LOCUS       NM_024487                960 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus GrpE-like 1, mitochondrial (Grpel1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_024487
VERSION     NM_024487.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 960)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   2  (bases 1 to 960)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 960)
  AUTHORS   Tamura,S., Kinouchi,H., Izaki,K., Okubo,A., Sugawara,T.,
            Kunizuka,H. and Mizoi,K.
  TITLE     Induction of heat shock protein 40 and GrpE mRNAs following
            transient focal cerebral ischemia in the rat
  JOURNAL   Brain Res 960 (1-2), 277-281 (2003)
   PUBMED   12505684
  REMARK    GeneRIF: reverse transcription-polymerase chain reaction and in
            situ hybridization analyses showed significant induction of GrpE
            mRNA in the ischemic cortex
REFERENCE   4  (bases 1 to 960)
  AUTHORS   Choglay,A.A., Chapple,J.P., Blatch,G.L. and Cheetham,M.E.
  TITLE     Identification and characterization of a human mitochondrial
            homologue of the bacterial co-chaperone GrpE
  JOURNAL   Gene 267 (1), 125-134 (2001)
   PUBMED   11311562
REFERENCE   5  (bases 1 to 960)
  AUTHORS   Naylor,D.J., Stines,A.P., Hoogenraad,N.J. and Hoj,P.B.
  TITLE     Evidence for the existence of distinct mammalian cytosolic,
            microsomal, and two mitochondrial GrpE-like proteins, the
            Co-chaperones of specific Hsp70 members
  JOURNAL   J Biol Chem 273 (33), 21169-21177 (1998)
   PUBMED   9694873
REFERENCE   6  (bases 1 to 960)
  AUTHORS   Naylor,D.J., Hoogenraad,N.J. and Hoj,P.B.
  TITLE     Isolation and characterisation of a cDNA encoding rat mitochondrial
            GrpE, a stress-inducible nucleotide-exchange factor of ubiquitous
            appearance in mammalian organs
  JOURNAL   FEBS Lett 396 (2-3), 181-188 (1996)
   PUBMED   8914984
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U62940.1.
            
            On Aug 30, 2012 this sequence version replaced NM_024487.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62940.1, FQ215495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-960               U62940.1           2-961
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..960
                     /gene="Grpel1"
                     /gene_synonym="GrpE#1; GrpE1"
                     /note="GrpE-like 1, mitochondrial"
                     /db_xref="GeneID:79563"
                     /db_xref="RGD:70947"
     exon            1..75
                     /gene="Grpel1"
                     /gene_synonym="GrpE#1; GrpE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..667
                     /gene="Grpel1"
                     /gene_synonym="GrpE#1; GrpE1"
                     /note="grpE protein homolog 1, mitochondrial; mt-GrpE#1;
                     stress-inducible chaperone mt-GrpE#1"
                     /codon_start=1
                     /product="grpE protein homolog 1, mitochondrial precursor"
                     /protein_id="NP_077813.1"
                     /db_xref="GeneID:79563"
                     /db_xref="RGD:70947"
                     /translation="MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLEEDL
                     GHCEPKTDPSSADKTLLEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLY
                     GIQGFCKDLLEVADILEKATQSVPKEEVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGL
                     LRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA"
     exon            76..238
                     /gene="Grpel1"
                     /gene_synonym="GrpE#1; GrpE1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..320
                     /gene="Grpel1"
                     /gene_synonym="GrpE#1; GrpE1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..960
                     /gene="Grpel1"
                     /gene_synonym="GrpE#1; GrpE1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggggta gtcatggcgg ctcggtgcgt gaggctggcg cggcgcagcc tcccggcttt
       61 ggcgctgtcg ttcaggcctt ctcctcgctt gttgtgcaca gctacaaaac aaaagaacaa
      121 tggccagaac ctggaagagg acttggggca ttgtgagcca aagacagatc catcctctgc
      181 agacaagacc ctcctggaag agaaggtgaa gctggaagag cagctgaagg agaccatgga
      241 aaaatacaaa cgtgctttgg cagataccga gaatctacgg cagagaagcc agaagctggt
      301 agaagaggcc aagttatatg gcatccaggg tttctgcaag gacttgctgg aggttgcaga
      361 catcctagag aaggcaaccc agagtgttcc aaaggaggag gtcagcaaca acaaccctca
      421 cctgaagagt ctttatgaag ggctcgtgat gactgaagtc cagattcaga aggtgttcac
      481 aaaacacggc ttgctcaggc ttgaccccat tggggcaaag ttcgaccctt atgaacatga
      541 ggccttgttc cacacccctg tggaggggaa agaaccaggc actgtggcac tagttagtaa
      601 ggtgggctac aagctgcatg gacgcaccct gaggccagct ttggtggggg tggtgaagga
      661 cgcttagctc tctccctcaa ggctctggac tttgtaggtc acttgctaga actcaaaggg
      721 tgggcgggct tgtaatttct catctgtgaa cacatctgac ccttgcccag ccttgttgga
      781 aatcttaagt aagctaagca gaacatgaag ctgcttgcac actgtgtcag agactctggg
      841 agtctggtca ttgagtttag cattacctac ttcagaagag ggccagcagg gcctcaggag
      901 tagcatgcta acgttgtatc tgttccacct tgtgattaag tactttacac aaataaaagg
//
