LOCUS       NM_012897               2374 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), mRNA.
ACCESSION   NM_012897 XM_346861
VERSION     NM_012897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2374)
  AUTHORS   Hejnova,L., Skrabalova,J. and Novotny,J.
  TITLE     Prolonged Morphine Treatment Alters Expression and Plasma Membrane
            Distribution of beta-Adrenergic Receptors and Some Other Components
            of Their Signaling System in Rat Cerebral Cortex
  JOURNAL   J Mol Neurosci 63 (3-4), 364-376 (2017)
   PUBMED   29081032
REFERENCE   2  (bases 1 to 2374)
  AUTHORS   Monto,F., Oliver,E., Vicente,D., Buendia,F., Rueda,J., Aguero,J.,
            Almenar,L., Valldecabres,C., Rovira,E., Muedra,V., Noguera,M.A.,
            Ivorra,M.D. and D'Ocon,P.
  TITLE     beta2- and beta1-Adrenoceptor Expression Exhibits a Common
            Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of
            Cardiovascular Diseases
  JOURNAL   J Cardiovasc Pharmacol 66 (5), 478-486 (2015)
   PUBMED   26248277
REFERENCE   3  (bases 1 to 2374)
  AUTHORS   Ahmed,M.R., Bychkov,E., Li,L., Gurevich,V.V. and Gurevich,E.V.
  TITLE     GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of
            Parkinson's disease via its RGS homology domain
  JOURNAL   Sci Rep 5, 10920 (2015)
   PUBMED   26043205
  REMARK    GeneRIF: Our findings reveal a novel mechanism of GRK3 control of
            the dopamine receptor signaling and the role of Gq in LID.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2374)
  AUTHORS   Tarrant,T.K., Billard,M.J., Timoshchenko,R.G., McGinnis,M.W.,
            Serafin,D.S., Foreman,O., Esserman,D.A., Chao,N.J., Lento,W.E.,
            Lee,D.M., Patel,D. and Siderovski,D.P.
  TITLE     G protein-coupled receptor kinase-3-deficient mice exhibit WHIM
            syndrome features and attenuated inflammatory responses
  JOURNAL   J Leukoc Biol 94 (6), 1243-1251 (2013)
   PUBMED   23935208
  REMARK    GeneRIF: the loss of GRK3-mediated regulation of CXCL12/CXCR4
            signaling contributes to some, but not all, of the complete WHIM
            phenotype and that GRK3 inhibition may be beneficial in the
            treatment of inflammatory arthritis.
REFERENCE   5  (bases 1 to 2374)
  AUTHORS   Alvaro-Bartolome,M. and Garcia-Sevilla,J.A.
  TITLE     Dysregulation of cannabinoid CB1 receptor and associated signaling
            networks in brains of cocaine addicts and cocaine-treated rodents
  JOURNAL   Neuroscience 247, 294-308 (2013)
   PUBMED   23727505
REFERENCE   6  (bases 1 to 2374)
  AUTHORS   Walensky,L.D., Roskams,A.J., Lefkowitz,R.J., Snyder,S.H. and
            Ronnett,G.V.
  TITLE     Odorant receptors and desensitization proteins colocalize in
            mammalian sperm
  JOURNAL   Mol Med 1 (2), 130-141 (1995)
   PUBMED   8529092
REFERENCE   7  (bases 1 to 2374)
  AUTHORS   Boekhoff,I., Inglese,J., Schleicher,S., Koch,W.J., Lefkowitz,R.J.
            and Breer,H.
  TITLE     Olfactory desensitization requires membrane targeting of receptor
            kinase mediated by beta gamma-subunits of heterotrimeric G proteins
  JOURNAL   J Biol Chem 269 (1), 37-40 (1994)
   PUBMED   8276821
REFERENCE   8  (bases 1 to 2374)
  AUTHORS   Schleicher,S., Boekhoff,I., Arriza,J., Lefkowitz,R.J. and Breer,H.
  TITLE     A beta-adrenergic receptor kinase-like enzyme is involved in
            olfactory signal termination
  JOURNAL   Proc Natl Acad Sci U S A 90 (4), 1420-1424 (1993)
   PUBMED   8381966
REFERENCE   9  (bases 1 to 2374)
  AUTHORS   Arriza,J.L., Dawson,T.M., Simerly,R.B., Martin,L.J., Caron,M.G.,
            Snyder,S.H. and Lefkowitz,R.J.
