LOCUS       NM_012706               1308 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus gastrin releasing peptide receptor (Grpr), mRNA.
ACCESSION   NM_012706
VERSION     NM_012706.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Yang,Y.Q., Sun,R.F., Ge,P., Li,W.X., Zhang,X., Zhang,J., Ye,L.,
            Zhang,N., Wang,S.Y., Lv,M.Q. and Zhou,D.X.
  TITLE     GRPR down-regulation inhibits spermatogenesis through Ca2+ mediated
            by PLCbeta/IP3R signaling pathway in long-term formaldehyde-exposed
            rats
  JOURNAL   Food Chem Toxicol 179, 113998 (2023)
   PUBMED   37604300
  REMARK    GeneRIF: GRPR down-regulation inhibits spermatogenesis through
            Ca[2+] mediated by PLCbeta/IP3R signaling pathway in long-term
            formaldehyde-exposed rats.
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Yu,Y.Q., Barry,D.M., Hao,Y., Liu,X.T. and Chen,Z.F.
  TITLE     Molecular and neural basis of contagious itch behavior in mice
  JOURNAL   Science 355 (6329), 1072-1076 (2017)
   PUBMED   28280205
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Li,P., Janczewski,W.A., Yackle,K., Kam,K., Pagliardini,S.,
            Krasnow,M.A. and Feldman,J.L.
  TITLE     The peptidergic control circuit for sighing
  JOURNAL   Nature 530 (7590), 293-297 (2016)
   PUBMED   26855425
  REMARK    GeneRIF: peptidergic pathways comprise the core of a sigh control
            circuit that integrates physiological and perhaps emotional input
            to transform normal breaths into sighs
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Pereira,P.J., Machado,G.D., Danesi,G.M., Canevese,F.F., Reddy,V.B.,
            Pereira,T.C., Bogo,M.R., Cheng,Y.C., Laedermann,C., Talbot,S.,
            Lerner,E.A. and Campos,M.M.
  TITLE     GRPR/PI3Kgamma: Partners in Central Transmission of Itch
  JOURNAL   J Neurosci 35 (49), 16272-16281 (2015)
   PUBMED   26658875
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Petronilho,F., Vuolo,F., Galant,L.S., Constantino,L., Tomasi,C.D.,
            Giombelli,V.R., de Souza,C.T., da Silva,S., Barbeiro,D.F.,
            Soriano,F.G., Streck,E.L., Ritter,C., Zanotto-Filho,A.,
            Pasquali,M.A., Gelain,D.P., Rybarczyk-Filho,J.L., Moreira,J.C.,
            Block,N.L., Roesler,R., Schwartsmann,G., Schally,A.V. and
            Dal-Pizzol,F.
  TITLE     Gastrin-releasing peptide receptor antagonism induces protection
            from lethal sepsis: involvement of toll-like receptor 4 signaling
  JOURNAL   Mol Med 18 (1), 1209-1219 (2012)
   PUBMED   22735756
  REMARK    GeneRIF: These findings highlight the role of GRPR signaling in
            sepsis outcome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Tokita,K., Katsuno,T., Hocart,S.J., Coy,D.H., Llinares,M.,
            Martinez,J. and Jensen,R.T.
  TITLE     Molecular basis for selectivity of high affinity peptide
            antagonists for the gastrin-releasing peptide receptor
  JOURNAL   J Biol Chem 276 (39), 36652-36663 (2001)
   PUBMED   11463790
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Battey,J., Wada,E., Corjay,M., Way,J., Fathi,Z., Shapira,H.,
            Harkins,R., Wu,J., Slattery,T., Mann,E. et al.
  TITLE     Molecular genetic analysis of two distinct receptors for mammalian
            bombesin-like peptides
  JOURNAL   J Natl Cancer Inst Monogr (13), 141-144 (1992)
   PUBMED   1327030
  REMARK    Review article
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Corjay,M.H., Dobrzanski,D.J., Way,J.M., Viallet,J., Shapira,H.,
            Worland,P., Sausville,E.A. and Battey,J.F.
