LOCUS       NM_031096               2157 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor kinase 1 (Grk1), mRNA.
ACCESSION   NM_031096 XM_346493
VERSION     NM_031096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Hu,J., Qiu,J., Zheng,Y., Zhang,T., Yin,T., Xie,X. and Wang,G.
  TITLE     AAMP Regulates Endothelial Cell Migration and Angiogenesis Through
            RhoA/Rho Kinase Signaling
  JOURNAL   Ann Biomed Eng 44 (5), 1462-1474 (2016)
   PUBMED   26350504
  REMARK    GeneRIF: AAMP Regulates Endothelial Cell Migration and Angiogenesis
            Through RhoA/Rho Kinase Signaling.
            Erratum:[Ann Biomed Eng. 2016 Mar;44(3):830-2. doi:
            10.1007/s10439-015-1537-7.. PMID: 26715208]
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Moreno-Dominguez,A., El-Yazbi,A.F., Zhu,H.L., Colinas,O.,
            Zhong,X.Z., Walsh,E.J., Cole,D.M., Kargacin,G.J., Walsh,M.P. and
            Cole,W.C.
  TITLE     Cytoskeletal reorganization evoked by Rho-associated kinase- and
            protein kinase C-catalyzed phosphorylation of cofilin and heat
            shock protein 27, respectively, contributes to myogenic
            constriction of rat cerebral arteries
  JOURNAL   J Biol Chem 289 (30), 20939-20952 (2014)
   PUBMED   24914207
  REMARK    GeneRIF: Cytoskeletal reorganization evoked by Rho-associated
            kinase- and protein kinase C-catalyzed phosphorylation of cofilin
            and heat shock protein 27, respectively, contributes to myogenic
            constriction of rat cerebral arteries.
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Gurevich,E.V., Tesmer,J.J., Mushegian,A. and Gurevich,V.V.
  TITLE     G protein-coupled receptor kinases: more than just kinases and not
            only for GPCRs
  JOURNAL   Pharmacol Ther 133 (1), 40-69 (2012)
   PUBMED   21903131
  REMARK    Review article
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Hagstrom,S.A., Watson,R.F., Pauer,G.J. and Grossman,G.H.
  TITLE     Tulp1 is involved in specific photoreceptor protein transport
            pathways
  JOURNAL   Adv Exp Med Biol 723, 783-789 (2012)
   PUBMED   22183407
REFERENCE   5  (bases 1 to 2157)
  AUTHORS   Phrommintikul,A., Tran,L., Kompa,A., Wang,B., Adrahtas,A.,
            Cantwell,D., Kelly,D.J. and Krum,H.
  TITLE     Effects of a Rho kinase inhibitor on pressure overload induced
            cardiac hypertrophy and associated diastolic dysfunction
  JOURNAL   Am J Physiol Heart Circ Physiol 294 (4), H1804-H1814 (2008)
   PUBMED   18245565
REFERENCE   6  (bases 1 to 2157)
  AUTHORS   Zhao,X., Haeseleer,F., Fariss,R.N., Huang,J., Baehr,W., Milam,A.H.
            and Palczewski,K.
  TITLE     Molecular cloning and localization of rhodopsin kinase in the
            mammalian pineal
  JOURNAL   Vis Neurosci 14 (2), 225-232 (1997)
   PUBMED   9147475
REFERENCE   7  (bases 1 to 2157)
  AUTHORS   Yamamoto,S., Sippel,K.C., Berson,E.L. and Dryja,T.P.
  TITLE     Defects in the rhodopsin kinase gene in the Oguchi form of
            stationary night blindness
  JOURNAL   Nat Genet 15 (2), 175-178 (1997)
   PUBMED   9020843
REFERENCE   8  (bases 1 to 2157)
  AUTHORS   Anant,J.S. and Fung,B.K.
  TITLE     In vivo farnesylation of rat rhodopsin kinase
  JOURNAL   Biochem Biophys Res Commun 183 (2), 468-473 (1992)
   PUBMED   1550556
REFERENCE   9  (bases 1 to 2157)
  AUTHORS   Palczewski,K., Carruth,M.E., Adamus,G., McDowell,J.H. and
            Hargrave,P.A.
  TITLE     Molecular, enzymatic and functional properties of rhodopsin kinase
            from rat pineal gland
  JOURNAL   Vision Res 30 (8), 1129-1137 (1990)
   PUBMED   2402884
REFERENCE   10 (bases 1 to 2157)
  AUTHORS   Ho,A.K., Somers,R.L. and Klein,D.C.
