LOCUS       NM_030829               2308 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor kinase 5 (Grk5), mRNA.
ACCESSION   NM_030829
VERSION     NM_030829.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Wang,M., Zhao,M., Xu,S., Zheng,Z., Zhang,J., Pan,W., Yin,Z.,
            Liu,J., Wei,C., Wan,J. and Xu,Y.
  TITLE     TRPA1 deficiency attenuates cardiac fibrosis via regulating
            GRK5/NFAT signaling in diabetic rats
  JOURNAL   Biochem Pharmacol 214, 115671 (2023)
   PUBMED   37380112
  REMARK    GeneRIF: TRPA1 deficiency attenuates cardiac fibrosis via
            regulating GRK5/NFAT signaling in diabetic rats.
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Nash,C.A., Nelson,C.P., Mistry,R., Moeller-Olsen,C.,
            Christofidou,E., Challiss,R.A.J. and Willets,J.M.
  TITLE     Differential regulation of beta2-adrenoceptor and adenosine A2B
            receptor signalling by GRK and arrestin proteins in arterial smooth
            muscle
  JOURNAL   Cell Signal 51, 86-98 (2018)
   PUBMED   30075183
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Sorriento,D., Santulli,G., Ciccarelli,M., Maione,A.S., Illario,M.,
            Trimarco,B. and Iaccarino,G.
  TITLE     The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy
            through the Regulation of Calcium-Calmodulin Dependent
            Transcription Factors
  JOURNAL   Int J Mol Sci 19 (3), 861 (2018)
   PUBMED   29543709
  REMARK    GeneRIF: Overexpression of GRK5-NT in cardiomyoblasts significantly
            reduced the activation and the nuclear translocation of NFAT and
            its cofactor GATA-4 in response to phenylephrine.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Zeng,X., Chen,S., Gao,Q., Zong,W., Jiang,D., Zeng,G., Zhou,L.,
            Chen,L., Luo,W., Xiao,J., Xiao,B., Ouyang,D. and Hu,K.
  TITLE     The expression of G protein-coupled receptor kinase 5 and its
            interaction with dendritic marker microtubule-associated protein-2
            after status epilepticus
  JOURNAL   Epilepsy Res 138, 62-70 (2017)
   PUBMED   29080472
  REMARK    GeneRIF: This study showed that the GRK5 was involved in the
            development of epilepsy. It was associated with dendritic formation
            in epilepsy.
            Erratum:[Epilepsy Res. 2018 Jan;139:180. doi:
            10.1016/j.eplepsyres.2017.12.007.. PMID: 29273340]
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Park,C.H., Lee,J.H., Lee,M.Y., Lee,J.H., Lee,B.H. and Oh,K.S.
  TITLE     A novel role of G protein-coupled receptor kinase 5 in urotensin
            II-stimulated cellular hypertrophy in H9c2UT cells
  JOURNAL   Mol Cell Biochem 422 (1-2), 151-160 (2016)
   PUBMED   27613164
  REMARK    GeneRIF: results suggest that GRK5 may be involved in a
            UII-mediated hypertrophic response via activation of NF-kappaB and
            HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent
            pathways.
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Simon,V., Robin,M.T., Legrand,C. and Cohen-Tannoudji,J.
  TITLE     Endogenous G protein-coupled receptor kinase 6 triggers homologous
            beta-adrenergic receptor desensitization in primary uterine smooth
            muscle cells
  JOURNAL   Endocrinology 144 (7), 3058-3066 (2003)
   PUBMED   12810562
  REMARK    GeneRIF: expression of (K215R)GRK5 had no effect on beta-adrenergic
            signaling in myometrium.
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Fan,X., Zhang,J., Zhang,X., Yue,W. and Ma,L.
  TITLE     Acute and chronic morphine treatments and morphine withdrawal
            differentially regulate GRK2 and GRK5 gene expression in rat brain
  JOURNAL   Neuropharmacology 43 (5), 809-816 (2002)
   PUBMED   12384166
  REMARK    GeneRIF: Acute and chronic morphine treatments and morphine
            withdrawal differentially regulate GRK2 and GRK5 gene expression in
            rat brain
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Yi,X.P., Gerdes,A.M. and Li,F.
