LOCUS       NM_001112712            2980 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor kinase 6 (Grk6),
            transcript variant 3, mRNA.
ACCESSION   NM_001112712
VERSION     NM_001112712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2980)
  AUTHORS   Tian,Y.Q., Li,J.H., Li,Y.C., Xu,Y.C., Zhang,P.A., Wang,Q., Li,R.
            and Xu,G.Y.
  TITLE     Overexpression of GRK6 alleviates chronic visceral hypersensitivity
            through downregulation of P2Y6 receptors in anterior cingulate
            cortex of rats with prenatal maternal stress
  JOURNAL   CNS Neurosci Ther 28 (6), 851-861 (2022)
   PUBMED   35349212
  REMARK    GeneRIF: Overexpression of GRK6 alleviates chronic visceral
            hypersensitivity through downregulation of P2Y6 receptors in
            anterior cingulate cortex of rats with prenatal maternal stress.
REFERENCE   2  (bases 1 to 2980)
  AUTHORS   Li,X., Xu,Y.C., Tian,Y.Q., Zhang,P.A., Hu,S.F., Wang,L.H.,
            Jiang,X.H. and Xu,G.Y.
  TITLE     Downregulation of GRK6 in arcuate nucleus promotes chronic visceral
            hypersensitivity via NF-kappaB upregulation in adult rats with
            neonatal maternal deprivation
  JOURNAL   Mol Pain 16, 1744806920930858 (2020)
   PUBMED   32484026
  REMARK    GeneRIF: Downregulation of GRK6 in arcuate nucleus promotes chronic
            visceral hypersensitivity via NF-kappaB upregulation in adult rats
            with neonatal maternal deprivation.
REFERENCE   3  (bases 1 to 2980)
  AUTHORS   Wang,L., Bao,H., Wang,K.X., Zhang,P., Yao,Q.P., Chen,X.H.,
            Huang,K., Qi,Y.X. and Jiang,Z.L.
  TITLE     Secreted miR-27a Induced by Cyclic Stretch Modulates the
            Proliferation of Endothelial Cells in Hypertension via GRK6
  JOURNAL   Sci Rep 7, 41058 (2017)
   PUBMED   28106155
  REMARK    GeneRIF: Study shows that secreted miR-27a induced by cyclic
            stretch modulates the proliferation of endothelial cells in
            hypertension via g-protein-coupled receptor kinase 6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2980)
  AUTHORS   Zhou,Y., Li,R.J., Li,M., Liu,X., Zhu,H.Y., Ju,Z., Miao,X. and
            Xu,G.Y.
  TITLE     Overexpression of GRK6 attenuates neuropathic pain via suppression
            of CXCR2 in rat dorsal root ganglion
  JOURNAL   Mol Pain 12, 1744806916646381 (2016)
   PUBMED   27145805
  REMARK    GeneRIF: GRK6 might be a key molecular involved in peripheral
            mechanism of neuropathic pain and that overexpression of GRK6 might
            be a potential strategy for treatment for neuropathic pain through
            inhibition of CXCR2 signal pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2980)
  AUTHORS   Oda,Y., Tadokoro,S., Takase,M., Kanahara,N., Watanabe,H.,
            Shirayama,Y., Hashimoto,K. and Iyo,M.
  TITLE     G protein-coupled receptor kinase 6/beta-arrestin 2 system in a rat
            model of dopamine supersensitivity psychosis
  JOURNAL   J Psychopharmacol 29 (12), 1308-1313 (2015)
   PUBMED   26174132
  REMARK    GeneRIF: The ratio of GRK6/ARRB2 in DSP model rats was
            significantly higher than that in controls.
REFERENCE   6  (bases 1 to 2980)
  AUTHORS   Premont,R.T., Macrae,A.D., Aparicio,S.A., Kendall,H.E., Welch,J.E.
            and Lefkowitz,R.J.
  TITLE     The GRK4 subfamily of G protein-coupled receptor kinases.
            Alternative splicing, gene organization, and sequence conservation
  JOURNAL   J Biol Chem 274 (41), 29381-29389 (1999)
   PUBMED   10506199
REFERENCE   7  (bases 1 to 2980)
  AUTHORS   Hall,R.A., Spurney,R.F., Premont,R.T., Rahman,N., Blitzer,J.T.,
            Pitcher,J.A. and Lefkowitz,R.J.
  TITLE     G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+)
            exchanger regulatory factor via a PDZ domain-mediated interaction
  JOURNAL   J Biol Chem 274 (34), 24328-24334 (1999)
   PUBMED   10446210
REFERENCE   8  (bases 1 to 2980)
  AUTHORS   Lombardi,M.S., Kavelaars,A., Schedlowski,M., Bijlsma,J.W.,
            Okihara,K.L., Van de Pol,M., Ochsmann,S., Pawlak,C., Schmidt,R.E.
            and Heijnen,C.J.
