LOCUS       NM_031040               3417 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 7 (Grm7), mRNA.
ACCESSION   NM_031040 XM_346722
VERSION     NM_031040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3417)
  AUTHORS   Bodzeta,A., Berger,F. and MacGillavry,H.D.
  TITLE     Subsynaptic mobility of presynaptic mGluR types is differentially
            regulated by intra- and extracellular interactions
  JOURNAL   Mol Biol Cell 33 (8), ar66 (2022)
   PUBMED   35511883
REFERENCE   2  (bases 1 to 3417)
  AUTHORS   Song,J.M., Kang,M., Park,D.H., Park,S., Lee,S. and Suh,Y.H.
  TITLE     Pathogenic GRM7 Mutations Associated with Neurodevelopmental
            Disorders Impair Axon Outgrowth and Presynaptic Terminal
            Development
  JOURNAL   J Neurosci 41 (11), 2344-2359 (2021)
   PUBMED   33500274
  REMARK    GeneRIF: Pathogenic GRM7 Mutations Associated with
            Neurodevelopmental Disorders Impair Axon Outgrowth and Presynaptic
            Terminal Development.
REFERENCE   3  (bases 1 to 3417)
  AUTHORS   Isozumi,N. and Ohki,S.
  TITLE     Met872 is the key residue determining the novel binominal binding
            of metabotropic glutamate receptor 7 to calmodulin
  JOURNAL   Biochem Biophys Res Commun 520 (3), 640-644 (2019)
   PUBMED   31627896
  REMARK    GeneRIF: Analyses of NMR data suggested that the binding between
            Ca(2+)-saturated calmodulin (Ca(2+)/CaM) and mGluR7 occurs in some
            conformational equilibrium manner. The unique CaM-binding
            properties caused by Met872 may be related to mGluR7's function.
REFERENCE   4  (bases 1 to 3417)
  AUTHORS   Marabese,I., Boccella,S., Iannotta,M., Luongo,L., de Novellis,V.,
            Guida,F., Serra,N., Farina,A., Maione,S. and Palazzo,E.
  TITLE     Metabotropic glutamate receptor subtype 7 in the dorsal striatum
            oppositely modulates pain in sham and neuropathic rats
  JOURNAL   Neuropharmacology 135, 86-99 (2018)
   PUBMED   29505788
  REMARK    GeneRIF: In control rats, mGluR7 stimulation facilitated pain
            responses and consistently modulated the rostral ventromedial
            medulla and dorsal reticular nucleus neuron activity. In
            neuropathic rats, AMN082 inhibited pain and consistently changed
            the rostral ventromedial medulla and dorsal reticular nucleus
            neural activity.
REFERENCE   5  (bases 1 to 3417)
  AUTHORS   Wei,X., Yang,D., Shi,T., Wang,J., Deng,Y., Qiao,X., Yang,C. and
            Xu,M.
  TITLE     Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for
            Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3
            Region of Rats
  JOURNAL   CNS Neurol Disord Drug Targets 16 (5), 610-616 (2017)
   PUBMED   27488423
  REMARK    GeneRIF: Findings demonstrated that the glutamic acid and mGluR7 in
            hippocampal CA3 region are involved in the modulation of
            nociceptive information transmission by regulating pain-evoked
            electric activities of pain-excited neurons and pain-inhibited
            neurons.
REFERENCE   6  (bases 1 to 3417)
  AUTHORS   Brandstatter,J.H., Koulen,P., Kuhn,R., van der Putten,H. and
            Wassle,H.
  TITLE     Compartmental localization of a metabotropic glutamate receptor
            (mGluR7): two different active sites at a retinal synapse
  JOURNAL   J Neurosci 16 (15), 4749-4756 (1996)
   PUBMED   8764662
REFERENCE   7  (bases 1 to 3417)
  AUTHORS   Bradley,S.R., Levey,A.I., Hersch,S.M. and Conn,P.J.
  TITLE     Immunocytochemical localization of group III metabotropic glutamate
            receptors in the hippocampus with subtype-specific antibodies
  JOURNAL   J Neurosci 16 (6), 2044-2056 (1996)
   PUBMED   8604049
REFERENCE   8  (bases 1 to 3417)
  AUTHORS   Li,J.L., Ohishi,H., Kaneko,T., Shigemoto,R., Neki,A., Nakanishi,S.
            and Mizuno,N.
