LOCUS       NM_022666               4306 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 4 (Grm4), mRNA.
ACCESSION   NM_022666
VERSION     NM_022666.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4306)
  AUTHORS   Hofmann,C.S., Carrington,S., Keller,A.N., Gregory,K.J. and
            Niswender,C.M.
  TITLE     Regulation and functional consequences of mGlu4 RNA editing
  JOURNAL   RNA 27 (10), 1220-1240 (2021)
   PUBMED   34244459
  REMARK    GeneRIF: Regulation and functional consequences of mGlu4 RNA
            editing.
REFERENCE   2  (bases 1 to 4306)
  AUTHORS   Zhang,Z., Zheng,X., Liu,Y., Luan,Y., Wang,L., Zhao,L., Zhang,J.,
            Tian,Y., Lu,H., Chen,X. and Liu,Y.
  TITLE     Activation of metabotropic glutamate receptor 4 regulates
            proliferation and neural differentiation in neural stem/progenitor
            cells of the rat subventricular zone and increases phosphatase and
            tensin homolog protein expression
  JOURNAL   J Neurochem 156 (4), 465-480 (2021)
   PUBMED   32052426
  REMARK    GeneRIF: Activation of metabotropic glutamate receptor 4 regulates
            proliferation and neural differentiation in neural stem/progenitor
            cells of the rat subventricular zone and increases phosphatase and
            tensin homolog protein expression.
REFERENCE   3  (bases 1 to 4306)
  AUTHORS   Isherwood,S.N., Robbins,T.W., Nicholson,J.R., Dalley,J.W. and
            Pekcec,A.
  TITLE     Selective and interactive effects of D2 receptor antagonism and
            positive allosteric mGluR4 modulation on waiting impulsivity
  JOURNAL   Neuropharmacology 123, 249-260 (2017)
   PUBMED   28487067
  REMARK    GeneRIF: This study investigated the role of mGluR4 in modulating
            two distinct forms of waiting impulsivity and its putative
            interaction with D2 receptors in modulating motor impulsivity on
            the five-choice serial reaction time task. The main findings
            indicate a prominent role of mGluR4 in modulating motor, and to
            some extent choice, impulsivity as well as aspects of visual
            attention.
REFERENCE   4  (bases 1 to 4306)
  AUTHORS   Liu,J., Zhang,Z., Moreno-Delgado,D., Dalton,J.A., Rovira,X.,
            Trapero,A., Goudet,C., Llebaria,A., Giraldo,J., Yuan,Q.,
            Rondard,P., Huang,S., Liu,J. and Pin,J.P.
  TITLE     Allosteric control of an asymmetric transduction in a G
            protein-coupled receptor heterodimer
  JOURNAL   Elife 6, e26985 (2017)
   PUBMED   28829739
  REMARK    GeneRIF: Whereas both glutamate metabotropic receptor 2 and
            glutamate metabotropic receptor 4 couple to G proteins, G protein
            activation is mediated by mGlu4 heptahelical domain (HD)
            exclusively in glutamate metabotropic receptor 2-4 heterodimers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4306)
  AUTHORS   Moreno Delgado,D., Moller,T.C., Ster,J., Giraldo,J., Maurel,D.,
            Rovira,X., Scholler,P., Zwier,J.M., Perroy,J., Durroux,T.,
            Trinquet,E., Prezeau,L., Rondard,P. and Pin,J.P.
  TITLE     Pharmacological evidence for a metabotropic glutamate receptor
            heterodimer in neuronal cells
  JOURNAL   Elife 6, e25233 (2017)
   PUBMED   28661401
  REMARK    GeneRIF: Although assumed to form exclusive homodimers, 16 possible
            heterodimeric mGluRs have been proposed but their existence in
            native cells remains elusive. Study identified mGlu2-4 specific
            pharmacological fingerprints that were also observed in a neuronal
            cell line and in lateral perforant path terminals naturally
            expressing mGlu2 and mGlu4. Results show the existence of mGlu2-4
            heterodimers in native cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4306)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   7  (bases 1 to 4306)
  AUTHORS   Pekhletski,R., Gerlai,R., Overstreet,L.S., Huang,X.P., Agopyan,N.,
            Slater,N.T., Abramow-Newerly,W., Roder,J.C. and Hampson,D.R.