  TITLE     Decreased expression and activity of G-protein-coupled receptor
            kinases in peripheral blood mononuclear cells of patients with
            rheumatoid arthritis
  JOURNAL   FASEB J 13 (6), 715-725 (1999)
   PUBMED   10094932
REFERENCE   9  (bases 1 to 2980)
  AUTHORS   Fehr,C., Fickova,M., Hiemke,C., Reuss,S. and Dahmen,N.
  TITLE     Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6)
            from brain tissue, and its mRNA expression in different brain
            regions and peripheral tissues
  JOURNAL   Brain Res Mol Brain Res 49 (1-2), 278-282 (1997)
   PUBMED   9387888
REFERENCE   10 (bases 1 to 2980)
  AUTHORS   Firsov,D. and Elalouf,J.M.
  TITLE     Molecular cloning of two rat GRK6 splice variants
  JOURNAL   Am J Physiol 273 (3 Pt 1), C953-C961 (1997)
   PUBMED   9316417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 22, 2021 this sequence version replaced NM_001112712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97439.1, SRR26643298.68431.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000017.1  9197726-9197954     c
            230-325             JAXUCZ010000017.1  9193837-9193932     c
            326-438             JAXUCZ010000017.1  9192853-9192965     c
            439-516             JAXUCZ010000017.1  9192681-9192758     c
            517-617             JAXUCZ010000017.1  9192231-9192331     c
            618-710             JAXUCZ010000017.1  9191863-9191955     c
            711-774             JAXUCZ010000017.1  9191700-9191763     c
            775-915             JAXUCZ010000017.1  9191440-9191580     c
            916-1106            JAXUCZ010000017.1  9190962-9191152     c
            1107-1144           JAXUCZ010000017.1  9190230-9190267     c
            1145-1234           JAXUCZ010000017.1  9190054-9190143     c
            1235-1443           JAXUCZ010000017.1  9188748-9188956     c
            1444-1581           JAXUCZ010000017.1  9188530-9188667     c
            1582-1719           JAXUCZ010000017.1  9184139-9184276     c
            1720-1854           JAXUCZ010000017.1  9183922-9184056     c
            1855-2980           JAXUCZ010000017.1  9182160-9183285     c
FEATURES             Location/Qualifiers
     source          1..2980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2980
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /note="G protein-coupled receptor kinase 6"
                     /db_xref="GeneID:59076"
                     /db_xref="RGD:61986"
     exon            1..229
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1908
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /EC_number="2.7.11.16"
                     /note="isoform c is encoded by transcript variant 3; g
                     protein-coupled receptor kinase GRK6"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 6 isoform c"
                     /protein_id="NP_001106183.1"
                     /db_xref="GeneID:59076"
                     /db_xref="RGD:61986"
                     /translation="MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEE
                     LRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVAEYEVTPDEKRKACG
                     RRLMQNFLSHTGPDLIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSMAPFAD
                     YLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE
                     KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY
                     HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV
                     HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKI
                     KREEVERLVKEVAEEYTDRFSPQARSLCSQLLNKDPAERLGCRGGGAREVKEHPLFKK
                     LNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVS
                     IPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRLFSRQDCCGNCS
                     DSEEELPTRL"
     exon            230..325
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            326..438
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            439..516
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            517..617
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            618..710
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            711..774
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            775..915
