LOCUS       NM_022928               1997 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor kinase 4 (Grk4), mRNA.
ACCESSION   NM_022928
VERSION     NM_022928.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Zhang,Y., Wang,S., Huang,H., Zeng,A., Han,Y., Zeng,C., Zheng,S.,
            Ren,H., Wang,Y., Huang,Y., Jose,P.A., Ma,X.L., Zeng,C. and Chen,K.
  TITLE     GRK4-mediated adiponectin receptor-1 phosphorylative
            desensitization as a novel mechanism of reduced renal sodium
            excretion in hypertension
  JOURNAL   Clin Sci (Lond) 134 (18), 2453-2467 (2020)
   PUBMED   32940654
  REMARK    GeneRIF: GRK4-mediated adiponectin receptor-1 phosphorylative
            desensitization as a novel mechanism of reduced renal sodium
            excretion in hypertension.
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Yang,Y., Li,M., Zou,X., Chen,C., Zheng,S., Fu,C., Chen,K.,
            Jose,P.A., Lan,C. and Liu,Y.
  TITLE     Role of GRK4 in the regulation of the renal ETB receptor in
            hypertension
  JOURNAL   FASEB J 34 (9), 11594-11604 (2020)
   PUBMED   32687659
  REMARK    GeneRIF: Role of GRK4 in the regulation of the renal ETB receptor
            in hypertension.
            Erratum:[FASEB J. 2021 Apr;35(4):e21429. PMID: 33734484]
REFERENCE   3  (bases 1 to 1997)
  AUTHORS   Chougule,R.A., P,S., Salimath,B.P. and Sosalegowda,A.H.
  TITLE     Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced
            angiogenesis by interacting with G protein-coupled receptor kinase
  JOURNAL   Appl Biochem Biotechnol 171 (2), 366-381 (2013)
   PUBMED   23839509
  REMARK    GeneRIF: Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced
            angiogenesis by interacting with G protein-coupled receptor kinase
REFERENCE   4  (bases 1 to 1997)
  AUTHORS   Wang,F.L., Tang,L.Q., Yang,F., Zhu,L.N., Cai,M. and Wei,W.
  TITLE     Renoprotective effects of berberine and its possible molecular
            mechanisms in combination of high-fat diet and low-dose
            streptozotocin-induced diabetic rats
  JOURNAL   Mol Biol Rep 40 (3), 2405-2418 (2013)
   PUBMED   23196710
REFERENCE   5  (bases 1 to 1997)
  AUTHORS   Kuwasako,K., Kitamura,K., Nagata,S., Hikosaka,T. and Kato,J.
  TITLE     Function of the cytoplasmic tail of human calcitonin receptor-like
            receptor in complex with receptor activity-modifying protein 2
  JOURNAL   Biochem Biophys Res Commun 392 (3), 380-385 (2010)
   PUBMED   20074556
REFERENCE   6  (bases 1 to 1997)
  AUTHORS   Speirs,H.J., Katyk,K., Kumar,N.N., Benjafield,A.V., Wang,W.Y. and
            Morris,B.J.
  TITLE     Association of G-protein-coupled receptor kinase 4 haplotypes, but
            not HSD3B1 or PTP1B polymorphisms, with essential hypertension
  JOURNAL   J Hypertens 22 (5), 931-936 (2004)
   PUBMED   15097232
REFERENCE   7  (bases 1 to 1997)
  AUTHORS   Iacovelli,L., Salvatore,L., Capobianco,L., Picascia,A.,
            Barletta,E., Storto,M., Mariggio,S., Sallese,M., Porcellini,A.,
            Nicoletti,F. and De Blasi,A.
  TITLE     Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in
            agonist-stimulated metabotropic glutamate receptor 1
            internalization and activation of mitogen-activated protein kinases
  JOURNAL   J Biol Chem 278 (14), 12433-12442 (2003)
   PUBMED   12519791
REFERENCE   8  (bases 1 to 1997)
  AUTHORS   Sallese,M., Salvatore,L., D'Urbano,E., Sala,G., Storto,M.,
            Launey,T., Nicoletti,F., Knopfel,T. and De Blasi,A.
  TITLE     The G-protein-coupled receptor kinase GRK4 mediates homologous
            desensitization of metabotropic glutamate receptor 1
  JOURNAL   FASEB J 14 (15), 2569-2580 (2000)
   PUBMED   11099476
REFERENCE   9  (bases 1 to 1997)
  AUTHORS   Premont,R.T., Macrae,A.D., Aparicio,S.A., Kendall,H.E., Welch,J.E.
            and Lefkowitz,R.J.
  TITLE     The GRK4 subfamily of G protein-coupled receptor kinases.
            Alternative splicing, gene organization, and sequence conservation
  JOURNAL   J Biol Chem 274 (41), 29381-29389 (1999)
   PUBMED   10506199
REFERENCE   10 (bases 1 to 1997)
  AUTHORS   Virlon,B., Firsov,D., Cheval,L., Reiter,E., Troispoux,C.,
            Guillou,F. and Elalouf,J.M.
