LOCUS       NM_001400993            1949 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gasdermin D (Gsdmd), transcript variant 1, mRNA.
ACCESSION   NM_001400993 XM_006241809
VERSION     NM_001400993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1949)
  AUTHORS   Shan,W., Wang,J., Cheng,R., Xuan,Y. and Yin,Z.
  TITLE     Erythropoietin alleviates astrocyte pyroptosis by targeting the
            miR-325-3p/Gsdmd axis in rat spinal cord injury
  JOURNAL   Inflammopharmacology 32 (1), 523-536 (2024)
   PUBMED   37578618
  REMARK    GeneRIF: Erythropoietin alleviates astrocyte pyroptosis by
            targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury.
REFERENCE   2  (bases 1 to 1949)
  AUTHORS   Li,X. and Yang,N.
  TITLE     Exosome miR-223-3p in the bone marrow-derived mesenchymal stem
            cells alleviates the inflammation and airway remodeling through
            NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway
  JOURNAL   Int Immunopharmacol 123, 110746 (2023)
   PUBMED   37549514
  REMARK    GeneRIF: Exosome miR-223-3p in the bone marrow-derived mesenchymal
            stem cells alleviates the inflammation and airway remodeling
            through NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway.
REFERENCE   3  (bases 1 to 1949)
  AUTHORS   Zeng,H., Yang,Y., Tou,F., Zhan,Y., Liu,S., Zou,P., Chen,Y. and
            Shao,L.
  TITLE     Bone marrow stromal cell-derived exosomes improve oxidative stress
            and pyroptosis in doxorubicin-induced myocardial injury in vitro by
            regulating the transcription of GSDMD through the PI3K-AKT-Foxo1
            pathway
  JOURNAL   Immun Inflamm Dis 11 (3), e810 (2023)
   PUBMED   36988259
  REMARK    GeneRIF: Bone marrow stromal cell-derived exosomes improve
            oxidative stress and pyroptosis in doxorubicin-induced myocardial
            injury in vitro by regulating the transcription of GSDMD through
            the PI3K-AKT-Foxo1 pathway.
REFERENCE   4  (bases 1 to 1949)
  AUTHORS   Wen-Yuan,W., Wan-Qing,Y., Qi-Yun,H., Yu-Si,L., Shao-Jie,Q.,
            Jin-Tao,L., Hui,M., Fang,C. and Hui-Ling,Y.
  TITLE     mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental
            Sevoflurane Neurotoxicity
  JOURNAL   Mol Neurobiol 60 (1), 116-132 (2023)
   PUBMED   36224321
  REMARK    GeneRIF: mTORC1-Dependent and GSDMD-Mediated Pyroptosis in
            Developmental Sevoflurane Neurotoxicity.
REFERENCE   5  (bases 1 to 1949)
  AUTHORS   Zhang,D., Mao,F., Wang,S., Wu,H., Wang,S. and Liao,Y.
  TITLE     Role of Transcription Factor Nrf2 in Pyroptosis in Spinal Cord
            Injury by Regulating GSDMD
  JOURNAL   Neurochem Res 48 (1), 172-187 (2023)
   PUBMED   36040608
  REMARK    GeneRIF: Role of Transcription Factor Nrf2 in Pyroptosis in Spinal
            Cord Injury by Regulating GSDMD.
REFERENCE   6  (bases 1 to 1949)
  AUTHORS   Zhang,D., Qian,J., Zhang,P., Li,H., Shen,H., Li,X. and Chen,G.
  TITLE     Gasdermin D serves as a key executioner of pyroptosis in
            experimental cerebral ischemia and reperfusion model both in vivo
            and in vitro
  JOURNAL   J Neurosci Res 97 (6), 645-660 (2019)
   PUBMED   30600840
  REMARK    GeneRIF: Study suggests that Gasdermin D may participate in
            caspase-1-mediated pyroptosis during cerebral ischemia and
            reperfusion injury both in vivo and in vitro, which could be a
            potential therapeutic target to reduce brain cerebral ischemia and
            reperfusion injury.