  TITLE     Immunohistochemical localization of a metabotropic glutamate
            receptor, mGluR7, in ganglion neurons of the rat; with special
            reference to the presence in glutamatergic ganglion neurons
  JOURNAL   Neurosci Lett 204 (1-2), 9-12 (1996)
   PUBMED   8929965
REFERENCE   9  (bases 1 to 3417)
  AUTHORS   Saugstad,J.A., Kinzie,J.M., Mulvihill,E.R., Segerson,T.P. and
            Westbrook,G.L.
  TITLE     Cloning and expression of a new member of the
            L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic
            glutamate receptors
  JOURNAL   Mol Pharmacol 45 (3), 367-372 (1994)
   PUBMED   8145723
REFERENCE   10 (bases 1 to 3417)
  AUTHORS   Okamoto,N., Hori,S., Akazawa,C., Hayashi,Y., Shigemoto,R.,
            Mizuno,N. and Nakanishi,S.
  TITLE     Molecular characterization of a new metabotropic glutamate receptor
            mGluR7 coupled to inhibitory cyclic AMP signal transduction
  JOURNAL   J Biol Chem 269 (2), 1231-1236 (1994)
   PUBMED   8288585
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D16817.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346722.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16817.1, U06832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..3417
                     /gene="Grm7"
                     /note="glutamate metabotropic receptor 7"
                     /db_xref="GeneID:81672"
                     /db_xref="RGD:619857"
     exon            1..916
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..3145
                     /gene="Grm7"
                     /note="metabotropic glutamate receptor subtype 7b;
                     metabotropic glutamate receptor 7; mGluR7; glutamate
                     receptor, metabotropic 7; metabotropic glutamate receptor
                     mGluR7"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 7 precursor"
                     /protein_id="NP_112302.1"
                     /db_xref="GeneID:81672"
                     /db_xref="RGD:619857"
                     /translation="MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIR
                     IEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLG
                     ARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSS
                     VSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGW
                     NYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLD
                     TPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAI
                     TIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTG
                     QERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK
                     YIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIED
                     MQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYD
                     QRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRAS
                     GRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYR
                     IFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNP
                     EQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTC
                     IVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNV
                     QKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLV
                     I"
     exon            917..1133
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1275
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1430
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1571
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1772
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1912
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2848
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..3095
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3417
                     /gene="Grm7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagagat ggatagcaag caagggaggg agagagggag tgggaggagg aggaggagga
       61 gagggagccc aacgaccatt taaagcgata gcaatccctg ccctctcccc agtgcttggc
      121 tgttggagag cgcaagaggc aagccaggga acggggagcg caagctggtg cgccggccag
