LOCUS       NM_017012               3919 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 5 (Grm5), mRNA.
ACCESSION   NM_017012
VERSION     NM_017012.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3919)
  AUTHORS   Chen,T., Li,Y.F., Ren,X. and Wang,Y.H.
  TITLE     The mGluR5-mediated Arc activation protects against experimental
            traumatic brain injury in rats
  JOURNAL   CNS Neurosci Ther 30 (8), e14695 (2024)
   PUBMED   39107945
  REMARK    GeneRIF: The mGluR5-mediated Arc activation protects against
            experimental traumatic brain injury in rats.
REFERENCE   2  (bases 1 to 3919)
  AUTHORS   Yang,H.M., Cheng,Y.Z., Hou,T.Z., Fan,J.K., Gu,L., Zhang,J.N. and
            Zhang,H.
  TITLE     Upregulation of Parkinson's disease-associated protein
            alpha-synuclein suppresses tumorigenesis via interaction with
            mGluR5 and gamma-synuclein in liver cancer
  JOURNAL   Arch Biochem Biophys 744, 109698 (2023)
   PUBMED   37487948
  REMARK    GeneRIF: Upregulation of Parkinson's disease-associated protein
            alpha-synuclein suppresses tumorigenesis via interaction with
            mGluR5 and gamma-synuclein in liver cancer.
REFERENCE   3  (bases 1 to 3919)
  AUTHORS   Cheng,S., Xu,J., Wang,W., Wang,R., Li,H., Jiang,Z., Liu,D. and
            Pan,F.
  TITLE     Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the
            prefrontal cortex and hippocampus and ameliorates PTSD-like
            behavior in rats
  JOURNAL   Psychopharmacology (Berl) 240 (4), 837-851 (2023)
   PUBMED   36725696
  REMARK    GeneRIF: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression
            in the prefrontal cortex and hippocampus and ameliorates PTSD-like
            behavior in rats.
            Erratum:[Psychopharmacology (Berl). 2023 Jun;240(6):1391. doi:
            10.1007/s00213-023-06368-w. PMID: 37145309]
REFERENCE   4  (bases 1 to 3919)
  AUTHORS   Eshraghi,A.A., Memis,I., Wang,F., White,I., Furar,E., Mittal,J.,
            Moosa,M., Atkins,C.M. and Mittal,R.
  TITLE     Genetic ablation of metabotropic glutamate receptor 5 in rats
            results in an autism-like behavioral phenotype
  JOURNAL   PLoS One 17 (11), e0275937 (2022)
   PUBMED   36383609
  REMARK    GeneRIF: Genetic ablation of metabotropic glutamate receptor 5 in
            rats results in an autism-like behavioral phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3919)
  AUTHORS   Yang,H.M., Hou,T.Z., Zhang,Y.N., Zhao,S.D., Wu,Y.L. and Zhang,H.
  TITLE     Blocked metabotropic glutamate receptor 5 enhances chemosensitivity
            in hepatocellular carcinoma and attenuates chemotoxicity in the
            normal liver by regulating DNA damage
  JOURNAL   Cancer Gene Ther 29 (10), 1487-1501 (2022)
   PUBMED   35396501
  REMARK    GeneRIF: Blocked metabotropic glutamate receptor 5 enhances
            chemosensitivity in hepatocellular carcinoma and attenuates
            chemotoxicity in the normal liver by regulating DNA damage.
REFERENCE   6  (bases 1 to 3919)
  AUTHORS   Lu,Y.M., Jia,Z., Janus,C., Henderson,J.T., Gerlai,R.,
            Wojtowicz,J.M. and Roder,J.C.
  TITLE     Mice lacking metabotropic glutamate receptor 5 show impaired
            learning and reduced CA1 long-term potentiation (LTP) but normal
            CA3 LTP
  JOURNAL   J Neurosci 17 (13), 5196-5205 (1997)
   PUBMED   9185557
REFERENCE   7  (bases 1 to 3919)
  AUTHORS   Lujan,R., Nusser,Z., Roberts,J.D., Shigemoto,R. and Somogyi,P.
  TITLE     Perisynaptic location of metabotropic glutamate receptors mGluR1
            and mGluR5 on dendrites and dendritic spines in the rat hippocampus
  JOURNAL   Eur J Neurosci 8 (7), 1488-1500 (1996)
   PUBMED   8758956
REFERENCE   8  (bases 1 to 3919)
  AUTHORS   Minakami,R., Katsuki,F., Yamamoto,T., Nakamura,K. and Sugiyama,H.
  TITLE     Molecular cloning and the functional expression of two isoforms of
            human metabotropic glutamate receptor subtype 5
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1136-1143 (1994)
   PUBMED   7908515
REFERENCE   9  (bases 1 to 3919)
  AUTHORS   Minakami,R., Katsuki,F. and Sugiyama,H.
