LOCUS       NM_001012067            1958 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus glutamate-rich WD repeat containing 1 (Grwd1),
            mRNA.
ACCESSION   NM_001012067 XM_218563
VERSION     NM_001012067.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Aizawa,M., Sugimoto,N., Watanabe,S., Yoshida,K. and Fujita,M.
  TITLE     Nucleosome assembly and disassembly activity of GRWD1, a novel
            Cdt1-binding protein that promotes pre-replication complex
            formation
  JOURNAL   Biochim Biophys Acta 1863 (11), 2739-2748 (2016)
   PUBMED   27552915
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Sugimoto,N., Maehara,K., Yoshida,K., Yasukouchi,S., Osano,S.,
            Watanabe,S., Aizawa,M., Yugawa,T., Kiyono,T., Kurumizaka,H.,
            Ohkawa,Y. and Fujita,M.
  TITLE     Cdt1-binding protein GRWD1 is a novel histone-binding protein that
            facilitates MCM loading through its influence on chromatin
            architecture
  JOURNAL   Nucleic Acids Res 43 (12), 5898-5911 (2015)
   PUBMED   25990725
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083883.1.
            
            On Feb 11, 2005 this sequence version replaced XM_218563.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083883.1, SRR8487227.68589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1958
                     /gene="Grwd1"
                     /note="glutamate-rich WD repeat containing 1"
                     /db_xref="GeneID:308592"
                     /db_xref="RGD:1310649"
     exon            1..242
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1393
                     /gene="Grwd1"
                     /codon_start=1
                     /product="glutamate-rich WD repeat-containing protein 1"
                     /protein_id="NP_001012067.1"
                     /db_xref="GeneID:308592"
                     /db_xref="RGD:1310649"
                     /translation="MAARKGRRHTCETGEPMEAETYDLGSEGPSQVYLPGRGPPLGEG
                     EELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLSLYLCAGTQAESAQSNR
                     LMMLRMHNLHGTRPPPSEGSDDEDDEDEEDEEERKPQLELAMVPHYGGINRVRVSWLG
                     EEPVAGVWSEKGQVEVFALRRLLQVVDDPQALAIFLRDEQARVKPIFSFAGHMGEGFA
                     LDWSPRVPGRLLTGDCQKNIHLWTPTDGGSWNVDQRPFVGHTRSVEDLQWSPTEDTVF
                     ASCSADASIRIWDIRAAPGKACMLTTAAAHDGDVNVISWSRREPFLLSGGDDGTLKVW
                     DLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADNQITQWDLAVERDPESGE
                     TETDPGLAALPQQLLFVHQGETDLKELHWHPQCPGVLISTALSGFTVFRTISV"
     exon            243..360
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..520
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..734
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..877
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1075
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1920
                     /gene="Grwd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggatccc ggaagtgacg ctagtacttc gcgtccgaag caagaaggtt cgaagatggc
       61 ggcgcgcaag ggccggaggc acacatgtga aaccggggag cccatggagg ctgaaaccta
      121 cgatctagga tccgaaggcc catcccaggt ctacctgccc ggcagagggc cgccactagg
      181 agaaggggag gagctggtaa tggatgaaga ggcctacgtg ctataccatc gtgcgcaaac
      241 tggcgcccct tgtctcagct ttgacatagt ccgagatcac ctgggcgaca accggacaga
      301 gctccctctc agtctttacc tgtgtgcggg aacccaggcg gagagcgccc agagcaatag
      361 actgatgatg cttcggatgc acaatctcca tgggaccagg ccgccaccct cagagggcag
      421 tgatgatgag gatgatgaag atgaagagga tgaagaggag cggaaacctc aactggagct
      481 ggccatggtt ccccactatg gtggcatcaa ccgagttcgg gtatcttggc tgggagagga
      541 gcccgtggct ggagtatggt cagagaaggg ccaggtggag gtgtttgcac tgcgacggct
      601 cctgcaggtg gtggatgacc cgcaggccct ggccatcttc ctccgcgatg agcaggcccg
      661 agtaaagccc atcttctcct ttgctggcca catgggtgag ggctttgctc ttgactggtc
      721 ccctcgggta cccggccgct tgttgactgg tgactgtcag aagaacatcc atctctggac
      781 acccacggat ggtggttcct ggaatgtgga ccagaggcca tttgtgggcc atacacgctc
      841 tgtggaggat ctgcagtggt cgccaacaga ggacacggtg tttgcctcgt gctctgcgga
      901 tgcctccatt cgcatctggg acatccgagc agccccaggc aaggcctgca tgctcaccac
      961 agccgctgcc catgatgggg atgtcaacgt catcagttgg agccgcaggg aacccttcct
     1021 gctcagtggt ggggatgatg ggaccctcaa agtctgggac ctgcgacagt tcaagtctgg
     1081 ctcccctgtg gccaccttca agcaacacgt ggcccccgtg acctccgttg aatggcaccc
     1141 tcaggacagt ggggtctttg cagcctcagg tgctgacaac cagatcacac agtgggacct
     1201 ggcagttgag cgggacccag agtcaggtga gacagagaca gaccctgggc tggcggcact
     1261 gccccagcag ttgctgttcg tgcatcaagg tgagactgac ctgaaggagc tacactggca
     1321 cccacagtgc cctggggtcc tgatcagcac cgccctgtca ggcttcaccg tcttcaggac
     1381 catcagtgtt tgagatggcc aacactgggc ctcaggcctt ggctcttcag gggaaccgga
     1441 tcagttaact tggcaaggat cattaggcct gtagactgca cctcagaaag gaagacttgt
     1501 tcagctggcc tctgtggaac agaaggaatg gattctactg acctactatc tctaatgatt
     1561 tggactgagc cttggctctg ccttacacca aagactaggt tcaggcaaag acccttgcct
     1621 gtcccagatg tagcctcagg atgagactgt cggtgtcgac cccaaggacc tctgactggg
     1681 aacccagttc tgactgttga tcgacttcag gaactttaag gcttttgcca tggctgggcc
     1741 aagtctgggt ctgggtccca gtggaatttc tctctttgcc ttcttctatc catttagatt
     1801 tgtttgagat ccaagttggg agccatctgg ggtgccctcc tgtgctcacc actgttgtac
     1861 tggaggatgg cctggggctt ctgctacagt aaaggaccac aataaggccc caaacactga
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
