LOCUS       NM_022920               4424 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 6 (Grm6), mRNA.
ACCESSION   NM_022920 XM_346394
VERSION     NM_022920.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4424)
  AUTHORS   Zhang,J., Zhang,L., Chen,Y., Shi,H., Huang,X., Wang,Y., Wang,Y.,
            Wei,Y., Xue,W. and Han,J.
  TITLE     Effect and mechanism of mGluR6 on the biological function of rat
            embryonic neural stem cells
  JOURNAL   Biosci Biotechnol Biochem 83 (6), 1027-1034 (2019)
   PUBMED   30739574
  REMARK    GeneRIF: effects of mGluR6 overexpression were reversed by mGluR6
            knockdown. In conclusion, mGluR6 promotes the proliferation of NSCs
            by activation of ERK1/2-Cyclin D1/CDK2 signaling pathway and
            inhibits the apoptosis of NSCs by blockage of the p38 MAPK
            signaling pathway
REFERENCE   2  (bases 1 to 4424)
  AUTHORS   Devi,S., Markandeya,Y., Maddodi,N., Dhingra,A., Vardi,N.,
            Balijepalli,R.C. and Setaluri,V.
  TITLE     Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium
            channel function and increases melanin content in human melanocytes
  JOURNAL   Pigment Cell Melanoma Res 26 (3), 348-356 (2013)
   PUBMED   23452348
REFERENCE   3  (bases 1 to 4424)
  AUTHORS   Cao,Y., Posokhova,E. and Martemyanov,K.A.
  TITLE     TRPM1 forms complexes with nyctalopin in vivo and accumulates in
            postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent
            manner
  JOURNAL   J Neurosci 31 (32), 11521-11526 (2011)
   PUBMED   21832182
  REMARK    GeneRIF: mGluR6 and TRPM1 are identified as nyctalopin binding
            partners; the postsynaptic accumulation of TRPM1 complex is
            dependent on mGluR6.
REFERENCE   4  (bases 1 to 4424)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 4424)
  AUTHORS   Koike,C., Obara,T., Uriu,Y., Numata,T., Sanuki,R., Miyata,K.,
            Koyasu,T., Ueno,S., Funabiki,K., Tani,A., Ueda,H., Kondo,M.,
            Mori,Y., Tachibana,M. and Furukawa,T.
  TITLE     TRPM1 is a component of the retinal ON bipolar cell transduction
            channel in the mGluR6 cascade
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 332-337 (2010)
   PUBMED   19966281
REFERENCE   6  (bases 1 to 4424)
  AUTHORS   Hirbec,H., Perestenko,O., Nishimune,A., Meyer,G., Nakanishi,S.,
            Henley,J.M. and Dev,K.K.
  TITLE     The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate
            receptor subtypes. Analysis of PDZ binding motifs
  JOURNAL   J Biol Chem 277 (18), 15221-15224 (2002)
   PUBMED   11891216
REFERENCE   7  (bases 1 to 4424)
  AUTHORS   Valerio,A., Ferraboli,S., Paterlini,M., Spano,P. and Barlati,S.
  TITLE     Identification of novel alternatively-spliced mRNA isoforms of
            metabotropic glutamate receptor 6 gene in rat and human retina
  JOURNAL   Gene 262 (1-2), 99-106 (2001)
   PUBMED   11179672
REFERENCE   8  (bases 1 to 4424)
  AUTHORS   Takao,M., Morigiwa,K., Sasaki,H., Miyoshi,T., Shima,T.,
            Nakanishi,S., Nagai,K. and Fukuda,Y.
  TITLE     Impaired behavioral suppression by light in metabotropic glutamate
            receptor subtype 6-deficient mice
  JOURNAL   Neuroscience 97 (4), 779-787 (2000)
   PUBMED   10842024
REFERENCE   9  (bases 1 to 4424)
  AUTHORS   Deng,A.Y. and Rapp,J.P.
  TITLE     Locus for the inducible, but not a constitutive, nitric oxide
            synthase cosegregates with blood pressure in the Dahl
            salt-sensitive rat
  JOURNAL   J Clin Invest 95 (5), 2170-2177 (1995)
   PUBMED   7537756
REFERENCE   10 (bases 1 to 4424)
  AUTHORS   Nakajima,Y., Iwakabe,H., Akazawa,C., Nawa,H., Shigemoto,R.,
            Mizuno,N. and Nakanishi,S.