      181 cggagccaca gtgccaggtg ccaaagactg gctgacgccc tgggacaccc ccaccctctc
      241 ctgctgcacc tcctcggtct cctccaccct ctgtgcctac agaagtccct gggcttcccc
      301 caaaggagct cacctccaga agcccggacc tgggagagcc caccagcata ccctccagcg
      361 ccgccgccgc cgctaccgca gcagcatccg gagcggcatg gtccagctgg ggaagctgct
      421 ccgcgtcctg actttgatga agttcccctg ctgcgtgctg gaggtgctcc tgtgcgtgct
      481 ggcggcggcg gcgcgcggcc aggagatgta cgccccgcac tcgatccgga tcgaggggga
      541 cgtcaccctt ggggggttgt tcccagtgca cgccaagggt cccagcggag tgccctgcgg
      601 cgacatcaag agggagaatg ggatccacag gctggaagct atgctttatg ccctggacca
      661 gatcaacagc gatcccaacc tgctgcccaa tgtaacgtta ggcgcgcgga tcctggacac
      721 ttgttccagg gacacttatg cgctcgaaca gtcgctcact ttcgtccagg cgcttatcca
      781 gaaggacacc tccgacgtgc gttgcaccaa cggagagccc ccggttttcg tcaagccaga
      841 gaaagtagtt ggagtgattg gggcttcggg gagctccgtc tccatcatgg tagccaacat
      901 cttgaggctt tttcagatcc ctcagattag ttatgcatcc acggctcctg aactcagtga
      961 tgaccggcgc tatgacttct tctctcgagt ggtcccgcct gattccttcc aagcccaggc
     1021 gatggttgac attgtaaagg ctttgggctg gaattacgtg tctactcttg catctgaagg
     1081 aagctatgga gagaaaggtg tggagtcctt cacacagatt tccaaagagg caggtgggct
     1141 ctgcattgcc cagtccgtga gaatccccca agagcgcaaa gacaggacca ttgactttga
     1201 tagaattatc aaacagctct tggacactcc caactccagg gccgtcgtga tttttgccaa
     1261 cgatgaggat ataaagcaga tccttgccgc cgccaaaaga gctgaccaag taggccattt
     1321 tctctgggtc gggtcagaca gctggggttc caaaatcaac ccactgcatc agcacgaaga
     1381 tattgcggaa ggagccataa caatccagcc taaaagggca accgtggaag gatttgatgc
     1441 ttacttcaca tcccggacac ttgaaaacaa caggagaaat gtatggtttg ccgaatactg
     1501 ggaagaaaac ttcaactgca agttgacaat tagtgggtcc aaaaaagaag acacagatcg
     1561 caaatgcaca ggacaggagc gaattggaaa agactccaat tatgagcagg aaggtaaagt
     1621 acagtttgtg attgatgctg tctatgccat ggcccatgct cttcatcaca tgaacaagga
     1681 tctgtgtgct gactaccgcg gagtgtgccc agagatggag caagcaggcg gcaagaagtt
     1741 gttgaagtat atccgccatg ttaacttcaa tggtagtgct ggaaccccag taatgtttaa
     1801 caaaaatggc gatgctccag ggcgttatga catcttccaa taccagacaa caaacacaac
     1861 caaccctggt tatcgtctca ttgggcagtg gacagatgaa cttcagctca atatagagga
     1921 catgcagtgg ggcaaaggag tccgagagat cccatcctct gtgtgtacat tgccatgcaa
     1981 gcctgggcaa aggaagaaga cacagaaggg aacgccttgc tgctggacct gtgagccctg
     2041 tgatggatac cagtatcagt ttgatgagat gacctgtcag cattgtccct acgaccagag
     2101 gcccaatgag aaccgaactg gctgtcagaa catcccaatc atcaaactgg agtggcactc
     2161 cccctgggct gtcattcctg tcttcctggc aatgttgggg atcattgcca ccatctttgt
     2221 catggcaact ttcatccgct acaatgacac acccattgtc agggcatctg ggcgggaact
     2281 cagctatgtt ttattgacag gcatctttct ctgctatatc atcaccttcc taatgattgc
     2341 caaaccagat gtggcagtgt gttctttccg acgtgtcttc ttgggcttgg gcatgtgtat
     2401 tagttatgct gcccttttaa caaagaccaa tcggatttat cgcatattcg agcagggcaa
     2461 gaaatcggtg acagctccca gactcataag cccaacgtca caactggcga tcacttccag
     2521 tttaatatcg gtgcagcttc taggtgtctt catttggttt ggggttgacc cccccaacat
     2581 tatcatagac tacgatgagc ataagaccat gaacccagaa caagcaaggg gtgttctcaa
     2641 atgtgacatc acagaccttc aaatcatttg ttccctggga tatagcattc ttctcatggt
     2701 cacatgtact gtgtatgcca tcaagactcg gggcgtacca gagaatttta atgaagccaa
     2761 gcccattggg ttcactatgt acacgacgtg tatcgtatgg cttgccttca tcccaatatt
     2821 ttttggcaca gcgcagtcag cagaaaagct ctacatacaa actaccacgc ttacaatctc
     2881 catgaaccta agtgcgtcag tggcgctggg aatgctatac atgccgaaag tgtacatcat
     2941 cattttccac cctgaactca atgtccagaa acggaagcga agcttcaagg ccgtagtcac
     3001 agcagccacc atgtcatcaa ggctgtcaca caaacccagt gacaggccca acggtgaggc
     3061 aaagacagaa ctctgtgaaa atgtagaccc aaacagccct gctgcaaaaa agaagtatgt
     3121 cagttataat aacctggtta tctaacctgt tccatgccat ggagccacag aggaggaaga
     3181 ccttcagtta ttctgtcacc cagcctggca ttggactctt ggtcctgccc gcttcctatc
     3241 tctggaggag cttctccacc cgggagagca atgttagagg atccacacat cctgaacagc
     3301 tgctttatga gacaccttta ctttatcttg gcttaagaag tcattggcat cagcactgcc
     3361 atcttggctg taattctgga ctccctaagc aaagggagag ttgagactca agtccca
//
