LOCUS       NM_001105712            3384 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 3 (Grm3), mRNA.
ACCESSION   NM_001105712 XM_001062001 XM_001069653
VERSION     NM_001105712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Joffe,M.E., Santiago,C.I., Oliver,K.H., Maksymetz,J., Harris,N.A.,
            Engers,J.L., Lindsley,C.W., Winder,D.G. and Conn,P.J.
  TITLE     mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance
            Thalamocortical Transmission and Exert Rapid Antidepressant-like
            Effects
  JOURNAL   Neuron 105 (1), 46-59 (2020)
   PUBMED   31735403
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Alese,O.O. and Mabandla,M.V.
  TITLE     Transgenerational deep sequencing revealed hypermethylation of
            hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and
            mGluR3 associated with behavioral changes in Sprague Dawley rats
            with history of prolonged febrile seizure
  JOURNAL   PLoS One 14 (11), e0225034 (2019)
   PUBMED   31710636
  REMARK    GeneRIF: significant decrease in mGluR5 mRNA expression with a
            resultant increased expression of mGluR3 mRNA expression and
            hypermethylation of mGluR1 gene across both generations of rats, is
            reported.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   Wong,A.M., Scott,A.K., Johnson,C.S., Mohr,M.A., Mittelman-Smith,M.
            and Micevych,P.E.
  TITLE     ERalphaDelta4, an ERalpha splice variant missing exon4, interacts
            with caveolin-3 and mGluR2/3
  JOURNAL   J Neuroendocrinol 31 (6), e12725 (2019)
   PUBMED   31050077
  REMARK    GeneRIF: ERalphaDelta4, an ERalpha splice variant missing exon4,
            interacts with caveolin-3 and mGluR2/3.
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Wood,C.M., Wafford,K.A., McCarthy,A.P., Hewes,N., Shanks,E.,
            Lodge,D. and Robinson,E.S.J.
  TITLE     Investigating the role of mGluR2 versus mGluR3 in
            antipsychotic-like effects, sleep-wake architecture and network
            oscillatory activity using novel Han Wistar rats lacking mGluR2
            expression
  JOURNAL   Neuropharmacology 140, 246-259 (2018)
   PUBMED   30005976
  REMARK    GeneRIF: studies illustrate the significant contribution of mGluR2
            to the antipsychotic-like, sleep and EEG effects of drugs acting on
            group II mGluRs; however, we also provide evidence of a role for
            mGluR3 activity in the control of sleep and wake cortical theta and
            gamma oscillations
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Nasca,C., Bigio,B., Zelli,D., de Angelis,P., Lau,T., Okamoto,M.,
            Soya,H., Ni,J., Brichta,L., Greengard,P., Neve,R.L., Lee,F.S. and
            McEwen,B.S.
  TITLE     Role of the Astroglial Glutamate Exchanger xCT in Ventral
            Hippocampus in Resilience to Stress
  JOURNAL   Neuron 96 (2), 402-413 (2017)
   PUBMED   29024663
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Tamaru,Y., Nomura,S., Mizuno,N. and Shigemoto,R.
  TITLE     Distribution of metabotropic glutamate receptor mGluR3 in the mouse
            CNS: differential location relative to pre- and postsynaptic sites
  JOURNAL   Neuroscience 106 (3), 481-503 (2001)
   PUBMED   11591452
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Chavis,P., Shinozaki,H., Bockaert,J. and Fagni,L.
  TITLE     The metabotropic glutamate receptor types 2/3 inhibit L-type
            calcium channels via a pertussis toxin-sensitive G-protein in
            cultured cerebellar granule cells
  JOURNAL   J Neurosci 14 (11 Pt 2), 7067-7076 (1994)
   PUBMED   7965099
REFERENCE   8  (bases 1 to 3384)
  AUTHORS   Guidi,B., Ronchi,S., Ori,E., Varni,P.F., Cassinadri,T., Tripodi,A.,
            Borghi,A., Mattei,F., Demaria,F., Galavotti,E. et al.