  TITLE     Molecular characterization of a novel retinal metabotropic
            glutamate receptor mGluR6 with a high agonist selectivity for
            L-2-amino-4-phosphonobutyrate
  JOURNAL   J Biol Chem 268 (16), 11868-11873 (1993)
   PUBMED   8389366
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022920.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840130, SAMN16418971
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-650               JAXUCZ010000010.1  35669003-35669652
            651-867             JAXUCZ010000010.1  35671287-35671503
            868-1003            JAXUCZ010000010.1  35672043-35672178
            1004-1158           JAXUCZ010000010.1  35673663-35673817
            1159-1299           JAXUCZ010000010.1  35674819-35674959
            1300-1500           JAXUCZ010000010.1  35675061-35675261
            1501-1646           JAXUCZ010000010.1  35676262-35676407
            1647-2270           JAXUCZ010000010.1  35676496-35677119
            2271-2582           JAXUCZ010000010.1  35680272-35680583
            2583-4424           JAXUCZ010000010.1  35681888-35683729
FEATURES             Location/Qualifiers
     source          1..4424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4424
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /note="glutamate metabotropic receptor 6"
                     /db_xref="GeneID:24419"
                     /db_xref="RGD:2747"
     exon            1..650
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2780
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /note="metabotropic glutamate receptor 6; glutamate
                     receptor, metabotropic 6"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 6 precursor"
                     /protein_id="NP_075209.1"
                     /db_xref="GeneID:24419"
                     /db_xref="RGD:2747"
                     /translation="MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHAR
                     GAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQ
                     ALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRL
                     FAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGN
                     YGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANE
                     DDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFD
                     QYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQE
                     GKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGT
                     PVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVP
                     PSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCR
                     PTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTG
                     IFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTP
                     PPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDM
                     SDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFF
                     GTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTS
                     TMAAPPQNENAEDAK"
     exon            651..867
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1003
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1158
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1299
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1500
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1646
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..2270
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2582
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..4424
                     /gene="Grm6"
                     /gene_synonym="mGluR6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcgactg agttgctggt gcgcgagtca ccaagtcacc aacttttcct gtgctctcgg
       61 tgtctggcca gattcccgaa gtgtcagcag agcacggggt gactccttcg tctaccggtg
      121 ctcaagacct cccggtaact ttctttcccg cagtccagga gcagatgggg aggctcccgg
      181 tgctgctgct atggctagcc tggtggttgt cgcaggcagg catagcctgc ggtgccggct
      241 ccgtgcgcct ggccggcggc ctgacgctgg gcggactatt cccagtgcac gcgcggggag
      301 ccgctggacg cgcgtgcggg gcgctgaaga aagagcaagg cgtgcaccgg ctggaagcga
      361 tgctctacgc gctggaccgc gtcaacgctg acccggagct gctgcccggc gtgcggctgg
      421 gcgcgcggct gctcgacacc tgctcgcggg acacctacgc tttggagcag gcgctgagct
      481 tcgtgcaggc gctcatccga ggccgcggag acggcgacga ggccagtgtg cgctgccctg
      541 ggggagttcc cccgctgcgc tccgcgcctc cagagcgcgt ggtggcggtg gtgggagcct
      601 cggctagctc cgtgtccatc atggtggcca acgtcttgcg cctgtttgcg ataccccaga
      661 tcagctatgc ctccacagcc ccagagctca gtgactccac acgctatgac ttcttctccc