  TITLE     Myocyte redistribution of GRK2 and GRK5 in hypertensive,
            heart-failure-prone rats
  JOURNAL   Hypertension 39 (6), 1058-1063 (2002)
   PUBMED   12052842
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Lombardi,M.S., Kavelaars,A., Schedlowski,M., Bijlsma,J.W.,
            Okihara,K.L., Van de Pol,M., Ochsmann,S., Pawlak,C., Schmidt,R.E.
            and Heijnen,C.J.
  TITLE     Decreased expression and activity of G-protein-coupled receptor
            kinases in peripheral blood mononuclear cells of patients with
            rheumatoid arthritis
  JOURNAL   FASEB J 13 (6), 715-725 (1999)
   PUBMED   10094932
REFERENCE   10 (bases 1 to 2308)
  AUTHORS   Nagayama,Y., Tanaka,K., Hara,T., Namba,H., Yamashita,S.,
            Taniyama,K. and Niwa,M.
  TITLE     Involvement of G protein-coupled receptor kinase 5 in homologous
            desensitization of the thyrotropin receptor
  JOURNAL   J Biol Chem 271 (17), 10143-10148 (1996)
   PUBMED   8626574
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030829.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34841.1, BC081792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000001.1  270014336-270014572
            238-333             JAXUCZ010000001.1  270097895-270097990
            334-446             JAXUCZ010000001.1  270139962-270140074
            447-524             JAXUCZ010000001.1  270155702-270155779
            525-625             JAXUCZ010000001.1  270181693-270181793
            626-718             JAXUCZ010000001.1  270182425-270182517
            719-782             JAXUCZ010000001.1  270185110-270185173
            783-923             JAXUCZ010000001.1  270186070-270186210
            924-1114            JAXUCZ010000001.1  270188993-270189183
            1115-1152           JAXUCZ010000001.1  270192038-270192075
            1153-1242           JAXUCZ010000001.1  270193590-270193679
            1243-1451           JAXUCZ010000001.1  270195721-270195929
            1452-1589           JAXUCZ010000001.1  270198627-270198764
            1590-1727           JAXUCZ010000001.1  270202214-270202351
            1728-1859           JAXUCZ010000001.1  270202799-270202930
            1860-2308           JAXUCZ010000001.1  270204278-270204726
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2308
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /note="G protein-coupled receptor kinase 5"
                     /db_xref="GeneID:59075"
                     /db_xref="RGD:61985"
     exon            1..237
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1958
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /EC_number="2.7.11.16"
                     /note="g protein-coupled receptor kinase GRK5"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 5"
                     /protein_id="NP_110456.2"
                     /db_xref="GeneID:59075"
                     /db_xref="RGD:61985"
                     /translation="MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCED
                     LRRTIDRDYYSLCDKQPIGRLLFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKG
                     KEIMTKYLSPKSPVFIAQVGQDLVSQTEKKLLQSPCKELFSACAQSVHDYLKGDPFHE
                     YLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE
                     KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY
                     NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV
                     KIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV
                     KREEVDRRVLETEEVYSPKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRN
                     MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVP
                     IPWQNEMIETECFKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQHQNNSKSS
                     PTPKTSCNHRINSNHINSNSTGSS"
     exon            238..333
