaga gagtttgcct ttctggacat gccagatggg
      841 ggtcaaggga tctcttcaca ggatgggcca ctacgtgttt taaaacaagc aaccctgcac
      901 ctagagagga gcttccgttc ctttgcggtg ttgcctgccc agcagcagat ggcgctgttc
      961 tgcatcctgc agaaaatcct gtttgatgaa gaactcctta gggccctgga gcaagtgtgt
     1021 gatgatgtgg ctggtggcct ctggtcctca caggctatat tggcaatgga ggagctgaca
     1081 ggcagtcagc agcaggacct cacagccttc ctgaaactgg tgggatacag ggtacaggga
     1141 gagcatcctg gcccgcagga tgaggtcagc aaccagaagc tctttgcaac agcctacttc
     1201 ttggtcagtg cactagcaga aatgccagat aatgccacag tcttcctggg gacttgctgc
     1261 aaactccatg ttattccttc actgtgccat ttgctccatg ctctgtctga tgacagtgtg
     1321 tgtgattttc aagaccccac cttggctcct ctgagagaca cagagaggtt tggcatcgtg
     1381 cagcgtttgt ttgcctccgc cgacattgcc ctggagagga tgcagttttc tgccaaagcc
     1441 accatcctga aggactcctg catgttcccg ctaattcttc atatcactct tagtgggctt
     1501 tacactttaa gcaaagagca tgaggaacat ctttttcagt cagaagtaca tgctaccagc
     1561 caagactagg tacttcttag gattaatact ttgggatttg gggccgaagc aggttaagcc
     1621 tgtcagtgaa ttccaatgca caccaggagt ggtatctttc tgtactgtgg acaagcactg
     1681 taaatgggta attttcatca gaggcctact gtgccaacac ctgagttaga gggaagaacc
     1741 accttttact ttattttcca ctcacttgtg atatacaaaa ccaaaaatct cagattttac
     1801 atcagttcat cataagctgt gaatgcacag ggaagcatgt cctttggaca tgctgtacaa
     1861 tgctgggtga ctgggaacta gaaatgctac tgggatatat aaaacaatta taataagaac
     1921 atctcatttt acccacctca acatgagaat ttaaatctat tcctcatatt tggctttgtt
     1981 atcctttgat gaacatacta tgtctggggc aattccagtg cattctggga atctgtcaca
     2041 tgttgcaatt gctatcgaag gcaattctga acatgtgtag ttggatgttc attaagtttt
     2101 gaagtccttc tgcttcccca gacttgaaca gtcttctcaa gtctcctgat tgcactgaga
     2161 gcatgttact attgatcaga cccaatgccc ctgggcacat caagcagtgg gatgaatgtt
     2221 agctcccact tcatccacgg gcaccttcag attataagga agagttaaca aagataaagt
     2281 acgtcgtttc ttttaaacat gagactcaac cttatgcagc tccctattac agggtttata
     2341 aagttgcaca ccagcaacac tgctcacgaa ctaaccataa a
//
