LOCUS       NM_133570                883 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus gastrin releasing peptide (Grp), mRNA.
ACCESSION   NM_133570
VERSION     NM_133570.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Yang,J., Yang,X., Xiao,X. and Ming,D.
  TITLE     The effects of gastrin-releasing peptide on the voltage-gated
            channels in rat hippocampal neurons
  JOURNAL   Neuropeptides 84, 102080 (2020)
   PUBMED   33059246
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Park,H.J., Kim,Y., Kim,M.K., Hwang,J.J., Kim,H.J., Bae,S.K. and
            Bae,M.K.
  TITLE     Inhibition of Gastrin-Releasing Peptide Attenuates
            Phosphate-Induced Vascular Calcification
  JOURNAL   Cells 9 (3), 737 (2020)
   PUBMED   32192106
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Ueland,T., Gullestad,L., Kou,L., Aukrust,P., Anand,I.S.,
            Broughton,M.N., McMurray,J.J., van Veldhuisen,D.J., Warren,D.J. and
            Bolstad,N.
  TITLE     Pro-gastrin-releasing peptide and outcome in patients with heart
            failure and anaemia: results from the RED-HF study
  JOURNAL   ESC Heart Fail 5 (6), 1052-1059 (2018)
   PUBMED   30145817
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Fang,L., Huang,Z., Lin,Y., Fu,J., Liang,X. and Liu,F.
  TITLE     Clinical Application of Pro-Gastrin-Releasing Peptide
  JOURNAL   Clin Lab 64 (7), 1259-1268 (2018)
   PUBMED   30146822
REFERENCE   5  (bases 1 to 883)
  AUTHORS   Yu,Y.Q., Barry,D.M., Hao,Y., Liu,X.T. and Chen,Z.F.
  TITLE     Molecular and neural basis of contagious itch behavior in mice
  JOURNAL   Science 355 (6329), 1072-1076 (2017)
   PUBMED   28280205
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Nicholls,D.P., Riley,M., Elborn,J.S., Stanford,C.F., Shaw,C.,
            McKillop,J.M. and Buchanan,K.D.
  TITLE     Regulatory peptides in the plasma of patients with chronic cardiac
            failure at rest and during exercise
  JOURNAL   Eur Heart J 13 (10), 1399-1404 (1992)
   PUBMED   1396815
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Lebacq-Verheyden,A.M., Kasprzyk,P.G., Raum,M.G., Van Wyke
            Coelingh,K., Lebacq,J.A. and Battey,J.F.
  TITLE     Posttranslational processing of endogenous and of
            baculovirus-expressed human gastrin-releasing peptide precursor
  JOURNAL   Mol Cell Biol 8 (8), 3129-3135 (1988)
   PUBMED   3211139
REFERENCE   8  (bases 1 to 883)
  AUTHORS   Lebacq-Verheyden,A.M., Krystal,G., Sartor,O., Way,J. and
            Battey,J.F.
  TITLE     The rat prepro gastrin releasing peptide gene is transcribed from
            two initiation sites in the brain
  JOURNAL   Mol Endocrinol 2 (6), 556-563 (1988)
   PUBMED   2843761
REFERENCE   9  (bases 1 to 883)
  AUTHORS   van den Pol,A.N.
  TITLE     Gamma-aminobutyrate, gastrin releasing peptide, serotonin,
            somatostatin, and vasopressin: ultrastructural immunocytochemical
            localization in presynaptic axons in the suprachiasmatic nucleus
  JOURNAL   Neuroscience 17 (3), 643-659 (1986)
   PUBMED   2422591
REFERENCE   10 (bases 1 to 883)
  AUTHORS   McDonald,T.J., Jornvall,H., Nilsson,G., Vagne,M., Ghatei,M.,
            Bloom,S.R. and Mutt,V.
  TITLE     Characterization of a gastrin releasing peptide from porcine
            non-antral gastric tissue
  JOURNAL   Biochem Biophys Res Commun 90 (1), 227-233 (1979)
   PUBMED   496973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1, BF567195.1 and AW524119.1.
            
            On Mar 23, 2010 this sequence version replaced NM_133570.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31176.1, SRR26643294.57951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000018.1  61658655-61658907
            254-488             BF567195.1         235-469
            489-883             AW524119.1         1-395               c
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..883
                     /gene="Grp"
                     /note="gastrin releasing peptide"
                     /db_xref="GeneID:171101"
                     /db_xref="RGD:621740"
     exon            1..253
                     /gene="Grp"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..552
                     /gene="Grp"
                     /codon_start=1
                     /product="gastrin-releasing peptide preproprotein"
                     /protein_id="NP_598254.2"
                     /db_xref="GeneID:171101"
                     /db_xref="RGD:621740"
                     /translation="MRGSELSLLLLALVLCQAPRGPAAPVSTGAGGGTVLAKMYPRGS
                     HWAVGHLMGKKSTDELPPLYAADRDGLKEQLRGYIRWEEAARNLLGLLEAAGNRSHQP
                     PQDQPLGSLQPTWDPEDGSYFSDAQNAKLVDSLLQVLKGKEGTAS"
     exon            254..498
                     /gene="Grp"
                     /inference="alignment:Splign:2.1.0"
     exon            499..866
                     /gene="Grp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgaagcggc agtggcagag ctcctgagaa ctgtcctcct gtcactgctc tgtcgggaca
       61 acgcactctc agcctagtgg agcgctctga gggcttccct ccaggaccat gcgcggctcc
      121 gagctctcgc tcttgctgtt ggctctggtc ctctgccagg ctccccgggg gccagctgcc
      181 ccggtgtcga caggcgcagg tggaggcaca gtcctggcca agatgtatcc gcgcggcagc
      241 cactgggctg taggacactt aatggggaag aagagcacag atgagttgcc gcccctgtat
      301 gcagctgaca gagatggcct gaaggagcaa ctgaggggat acatccgctg ggaagaagct
      361 gcaaggaatt tgcttggcct cctcgaagcc gcggggaaca gaagccacca gccacctcag
      421 gatcagcctc tgggcagtct ccagcctact tgggatccag aggatggcag ctacttcagt
      481 gatgctcaaa atgctaagtt ggtagactct ctgctccagg ttctcaaggg gaaggaagga
      541 actgccagct gaagggacca tgacaagggc ggcttccaag gagcaaaaca aaacccccca
      601 gagactgcct tctgcaaaca ttgattctac tggaccatca acaagattcc ctttgtgcaa
      661 tttacgtaac tattctcatg tcactcaact gcaactaaac tcgtgatttt tgagcagcat
      721 cttctggttt gaacctgttt ctgtgaacaa ctacctagga agagctttcc agtgaacgct
      781 ttttccagct aggctttttt gctgattgga tttggggctc caatctgcta ccattcacaa
      841 taaaaagctt cagtaatcac actgtcaaaa aaaaaaaaaa aaa
//