REFERENCE   7  (bases 1 to 1949)
  AUTHORS   Lei,Q., Yi,T. and Chen,C.
  TITLE     NF-kappaB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and
            NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3)
            Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial
            Infarction
  JOURNAL   Med Sci Monit 24, 6044-6052 (2018)
   PUBMED   30161099
  REMARK    GeneRIF: Authors demonstrated that the NF-kappaB-GSDMD axis
            functioned as a bridge between oxidative stress and NLRP3
            inflammasome-mediated cardiomyocyte pyroptosis. Findings provide
            important insight into the mechanism of myocardial
            infarction-related ventricular remodeling.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1949)
  AUTHORS   Liu,X., Zhang,Z., Ruan,J., Pan,Y., Magupalli,V.G., Wu,H. and
            Lieberman,J.
  TITLE     Inflammasome-activated gasdermin D causes pyroptosis by forming
            membrane pores
  JOURNAL   Nature 535 (7610), 153-158 (2016)
   PUBMED   27383986
REFERENCE   9  (bases 1 to 1949)
  AUTHORS   He,W.T., Wan,H., Hu,L., Chen,P., Wang,X., Huang,Z., Yang,Z.H.,
            Zhong,C.Q. and Han,J.
  TITLE     Gasdermin D is an executor of pyroptosis and required for
            interleukin-1beta secretion
  JOURNAL   Cell Res 25 (12), 1285-1298 (2015)
   PUBMED   26611636
REFERENCE   10 (bases 1 to 1949)
  AUTHORS   Leimeister,C., Bach,A., Woolf,A.S. and Gessler,M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006241809.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.40488.1,
                                           SRR26643291.20994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               JAXUCZ010000007.1  109423209-109423527
            320-543             JAXUCZ010000007.1  109424212-109424435
            544-736             JAXUCZ010000007.1  109424649-109424841
            737-905             JAXUCZ010000007.1  109425369-109425537
            906-1008            JAXUCZ010000007.1  109425780-109425882
            1009-1062           JAXUCZ010000007.1  109426117-109426170
            1063-1152           JAXUCZ010000007.1  109426462-109426551
            1153-1325           JAXUCZ010000007.1  109426678-109426850
            1326-1470           JAXUCZ010000007.1  109426925-109427069
            1471-1547           JAXUCZ010000007.1  109427159-109427235
            1548-1949           JAXUCZ010000007.1  109427370-109427771
FEATURES             Location/Qualifiers
     source          1..1949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1949
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /note="gasdermin D"
                     /db_xref="GeneID:315084"
                     /db_xref="RGD:1307261"
     exon            1..319
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..543
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1790
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /note="gasdermin domain containing 1"
                     /codon_start=1
                     /product="gasdermin-D"
                     /protein_id="NP_001387922.1"
                     /db_xref="GeneID:315084"
                     /db_xref="RGD:1307261"
                     /translation="MPSAFAGVVKNVIKEVGGSGGELIPVDCLRNSTSFKPYCLLSRK
                     LSSSWFWKPRYTCVNLSIKDILEPSAPEPEPECFGNFQVSDVVDGNIQGSVTLSGTGQ
                     GKISGGAAVSGSSSASMNVCMLRVTQQTWEIMQRERHLQQPENKILQQLRNRGDDVFV
                     VTEVLQTKEEVQITQVHSHEGSGQFTLPGASCLQGEGKGHQSRKKMVTIPAGSILAFR