  TITLE     Development and regulation of rhodopsin kinase in rat pineal and
            retina
  JOURNAL   J Neurochem 46 (4), 1176-1179 (1986)
   PUBMED   3950623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U63971.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346493.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2157
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /note="G protein-coupled receptor kinase 1"
                     /db_xref="GeneID:81760"
                     /db_xref="RGD:619712"
     exon            1..883
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1879
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /EC_number="2.7.11.14"
                     /note="RK; G protein-coupled receptpr kinase 1"
                     /codon_start=1
                     /product="rhodopsin kinase GRK1"
                     /protein_id="NP_112358.1"
                     /db_xref="GeneID:81760"
                     /db_xref="RGD:619712"
                     /translation="MDFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPL
                     SKCEGLRDSISLEFDNLCSEQPIGKRLFQQFLKTDERHVPALELWKDIEDYDTADDDL
                     RPQKAQAILAEYLDPQGTLFCNFLDQGMVARVKEGPTGSQDGLFQPLLQATLEHLSQG
                     PFQEYLGSLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYAC
                     KKLNKKRLKKRKGYQGAIVEKRILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVR
                     YHIYNVDEENPGFPEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRIS
                     DLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPF
                     RARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALR
                     ANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQE
                     FASGNCSIPWQEEMIETGFFGDLNVWRPDGQMPDDMKGITVEEAAPTAKSGMCLIS"
     exon            884..1011
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1169
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1253
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1378
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1580
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2117
                     /gene="Grk1"
                     /gene_synonym="Rhok"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggccatt cggtgggatc ccaagcaccc tggccacggc cgtgtgcctc cctttgtccc
       61 acaagggcag gaacaggcca taggccaagg gcaccaggtc aagcctgctt tggctgctgg
      121 tgccttgagc ttgacttcag cttatgggtc ttaacacttg aagtggacac agggcatcag
      181 caggatggat ttcgggtcct tggaaaccgt ggtggccaac tctgccttca ttgcggcccg
      241 aggcagcttt gacggaagca gcaccccctc ttcccgagac aagaagtatc tggccaagct
      301 ccggttgccc ccactgtcca agtgtgaggg tctccgtgac agcatcagcc tagagtttga
      361 caacctgtgc tcggagcagc ccattggcaa gaggctcttc cagcagttcc tgaagacaga
      421 cgagaggcat gtgccggctc tggagctctg gaaggacatc gaggactatg acactgccga
      481 tgacgaccta cggccacaga aggctcaggc catcctggct gagtacctgg acccacaggg
      541 cacactcttc tgcaacttcc tggaccaggg catggtggca agagtgaagg aagggccaac
      601 tgggagccag gatgggctct tccagcctct gctgcaggcc acactggagc acttgagtca
      661 gggccccttc caggagtacc tgggaagcct atatttcctg cggtttcttc agtggaagtg
      721 gttggaagcc cagcccatag gtgaagactg gtttttggac ttcagggtcc tggggaaggg
      781 gggctttggg gaagtgtccg cctgccaaat gaaggcgacc ggcaagatgt acgcttgcaa
      841 gaagctgaac aagaagcggc tgaagaagag gaaggggtac cagggcgcca tcgttgagaa
      901 gaggattcta gctaaagtac acagcaggtt catcgtgtct ctggcctatg cattcgaaac
      961 caagaccgac ctctgtctgg tgatgaccat catgaatgga ggtgacgtaa ggtaccacat
     1021 ctacaatgtg gatgaggaga accccggctt tccggagcca cgagccatct actacacagc
     1081 acagatcatc agtggcctgg agcacctgca tcagagacgc attgtctacc gtgacctcaa
     1141 gccagagaac gtgctgctgg acaacgatgg caacatccga atttctgacc ttggactggc
     1201 cgtcgagttg aaggaagggc agaataagac caagggctat gcagggaccc caggtttcat
     1261 ggcccccgag ctcctgcgag gcgaagagta cgacttctct gtggactact ttgccctggg
     1321 ggtcacattg tacgagatga tcgcagccag aggacccttc cgagcccgag gagagaaggt
     1381 ggagaacaag gagcttaaac agcgcatcat ctcagagccc gtgaagtacc cagagaagtt
     1441 cagccaggcc agcaaggact tctgtgagca gctgttagag aaggacccgg agaagcgcct
     1501 gggtttccgg gatggaacct gtgacgccct aagggcgaat gtcctcttca aagatatcag
     1561 ctggagacag ctcgaagccg gaatgctcat ccctccgttc atcccagact ctaggactgt
     1621 ctatgccaag aacattcagg atgtgggtgc cttttccaca gtcaagggtg tggtttttga
     1681 caaagcagac acagaattct tccaagaatt cgcctccggc aactgctcca ttccctggca
     1741 ggaggagatg attgagactg ggttcttcgg ggacctcaac gtgtggcgcc cagacggtca
     1801 aatgcccgat gacatgaagg gaatcaccgt ggaggaggca gcccctacag ccaaatcagg
     1861 gatgtgtctc atctcctagc ctagtgtttg ggggaagcct ggggctggct gtatagagag
     1921 agggaaggat acagagctca ggggaggaga gtgaccctgg tgtcagcctg tgcccactcc
     1981 atccaggtca ccatgcaact gtgtcttcac aaggagccag caagaatccc ggtttagacc
     2041 ctagaagcat ggcagtccat tttttttgtc ctgattcatt caaaaaagac aaaaaaaggc
     2101 cacagattga acaataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