  TITLE     Rat G protein-coupled receptor kinase GRK4: identification,
            functional expression, and differential tissue distribution of two
            splice variants
  JOURNAL   Endocrinology 139 (6), 2784-2795 (1998)
   PUBMED   9607785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X97568.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022928.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1997
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /note="G protein-coupled receptor kinase 4"
                     /db_xref="GeneID:59077"
                     /db_xref="RGD:61858"
     exon            1..240
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1916
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /EC_number="2.7.11.16"
                     /note="g protein-coupled receptor kinase GRK4; G
                     protein-coupled receptor kinase 2, groucho gene related"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 4"
                     /protein_id="NP_075217.1"
                     /db_xref="GeneID:59077"
                     /db_xref="RGD:61858"
                     /translation="MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDL
                     RHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGL
                     SIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEE
                     YQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE
                     KKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIY
                     NLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLAL
                     EIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKV
                     NREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKD
                     INFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVT
                     IPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAH
                     SEEREPTEH"
     exon            241..333
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            334..446
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            447..521
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            522..628
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            629..721
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            722..785
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            786..926
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1117
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1155
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1245
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1454
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1592
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1730
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1865
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1997
                     /gene="Grk4"
                     /gene_synonym="Gprk2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggaggag gaggcgacag aggcggtcaa gcatcccgaa gccctgtagc tcaaaggaca
       61 agggatgccc ggagggtgca ccagtggcgt taggatctcc tccccggcag ccttccctgc
      121 ctcaattgcc tggacccaga aaagttcgac gccggaaacc gcggcatcga cggcgcaggc
      181 gggggatcat ggaactggag aacttcatgg ccaacacttt gttgctgaag gctcgtcaag
      241 gatttaccaa aaagactggt cgcagtaaaa agtggagaga gctcctgaag ttgcccccag
      301 tcagcatgtg cagtgactta cgacactcca tcgaaaagga ttttagcagt ctttgtgacc
      361 aacagccaat cggaagactt cttttcagac aattctgtaa tacgaaacca gatctaaaga
      421 ggtgcattga attcttggat gcagcggcag agtatgaagt taccatcgaa gaggaacaaa
      481 gagaatttgg actatccatc tacagtagat tcttcaaaga gaattcagaa gtctccttac
      541 cacagatacc tccagatctt gtgaaggagt gtaaatgcaa tctgaagcag agttctccct
      601 ctcaaaatgt gttccaggac tgtgctggag ttatctataa gtatttgagt gaaaaaccat
      661 ttgaagaata ccaagagagt acatactata atcgattttt acaatggaaa tggctagaaa
      721 ggcgtccagt aacaaagaac acattcagac aatacagagt tttaggaaaa ggcggatttg
      781 gagaggtttg tgcctgtcaa gtgcgagcta caggaaaaat gtatgcctgc aaaaaactag
      841 aaaaaaaaag aataaagaag aggaaaggtg aagccatggc tctgaatgaa aaaagaatct
      901 tagaaaaatt gcatagtaga tttgtagtta gtttagccta cacttatgaa accaaggatg
      961 ctttgtgttt ggtgctaacc attatgaatg gaggggattt gaagtaccac atttacaacc
     1021 tgggcaatcc tggctttgag gagcagagag ctgtgttcta tgctgcagag ctgtgctgtg
     1081 gcttggaaga tttacagagg gaaagaattg tatacagaga cctaaaacca gagaatatcc
     1141 tccttgatga tcatggacac atccgaattt cagatcttgg tctagctctg gaaatcccag
     1201 aaggggagat ggttcgagga agagttggta ctgttggcta catggctcca gaaattatca
     1261 gtcatgaaaa gtatacattt agtcctgatt ggtggggact tggctgtctg atatatgaaa
     1321 tgattgcggg acattctcca ttcagaaaat ataaagaaaa agtcaaccgg gaggaaatgg
     1381 aaagaagagt gaagactgaa actgaggagt actctgagag gttttcagag aatgccaagt
     1441 ccatctgcag catgttactt accaaggatc caagtaaaag gctgggctgc cagagtgatg
     1501 gagcctctgc tgtaaagcag cacccaatat tcaaggatat taacttcagc agactggaag
     1561 caaatatgtt agacccacct ttctgtcctg atcctgaggc catttattgt aaggatatct
     1621 tggatattgg acagttctct gtggtgaaag gagtcaacct ggacaccaat gatgagatct
     1681 tctacactca atttgcgaca gggtgtgtca ccattccctg gcagaatgag atgattgaat
     1741 ctggatgttt caaggacctc aatgaatatg aagataaagg tctgtcacca cttgaaaaac
     1801 acaagatatg ttcctgtatt cttagaccaa agagaaactt cttccataga ctcttcagaa
     1861 gagcggcctg cctgaacatt gcccacagtg aggagaggga gccaacagaa cactgaccat
     1921 tcactgtgca gaccacaaag caagaccctg gtgttaagaa ggaatctgtc acatacccag
     1981 tgtcttgtcc tttccat
//