  TITLE     Impaired cerebellar synaptic plasticity and motor performance in
            mice lacking the mGluR4 subtype of metabotropic glutamate receptor
  JOURNAL   J Neurosci 16 (20), 6364-6373 (1996)
   PUBMED   8815915
REFERENCE   8  (bases 1 to 4306)
  AUTHORS   Makoff,A., Lelchuk,R., Oxer,M., Harrington,K. and Emson,P.
  TITLE     Molecular characterization and localization of human metabotropic
            glutamate receptor type 4
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 239-248 (1996)
   PUBMED   8738157
REFERENCE   9  (bases 1 to 4306)
  AUTHORS   O'Hara,P.J., Sheppard,P.O., Thogersen,H., Venezia,D.,
            Haldeman,B.A., McGrane,V., Houamed,K.M., Thomsen,C., Gilbert,T.L.
            and Mulvihill,E.R.
  TITLE     The ligand-binding domain in metabotropic glutamate receptors is
            related to bacterial periplasmic binding proteins
  JOURNAL   Neuron 11 (1), 41-52 (1993)
   PUBMED   8338667
REFERENCE   10 (bases 1 to 4306)
  AUTHORS   Tanabe,Y., Masu,M., Ishii,T., Shigemoto,R. and Nakanishi,S.
  TITLE     A family of metabotropic glutamate receptors
  JOURNAL   Neuron 8 (1), 169-179 (1992)
   PUBMED   1309649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 5, 2021 this sequence version replaced NM_022666.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M90518.1, SRR26643298.77805.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000020.1  5574356-5574668     c
            314-1191            JAXUCZ010000020.1  5564249-5565126     c
            1192-1408           JAXUCZ010000020.1  5532671-5532887     c
            1409-1544           JAXUCZ010000020.1  5515634-5515769     c
            1545-1699           JAXUCZ010000020.1  5513278-5513432     c
            1700-1840           JAXUCZ010000020.1  5511423-5511563     c
            1841-2041           JAXUCZ010000020.1  5498919-5499119     c
            2042-2178           JAXUCZ010000020.1  5498592-5498728     c
            2179-3114           JAXUCZ010000020.1  5494657-5495592     c
            3115-3361           JAXUCZ010000020.1  5491276-5491522     c
            3362-4306           JAXUCZ010000020.1  5486025-5486969     c
FEATURES             Location/Qualifiers
     source          1..4306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4306
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /note="glutamate metabotropic receptor 4"
                     /db_xref="GeneID:24417"
                     /db_xref="RGD:2745"
     exon            1..313
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1191
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             673..3411
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /note="metabotropic glutamate receptor 4; glutamate
                     receptor, metabotropic 4"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 4 precursor"
                     /protein_id="NP_073157.2"
                     /db_xref="GeneID:24417"
                     /db_xref="RGD:2745"
                     /translation="MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIR
                     IDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLG
                     ARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSS
                     VSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKW
                     NYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETS
                     NARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTI
                     LPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRE
                     RIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYI
                     RNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQW
                     PGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRP
                     TENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRE
                     LSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFE
                     QGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFA
                     RGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVW
                     LAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKR
                     KRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI"
     exon            1192..1408
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1544
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1699
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1840
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2041
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2178
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..3114
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3361
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..4306
                     /gene="Grm4"
                     /gene_synonym="mGluR4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcggc ggcggcagca gcagcagcat cagcagcacg ggcaccgtgg cggccgctcc
       61 cagctccagc ttcccgggag cagccgccga gcgccgctcg ctgctccgag actccggccg
      121 cttggccgcc agctcctccc cgccgcgccc gggaccgccg gcggctcggc gccccgcttg
      181 gtccgcagcg tcagcgccgc ccgccgcggc ccgggctccc ggcagtgcga gcagctaagg
      241 gctggccgcc gcctccctga gctcccccgg cgcagccgac ccctggtcgc ggcgttcacc
      301 tcgccgatgc gcggttggta ggagtgaccg gagccattct ctcctcgttg ataagattcc
      361 ctaccaggat aggagcctat ctccctttcc acagcaggac acagaaatct ggccttcagt
      421 actttgggaa aaggatctga gacctcccgg agctctgacc actggctgtc atctgtggct
      481 ctggcctgtg tgggccactg agctctactc aaacattaaa gaggaggagg ggagatctgt
      541 ggaatgggcc accccgttgg cctgctgcat tactgaacct gcgctgtcca cacgcgccca
      601 gatcatggga cccagggcct gctagggcta ggagcggggc ccagtattca tgggtctcta
      661 ggcctttccg aaatgtccgg gaagggaggc tgggcctggt ggtgggcccg gctgcccctc
      721 tgcctactcc tcagccttta tgccccctgg gtgccttcat ccttgggaaa gcccaagggt
      781 cacccccaca tgaactctat ccgaattgac ggggacatca cactgggagg cctgtttccc
      841 gtccacggcc gtggctctga gggtaaggcc tgcggggagc tgaagaagga gaaaggcatc
      901 caccgcctgg aggccatgct gtttgccctg gaccgcatca acaatgaccc ggacctactg
      961 cccaacatca cgttgggcgc ccgcattctg gacacctgct cgagggacac ccacgccctg
     1021 gagcagtcac tgacctttgt gcaggcgctc atcgagaagg acggcacgga ggtccgctgc
     1081 ggcagcgggg gcccgcccat catcaccaag cccgaacgag tggtgggtgt cattggagct
     1141 tcggggagct ccgtctcgat catggtggcc aacatcctcc gcctcttcaa gatccctcag
     1201 atcagctatg cctccacggc ccctgacttg agtgacaaca gccgctatga cttcttctcc
     1261 cgggtggtgc cctcagacac ataccaggcc caggccatgg tggatattgt ccgagccctc
     1321 aagtggaact atgtgtccac actggcctca gagggcagct acggtgagag tggtgtggag
     1381 gcctttatcc agaagtcccg agagaacgga ggtgtgtgca ttgcccagtc ggtgaagatt
     1441 ccacgggaac ccaagacggg ggagttcgac aagatcatca aacgcctact ggaaacatcc
     1501 aatgccaggg gtatcatcat ctttgccaat gaggatgaca tcaggagggt gttggaggca
     1561 gctcgcaggg ccaaccagac cggccacttc ttttggatgg gttctgatag ctggggctcc
