LOCUS       NM_022202               2793 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 8 (Grm8), mRNA.
ACCESSION   NM_022202 XM_347218
VERSION     NM_022202.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Xie,Y., Chen,L., Chen,J., Luo,Y., Peng,Z., Zhang,H., Pan,Z. and
            Chen,Y.
  TITLE     Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in
            Microglia by Alleviating Endoplasmic Reticulum Stress and
            Mitochondrial Dysfunction
  JOURNAL   J Integr Neurosci 23 (2), 26 (2024)
   PUBMED   38419440
  REMARK    GeneRIF: Metabotropic Glutamate Receptor 8 Suppresses M1
            Polarization in Microglia by Alleviating Endoplasmic Reticulum
            Stress and Mitochondrial Dysfunction.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Katona,L., Hartwich,K., Tomioka,R., Somogyi,J., Roberts,J.D.B.,
            Wagner,K., Joshi,A., Klausberger,T., Rockland,K.S. and Somogyi,P.
  TITLE     Synaptic organisation and behaviour-dependent activity of
            mGluR8a-innervated GABAergic trilaminar cells projecting from the
            hippocampus to the subiculum
  JOURNAL   Brain Struct Funct 225 (2), 705-734 (2020)
   PUBMED   32016558
  REMARK    GeneRIF: Synaptic organisation and behaviour-dependent activity of
            mGluR8a-innervated GABAergic trilaminar cells projecting from the
            hippocampus to the subiculum.
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Carmichael,R.E., Wilkinson,K.A., Craig,T.J., Ashby,M.C. and
            Henley,J.M.
  TITLE     MEF2A regulates mGluR-dependent AMPA receptor trafficking
            independently of Arc/Arg3.1
  JOURNAL   Sci Rep 8 (1), 5263 (2018)
   PUBMED   29588465
  REMARK    GeneRIF: This study shows via knockdown of endogenous MEF2A in
            primary neuronal culture, that MEF2A is specifically required for
            Group I metabotropic glutamate receptor (mGluR)-mediated GluA2
            internalisation, but does not regulate AMPAR expression or
            trafficking under basal conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Govea,R.M., Zhou,S. and Carlton,S.M.
  TITLE     Group III mGluR8 negatively modulates TRPA1
  JOURNAL   Neuroscience 334, 134-147 (2016)
   PUBMED   27497709
  REMARK    GeneRIF: Results show that group III mGluRs negatively modulate
            TRPA1 activity on cutaneous nociceptors. Furthermore, it is likely
            that this modulation occurs intracellularly at the level of the
            cAMP/PKA pathway. This study demonstrates that group III agonists
            may be effective in the treatment of mechanical hypersensitivity
            which can develop as a result of inflammation, nerve injury,
            chemotherapy and other disease states.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Long,E.C., Aliev,F., Wang,J.C., Edenberg,H.J., Nurnberger,J. Jr.,
            Hesselbrock,V., Porjesz,B. and Dick,D.M.
  TITLE     Further Analyses of Genetic Association Between GRM8 and Alcohol
            Dependence Symptoms Among Young Adults
  JOURNAL   J Stud Alcohol Drugs 76 (3), 414-418 (2015)
   PUBMED   25978827
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Corti,C., Restituito,S., Rimland,J.M., Brabet,I., Corsi,M.,
            Pin,J.P. and Ferraguti,F.
  TITLE     Cloning and characterization of alternative mRNA forms for the rat
            metabotropic glutamate receptors mGluR7 and mGluR8
  JOURNAL   Eur J Neurosci 10 (12), 3629-3641 (1998)
   PUBMED   9875342
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Shigemoto,R., Kinoshita,A., Wada,E., Nomura,S., Ohishi,H.,
            Takada,M., Flor,P.J., Neki,A., Abe,T., Nakanishi,S. and Mizuno,N.
  TITLE     Differential presynaptic localization of metabotropic glutamate
            receptor subtypes in the rat hippocampus
  JOURNAL   J Neurosci 17 (19), 7503-7522 (1997)
   PUBMED   9295396
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Saugstad,J.A., Kinzie,J.M., Shinohara,M.M., Segerson,T.P. and
            Westbrook,G.L.
  TITLE     Cloning and expression of rat metabotropic glutamate receptor 8
            reveals a distinct pharmacological profile
  JOURNAL   Mol Pharmacol 51 (1), 119-125 (1997)
   PUBMED   9016353
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Duvoisin,R.M., Zhang,C. and Ramonell,K.
  TITLE     A novel metabotropic glutamate receptor expressed in the retina and
            olfactory bulb
  JOURNAL   J Neurosci 15 (4), 3075-3083 (1995)
   PUBMED   7722646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U63288.1.
