LOCUS       NM_001395028            3669 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gamma-secretase activating protein (Gsap), mRNA.
ACCESSION   NM_001395028 XM_006235935
VERSION     NM_001395028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3669)
  AUTHORS   Hussain,I., Fabregue,J., Anderes,L., Ousson,S., Borlat,F.,
            Eligert,V., Berger,S., Dimitrov,M., Alattia,J.R., Fraering,P.C. and
            Beher,D.
  TITLE     The role of gamma-secretase activating protein (GSAP) and imatinib
            in the regulation of gamma-secretase activity and amyloid-beta
            generation
  JOURNAL   J Biol Chem 288 (4), 2521-2531 (2013)
   PUBMED   23209290
  REMARK    GeneRIF: gamma-secretase activating protein (GSAP) and imatinib
            have roles in the regulation of gamma-secretase activity and
            amyloid-beta generation
REFERENCE   2  (bases 1 to 3669)
  AUTHORS   He,G., Luo,W., Li,P., Remmers,C., Netzer,W.J., Hendrick,J.,
            Bettayeb,K., Flajolet,M., Gorelick,F., Wennogle,L.P. and
            Greengard,P.
  TITLE     Gamma-secretase activating protein is a therapeutic target for
            Alzheimer's disease
  JOURNAL   Nature 467 (7311), 95-98 (2010)
   PUBMED   20811458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 17, 2022 this sequence version replaced NM_001395028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.558795.1,
                                           SRR26643287.10256.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000004.1  14799838-14800005   c
            169-236             JAXUCZ010000004.1  14790425-14790492   c
            237-293             JAXUCZ010000004.1  14789263-14789319   c
            294-363             JAXUCZ010000004.1  14781467-14781536   c
            364-414             JAXUCZ010000004.1  14781136-14781186   c
            415-503             JAXUCZ010000004.1  14771552-14771640   c
            504-573             JAXUCZ010000004.1  14767494-14767563   c
            574-623             JAXUCZ010000004.1  14765708-14765757   c
            624-728             JAXUCZ010000004.1  14760559-14760663   c
            729-788             JAXUCZ010000004.1  14760113-14760172   c
            789-832             JAXUCZ010000004.1  14759235-14759278   c
            833-918             JAXUCZ010000004.1  14758070-14758155   c
            919-996             JAXUCZ010000004.1  14749099-14749176   c
            997-1074            JAXUCZ010000004.1  14747486-14747563   c
            1075-1167           JAXUCZ010000004.1  14741837-14741929   c
            1168-1382           JAXUCZ010000004.1  14741514-14741728   c
            1383-1452           JAXUCZ010000004.1  14738802-14738871   c
            1453-1535           JAXUCZ010000004.1  14738206-14738288   c
            1536-1589           JAXUCZ010000004.1  14734423-14734476   c
            1590-1718           JAXUCZ010000004.1  14723229-14723357   c
            1719-1777           JAXUCZ010000004.1  14722459-14722517   c
            1778-1809           JAXUCZ010000004.1  14721781-14721812   c
            1810-1871           JAXUCZ010000004.1  14719941-14720002   c
            1872-1967           JAXUCZ010000004.1  14718174-14718269   c
            1968-2038           JAXUCZ010000004.1  14715190-14715260   c
            2039-2133           JAXUCZ010000004.1  14714673-14714767   c
            2134-2253           JAXUCZ010000004.1  14709185-14709304   c
            2254-2315           JAXUCZ010000004.1  14708323-14708384   c
            2316-2417           JAXUCZ010000004.1  14707046-14707147   c
            2418-2517           JAXUCZ010000004.1  14706790-14706889   c
            2518-3669           JAXUCZ010000004.1  14705237-14706388   c
FEATURES             Location/Qualifiers
     source          1..3669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3669
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /note="gamma-secretase activating protein"
                     /db_xref="GeneID:311984"
                     /db_xref="RGD:1563271"
     exon            1..168