      721 gagtggtgcc tcctgactcc taccaggccc aggccatggt ggacattgtg cgggcactgg
      781 gatggaatta cgtgtctaca ttggcctctg agggcaacta tggcgagagc ggggttgagg
      841 cctttgtgca gatttcccgt gaggctggag gtgtctgtat tgcccagtca ataaagattc
      901 ccagggagcc aaagccggga gagttccaca aagtgatccg gaggctcatg gagacaccca
      961 acgcccgtgg catcatcatc tttgccaatg aggatgacat caggagggtc ttggaggcaa
     1021 cacgccaggc caacctgact ggccacttcc tgtgggttgg ctcagacagc tggggatcca
     1081 agatctctcc catcttgaac ctagaggaag aggctgtggg ggccatcact atcttgccca
     1141 aaagggcttc aatcgacgga tttgaccaat acttcatgac tcgttccttg gagaacaacc
     1201 gcagaaacat ctggtttgcc gagttctggg aagagaattt taactgcaaa ctaaccagct
     1261 ccggtggcca gtcagatgat tccacccgga aatgcacagg tgaggaacgc atcggccagg
     1321 actccgccta tgagcaggag gggaaggtgc agttcgtgat agacgctgtg tacgccattg
     1381 ctcacgctct gcatagcatg caccaagcgc tctgcccagg ccacacaggt ctgtgcccag
     1441 ccatggagcc tactgatggc cggacgctgc tgcactacat ccgagcagtc cgcttcaatg
     1501 gtagtgcagg aaccccagtg atgttcaatg agaatggaga tgcccccggg cgctatgaca
     1561 tcttccagta ccaggcaacc aacggaagcg ccagcagcgg cgggtaccag gccgtgggcc
     1621 aatgggcaga ggcccttaga ctggatatgg aagttctacg gtggtcaggc gacccccatg
     1681 aagtgccccc ttctcagtgc agcctcccct gcgggcccgg tgaacggaaa aagatggtga
     1741 agggtgtccc ctgctgttgg cactgtgagg cctgcgacgg gtaccgcttc caggtggacg
     1801 agttcacatg cgaggcctgc ccaggggaca tgaggcccac ccccaaccac actggttgcc
     1861 gtcccacacc cgtggtgcgc ctgacctggt cctctccatg ggcagctctg ccccttctcc
     1921 tggctgtcct gggcatcatg gctaccacca ccattatggc caccttcatg cgacacaatg
     1981 acactcccat agtccgcgcc tctggccgtg agcttagcta cgtgctgctc actggcatct
     2041 tcctgatcta cgccatcacc ttcctcatgg tagccgagcc ttgtgcagcc atctgtgctg
     2101 cccgcagact cttgcttggc ttgggcacca cgctcagcta ctcagccctg ctcaccaaga
     2161 ccaaccgcat ctaccgcatc tttgagcaag ggaagcgctc tgtcacacca ccacccttca
     2221 tcagccccac ttcgcaacta gtcatcacct tcggcctcac ctccctgcag gtggtgggag
     2281 tgatagcatg gctgggggcc cagcctccac acagcgtgat tgactacgag gagcagagga
     2341 cggtggaccc cgagcaggcc aggggtgtgc tcaagtgtga tatgtctgat ctgtccctca
     2401 ttggttgcct gggctacagt ctcctgctca tggtcacgtg tacagtgtat gccatcaagg
     2461 cccgaggtgt gcctgagacc ttcaatgagg ccaagcccat cggcttcacc atgtacacca
     2521 cctgtattat ctggctggct tttgttccca tcttctttgg taccgcccag tcagctgaga
     2581 agatctacat ccaaaccacc acactaactg tgtcactgag cctgagcgca tcagtgtccc
     2641 tcggcatgct ctacgtgccc aaaacctacg tcatcctgtt ccatccagag cagaacgtac
     2701 agaagcggaa gcgcagcctc aagaagacct ccacgatggc agccccaccc cagaacgaga
     2761 acgcagagga cgccaagtag caaggttgag tgtgggtgcc acaggttgct ccctgccctt
     2821 tctctgcttc tcctggcttc aaagtggaag ctgtgaaaga tccacagaga ccatcggagg
     2881 ccaggaatgt gtaaagacca tgcccatggt cttttccgaa ggaaaaagct aaaccccgac
     2941 cacgctggac ttgtgctttc ctgggcacgc caaccacatc attctgcccc tccgacccac
     3001 tgtaagaaat actgcttcca ggaatcttcc tgaagagaga cgaaactgac accttctggg
     3061 caggcattca aaaccatagt gaagccaggg cttggccagg ttgggataag atttatcttg
     3121 atccaacact acaacctagg ggctggccag ggtgtctgtc agaatgtgta aaccccaaca
     3181 agaaatccag gattagagct gggtgggggg tgcaatcacc acaataggaa acttagaggt
     3241 ctgaatttgg ggaaatactt ccctgagcag agcctgtatg agggttctgg gaactgagtg
     3301 tgagcctgca gcagagagag gagcagtaca gggaactggg gcaggcttct gtgaggtcgc
     3361 ttcccttgtg gtcttttccc cagggtcatc caaaagattg gacagttttt ctctgctgtg
     3421 tatgtttcca tagattactc caacttgaag aaatgccaac acattacagt gggtaagaga
     3481 tggtaaggta tagctagact ttggtcagag tgtccatgaa ttgtcttgtt tctgcactta
     3541 agagttgttg ttgttgttgt tgttgttgtt gttattatta ttattattat tattattatt
     3601 attattatta ttattatcat tatctagagt gagggtctca ctatgtaact ctggctgtcc
     3661 tagaacttac tatgtagacc aggttggcca tgaactcaca gagatctgct ggcttctgcc
     3721 tcccaagtgc tgggatcaaa ggtgtgtgtc actatgccca gcttaaaatt ttaattacta
     3781 ggatgagcac aaaagctccc ctgcatagag tcttggagcg cccacctgaa aggtggtgga
     3841 ggcatgtgga gggactcatg ggaacaccat gcacgggctt tagttttgac tattagtttt
     3901 acagagctgg tttttagtta gggaactttt ctttcgtcgt tttttgttgt tgtttcgttg
     3961 tttgggtttt tttttcattt gtttgtttta atgtatagag ctaaatgctt taatttattg
     4021 tgaattctcc agtatttaag gtacagaact aagttttgaa agtatgctag ctacacttca
     4081 atggacagat gctccaaggt gtaatgagct ttgatcttga gatgtaatac tttacttagt
     4141 atcttaaagg caacaggctt ctctctagaa catctctgct gttccgctct tcctcacttg
     4201 ctgtgttccc ggtttcccac ggtgcaaagc acagctcagc atttactgct gagtgagctc
     4261 tgatgctccg ttctgaggct tctgtgctat gtcaaccctc aaagtgtgaa atgtgttctc
     4321 ccgggagagc cttgtccacg tgaccgtctg catggtgttt ttctcctctg ggatctcttc
     4381 tagagtcggt gagccaaggt ctgaataaag gttttcttgc actt
//