  TITLE     The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are
            widely distributed at synapses in rat brain
  JOURNAL   J Neurosci 12 (10), 4045-4055 (1992)
   PUBMED   1403099
REFERENCE   10 (bases 1 to 2374)
  AUTHORS   Benovic,J.L., Onorato,J.J., Arriza,J.L., Stone,W.C., Lohse,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Caron,M.G. and
            Lefkowitz,R.J.
  TITLE     Cloning, expression, and chromosomal localization of
            beta-adrenergic receptor kinase 2. A new member of the receptor
            kinase family
  JOURNAL   J Biol Chem 266 (23), 14939-14946 (1991)
   PUBMED   1869533
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000229.1.
            
            [WARNING] On Mar 29, 2024 this sequence was replaced by
            NM_012897.4.
            
            On Nov 27, 2020 this sequence version replaced NM_012897.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JACYVU010000229.1  6220703-6220818
            117-193             JACYVU010000229.1  6251434-6251510
            194-267             JACYVU010000229.1  6267692-6267765
            268-369             JACYVU010000229.1  6273037-6273138
            370-444             JACYVU010000229.1  6275198-6275272
            445-506             JACYVU010000229.1  6280026-6280087
            507-558             JACYVU010000229.1  6284199-6284250
            559-650             JACYVU010000229.1  6286317-6286408
            651-750             JACYVU010000229.1  6287835-6287934
            751-829             JACYVU010000229.1  6295371-6295449
            830-960             JACYVU010000229.1  6296960-6297090
            961-1055            JACYVU010000229.1  6301144-6301238
            1056-1163           JACYVU010000229.1  6304870-6304977
            1164-1230           JACYVU010000229.1  6313809-6313875
            1231-1331           JACYVU010000229.1  6314773-6314873
            1332-1398           JACYVU010000229.1  6317857-6317923
            1399-1494           JACYVU010000229.1  6319100-6319195
            1495-1657           JACYVU010000229.1  6321814-6321976
            1658-1794           JACYVU010000229.1  6323186-6323322
            1795-1908           JACYVU010000229.1  6325553-6325666
            1909-2374           JACYVU010000229.1  6326600-6327065
FEATURES             Location/Qualifiers
     source          1..2374
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2374
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /note="G protein-coupled receptor kinase 3"
                     /db_xref="GeneID:25372"
                     /db_xref="RGD:2063"
     exon            1..116
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..2070
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /EC_number="2.7.11.15"
                     /note="adrenergic receptor kinase, beta 2
                     (G-protein-linked receptor kinase); beta-adrenergic
                     receptor kinase 2; beta-ARK-2; beta ARK2; adrenergic,
                     beta, receptor kinase 2"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 3"
                     /protein_id="NP_037029.2"
                     /db_xref="GeneID:25372"
                     /db_xref="RGD:2063"
                     /translation="MADLEAVLADVSYLMAMEKSKAAPAARASKKVVLPEPSIRSVMQ
                     RYLAERNEITFDKIFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRL
                     HRSRQMYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTPTLFQPYIEEICESLRGD
                     IFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYA
                     MKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNG
                     GDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRIS
                     DLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFR
                     QHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCCGGGARELKEH
                     IFFKGIDWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKN
                     FPLVISERWQQEVVETIYDAVNAETDKIEARKKAKNKQLCQEEDYAMGKDCIMHGYML
                     KLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQIMSVEETQIKDRKCILLRV
                     KGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCH
                     RNSSGL"
