LOCUS       NM_017113               2190 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus granulin precursor (Grn), transcript variant 1,
            mRNA.
ACCESSION   NM_017113
VERSION     NM_017113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Liao,A., Zheng,W., Wang,S., Wang,N., Li,Y., Chen,D. and Wang,Y.
  TITLE     Sortilin is associated with progranulin deficiency and autism-like
            behaviors in valproic acid-induced autism rats
  JOURNAL   CNS Neurosci Ther 30 (9), e70015 (2024)
   PUBMED   39218796
  REMARK    GeneRIF: Sortilin is associated with progranulin deficiency and
            autism-like behaviors in valproic acid-induced autism rats.
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Horinokita,I., Hayashi,H., Oteki,R., Mizumura,R., Yamaguchi,T.,
            Usui,A., Yuan,B. and Takagi,N.
  TITLE     Involvement of Progranulin and Granulin Expression in Inflammatory
            Responses after Cerebral Ischemia
  JOURNAL   Int J Mol Sci 20 (20), 5210 (2019)
   PUBMED   31640144
  REMARK    GeneRIF: Study demonstrated that the level of PGRN protein in the
            cerebral cortex was significantly increased after
            microsphere-induced cerebral embolism (ME). Furthermore, PGRN was
            expressed in the microglia of the ipsilateral hemisphere after ME.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2190)
  AUTHORS   Wang,S., Wei,J., Fan,Y., Ding,H., Tian,H., Zhou,X. and Cheng,L.
  TITLE     Progranulin Is Positively Associated with Intervertebral Disc
            Degeneration by Interaction with IL-10 and IL-17 Through TNF
            Pathways
  JOURNAL   Inflammation 41 (5), 1852-1863 (2018)
   PUBMED   29992506
  REMARK    GeneRIF: PGRN is associated with intervertebral disc degeneration
            through interfering with IL-10 and IL-17
REFERENCE   4  (bases 1 to 2190)
  AUTHORS   Chen,L., Li,Q., Wang,J., Jin,S., Zheng,H., Lin,J., He,F., Zhang,H.,
            Ma,S., Mei,J. and Yu,J.
  TITLE     MiR-29b-3p promotes chondrocyte apoptosis and facilitates the
            occurrence and development of osteoarthritis by targeting PGRN
  JOURNAL   J Cell Mol Med 21 (12), 3347-3359 (2017)
   PUBMED   28609022
  REMARK    GeneRIF: MiR-29b-3p promotes chondrocyte apoptosis and facilitates
            the occurrence and development of osteoarthritis by targeting PGRN.
REFERENCE   5  (bases 1 to 2190)
  AUTHORS   Lee,C.W., Stankowski,J.N., Chew,J., Cook,C.N., Lam,Y.W.,
            Almeida,S., Carlomagno,Y., Lau,K.F., Prudencio,M., Gao,F.B.,
            Bogyo,M., Dickson,D.W. and Petrucelli,L.
  TITLE     The lysosomal protein cathepsin L is a progranulin protease
  JOURNAL   Mol Neurodegener 12 (1), 55 (2017)
   PUBMED   28743268
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2190)
  AUTHORS   Suzuki,M., Bannai,M., Matsumuro,M., Furuhata,Y., Ikemura,R.,
            Kuranaga,E., Kaneda,Y., Nishihara,M. and Takahashi,M.
  TITLE     Suppression of copulatory behavior by intracerebroventricular
            infusion of antisense oligodeoxynucleotide of granulin in neonatal
            male rats
  JOURNAL   Physiol Behav 68 (5), 707-713 (2000)
   PUBMED   10764901
REFERENCE   7  (bases 1 to 2190)
  AUTHORS   Bhandari,V., Giaid,A. and Bateman,A.
  TITLE     The complementary deoxyribonucleic acid sequence, tissue
            distribution, and cellular localization of the rat granulin
            precursor
  JOURNAL   Endocrinology 133 (6), 2682-2689 (1993)
   PUBMED   8243292
REFERENCE   8  (bases 1 to 2190)
  AUTHORS   Plowman,G.D., Green,J.M., Neubauer,M.G., Buckley,S.D.,
            McDonald,V.L., Todaro,G.J. and Shoyab,M.
  TITLE     The epithelin precursor encodes two proteins with opposing
            activities on epithelial cell growth
  JOURNAL   J Biol Chem 267 (18), 13073-13078 (1992)
   PUBMED   1618805
REFERENCE   9  (bases 1 to 2190)
  AUTHORS   Bateman,A., Belcourt,D., Bennett,H., Lazure,C. and Solomon,S.
  TITLE     Granulins, a novel class of peptide from leukocytes
  JOURNAL   Biochem Biophys Res Commun 173 (3), 1161-1168 (1990)
   PUBMED   2268320
REFERENCE   10 (bases 1 to 2190)
  AUTHORS   Shoyab,M., McDonald,V.L., Byles,C., Todaro,G.J. and Plowman,G.D.
  TITLE     Epithelins 1 and 2: isolation and characterization of two
            cysteine-rich growth-modulating proteins
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 7912-7916 (1990)
   PUBMED   2236009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB731349.1, X62322.1, CK365572.1 and BC072469.1.
