LOCUS       NM_001105711            4580 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 2 (Grm2), mRNA.
ACCESSION   NM_001105711 XM_001073809 XM_343470
VERSION     NM_001105711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   De Gasperi,R., Gama Sosa,M.A., Perez Garcia,G., Perez,G.M.,
            Pryor,D., Morrison,C.L., Lind,R., Abutarboush,R., Kawoos,U.,
            Statz,J.K., Patterson,J., Hof,P.R., Zhu,C.W., Ahlers,S.T.,
            Cook,D.G. and Elder,G.A.
  TITLE     Metabotropic Glutamate Receptor 2 Expression Is Chronically
            Elevated in Male Rats With Post-Traumatic Stress Disorder Related
            Behavioral Traits Following Repetitive Low-Level Blast Exposure
  JOURNAL   J Neurotrauma 41 (5-6), 714-733 (2024)
   PUBMED   37917117
  REMARK    GeneRIF: Metabotropic Glutamate Receptor 2 Expression Is
            Chronically Elevated in Male Rats With Post-Traumatic Stress
            Disorder Related Behavioral Traits Following Repetitive Low-Level
            Blast Exposure.
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Bodzeta,A., Berger,F. and MacGillavry,H.D.
  TITLE     Subsynaptic mobility of presynaptic mGluR types is differentially
            regulated by intra- and extracellular interactions
  JOURNAL   Mol Biol Cell 33 (8), ar66 (2022)
   PUBMED   35511883
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Khodagholi,F., Maleki,A., Motamedi,F., Mousavi,M.A., Rafiei,S. and
            Moslemi,M.
  TITLE     Oxytocin Prevents the Development of 3-NP-Induced Anxiety and
            Depression in Male and Female Rats: Possible Interaction of OXTR
            and mGluR2
  JOURNAL   Cell Mol Neurobiol 42 (4), 1105-1123 (2022)
   PUBMED   33201416
  REMARK    GeneRIF: Oxytocin Prevents the Development of 3-NP-Induced Anxiety
            and Depression in Male and Female Rats: Possible Interaction of
            OXTR and mGluR2.
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Elhussiny,M.E.A., Carini,G., Mingardi,J., Tornese,P., Sala,N.,
            Bono,F., Fiorentini,C., La Via,L., Popoli,M., Musazzi,L. and
            Barbon,A.
  TITLE     Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA
            and metabotropic glutamate receptors in the rat hippocampus
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 104, 110033 (2021)
   PUBMED   32640261
  REMARK    GeneRIF: Modulation by chronic stress and ketamine of ionotropic
            AMPA/NMDA and metabotropic glutamate receptors in the rat
            hippocampus.
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Sweeten,B.L.W., Adkins,A.M., Wellman,L.L. and Sanford,L.D.
  TITLE     Group II metabotropic glutamate receptor activation in the
            basolateral amygdala mediates individual differences in
            stress-induced changes in rapid eye movement sleep
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 104, 110014 (2021)
   PUBMED   32534177
  REMARK    GeneRIF: Group II metabotropic glutamate receptor activation in the
            basolateral amygdala mediates individual differences in
            stress-induced changes in rapid eye movement sleep.
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Lujan,R., Roberts,J.D., Shigemoto,R., Ohishi,H. and Somogyi,P.
  TITLE     Differential plasma membrane distribution of metabotropic glutamate
            receptors mGluR1 alpha, mGluR2 and mGluR5, relative to
            neurotransmitter release sites
  JOURNAL   J Chem Neuroanat 13 (4), 219-241 (1997)
   PUBMED   9412905
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Yokoi,M., Kobayashi,K., Manabe,T., Takahashi,T., Sakaguchi,I.,
            Katsuura,G., Shigemoto,R., Ohishi,H., Nomura,S., Nakamura,K.,
            Nakao,K., Katsuki,M. and Nakanishi,S.
  TITLE     Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
  JOURNAL   Science 273 (5275), 645-647 (1996)
   PUBMED   8662555
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Chavis,P., Shinozaki,H., Bockaert,J. and Fagni,L.
  TITLE     The metabotropic glutamate receptor types 2/3 inhibit L-type
            calcium channels via a pertussis toxin-sensitive G-protein in
            cultured cerebellar granule cells
  JOURNAL   J Neurosci 14 (11 Pt 2), 7067-7076 (1994)
   PUBMED   7965099
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Guariso,G., Fait,P., Rini,A. and Zancan,L.
  TITLE     [Liver transplant in childhood: our experience]
  JOURNAL   Pediatr Med Chir 14 (6), 603-607 (1992)
   PUBMED   1298933
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Tanabe,Y., Masu,M., Ishii,T., Shigemoto,R. and Nakanishi,S.