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2609
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /note="protein pigeon homolog"
                     /codon_start=1
                     /product="gamma-secretase-activating protein"
                     /protein_id="NP_001381957.1"
                     /db_xref="GeneID:311984"
                     /db_xref="RGD:1563271"
                     /translation="MALRLVTHFDVLADVLPSLLVQAATADEGDEGAETTLGSLRVLN
                     IERNGDIIYTYKDNKGNAVFGIFDCQTRENEHLYTFEKDMQAVSCSVNSERTVLAASF
                     IQYTEGVRSELQPGSKCLTLLVEIHPVNNVTVLKAVDSCVWVQFLYPQAESHLLAQNH
                     LLLISEEKYIERFHIQITREDGNRVVIRNSSHLPRERIAEDFVWAQWDVSEQRIHYIE
                     LQESRSILKCVQFWADESFTIMFEMPLDISLSGLRFKLVNFGYDYRQDQAKLCHQPSL
                     CIFTNHTGSLCVCYSPKSDSWKEITYSVFYLHKGYRKTFTVAPGSTDSQVANGVTFLN
                     LGYFVAVYSPCRFLHLLNIRHPDLICHSLFLTGNNKTAAVLPPSPLQSLPGSLILDCS
                     SGKVYRATLDQSYLMGFLWNAQLDCEKMAALHCALSCDSDPGFPEQIVQWVSERVSAC
                     HSFDLIQEFLIASSYWSVYPGLDDVDLLLPYSSVLTWDTEIPGMKLVTEELPLPLMKV
                     YSLKGYWAKLNSNLEYIKYTKPHLHYHNSVVRREWHNLISEERTGKRRSTMYVRNILD
                     NAVKVISNMEMKTFEPRLIPLLQEEDRHQRLLMGLMVSELRDHLLRHLQGVEKKKIEQ
                     MVLDYISKLLDLVWCLLETSWRKHSVHPWVLHLNEHGSPADFEVFHLMTRILDAASSL
                     CFPLPPGFHSLHTILGVHCLPLYNLLHYIDNGVLLLTETVVTRLMKDLDNSEKNEKLK
                     FSIIVRLPPLIGQKVCRLWDHPMSSNIISRNHVAQLLKNYKKEPQSSMIDKSSFPVEF
                     LPLNYFIEILMHLESSNQALHGFEGHDNVDAEFVEEAALKHTTSLLGL"
     exon            169..236
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            237..293
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            294..363
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            364..414
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            415..503
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            504..573
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            574..623
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            624..728
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            729..788
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            789..832
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            833..918
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            919..996
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1074
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1167
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1382
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1452
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1535
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1589
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1718
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1777
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1809
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1871
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1967
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2038
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2133
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2253
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2315
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2417
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2517
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..3669
                     /gene="Gsap"
                     /gene_synonym="Pion"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggcggc tgcaggctgg gaggtgtgag cctgcccgga atgtccgccc cgccgctgtt
       61 tgcgagccat ggctctgcgg ctggtcaccc acttcgacgt gctggcggac gtgctcccga
      121 gtctgctcgt ccaggcagcg acagcagatg aaggagacga aggcgcagaa acaactcttg
      181 ggagcttacg tgtactaaac atcgaaagaa atggagacat tatttatacc tataaggaca
      241 acaaaggaaa tgcggtcttc ggaatatttg actgccaaac cagagaaaat gagcatctgt
      301 acaccttcga gaaggacatg caagctgtca gttgctcagt caacagcgag aggacagtgc
      361 ttgctgcaag cttcattcag tacacggaag gagtaaggag tgagcttcag ccaggatcga