  TITLE     [Lead concentrations in breast milk of women living in urban areas
            compared with women living in rural areas]
  JOURNAL   Pediatr Med Chir 14 (6), 611-616 (1992)
   PUBMED   1298935
REFERENCE   9  (bases 1 to 3384)
  AUTHORS   Tanabe,Y., Masu,M., Ishii,T., Shigemoto,R. and Nakanishi,S.
  TITLE     A family of metabotropic glutamate receptors
  JOURNAL   Neuron 8 (1), 169-179 (1992)
   PUBMED   1309649
REFERENCE   10 (bases 1 to 3384)
  AUTHORS   Lipovskii,S.M.
  TITLE     [Levels of histamine in the tissues of the stomach and liver of
            non-pregnant and pregnant guinea pigs, their fetuses, in the blood
            of pregnant females and in fetal fluids]
  JOURNAL   Fiziol Zh SSSR Im I M Sechenova 61 (1), 90-95 (1975)
   PUBMED   1109982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474013.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001062001.1, XM_001069653.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M92076.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760393, SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3384
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /note="glutamate metabotropic receptor 3"
                     /db_xref="GeneID:24416"
                     /db_xref="RGD:2744"
     exon            1..82
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            83..691
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2863
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /note="metabotropic glutamate receptor 3; glutamate
                     receptor, metabotropic 3"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 3 precursor"
                     /protein_id="NP_001099182.1"
                     /db_xref="GeneID:24416"
                     /db_xref="RGD:2744"
                     /translation="MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGL
                     FPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRD
                     TYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANL
                     LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVAS
                     EGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFM
                     RSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFD
                     RYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMF
                     VVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGA
                     DSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQ
                     CSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLP
                     EDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSL
                     SYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKF
                     ISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLIS
                     LTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRV
                     QTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQS
                     SASTYVPTVCNGREVLDSTTSSL"
     exon            692..1547
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..2614
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2789
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..3384
                     /gene="Grm3"
                     /gene_synonym="mGluR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccagagc ctgggtgcag gctcaccgct gccgctacca ccgcggtcag cttcagttcc
       61 tgccaggagt tgacggtgcg aggaattcgg tgacgggctc tttcagccca atcctccctt
      121 atctgaagga caggcaaaag attccacttg gaaatgagag aagactagaa ggaaacattg
      181 gcttcaccaa gtgatatctc caagagatat agaaacagga ttcatgaaga tgttgacaag
      241 actacaaatt cttatgttag ctttgttttc aaagggattt ttactctctt taggagatca
      301 caactttatg aggagggaaa ttaaaataga aggagacctt gttttaggag gcttatttcc
