LOCUS       NM_138535               5179 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus glutamate receptor interacting protein 2 (Grip2),
            mRNA.
ACCESSION   NM_138535
VERSION     NM_138535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5179)
  AUTHORS   Fouillade,C., Baron-Menguy,C., Domenga-Denier,V., Thibault,C.,
            Takamiya,K., Huganir,R. and Joutel,A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   2  (bases 1 to 5179)
  AUTHORS   Mao,L., Takamiya,K., Thomas,G., Lin,D.T. and Huganir,R.L.
  TITLE     GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via
            exocyst complex interactions
  JOURNAL   Proc Natl Acad Sci U S A 107 (44), 19038-19043 (2010)
   PUBMED   20956289
  REMARK    GeneRIF: GRIP1 and 2 regulate activity-dependent AMPA receptor
            recycling via exocyst complex interactions.
REFERENCE   3  (bases 1 to 5179)
  AUTHORS   Misra,C., Restituito,S., Ferreira,J., Rameau,G.A., Fu,J. and
            Ziff,E.B.
  TITLE     Regulation of synaptic structure and function by palmitoylated AMPA
            receptor binding protein
  JOURNAL   Mol Cell Neurosci 43 (4), 341-352 (2010)
   PUBMED   20083202
  REMARK    GeneRIF: postsynaptic palmitoylated ABP induces pre and
            postsynaptic changes that are dependent on palmitoylation and
            likely achieved through ABP association with a multi-molecular cell
            surface signaling complex.
REFERENCE   4  (bases 1 to 5179)
  AUTHORS   Marsden,K.C., Beattie,J.B., Friedenthal,J. and Carroll,R.C.
  TITLE     NMDA receptor activation potentiates inhibitory transmission
            through GABA receptor-associated protein-dependent exocytosis of
            GABA(A) receptors
  JOURNAL   J Neurosci 27 (52), 14326-14337 (2007)
   PUBMED   18160640
REFERENCE   5  (bases 1 to 5179)
  AUTHORS   Lu,W. and Ziff,E.B.
  TITLE     PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
  JOURNAL   Neuron 47 (3), 407-421 (2005)
   PUBMED   16055064
REFERENCE   6  (bases 1 to 5179)
  AUTHORS   Dong,H., Zhang,P., Song,I., Petralia,R.S., Liao,D. and Huganir,R.L.
  TITLE     Characterization of the glutamate receptor-interacting proteins
            GRIP1 and GRIP2
  JOURNAL   J Neurosci 19 (16), 6930-6941 (1999)
   PUBMED   10436050
REFERENCE   7  (bases 1 to 5179)
  AUTHORS   Wyszynski,M., Valtschanoff,J.G., Naisbitt,S., Dunah,A.W., Kim,E.,
            Standaert,D.G., Weinberg,R. and Sheng,M.
  TITLE     Association of AMPA receptors with a subset of glutamate
            receptor-interacting protein in vivo
  JOURNAL   J Neurosci 19 (15), 6528-6537 (1999)
   PUBMED   10414981
REFERENCE   8  (bases 1 to 5179)
  AUTHORS   Bruckner,K., Pablo Labrador,J., Scheiffele,P., Herb,A.,
            Seeburg,P.H. and Klein,R.
  TITLE     EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft
            membrane microdomains
  JOURNAL   Neuron 22 (3), 511-524 (1999)
   PUBMED   10197531
REFERENCE   9  (bases 1 to 5179)
  AUTHORS   Srivastava,S., Osten,P., Vilim,F.S., Khatri,L., Inman,G.,
            States,B., Daly,C., DeSouza,S., Abagyan,R., Valtschanoff,J.G.,
            Weinberg,R.J. and Ziff,E.B.
  TITLE     Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA
            receptor-binding protein ABP
  JOURNAL   Neuron 21 (3), 581-591 (1998)
   PUBMED   9768844
REFERENCE   10 (bases 1 to 5179)
  AUTHORS   Nishimune,A., Isaac,J.T., Molnar,E., Noel,J., Nash,S.R., Tagaya,M.,
            Collingridge,G.L., Nakanishi,S. and Henley,J.M.
  TITLE     NSF binding to GluR2 regulates synaptic transmission
  JOURNAL   Neuron 21 (1), 87-97 (1998)
   PUBMED   9697854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF205193.1 and JAXUCZ010000004.1.