  TITLE     A variant of metabotropic glutamate receptor subtype 5: an
            evolutionally conserved insertion with no termination codon
  JOURNAL   Biochem Biophys Res Commun 194 (2), 622-627 (1993)
   PUBMED   7688218
REFERENCE   10 (bases 1 to 3919)
  AUTHORS   Abe,T., Sugihara,H., Nawa,H., Shigemoto,R., Mizuno,N. and
            Nakanishi,S.
  TITLE     Molecular characterization of a novel metabotropic glutamate
            receptor mGluR5 coupled to inositol phosphate/Ca2+ signal
            transduction
  JOURNAL   J Biol Chem 267 (19), 13361-13368 (1992)
   PUBMED   1320017
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10891.1, SRR26360176.1394876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000001.1  150733753-150733821
            70-925              JAXUCZ010000001.1  150739836-150740691
            926-1175            JAXUCZ010000001.1  150955506-150955755
            1176-1411           JAXUCZ010000001.1  151147713-151147948
            1412-1658           JAXUCZ010000001.1  151180995-151181241
            1659-1827           JAXUCZ010000001.1  151195448-151195616
            1828-1954           JAXUCZ010000001.1  151199363-151199489
            1955-2894           JAXUCZ010000001.1  151239390-151240329
            2895-3919           JAXUCZ010000001.1  151292535-151293559
FEATURES             Location/Qualifiers
     source          1..3919
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3919
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /note="glutamate metabotropic receptor 5"
                     /db_xref="GeneID:24418"
                     /db_xref="RGD:2746"
     exon            1..69
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            70..925
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..3783
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /note="metabotropic glutamate receptor 5; metabotropic
                     glutamate receptor 5b; metabotropic glutamate receptor
                     (mGluR5); glutamate receptor, metabotropic 5"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 5 precursor"
                     /protein_id="NP_058708.1"
                     /db_xref="GeneID:24418"
                     /db_xref="RGD:2746"
                     /translation="MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVH
                     HQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHS
                     AVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNL
                     LQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHT
                     EGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACF
                     CEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVK
                     WFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQ
                     DSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSG
                     DMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRS
                     VCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDL
                     IPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGI
                     CLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTK
                     KPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVV
                     TPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKI
                     ITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAAS
                     RSSSLVNLWKRRGSSGETLSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTA
                     VIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEE
                     SFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVT
                     RFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVT
                     GGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSES
                     ALCIPSSPKYDTLIIRDYTQSSSSL"
     exon            926..1175
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1411
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1658
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1827
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1954
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2894
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3919
                     /gene="Grm5"
                     /gene_synonym="mGlur5; mGluR5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagacatct cttgagaaac tcagcctagt ttatccagct gttttgtcca catatgttca
       61 taaaatctag ttatgaatat tctgatcgta tggatgcacc taactcgaca gtttctgggg
      121 actttgctat cttttagaga atatatctaa attgctgact aattcctcaa tgcgccactc
      181 aacgcagggc atcatttggc tgtacctatt ggagctctga gtttcctcca tcatgatatc