      361 tattaatgaa aaaggcactg gaactgaaga gtgtgggcga atcaatgaag accgaggtat
      421 ccaacgcctg gaggccatgt tgtttgccat cgacgagatt aacaaagaca attacttgct
      481 cccaggagtg aagctgggtg ttcatatttt ggatacatgt tcaagggata cctatgcatt
      541 agagcaatca ctggagtttg tcagggcatc tttgactaaa gtggatgaag ccgagtatat
      601 gtgtcctgat ggatcatatg ctattcaaga aaacatccca ctgctcattg caggagtcat
      661 tggtggttca tacagcagtg tttccataca ggtggcaaac ctgctgaggc tcttccagat
      721 ccctcagata agctacgcct ccaccagcgc caaactcagt gacaagtcgc gctatgatta
      781 ctttgccagg accgtgcccc ctgacttcta ccaggccaaa gccatggccg agatcttgcg
      841 cttcttcaac tggacctatg tgtccaccgt tgcctctgag ggtgactatg gggagacagg
      901 gattgaggcc ttcgagcagg aagcacggct gcgtaacatc tgcatcgcca ctgctgaaaa
      961 ggtgggccgc tccaacatcc gcaagtccta cgacagcgtg atacgtgagc tcctgcagaa
     1021 acccaatgcg cgggtcgtgg tcctgttcat gcgcagtgac gactcacgag agctgatcgc
     1081 ggcagccaac cgcgtgaatg cctccttcac ctgggtggcc agcgacggct ggggtgctca
     1141 ggagagcata gtcaagggca gtgagcatgt agcctatggc gccatcaccc ttgagctggc
     1201 atctcacccg gttcgccagt ttgatcgcta cttccagagc ctcaacccct acaacaatca
     1261 tcgtaacccc tggttccgag acttctggga gcagaagttc cagtgcagcc tccagaacaa
     1321 gagaaaccac agacaggttt gtgacaagca cctggccatt gacagcagca actatgagca
     1381 agaatccaag attatgtttg tggtgaatgc agtgtacgcc atggcgcatg cgctgcacaa
     1441 aatgcagcgc accctctgtc ccaacaccac caagctctgt gatgcaatga agatcctaga
     1501 tggaaagaaa ttgtacaagg agtatttgct gaaaatcaac ttcacagctc cattcaaccc
     1561 aaataaagga gcagacagca ttgtgaagtt tgacactttt ggagacggga tgggaagata
     1621 caacgtgttc aacttgcagc agacaggtgg gaagtattct tacttgaagg ttggccactg
     1681 ggcagaaacc ttgtctctag atgtggactc tatccattgg tcccggaact cagtccccac
     1741 ttcccagtgc agtgatccct gtgccccgaa tgaaatgaag aacatgcagc ccggggatgt
     1801 ttgctgctgg atctgtatcc cctgtgagcc ctatgaatac ctggtcgatg agttcacctg
     1861 tatggattgt ggccctggcc agtggcccac tgcagaccta tctggatgct acaaccttcc
     1921 agaggattac atcaaatggg aagacgcctg ggcaataggc ccggtcacca ttgcctgcct
     1981 gggctttctg tgtacatgca tagttataac tgtttttatc aagcacaaca acacaccctt
     2041 ggtcaaagca tcaggtcgag aactctgcta catcttgtta tttggagtta gcctgtccta
     2101 ttgcatgaca ttcttcttca ttgctaagcc atcgcctgtc atctgtgcgt tgcgccgact
     2161 tgggcttggg acctctttcg ccatctgtta ttcagcgctg ctgaccaaga caaactgcat
     2221 tgctcgcatc ttcgatgggg tcaagaacgg cgctcagagg ccgaaattca tcagccccag
     2281 ttctcaggtt tttatttgcc tgggtttgat actggtgcaa attgtgatgg tgtccgtgtg
     2341 gcttatcctg gagactccag gtactagaag atacaccctt ccagagaagc gggaaacagt
     2401 catcctgaaa tgcaatgtca aagattccag catgttgatc tctctgacct atgacgtggt
     2461 cctggtgatc ctatgcactg tgtatgcctt caaaacgagg aagtgtcctg aaaacttcaa
     2521 tgaagccaag tttataggct tcaccatgta caccacctgc atcatctggt tggcattcct
     2581 ccctatattt tatgtgacat caagtgacta cagagtgcag acgacaacaa tgtgcatctc
     2641 cgttagcctg agcggtttcg tggtcttggg ctgtttgttt gcccccaagg tgcacatcgt
     2701 cctgttccaa ccccagaaga atgtggtcac acacagactt cacctcaaca ggttcagcgt
     2761 cagcggaact gcaaccacct attctcagtc ctctgcaagc acatatgtcc caacagtgtg
     2821 caacggaagg gaagtcctgg actccaccac ctcatctctg tgattgtgat acgcagttca
     2881 gttctcatgt ttttaggctg ttagacaaag tgctcacatg ctgctccaga acatggaaac
     2941 agaacaaaac aacaacccta gtatcttttt ttttcttttt ttagaaacag tacaataaat
     3001 tatttttgag gactgtatgg tatgtagtga tgtgctacaa ctttctaggc tgattttagt
     3061 gccctaatta acagcccctt ccccaggaca tggaaataac cattgtttac agagctgagc
     3121 attggtgaca gggtctgaca gggtcagtct actaaaacga aaaacaaaaa agacaaaaca
     3181 aaaaaaaata cagtggcaat attaggtaac cttttttcct atgaagtctt ttgtaggttc
     3241 ttgttgtaac taatttaggg tgagtttcta cgttgtatat taaagttaca ttacgtgtaa
     3301 cggagcgttt ttctcagtac aaaataaaaa agcatctgtg ttaatgtcaa gataatggga
     3361 ataaaacctt caaggttttc aagc
//