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            334..446
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            447..524
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            525..625
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            626..718
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            719..782
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            783..923
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1114
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1152
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1242
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1451
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1589
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1727
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1859
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2308
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcggc tcttcggtgc agagggggaa actccgcggg ctcgtagaaa gaataatgcg
       61 gtagcgaggc aggctgcttg ctctggggtt tggcagcagc ggcggcagct cgagcagcgg
      121 cagcggcatc accccagacg ctgacagccc cgccggccgg ctccctcact gactgccgac
      181 tgtcaatgga gctggaaaac atcgtggcca acacggtctt gctgaaagcc cgggaagggg
      241 gtggaggaaa acgcaaaggg aaaagcaaga agtggaagga aatcctgaag tttcctcaca
      301 tcagccagtg tgaagacctc cggagaacca tagacagaga ttactacagt ctatgtgaca
      361 agcaaccaat tgggagactg ctttttcgac aattctgtga aaccaggcct ggactggagt
      421 gctacattca gttcctggac ttagtggcag aatatgaaat tactccagat gaaaaccttg
      481 gggcaaaggg gaaggaaata atgaccaagt acctctctcc aaagtcccca gtcttcattg
      541 cccaagttgg acaggacctg gtctcccaga cagagaagaa gctcctgcag agcccctgca
      601 aagaactctt ctctgcttgt gctcagtctg tccatgacta cttgaaggga gaccccttcc
      661 acgagtacct ggacagcatg tattttgacc gttttctgca gtggaaatgg ttagaaagac
      721 aaccagtgac caaaaacact ttccggcagt accgagtgct gggcaaaggg ggctttggag
      781 aggtttgtgc ctgccaggtt cgggccactg gtaaaatgta tgcttgcaaa cgcttagaga
      841 agaagaggat caaaaaaagg aaaggagagt ccatggcact caatgaaaag cagattcttg
      901 agaaagtcaa cagccagttt gtggtcaacc tggcctatgc ctacgagacc aaagatgcac
      961 tgtgcttggt tctgaccatt atgaatggag gtgacctgaa gtttcacatc tacaacatgg
     1021 gaaatcctgg ctttgaggaa gaacgagcct tgttttatgc agctgagatc ctctgtggcc
     1081 tggaagactt acaccgtgag aacactgtct atagagatct aaaaccagaa aacatcttgc
     1141 tggatgatta tggccacatc aggatctcag acctaggact ggctgtgaag atccctgagg
     1201 gggaccttat ccgtggccgg gtaggcactg ttggctacat ggccccagaa gttctgaaca
     1261 accagcgata tggcctgagc cctgactact ggggcctggg ctgcctcatc tatgagatga
     1321 tcgagggcca gtcaccattc cgaggccgca aggagaaggt gaagcgggaa gaggtggatc
     1381 gccgggtgct ggagactgag gaagtgtatt cccccaagtt ctctgaagag gccaagtcca
     1441 tctgcaacat gctgctcacc aaagactcga agcagaggct gggctgccag gaggaggggg
     1501 ctgccgaggt caagaggcac cccttcttca ggaacatgaa ctttaaacgc ctggaggctg
     1561 ggatgttgga ccctcccttc gttccagatc cccgggctgt atactgcaag gatgtgctgg
     1621 acatagagca gttctccact gtgaaaggtg tcaacttgga ccatacggac gatgacttct
     1681 actcaaagtt ctccacaggc tctgtgccaa tcccatggca aaacgagatg atagaaacag
     1741 aatgtttcaa ggagctgaat gtgttcggac ccaacggtac cctctcacca gacctgaaca
     1801 gaagtcagcc tccagaacca ccaaagaaag ggctgttcca cagactcttc aggcgtcagc
     1861 atcaaaacaa ttccaagagt tcacctactc ctaagaccag ttgtaaccac cgcataaatt
     1921 caaaccacat caattcaaac tccactggaa gcagctagtt tcagctctgg ccttgaagtc
     1981 aaaagtggaa ccagctcaga gccttctact tggaagcaga acttgtaacc aggggagctc
     2041 ccactgtggc tcagtggcca ggaaagctcc actgggaacc aggataggat actgttcccc
     2101 caataacaaa cctccaagtt tctcaaagaa atttccactc aggtctgttt tccaaggtgg
     2161 ccccaagctg gggtggacta gaattttcct tgttgaacat tgcaatagaa acacaatggg
     2221 atatgacagc ttgcacggat tttaatagca tcccaactag aactgaattt tgtctttatt
     2281 atttttaaag gaaagttttg taaatttc
//