                     VAQLLIGSEWDILLISNEKKRTFELPSSGHKGAVGQRRHDFSLLAVLHSIGERLSLKS
                     DGTNEEEVIREDFQGLRAEVEAGSSELRSLEMELRQQLLVDIGRILQDQPSMEALEAS
                     LEQGLCSGEQVEPLEGPAGSILECLVLDSGELVPELAAPVFYLLGALAGLSETQQQLL
                     ATKALEATVLSKELELVKHVLEQSTPWQEQRSVPLPSRLLGDSWDEEALTWVLLEECG
                     LTLQVEPPQVYWEPTSQGPICALYASLALLSSLGQKSC"
     exon            544..736
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..905
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1008
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1062
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1152
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1325
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1470
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1547
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1949
                     /gene="Gsdmd"
                     /gene_synonym="Gsdmdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttttgtgt cctgactctt cgagaaccgc tcttgctggt ggctccccgt ggctcccgtg
       61 gctcccgttt ctcccagggt gagccgacaa gagacccctc ctcagcaccc cggcacagcc
      121 ctgctacgct tggtgggccc agatacctca gcaggggtga agatcgtggt gagccaccct
      181 gctattcagc cctcccggaa cccagccgcc cctactctgg tttgtctact ctattgcctg
      241 gatgcctgct tgttgagttg gggattcagc acttcccaga agccccacta taccagacag
      301 cttgaagaga ccctaagagg atcatgccgt cagcctttgc gggagtggtc aagaatgtga
      361 tcaaagaggt gggcggcagc ggaggagagc tcatcccagt ggactgcctt cggaattcta
      421 ccagcttcaa gccctactgc ctcctgagca ggaaactctc aagctcatgg ttctggaaac
      481 cccgttatac atgtgtcaac ctgtcaatca aggacatcct ggagcccagt gctccagaac
      541 cagaaccgga gtgttttggc aacttccaag tctccgatgt cgtcgatggg aacattcagg
      601 gcagtgtgac gttgtcaggc acgggacaag ggaaaatttc tggtggggct gcagtgtctg
      661 gcagttccag tgcctccatg aatgtgtgta tgctgcgtgt gactcagcag acctgggaga
      721 tcatgcaacg tgaaaggcac ctgcagcagc ctgaaaacaa aatcctgcaa cagctgcgga
      781 atcgtgggga tgacgtgttt gtggtgaccg aggtgctgca gacaaaggag gaggtgcaga
      841 tcacccaggt ccacagccac gagggctcag gccagttcac actgcctgga gcctcgtgct
      901 tgcagggtga aggcaagggc caccaaagcc ggaagaagat ggtgaccatt cctgcaggca
      961 gcatccttgc attccgagtg gcccagctgc tcattggctc tgaatgggat attcttctca
     1021 tctcaaatga gaaaaagagg acctttgagc tgccctcctc aggccacaaa ggagcagtgg
     1081 gccagaggcg gcatgacttt agtctgcttg ccgtactcca ttccatcggg gagcggctga
     1141 gtctcaagtc agatggaacc aatgaggaag aagtaatcag ggaagacttc caaggcctgc
     1201 gtgcggaggt ggaggcaggc tcttcagaac tgcggagctt agaaatggag ttgagacaac
     1261 agctactagt agacatcggg aggattttac aggaccagcc cagcatggaa gccttagagg
     1321 cctcactaga gcagggtctg tgcagtggtg agcaggtaga gcctctggaa ggcccagcag
     1381 gcagcatcct tgagtgtctg gtgctcgact ctggagaact ggtgccggaa cttgcagccc
     1441 ccgtcttcta cctgttggga gcactggctg ggttgagtga aacccagcag cagctactgg
     1501 ctactaaggc tctggaggca acggtgctgt caaaggagct agagttggtg aagcacgtct
     1561 tggaacagag caccccatgg caggagcaga gatctgtgcc cctgccctcc aggctccttg
     1621 gggacagctg ggatgaggag gctctcacct gggtcttgct agaagaatgt ggcctaacgc
     1681 tgcaggtgga acccccccag gtatactggg aaccaacatc tcagggcccc atatgtgcac
     1741 tctatgcctc cctggcccta ttgtcaagtc taggccagaa atcgtgttag cctgcacacc
     1801 acccttccca caacatcttc atatcctacc ctccagggca gaaacttgcc aagtccagcc
     1861 tctaggccaa gaacctaact cagtcacagg gttagaatgc agcaagaccc aggagttggg
     1921 aaaaactcaa taaatgtaca aagaaaaaa
//