  TITLE     A family of metabotropic glutamate receptors
  JOURNAL   Neuron 8 (1), 169-179 (1992)
   PUBMED   1309649
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001073809.1, XM_343470.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M92075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4580
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /note="glutamate metabotropic receptor 2"
                     /db_xref="GeneID:24415"
                     /db_xref="RGD:2743"
     exon            1..62
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /inference="alignment:Splign:2.1.0"
     exon            63..648
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2817
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /note="metabotropic glutamate receptor 2; mGluR2;
                     glutamate receptor, metabotropic 2"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 2 precursor"
                     /protein_id="NP_001099181.1"
                     /db_xref="GeneID:24415"
                     /db_xref="RGD:2743"
                     /translation="MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKG
                     GPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQA
                     LDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQI
                     PQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGE
                     TGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDAR
                     ELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSL
                     DPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHAL
                     HNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGI
                     GRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNE
                     VKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDA
                     WAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFI
                     AKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAI
                     CLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIA
                     LCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV
                     SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVP
                     TVCNGREVVDSTTSSL"
     exon            649..1486
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2562
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2743
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..4580
                     /gene="Grm2"
                     /gene_synonym="mGlu2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccagcg agagagccag caagcgggaa ccggagcccc gcgccagagc tgggcgcgcc
       61 aggagctgac cccctcctca tctctcttcc tgtctgtcct ttcctggccc ctgtttcctc
      121 ctctctttgc ctttgctgct tctgtcctca cccctagaag accctggtct gctggaccta
      181 gccatccctt ttggggccat ggaatcactg cttgggtttc tggcactgct gctgctgtgg
      241 ggtgccgtgg ccgagggccc ggccaagaag gtgctgaccc tggaggggga cctggtgctg
      301 ggtgggctgt tcccagtgca ccagaagggt ggcccagccg aggagtgtgg acctgttaat
      361 gagcaccgag gcatacagcg cctagaggct atgctttttg cactggaccg catcaaccgc
      421 gacccccacc tgctgcctgg tgtgcgcttg ggtgcgcaca tcctcgacag ctgctccaag
      481 gatacacacg ccctggagca ggcgctggac tttgtgcgtg cctcactcag tcgtggcgct
      541 gacggctcac gccacatctg tcctgatggc tcctatgcca cccacagtga tgctcctaca
      601 gctgtcaccg gtgtcattgg tggctcctac agtgatgtct ccatccaggt ggccaatctc
      661 ctgcggctgt tccagatccc acagatcagc tatgcctcca ccagtgccaa gctgagtgac
      721 aagtcccgtt acgattactt tgctcgcact gtgcccccag acttcttcca agccaaggcc
      781 atggctgaga ttctccgctt tttcaactgg acatatgtgt ctacggtggc atctgagggt
      841 gactatggtg agacaggcat tgaggctttc gagctcgagg ctcgggcacg caacatctgc
      901 gtggccactt ctgagaaggt gggccgtgcc atgagccgcg ctgccttcga gggcgtggtg
      961 cgagccctgt tgcagaaacc cagtgcccgt gtggctgtgc tcttcacccg gtccgaggat
     1021 gcccgtgagc tgcttgcagc cacccagcgc ctcaacgcca gcttcacatg ggtggccagc
     1081 gacggctggg gggccctgga gagcgtggtg gcaggcagtg aaagggctgc tgagggcgcc
     1141 atcaccattg aactggcctc ctaccccatc agtgactttg cttcctactt ccagagcttg
     1201 gatccgtgga acaacagcag aaacccttgg ttccgtgagt tctgggagga gaggttccat