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1106
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1144
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1234
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1443
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1581
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1719
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1854
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2980
                     /gene="Grk6"
                     /gene_synonym="Gprk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagtgcg cggcgggcgg cggcggccgg ggaggccggt gaggcccggg aggccgcggc
       61 gcggtcagtc gagccgagcc gagccgagcc gagccgcgcc gatcgccatc ggccccggct
      121 ctcgtgggcg gtcccggccg gcggcgcggc ctggcgggcc gggcggcgct gcagcccatg
      181 gagctcgaga acatcgtagc gaacacggtg ctactcaagg cccgggaagg tggtggcggg
      241 aatcgtaaag gcaagagcaa gaaatggcgc cagatgctgc agttccccca catcagccag
      301 tgtgaagagc tccggctcag ccttgaacgt gactaccaca gcctgtgtga gcgtcagccc
      361 attgggcgcc tgttatttcg tgagttctgc gctacgaggc ctgagctgac ccgctgtact
      421 gccttcctgg atggggtggc tgagtatgag gtgacccctg atgagaaacg gaaggcatgt
      481 gggcgtcggc taatgcagaa ttttctgagc cacacgggtc ctgacctcat ccctgaagtt
      541 ccccggcagc tggtgagtaa ctgtgcccag cggctagagc agggaccctg caaagacctc
      601 ttccaggagc tgacccggct gacccatgag tacctaagca tggccccttt tgccgactac
      661 ctcgacagca tctacttcaa ccgtttcctg cagtggaagt ggctggaaag gcagccagtg
      721 accaaaaaca cctttaggca gtaccgagtc ctgggcaaag gtggctttgg ggaggtgtgt
      781 gcctgccagg tgcgggcaac aggcaagatg tatgcgtgca aaaaactgga aaagaaacga
      841 ataaagaagc ggaaggggga ggccatggct ctcaacgaga agcagatcct ggagaaagtg
      901 aacagtaggt ttgtagtgag cttagcctac gcatatgaga ccaaggatgc actgtgcctg
      961 gtgctgacat tgatgaatgg aggcgacctc aagttccaca tctaccacat gggccaggct
     1021 ggctttcccg aagcacgtgc tgtcttctat gctgccgaga tctgctgtgg tctggaggac
     1081 ttacaccggg aacgcatcgt gtacagggac ctaaagccag agaatatcct tctggatgac
     1141 catggccaca ttcgaatctc cgacctgggc ctggctgtgc atgttcctga gggccagacc
     1201 atcaaaggcc gtgtgggcac tgtgggctac atggctccag aggtggtgaa gaatgagcgc
     1261 tacacattca gtcctgactg gtgggcgcta ggctgcctcc tgtacgagat gattgcggga
     1321 cagtcgccct tccagcagag gaagaagaag atcaagcggg aggaggtgga gcggctggtc
     1381 aaggaggtgg ctgaggagta caccgaccgc ttctccccac aggcacgctc actctgttct
     1441 cagcttctca acaaggaccc tgctgagcgc ctggggtgtc gtggaggtgg tgcccgtgag
     1501 gtaaaggagc accccctttt caagaaactg aatttcaagc ggctgggagc tggaatgcta
     1561 gaaccacctt ttaaacctga cccccaggcc atttactgca aggacgtgct ggacattgaa
     1621 cagttctcca cagttaaagg tgtggatctg gagcccacag accaagactt ctaccagaag
     1681 tttgccacgg gtagtgtgtc catcccctgg cagaacgaga tggtggagac tgagtgcttc
     1741 caggaactaa atgtctttgg gctggatggg tctgttcccc cagacctgga ctggaagggc
     1801 cagcccactg caccccccaa gaagggattg ctacagagac tcttcagtag acaagattgc
     1861 tgtgggaact gcagcgacag tgaagaagag ctccccaccc gcctctagcc cccaggccga
     1921 ggcccccacc ggcggctggc ggtagcagct actcagtgac tgacgttgac agttttgcac
     1981 agtgctgttt ccagttgtcc acgccagtcg tggtctgtgg aacacagccg gaactgtccc
     2041 cagtgtcctc cgttcctcag ccactggccc agctgagttt gacgaggcct gggccatctt
     2101 gggacaaagg tgcgtccctt cagctcttct ctgtggagct cggggcttta tgtgtttatg
     2161 tatttgtacg aatgtatata gctaccagag cgttcttaac tccaccctgg gtctggcacc
     2221 ccagggcaac tagccctggc caggagagcc aggagctggc aagaggaacc agtgccaacc
     2281 tccaggctaa tggggcccag tccagatgag caagcagagt gtgggccagg tcagacctct
     2341 gaccacagca ttgctccggc caccatcaga ctcaagtgag actcgtgcct gtctgttgtg
     2401 gactgaggcc accatgctcc agttgcccaa tgctttcatt ccgtctcagc gtttgtcaga
     2461 gctggagacg ggggctttgt gttctccggg cctgggtcac agtgtgactg caaactgagc
     2521 tgacggggac ctatcacacc actgccccag atgggttgct ttttgccttc cagctcccag
     2581 agcacattgg tccttattct gggtcatatc caggccataa gaggggttag aattagccct
     2641 ccaacattcc agaatccctc ataaaagtag acatgtgccc agcaataatc caaccttcct
     2701 gtgtgtgcct gcgggaggcg ggtgtgagtg tatatcattg tgtgaagaga gtagggtaag
     2761 gctgtgccta agccccagac cctagcccta gcctttccca gactgtgatg gctgtcctga
     2821 tgctagtaag gacagtatgg gaccatacgg ccctggcgtt tccatgttta aagccaatgt
     2881 gagctgccat gtgtctatga ccaatgtaag ctgccatgtg tctgtctgtg tgaatacagt
     2941 ctgagcacaa ggctggccag ccgcccctgc tgcctcttta
//