  TITLE     Two distinct bombesin receptor subtypes are expressed and
            functional in human lung carcinoma cells
  JOURNAL   J Biol Chem 266 (28), 18771-18779 (1991)
   PUBMED   1655761
REFERENCE   9  (bases 1 to 1308)
  AUTHORS   Battey,J.F., Way,J.M., Corjay,M.H., Shapira,H., Kusano,K.,
            Harkins,R., Wu,J.M., Slattery,T., Mann,E. and Feldman,R.I.
  TITLE     Molecular cloning of the bombesin/gastrin-releasing peptide
            receptor from Swiss 3T3 cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 395-399 (1991)
   PUBMED   1671171
REFERENCE   10 (bases 1 to 1308)
  AUTHORS   Hollingsworth,E.B.
  TITLE     Gastrin-releasing peptide receptor in rat brain membranes: specific
            binding and stimulation of phosphoinositide breakdown
  JOURNAL   Mol Pharmacol 35 (5), 689-694 (1989)
   PUBMED   2542758
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X56661.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_012706.3.
            
            On Apr 19, 2007 this sequence version replaced NM_012706.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1308              X56661.1           93-1400
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..1308
                     /gene="Grpr"
                     /note="gastrin releasing peptide receptor"
                     /db_xref="GeneID:24938"
                     /db_xref="RGD:2750"
     exon            1..466
                     /gene="Grpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1205
                     /gene="Grpr"
                     /note="GRP-R; GRP-preferring bombesin receptor"
                     /codon_start=1
                     /product="gastrin-releasing peptide receptor"
                     /protein_id="NP_036838.1"
                     /db_xref="GeneID:24938"
                     /db_xref="RGD:2750"
                     /translation="MDPNNCSHLNLEVDPFLSCNNTFNQTLSPPKMDNWFHPGIIYVI
                     PAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKY
                     LADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICL
                     KAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLV
                     FYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAF
                     CWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQF
                     NTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV"
     exon            467..818
                     /gene="Grpr"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1308
                     /gene="Grpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttacaaa gcagcatctt gaaggcgcat ttgaagagag aagctttgag atggatccaa
       61 ataattgttc ccacctgaac ttggaagtgg atcctttcct gtcctgcaac aacaccttca
      121 atcaaactct gagtcccccc aagatggaca actggtttca cccgggaatc atctatgtca
      181 ttcctgcagt ttatgggctt atcatcgtga taggcctcat tggcaacatc accctgatca
      241 agatcttctg tacggtcaag tccatgcgaa acgtgccaaa cctgttcatc tctagcctgg
      301 cattgggaga cctactgctg ctggttacat gcgcccctgt ggatgccagc aagtacctgg
      361 ctgacaggtg gctatttggc aggattggct gcaaactgat cccctttata caacttactt
      421 cagtgggggt gtctgtcttc acacttacgg cactgtcagc tgacaggtac aaagccatcg
      481 tcaggccaat ggatatccag gcatcccatg ccctgatgaa gatctgtctc aaagctgcct
      541 taatctggat cgtctctatg ctgttggcca tcccagaggc tgtattttcg gaccttcacc
      601 cctttcatgt gaaagatacc aaccaaacct tcattagttg tgccccctac ccacactcca
      661 atgagctgca ccctaaaatc cattccatgg cttcctttct ggtcttttac attatcccac
      721 tgtcgatcat ctctgtctac tactacttca ttgcccgaaa tctgattcag agtgcctaca
      781 atcttcctgt ggaaggaaat atacatgtca agaagcagat cgaatcccgg aagcggcttg
      841 ccaagacagt actggtgttt gtgggcctct tcgccttctg ctggctcccc aatcatgtca
      901 tctacctgta ccgttcctac cactactctg aggtggacac ctccatgctc cactttatca
      961 ccagcatctg tgcccgcctc ctggccttca ccaactcctg tgtgaacccc tttgccctgt
     1021 atctgctgag caagagcttc aggaagcagt tcaacactca acttctctgc tgccagccca
     1081 gcctgttgaa caggtctcac agcacaggca gaagtaccac ctgcatgacc tccttcaaga
     1141 gcaccaaccc ctcagctacc ttcagcctca tcaacggaaa tatctgccat gaggggtatg
     1201 tctagacaaa ccttcagcct cgactcttaa ggaactcctg gtactattct acagatatct
     1261 aggatccctg aaattgattg ttgtctctat accttccaaa gacccttc
//