            
            On Dec 17, 2003 this sequence version replaced XM_347218.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63288.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="glutamate metabotropic receptor 8"
                     /db_xref="GeneID:60590"
                     /db_xref="RGD:619858"
     exon            1..576
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="G protein-coupled receptor, family C, group 1,
                     member H; metabotropic glutamate receptor subtype 8b;
                     metabotropic glutamate receptor 8; glutamate receptor,
                     metabotropic 8"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 8 precursor"
                     /protein_id="NP_071538.1"
                     /db_xref="GeneID:60590"
                     /db_xref="RGD:619858"
                     /translation="MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDG
                     DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI
                     LDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI
                     MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYV
                     STLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR
                     AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPK
                     RASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIAR
                     DSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVN
                     FNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANRE
                     HTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINR
                     TGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYV
                     LLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKK
                     SVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVL
                     KCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFI
                     PIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF
                     KAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI"
     exon            577..793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            794..929
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1084
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1222
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1423
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1560
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2496
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2743
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctacccctt cttctgtggc aagaataaac ttctggtcgc tgactgcaat accccccgtg
       61 gagaaaatgg tatgcgaggg aaagcgctta gcctcttgcc cttgcttctt cctcttgact
      121 gccaagttct actggatcct cacaatgatg caaagaactc acagccaaga gtatgcccat
      181 tccatccggg tggatgggga catcattttg gggggtcttt ttcctgttca tgccaaggga
      241 gaaagagggg tgccttgtgg ggagctgaag aaggaaaagg ggatccacag acttgaggcc
      301 atgctttatg caatcgacca gattaacaaa gaccctgatc ttctctccaa tatcactctg
      361 ggggtccgga tccttgacac gtgttccagg gacacctacg ctttggagca gtcactgacc
      421 ttcgtgcagg cactgataga gaaagatgcg tctgatgtga agtgtgctaa tggagatccg
      481 cccatattca ccaagcccga caagatttct ggcgtcatag gtgctgcagc aagctctgtg
      541 tccatcatgg tggctaacat tttaagacta tttaagatac ctcagattag ctatgcatcc
      601 acagccccag agctaagtga caacaccagg tatgatttct tttctcgggt ggtcccgcct
      661 gactcctacc aagcccaagc catggtggac attgtgacgg ccctgggatg gaattatgtg
      721 tcaacactgg cttccgaggg gaactatgga gagagtggtg ttgaggcctt cactcagatc
      781 tcaagggaga ttggtggtgt ttgcattgct caatcacaga aaatcccacg tgaaccaaga
      841 cctggggaat ttgaaaaaat tatcaaacgc ctgctggaga cacctaacgc tcgcgcagtg
      901 attatgtttg ccaacgagga tgacatcagg aggatattgg aagcagcaaa aaaattaaac
      961 cagagtgggc attttctatg gattggctct gatagttggg gatccaaaat tgcgcccgtc
     1021 taccagcagg aggagatcgc agaaggagcg gtgacaattt tgcctaaaag agcatcaatt
     1081 gatgggtttg atcgatactt tagaagccga actcttgcta ataatcgaag aaatgtgtgg
     1141 tttgcagaat tttgggagga gaattttgga tgcaaattag gatcacatgg gaagaggaac
     1201 agtcacataa agaaatgcac agggctggag cgaattgcac gggattcatc ttatgaacaa
     1261 gaaggaaagg ttcaatttgt tattgatgca gtgtattcca tggcttatgc actgcataac
     1321 atgcacaaag agcgctgtcc tggatacata ggtctttgcc caagaatggt caccatcgat
     1381 gggaaagagc tactgggtta catcagggcc gtgaatttta atggcagtgc tggtacacct
     1441 gtcactttta atgaaaatgg agatgctcct ggacgctacg atatcttcca gtatcagata
     1501 aacaacaaaa gtacagagta caaaatcatc gggcactgga caaatcaact tcatctaaag
     1561 gtggaagata tgcagtgggc taatagagag cacacgcacc cagcatctgt ctgcagcctg
     1621 ccgtgcaagc ccggggagag gaagaaaacc gtgaaagggg tcccttgctg ctggcactgt
     1681 gaacgttgtg agggttataa ctaccaggtg gatgaactgt cctgtgaact ttgccctttg
     1741 gatcagagac caaacatcaa ccgcacaggc tgccagagga tccccatcat caagttggag
     1801 tggcattcgc cctgggctgt ggtacctgtg ttcatagcaa tattgggaat cattgctacc
     1861 acctttgtga ttgtgacctt tgtccgctat aatgacacgc ccatcgtgag agcttctggg
     1921 cgggaactta gttacgtgct cctaacgggg atttttctct gttactccat cacctttttg
     1981 atgattgccg cacctgacac gatcatctgc tccttccgac ggatcttctt gggacttggt
     2041 atgtgtttca gctatgcagc acttttgacc aaaacaaacc gtatccaccg aatattcgag
     2101 caagggaaga aatctgtcac agcacctaag tttatcagcc cagcatccca actggtgatc
     2161 accttcagcc tcatctctgt ccagctcctc ggagtgtttg tgtggtttgt cgtggatccc
     2221 ccccacacca tcattgacta tggcgaacag cgaacgctgg atcctgagaa cgccagggga
     2281 gtgctcaagt gtgatatttc ggatctgtca ctcatttgtt ccctgggata cagtatcctc
     2341 ctgatggtca cctgtactgt ttatgccatt aaaaccagag gggtcccaga gacgttcaat
     2401 gaagccaaac ctattggctt tacaatgtac accacgtgca tcatttggtt agctttcatc
     2461 cccatctttt ttggtacagc ccagtcagca gaaaagatgt acatccagac aacgacactt
     2521 actgtttcca tgagtttaag tgcttcagtg tctctgggaa tgctctatat gcccaaagtt
     2581 tatattataa tttttcatcc agagcagaat gttcaaaaac gcaagagaag cttcaaggct
     2641 gtggtcacag ctgctaccat gcaaagcaaa ctgatccaaa agggaaatga cagaccaaat
     2701 ggcgaggtga aaagtgaact ctgtgagagt cttgaaacca acacgtcttc taccaagaca
     2761 acatacatca gctacagtaa tcattcgatc tga
//