     1621 aagagtgccc ctgtgctgcg ccttgaggag gtggccgagg gcgcagtcac cattctcccc
     1681 aagaggatgt ctgttcgagg gttcgaccga tacttctcca gccgcacgct ggacaacaac
     1741 aggcgcaaca tctggtttgc cgagttctgg gaggacaact tccattgcaa gttgagccgc
     1801 cacgcgctca agaagggaag ccacatcaag aagtgcacca accgagagcg catcgggcag
     1861 gactcggcct atgagcagga ggggaaggtg cagttcgtga ttgacgctgt gtacgccatg
     1921 ggccacgcgc tgcacgccat gcaccgtgac ctgtgtcctg gccgcgtagg actctgccct
     1981 cgcatggacc ccgtggatgg cacccagctg cttaagtaca tcaggaacgt caacttctca
     2041 ggcattgcgg ggaaccctgt aaccttcaat gagaacggag acgcaccggg gcgctacgac
     2101 atctaccagt accaactgcg caatggctcg gccgagtaca aggtcatcgg ctcgtggaca
     2161 gaccacctgc acctcagaat agagcggatg cagtggccag ggagtggcca gcagctgccg
     2221 cgctccatct gcagtctgcc ctgccagccc ggggagcgaa agaagactgt gaagggcatg
     2281 gcttgctgct ggcactgcga gccctgcacc gggtaccagt accaagtgga ccgctacacc
     2341 tgtaagacct gcccctacga catgcggccc acagagaacc gcacgagctg ccagcccatc
     2401 cccatcgtca agttggagtg ggactcgccg tgggccgtgc tgcccctctt cctggccgtg
     2461 gtgggcatcg ccgccacgct gttcgtggtg gtcacgtttg tgcgctacaa cgataccccc
     2521 atcgtcaagg cctcgggccg ggagctgagc tacgtgctgc tggcgggcat ctttctgtgc
     2581 tacgccacta ccttcctcat gatcgcagag ccggacctgg ggacctgttc gctccgccgc
     2641 atcttcctag ggctcggcat gagcatcagc tacgcggccc tgctgaccaa gaccaaccgc
     2701 atttaccgca tctttgagca gggcaaacgg tcggtcagtg ccccgcgttt catcagcccg
     2761 gcctcgcagc tggccatcac cttcatcctc atctccctgc agctgctcgg catctgcgtg
     2821 tggttcgtgg tggacccctc ccactcggtg gtggacttcc aggaccaacg gacacttgac
     2881 ccccgctttg ccaggggcgt gctcaagtgc gacatctcgg acctgtccct catctgcctg
     2941 ctgggctaca gcatgctgct gatggtcacg tgtactgtgt acgccatcaa gacccgaggc
     3001 gtgcccgaga ccttcaacga ggccaagccc atcggcttca ccatgtacac cacctgcatt
     3061 gtctggctgg ccttcatccc catctttttt ggcacctcac agtcagccga caagctgtac
     3121 atccagacaa ccacactgac ggtctccgtg agtctgagcg cttcagtgtc cctggggatg
     3181 ctctacatgc ccaaagtcta catcatcctc ttccacccgg agcagaacgt gcccaagcgc
     3241 aagcgcagtc tcaaagccgt ggtcaccgcc gccaccatgt ccaacaagtt cacacagaag
     3301 ggcaacttca ggcccaatgg ggaagccaaa tcagagctgt gtgagaacct ggagacccca
     3361 gcgctggcta ccaaacagac ctacgtcacc tacaccaacc atgccatcta gccgggccgc
     3421 ggagccaagc aggctaagga gccacaacct ctgaggatgg cacattgggc cagggccgtt
     3481 cccgagggcc ctgccgatgt ctgcccgcct cccgggcatc cacgaatgtg gcttggtgct
     3541 gaggacagta gagaccccgg ccatcactgc tgggcaagcc gtggtgggca accagaggag
     3601 gccgagtggc tggggcagtt ccaggttatg ccacacacag gtcttccttc tggaccactg
     3661 ttgggcccag ccccaaagca caggggctcg gtctccagag cccagccctg gcttcctctc
     3721 cttcctcctg cctccgtctg tcctgtgggt gaccccggtt ggtccctgcc ccgtctttac
     3781 gtttctcttc cgtctttgct ctgcatgtgt tgtctgtttg ggccctctgc ttccatattt
     3841 ttccattctg ctcctggcct tcccctgcca tctgccctgc cccctgcccc tcctccctga
     3901 gctgccccat ccccgccatc attttctctt ctgttccccc tcgatctcat ttcctaccag
     3961 ccttccccct acttggcttc atccaccaac tctttcacca cgttgcaaaa gagaaaaaaa
     4021 aagggggggg ggaatcaccc cctacaaaaa agcccaaaca aaaactaatc ttgagtgtgt
     4081 ttcgaagtgc tgcgtcctcc tggtggcctg tgtgtccctg tggcctgcag cctgctcgcc
     4141 cgccctaccc gtctgccgtg tgtcctgccc gcccgcctgc ccgccttgcc cttcctgcta
     4201 acgacacgga gttcagtgcc tgggtgtttg gtgatggtct ctgatgtgta gcatgtctgt
     4261 ttttataccg agaacatttc taataaagat aaacacatgg ttttgc
//