      241 tttattagct tgaattcctt tcctaaaatg gtccttctgt tgatcctgtc agtcctactt
      301 ctgaaagaag atgtacgagg gagtgcacag tccagtgaga ggagggtggt ggctcacatg
      361 ccaggtgaca tcattattgg cgctctcttc tctgtccacc accaaccaac tgtggacaaa
      421 gttcatgaga ggaagtgtgg tgcagttcgt gagcaatatg ggattcagag agtggaggcc
      481 atgctgcata ccttggaaag gatcaactca gatcccacac tcttgcccaa catcacactt
      541 ggctgtgaga tcagagattc ctgctggcat tccgctgtgg ccctagaaca aagcattgag
      601 tttataaggg attccctcat ctcttcagaa gaggaggaag gtttggtacg ctgtgtagat
      661 ggatcttctt ccttccgctc caagaaaccc atagtgggag tcattgggcc tggctctagt
      721 tctgtggcca ttcaagtcca gaacttactc cagcttttca acataccaca gattgcttac
      781 tctgcaacca gcatggattt gagtgacaag actctattca agtacttcat gagggttgta
      841 ccttccgatg cccagcaagc tcgagccatg gtagacatag tgaagagata caactggact
      901 tatgtctcag ctgtgcacac agaaggcaac tatggagaaa gtgggatgga ggctttcaaa
      961 gatatgtcag cgaaggaagg gatttgcatc gcccactctt acaaaattta cagcaatgct
     1021 ggggaacaga gctttgacaa gctgttgaaa aaactcagaa gtcatttacc taaagcccgg
     1081 gtggtagctt gcttctgtga aggcatgaca gttcgaggtc tgctcatggc catgagacgc
     1141 ttgggtctag caggggagtt tctacttctg ggcagtgatg gctgggccga caggtatgac
     1201 gtgacagatg gatatcagcg agaagctgtc ggtggaatta caatcaagct tcagtctcct
     1261 gatgtcaagt ggtttgatga ttattatctg aaactccggc cagaaacaaa cctcagaaac
     1321 ccttggtttc aagaattttg gcagcatcgt tttcagtgcc ggctggaagg gtttgcacag
     1381 gagaacagca agtacaacaa gacttgcaac agttctctga ctctgagaac acatcatgtt
     1441 caagattcca aaatgggatt tgtgataaat gcaatctatt ctatggctta tggactccac
     1501 aatatgcaga tgtccctgtg tccaggctat gcaggcctct gtgatgcgat gaagccaatt
     1561 gatggacgga aacttttgga ttccctgatg aaaaccaatt ttactggagt ttctggagat
     1621 atgatcctgt ttgatgaaaa tggagactct ccaggaaggt atgaaataat gaatttcaag
     1681 gaaatgggaa aagattattt tgattacatc aatgttggaa gttgggacaa tggggaatta
     1741 aaaatggatg atgacgaagt gtggtccaag aaaaataaca tcatcagatc tgtgtgcagt
     1801 gaaccatgtg agaaaggcca aataaaggtg atccggaagg gagaagtcag ctgttgttgg
     1861 acctgcacac cttgtaaaga gaatgagtat gtgtttgatg agtacacctg caaggcatgc
     1921 caactgggct cctggcccac tgacgacctg acaggctgtg acttgatccc agtccagtat
     1981 cttcgctggg gtgaccctga gccgattgca gctgtggtgt ttgcctgcct cggtctgcta
     2041 gccaccttat tcgttactgt aatcttcatc atttatcggg acactccggt ggtcaagtcc
     2101 tccagcaggg agctctgcta cattatcctt gctggcatct gcctgggata cttatgtacc
     2161 ttttgcctca ttgcaaagcc caagcagatt tactgctatc ttcagagaat tggcattgga
     2221 ctctctccag ccatgagcta ctcagccctt gtaaccaaga ccaaccgtat tgcaaggatt
     2281 ctagctggaa gcaagaagaa aatctgtacc aagaagccca gattcatgag cgcctgtgct
     2341 cagttagtga tcgctttcat tctcatctgt attcagctgg gcattatcgt ggccctcttt
     2401 atcatggagc ctccggatat aatgcatgac tatccaagca tccgagaagt ctacttgatt
     2461 tgtaacacca ccaacctagg ggttgttact cctcttggat acaatggatt attgattttg
     2521 agttgcacgt tctatgcgtt taagaccaga aatgttccag ccaactttaa tgaggccaaa
     2581 tatattgctt tcaccatgta cacaacctgc atcatatggc tggccttcgt gcctatctac
     2641 tttggcagca actacaaaat catcaccatg tgtttttcag tcagcctcag tgccacagtg
     2701 gccctgggtt gcatgtttgt cccgaaggtg tacatcatcc tagccaaacc ggagagaaat
     2761 gtgcgcagcg ccttcacaac ctctacagtg gtacgcatgc atgtaggaga cggcaaatca
     2821 tcgtccgctg ccagcagatc cagcagccta gtcaacctgt ggaagaggag gggctcctct
     2881 ggggaaaccc taagctccaa cggaaaatct gtgacttggg cccagaatga gaagagtacc
     2941 cgggggcaac atttgtggca gcgactgtct gtccacatca acaagaagga gaaccccaac
     3001 caaacggcgg tcatcaaacc ctttcccaag agcacagaga accgggggcc tggtgcagcg
     3061 gcaggtggtg gctcgggtcc cggtgtagct ggtgctggta acgcaggatg cacagcaaca
     3121 ggtggcccgg agccaccgga cgccggtccc aaagcgcttt atgatgtggc ggaggcagag
     3181 gagagcttcc ccgcggctgc caggccgcgc tcgccatcgc ccatcagcac gttgagccac
     3241 ctcgcaggct cggcgggccg cacagatgat gatgcgccgt cgctgcactc tgagacagct
     3301 gctcgcagca gctcgtccca gggctcgctc atggagcaga tcagcagcgt agtgacgcgc
     3361 ttcacagcca acatctccga gctcaactcc atgatgttgt ccaccgcggc cacgccgggg
     3421 ccccctggta ctccaatctg ctcctcctac ctgatcccca aagagattca gctgcccacg
     3481 accatgacga ccttcgcaga gatccagccg ctgccggcca tcgaggtgac cggaggagct
     3541 cagggggcga caggggtatc acctgcccag gagacgccca caggagctga atccgccccg
     3601 ggcaaaccag atctggagga gcttgtggcc ctcactccac catcgccctt cagggactcg
     3661 gtggactcgg ggagcaccac cccaaactct ccagtctcag aatcggccct ctgcatccca
     3721 tcctctccca aatatgacac tctcatcatc agagattaca cgcagagttc ttcatcgttg
     3781 tgagccactg gaaacttccc tgagataggc ctgagcagca gacctcggtg ttcacagatg
     3841 ggcgcagcga cacccatagt caccccaaca gagaacccga ggtgaaaaat gccaaggaca
     3901 cacacggtgg agacatgag
//