            
            On Mar 13, 2009 this sequence version replaced NM_017113.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X62322.1, SRR8487226.222781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CB731349.1         32-57
            27-375              X62322.1           1-349
            376-750             CK365572.1         369-743
            751-2163            X62322.1           725-2137
            2164-2190           BC072469.1         1924-1950
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2190
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /note="granulin precursor"
                     /db_xref="GeneID:29143"
                     /db_xref="RGD:61983"
     exon            1..49
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1826
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; granulins; acrogranin; progranulin;
                     proepithelin; prostate cancer cell-derived growth factor;
                     epithelin"
                     /codon_start=1
                     /product="progranulin isoform a precursor"
                     /protein_id="NP_058809.2"
                     /db_xref="GeneID:29143"
                     /db_xref="RGD:61983"
                     /translation="MPPRERGPRRRQTMWILVSWLALVARLVAGTQCPDGQFCPVACC
                     LDQGGANYSCCNPLLDTWPIITSRRLDGSCQIRDHCPDGYSCLLTVSGTSSCCPFSEG
                     VSCDDGQHCCPRGFHCSVDGKSCSQISDSLLGAVQCPGSQFECPDSATCCIMIDGSWG
                     CCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTGTHPLLKKFPAQRTNRAVAFPFSV
                     VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISKD
                     YTTDLMTKLPGYPVNEVKCDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCP
                     AGFQCHTETGTCELGVLQVPWMKKVTASLSLPDPQILKNDVPCDDFSSCPSNNTCCRL
                     SSGDWGCCPIPEAVCCLDHQHCCPQGFKCMDEGYCQKGDRMVAGLEKMPVRQTTLLQH
                     GDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEK
                     DAGSVQPSMDLTFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRH
                     CCPIGFHCSAKGTKCLRKKTPRWDILLRDPAPRPLL"
     exon            50..194
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            195..320
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            321..405
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            406..515
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            516..651
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            652..761
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            762..885
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            886..983
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1229
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1463
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1688
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..2167
                     /gene="Grn"
                     /gene_synonym="PEPI; PGRN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagctga ccgccagatg cctcccaggg agcgcggacc ccgacgcagg cagaccatgt
       61 ggatcctggt gagctggctg gccttagtgg caaggctggt ggctggaaca cagtgcccag
      121 atggtcaatt ctgccctgtt gcctgctgcc ttgaccaggg aggagccaac tacagctgct
      181 gtaaccctct tctggacaca tggcctataa taacgagccg tcgtctagat ggctcctgcc
      241 agatccgtga ccactgtcct gatggctact cttgtcttct cactgtgtct gggacttcca
      301 gctgctgccc gttctctgag ggtgtatctt gtgatgatgg ccagcactgc tgcccccggg
      361 gcttccactg tagtgtggat gggaaatcct gctctcagat atcagatagc ctcttgggtg
      421 ctgtccagtg tcctggtagc cagttcgaat gtcctgactc cgccacctgc tgtattatga
      481 ttgatggttc ctgggggtgc tgccccatgc cccaggcctc ttgctgtgaa gacagagtgc
      541 attgctgtcc ccacggggcc tcctgtgacc tggttcacac gcgatgcatt tcacccacgg
      601 gcacccaccc cttactaaag aaattccccg cacaaaggac caacagggca gtggctttcc
      661 ctttttccgt ggtgtgccct gatgctaaga cccagtgccc tgatgactct acctgctgtg
      721 agctacccac tgggaagtat ggctgttgtc caatgcccaa cgccatctgc tgttccgacc
      781 acctgcactg ctgcccccag gacactgtat gtgacctgat ccagagcaag tgcatatcca
      841 aggactacac cacagatctc atgaccaagc tgcctggata cccagtgaat gaggtgaagt
      901 gcgacttgga ggtgagctgt cctgatggct acacctgctg ccgcctcaac actggggcct
      961 ggggctgctg tccattcacc aaggctgtgt gttgtgaaga ccacattcac tgctgcccag
     1021 ccgggtttca gtgtcacaca gagacaggaa cctgtgaact gggagtcctt caggtaccct
     1081 ggatgaaaaa ggtcacggcc tccctcagcc tgccagaccc acagatcttg aagaatgatg
     1141 tcccctgtga tgacttcagt agctgtcctt ctaacaatac ctgctgcaga ctcagttctg
     1201 gggactgggg ctgctgtccc atcccagagg ctgtctgctg cttagaccac cagcattgct
     1261 gccctcaggg tttcaaatgt atggatgagg ggtactgtca gaagggagac agaatggtgg
     1321 ctggcctgga gaagatgcct gtccgccaga caactctgct ccaacatgga gatattggtt
     1381 gtgaccagca taccagctgc ccagtagggc aaacatgctg cccaagcctg aagggaagtt
     1441 gggcctgctg ccagttgccc catgctgtgt gctgtgagga ccggcagcac tgttgcccgg
     1501 ctgggtacac ctgcaacgtg aaggcgagaa cctgtgagaa ggatgcaggc tctgtccagc
     1561 cttccatgga cctgaccttt ggctctaagg ttgggaatgt ggaatgtggt gccggacatt
     1621 tctgccatga taaccagtcc tgttgtaaag acagccaagg aggctgggcc tgctgtccct
     1681 atgtaaaggg tgtctgctgt agagatggac gtcactgttg tcccattggc ttccactgtt
     1741 cagccaaggg aaccaagtgt ttgcggaaga agacccctcg ctgggacata cttttgaggg
     1801 atccagcccc aagaccgcta ctgtgaggaa gggctaacga ctaaagaact ccacagtcct
     1861 gggaaccctg ttctgagggt atccaccact caggcctccc tggcacctct tcctttagtc
     1921 tccccggcct actcattctg agtcacccca tcaccatgga aggtggggcc tcaaactaag
     1981 accttctctt atggaaagaa ggctgtggca aaagccccgt atcaaactgc catttcttct
     2041 gatttctgtg gaccttgtgg ccaggtgctc ttctcgatcc acaggtgttg tgtgagcttg
     2101 cttttgtgtg tgtgtgtgtg cgcgcgtgcg agcgtgttgc tccaataaag tttgtacact
     2161 ttcttaaaaa aaaaaaaaaa aaaaaaaaaa
//