      421 agtgtctaac tttgctggtt gaaatccacc ctgtcaacaa cgtgacggtt ctgaaagctg
      481 tggatagctg cgtttgggta cagttcctct acccacaagc tgaaagtcat cttcttgcac
      541 agaaccacct gttactgatt tcagaagaga aatatattga acggtttcat atccagatca
      601 ccagagaaga tggaaacaga gtggtaatta gaaattctag ccatctccca agagaaagaa
      661 tagctgaaga cttcgtttgg gctcagtggg atgtgtcaga gcagagaatc cactacattg
      721 aactgcagga gtcaaggagt atcttgaaat gcgtccagtt ctgggcagat gaaagcttta
      781 ccataatgtt tgaaatgccc ttggacatat cattaagtgg cttgagattt aaactcgtca
      841 acttcggcta tgattatcgt caagaccaag ccaagctttg ccatcagcca tccctctgca
      901 tttttaccaa ccacacaggg agtttgtgtg tgtgttacag cccgaagtct gactcttgga
      961 aagaaatcac gtattcagtg ttttacctcc ataaagggta cagaaagacc ttcaccgtag
     1021 ctcctggaag cactgactcg caggtcgcca acggcgtcac ctttctcaac cttggctact
     1081 ttgtggctgt ttattccccc tgccgtttcc ttcatttact taacattcgg catccagact
     1141 tgatctgcca cagtctgttt ctcacaggaa acaacaaaac ggccgctgtg ctacctccga
     1201 gtcctttgca gtccctgccg gggtccctca ttctggactg ctcttctgga aaggtctata
     1261 gagcaactct tgaccagtca tacttgatgg gtttcctgtg gaacgcccag ctagactgtg
     1321 agaaaatggc tgcgctgcat tgtgcactgt cctgtgattc agacccaggt ttcccagaac
     1381 agatcgttca gtgggtttct gagcgtgtct ctgcctgcca ttcatttgac ctcattcaag
     1441 aattcctaat tgcgtcctcc tattggagtg tgtatccagg gctggatgac gtggacctgc
     1501 tcttacccta ctcctctgtg ctgacatggg acacagaaat tcctggaatg aagcttgtga
     1561 cagaagagct cccgttacct cttatgaagg tctacagctt gaaggggtac tgggcaaagc
     1621 tgaactccaa cctcgagtat attaagtaca ccaagcctca cctgcactac cacaacagcg
     1681 tcgtgaggag agagtggcat aacctgatct ctgaagagag aacgggaaaa aggaggtcca
     1741 caatgtacgt gaggaacatt cttgacaacg ctgtgaaggt gatttctaac atggaaatga
     1801 aaacattcga gccaaggtta atacccctct tacaagagga agacaggcac cagaggctgc
     1861 tcatgggcct gatggtgtct gagctaagag accatctact gagacacctg cagggtgtag
     1921 aaaagaagaa aattgaacag atggttctgg actacatttc aaaactgctg gatctcgttt
     1981 ggtgcttgct ggaaaccagt tggaggaaac acagtgtgca cccctgggtt ctccacctta
     2041 atgagcacgg cagccccgca gatttcgaag tctttcatct catgaccagg attttggatg
     2101 ccgctagcag tttgtgtttc cctctgcctc ctggtttcca ctctctgcac acaatccttg
     2161 gggtccactg tctccctttg tacaaccttc tgcactacat tgataacggc gtgctgctgc
     2221 tcaccgagac tgtggtcacg aggcttatga aagatctgga taattcagag aaaaatgaaa
     2281 aactgaaatt tagcatcatt gtccggcttc ctccgcttat tggccagaag gtctgtcggc
     2341 tttgggacca tcccatgagt tccaacatca tttcacggaa ccacgtggcc cagcttctga
     2401 agaactacaa gaaagagcct cagagctcta tgattgacaa gtcatcattt ccagtagaat
     2461 ttcttcctct gaactacttc attgaaattc tgatgcacct ggagtcctcc aaccaagcac
     2521 tacatggctt tgaaggacat gacaatgtgg atgcagaatt tgtagaggaa gctgctctga
     2581 aacacaccac ctcacttttg ggcttatgaa catccagatg accagttcca acacttcgcc
     2641 tccctttcct ggggagtctt caactgtctt taagagtggt aacagctcag aatatactgc
     2701 agggctgttg ggcttctgta tagttcttat tcagaggcag tggccacgcc tctcagttcg
     2761 agcagccagt aaacagccaa gaggaaagaa caagtccaag gctgtgcact gtggcaggca
     2821 cagcgccctt cctgggggcc cagcaggccg ggaactggtt ctgttgcact acagaatcta
     2881 ataaaaaaca gaggaccatg ctcagagcag taagagccag gcagatcact ggaaggaagg
     2941 taaaacaagc agaaaaagtg actgtctcga agaggatttc agaagaacct gaaactggag
     3001 taaacaagat gtctttccag tatggagcaa ctgtgacaaa tcatttgtac acatggcact
     3061 taaaccagcc tttgtctttg gggcgattca gatagagcca tatttaattt tatatttatg
     3121 acttagtact atcttatcat taaatacaac ctcagatgct ttggtctgag tctccctagg
     3181 ttttgggtgt agccttcttt gcataaggca ctttgagtcc tgacacctga cgaggtgctc
     3241 cgtccttccg tccttcctcg tctgtctcct gcagtgacgt cactgacccg tatggctcag
     3301 ctttgcaaac tcagttctgc ttctttgtgg ccattactgg ttcccattca tgtggtgaaa
     3361 ttttaatgat tctgtaacgc cactgaccca tgtgcaattc tccatatttt ctgcaacttt
     3421 tgttgtgctc tagaaactgt cctggcctat agaatttccc gtttgctcca aatggtcagc
     3481 caggctcaga atcttgtcac caagtcacaa tgcagcaata aggtatgttc acattacttc
     3541 tgtctgttca catgacttgt gttacaaatt actctgtact gaagacagca ggttttattt
     3601 agttcaaatt aaaattcaaa aatcctcttc gataataaaa cttgcagaac acttaatttg
     3661 gactttaaa
//