     exon            117..193
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            194..267
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..369
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..444
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..506
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..558
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..650
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..750
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..829
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..960
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1055
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1163
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1230
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1331
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1398
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1494
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1657
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1794
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1908
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2374
                     /gene="Grk3"
                     /gene_synonym="Adrbk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatggcgg acctggaggc cgtgctggcc gacgtcagct acctgatggc catggagaag
       61 agcaaggcgg cgccggccgc gcgcgccagc aagaaggtcg tcctgccgga gcccagtatc
      121 cggagtgtga tgcagaggta tctggcagaa agaaacgaaa taacctttga caagattttc
      181 aatcagaaaa tcggcttcct gctatttaaa gatttctgct tgaatgaaat cggtgaagcg
      241 gtgcctcagg tgaaatttta tgaagagata aaggaatacg agaaactgga caacgaagaa
      301 gaccggctgc accggagtcg gcagatgtac gacgcctaca tcatgaggga gcttctgtcc
      361 agcacacacc aattctcaaa gcaagctgta gaacatgtcc agagccatct ctccaagaag
      421 caggtgacgc ctaccctttt tcagccgtac atagaagaaa tctgcgaaag ccttcgaggc
      481 gacatcttcc aaaagtttat ggaaagcgaa aaattcacta gattctgtca gtggaagaat
      541 gtggaattga atattcacct gagcatgaac gacttcagtg tgcacaggat catcggccga
      601 ggagggtttg gggaagttta cggctgcagg aaagcagaca ccgggaaaat gtatgccatg
      661 aagtgcttag acaagaagag agtgaagatg aaacagggag agacactggc tttgaacgag
      721 aggatcatgt tgtctctcgt cagcactggg gactgtccct tcattgtctg catgacctat
      781 gccttccaca caccagacaa actctgcttc atcctggacc tgatgaacgg gggcgacatg
      841 cactaccacc tctcccagca cggggtgttc tctgagaagg agatgcgatt ttatgccagc
      901 gagatcatcc tgggcctcga gcacatgcac acctgctttg tagtctacag agacctgaag
      961 cctgcgaaca tcctcctgga tgaatatggg catgtgagga tatcggatct tggcctggcc
     1021 tgcgatttct ctaaaaagaa gcctcacgcc agtgtgggca cccatgggta catggctccc
     1081 gaggtgttgc agaaggggac atgctacgac agcagcgccg actggttctc cctgggctgc
     1141 atgctcttca agctcctgcg gggccacagc cctttcaggc agcataaaac caaagacaag
     1201 catgagatag accgcatgac cctgaccgtg aacgtgcagc ttccagatgc cttctcccct
     1261 gagctgaggt ccctcttgga gggtttgctc cagcgggatg tgagccagcg actgggctgc
     1321 tgcggaggag gggcacgaga gttgaaggag cacatcttct tcaagggcat cgactggcag
     1381 tatgtgtact tacggaagta cccgccaccc ctaatccctc ctcggggaga ggtcaatgcc
     1441 gcagacgcct ttgatattgg ctcgtttgat gaagaagata ccaaaggcat taagctgttg
     1501 gactgcgacc aggacctcta taagaacttc ccgctggtga tttctgagcg ctggcagcag
     1561 gaagtagtgg agaccatcta cgacgccgtc aatgccgaaa ctgataaaat tgaggccagg
     1621 aagaaggcta aaaataaaca gctttgtcaa gaagaagatt atgccatggg gaaggactgc
     1681 atcatgcacg gatacatgct gaagctgggg aacccctttc tcacacagtg gcaaagacgt
     1741 tatttttacc tgtttcccaa cagactggag tggagaggag agggcgagtc tcggcaaaat
     1801 ctactgacca tggaacagat catgtctgtg gaggagaccc aaattaaaga cagaaaatgc
     1861 attttactca gggtaaaagg agggaagcag tttgttttgc aatgtgagag tgaccccgag
     1921 tttgcacagt ggctgaaaga gctgacgtgc accttcaacg aggcccagag actgctgcgc
     1981 cgcgccccca agttcctcaa caaaccacgt gccgccatcc tggagttctc caagccaccg
     2041 ctgtgtcaca gaaatagcag cggcctctga accacagagc agcagggcct gaaggaggcc
     2101 cccccccccc cggctcttca gcccagcagt ggaatggagc cacggggaac cgtgtggggc
     2161 tgagacacag tggctctgag cactgggctg ctccaggctg aggaggccca caacaccggg
     2221 gtggcccttc aggaactagg acatccttgg ggctggccta tccacactcg aaattactga
     2281 agaagcagag gcatttttct gtgcaaccct ctcactttgg tatccatgga cccagaacgt
     2341 aaaatggttc ttacctctca agcttttatg tctg
//