     1261 tgcagcttcc ggcagcgaga ctgtgccgcc cactctctgc gggccgtgcc ctttgaacag
     1321 gagtcaaaga tcatgtttgt ggttaatgcc gtctatgcca tggcccacgc tctacacaac
     1381 atgcaccgtg ccctctgtcc caacaccacc cacctctgcg atgctatgag gcctgtcaat
     1441 gggcgccgcc tctacaaaga cttcgtgctc aatgtcaagt ttgacgcccc ctttcgccca
     1501 gcagatactg acgatgaggt ccgcttcgac cgctttggtg acggtattgg ccgctacaac
     1561 atcttcacct atctgcgggc aggcagtggg cgctatcgct accagaaggt aggctactgg
     1621 gcagaaggtc tgactctgga cactagcttc attccatggg cctccccatc agccggacct
     1681 cttcctgcct ctcgctgtag cgagccctgc cttcagaacg aggtgaagag cgtgcagccg
     1741 ggcgaggtct gctgttggct ctgcattccc tgtcagccct atgagtacag gctggatgag
     1801 ttcacctgcg ctgactgtgg cctgggctac tggcctaatg ccagtctgac tggctgcttt
     1861 gagctgcccc aggagtacat ccgctggggt gatgcctggg cggtgggacc tgtcaccatc
     1921 gcctgcctgg gtgccctggc gacactcttt gtgttgggtg tctttgtgag gcataatgcc
     1981 acacccgtgg tcaaggcttc cggtcgggag ctttgctaca ttctgctggg cggtgtcttc
     2041 ctttgctatt gtatgacctt cgtcttcatt gctaagcctt ccacggccgt ctgtaccttg
     2101 aggcgcctcg gtttgggtac cgccttctct gtctgctact cagccctcct caccaagacc
     2161 aatcgcattg ctcgcatatt tggcggggcc cgggagggtg cccagcggcc acgcttcatc
     2221 agtcccgcct cacaggtggc catctgcttg gcacttatct cgggccagct gctcattgtc
     2281 gctgcctggc tggtggtgga ggcacctggc acaggcaagg agacagcccc tgaacggcgg
     2341 gaagtggtga cattgcgctg taaccaccgt gacgcgagca tgctcggctc actggcctac
     2401 aatgtgctcc tcatcgcgct ctgcacgctc tatgccttca agacccgcaa gtgcccggag
     2461 aacttcaacg aagccaagtt catcggcttc accatgtaca ccacctgcat catctggctg
     2521 gctttccttc ctatcttcta tgtcacctcc agtgattatc gggtgcagac caccacgatg
     2581 tgcgtgtccg tcagcctcag tggctctgtg gtgcttggct gcctctttgc acccaagttg
     2641 cacatcatcc ttttccagcc acagaagaat gtggtgagcc accgggcacc taccagccgc
     2701 tttggcagcg ctgcccccag ggccagcgcc aaccttggtc aagggtctgg atcccagttt
     2761 gttcccactg tttgcaacgg ccgtgaggtg gtggactcaa caacgtcgtc gctttgaaga
     2821 tcccacactc ctgccctgac atggctgctc ccaaacccag catagaccct catccacgac
     2881 caggaggaag ttggctggga gcactgcaat aacacccacc ccatgcctgc ccccagagcc
     2941 acttacccac ctcctggatt cccagccctt taggtcagaa gccagagtcc ttagctgggg
     3001 agcctctgca atggccagta actgtccttg tagctatgcc ccgtgtttgc caggcctggg
     3061 actcagaggg ggagatgacc agtgtctact gtgttctaga acagtgtggc tgaggacgac
     3121 aggcccaacc cccatgcaaa ggtgcttcca gaccagcccc tgccccaggc ctttttaatt
     3181 ttttataagt tactctggga tagagaggat ggttactgtg gggatcattc cctcccctcc
     3241 ttacccagta gtttgtcccg tggtttattt tgtattacct gtaaataaag tgtctttatt
     3301 taaacggttt tttaatttta tagacagagc ctcgtgtata ccaaggtgac tgcaaactta
     3361 ctatgtagct gagcatgact tgaaacttct gacctgcctc tgcctcccaa gtactgggtg
     3421 ggattaaagg agtgcacatc ggggggttgg ggatttagct cagtggtaga gagcttgcct
     3481 agcaagcgca aggccctggg ttcggtcccc agttccgaaa aaaaagagaa aaaggagtgc
     3541 acatcgggct tctgcagcac atgcatgcag tgcccacaga gaccagaagg gggcggcaga
     3601 tcccctagga caggagttac agttggttgt aagctaccca gtcagggctg ggaattaaac
     3661 ctgaatcctc tggaaaagca gcaagtactc ttaaacgttg agccatctct ccagcccatt
     3721 tatttgtttg tttgttcgtc tgtccattta tttaaaaata actctgacat gaggattccc
     3781 tcctcagtct tccactgttc attctgctaa tgggtgtcat ctcagcgcag ccaccaaggc
     3841 aaacccaacg ctgcttccta tggaggccga aaaggtgtca actatccttc ccttaaagga
     3901 gccattgaag attggtcagc accctctaga attgtctggt cttcaggaga cggttttcct
     3961 cagagaccca gcctacggta tggtgtgggg agtgggatac taactgtgga cttttcatga
     4021 caggctgact ggaatttgga caagccagag ccagggtgag tgtttgacgc aaaaaggaac
     4081 catcaataac acacttggga ctgaatgttt cctattcaca ggtaccatcg atagccagaa
     4141 gggggcccac aaggaaatgg tgaggcaagg ggcacagaca ctagggtgga gaggccatct
     4201 gtggctgtca tcagaaaagg gtccttttca atctctggag gacttcctgc ctgaagattg
     4261 ccggctgagc ttggctgccg cgggcatctc ccacgttcac catctggagc tgaccagtag
     4321 agggctccaa ggtgcagcct cggcttcgct ccctgggcag gcctctcagc agcctcccaa
     4381 ggcctagagg atgcggagca gtaagctgga agaatatggc tgctgcaggc aggggttcgg
     4441 taactcacgg ggacagaagt cctgtgtgag aacaccagcc agagacattg atttttcaag
     4501 cgagctaatt tacatcagtg ggctggtgag tctctggaaa tgtgggttaa caagtttaaa
     4561 aaagtagaaa taaagacaag
//