            
            On Oct 10, 2007 this sequence version replaced NM_138535.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205193.1, AF072509.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3302              AF205193.1         1-3302
            3303-5179           JAXUCZ010000004.1  125828609-125830485 c
FEATURES             Location/Qualifiers
     source          1..5179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..5179
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /note="glutamate receptor interacting protein 2"
                     /db_xref="GeneID:171571"
                     /db_xref="RGD:621668"
     exon            1..151
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3228
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /note="AMPA receptor-interacting protein GRIP2; GRIP-2;
                     AMPA receptor binding protein"
                     /codon_start=1
                     /product="glutamate receptor-interacting protein 2"
                     /protein_id="NP_612544.2"
                     /db_xref="GeneID:171571"
                     /db_xref="RGD:621668"
                     /translation="MLAVSLKWRLGVVRRRPKDDGPYSKGGKDTAGTDGALVCRRQSI
                     PEEFRGITMVELIKREGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIR
                     SVNGIRLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEG
                     NSFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHA
                     TAIATLQQCSHEALFQVEYDVATPDTVANASGPLVVEIAKTPGSALGISLTTGSHRNK
                     PAITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEIL
                     PAPQSRRPLKPPEAVRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAPGGQDQSRSVS
                     STPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQ
                     IVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVRFIEPDSPAERCGLLQVGD
                     RVLAINGIATEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLPKRR
                     GVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEYA
                     VQILRQCEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPI
                     IISGLTKRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQL
                     DRPLLPRQSGSLSEASDVDEDPPEALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGF
                     GGSGSYTPQVAVRSVTPQEWRSSRLKSSPPPLEPRRTSYTPGPTDESFPEEEEGDWEP
                     PMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTGTVQSVAVDGRPGSR
                     PWRRSREVGTSPEDLQELLLPTPLEMHRVTLHKDPVRNDFGFSVSDGLLEKGVYVHTV
                     RIDGPAQHGGLQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILELVVSRNPLAQSRR
                     TPGAPGPSSPQMI"
     exon            152..232
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            233..368
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            369..514
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            515..601
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..677
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            678..823
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            824..971
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1141
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1264
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1408
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1595
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1741
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1822
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1889
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2035
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2180
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2320
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2500
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2672
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2778
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2922
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3069
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..5179
                     /gene="Grip2"
                     /gene_synonym="Abp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcagag gcgccagctc ccggctccga ggctgcgggg cggctgcagg gaggttgcag
       61 ggctccgggt ctgggacctg ccggcgggca agagtgatgt tggcggtgtc actcaagtgg
      121 cggctgggcg tggtgaggcg gcggcccaaa gacgatgggc cttactcaaa ggggggaaag
      181 gacacagcgg ggactgatgg ggccctggtg tgccgccgcc agagcattcc agaggagttc
      241 cggggcatca ccatggtgga gctgatcaag cgtgagggca gcactctggg cctgactatc
      301 tcaggaggga ctgacaagga cgggaagccc agagtctcca acctgagacc cgggggcctt
      361 gcagccagga gcgatctact gaatgtgggc gactatatcc gctcagtgaa tgggatccgt
      421 ctgacccggc tccgacatga cgagatcatc acattgctga agaatgtggg cgagcgcgtg
      481 gtgctggagg tggagtatga gctgcccccg cccgctcccg aaaacaaccc gaggatcatt
      541 tccaagacgg tggacgtctc cctctacaag gaaggcaaca gttttggctt tgtcctcaga
      601 ggaggtgccc atgaggacct gcacaaatcc cgcccattgg tcctgactta cgtgcggcct
      661 ggtggcccag cagacaggga gggttcctta aaggtgggcg acaggctgct cagcatagat
      721 gggatcccac tgcacggggc cagccatgct accgcaatag ccaccctgca gcagtgcagc
      781 catgaggccc tcttccaggt ggagtacgat gtggccaccc cagacacggt ggccaatgct
      841 tcaggccctt tggtggtaga aatagccaag accccaggat ctgccctggg gatctctctc
      901 accactggct cccaccggaa caaaccagct atcactatcg accgcatcaa gccggctagc
      961 gtggtggaca ggagtggtgc cctgcatgct ggagaccaca tcctggccat cgatggcacc
     1021 agcacagaac actgctctct ggtcgaggcc acgaagctct tggccagtgt gaccgagaaa
     1081 gttcgactgg agatcttgcc tgcaccccag agtcggcggc ccctgaagcc cccagaggca
     1141 gtgagaatac agaggagtga gcaactgcac cactgggacc cctgtgttcc ctcttgccat
     1201 agcccaaggc caagccactg cagggcaccc acctgggcac ctggaggcca ggaccagagc
     1261 cgatccgtgt cctcgactcc cttctcctcg ccaactatga accctgcctt tccctgtgcc
     1321 aacgccagca ccctgcccag aggacccatg agccccagaa caacagcggg gaggagaagg
     1381 cagcgaagga aagaacacag gagctctttg tcactggcct ccagcacggt agggcccggt
     1441 gggcagatcg ttcacacgga gacgacggag gtagtgctct gtggagaccc cctcagtggc
     1501 ttcggcctcc agctgcaggg gggcattttt gctaccgaga ccctgtcctc cccacccttg
     1561 gtgcgattta ttgaacctga cagccctgct gagaggtgtg gtctgctgca ggtgggggac
     1621 cgcgtcctag ccataaatgg cattgctact gaggatggga ccatggagga agccaaccag
     1681 ctgttgcggg atgctgcact ggcccgcaaa gttgttttgg agatcgagtt tgatgtggcg
     1741 gagtctgtca tcccaagcag tgggaccttc cacgtgaagt tacccaaaag gcgtggtgtg
     1801 gagctgggca tcaccattag ctcggccagc agaaagcgag gggaacccct gatcatctct
     1861 gacatcaaga aaggcagcgt ggcgcacagg actggcaccc tcgagccggg cgacaagctg
     1921 ctggccattg acaatattcg cctggaccat tgccccatgg agtatgctgt gcaaatcctg
     1981 cgccaatgtg aggacctggt gaagctgaag atccggaagg acgaggacaa ctcagatgag
     2041 caggagagct cgggcgcagt cagctacaca gtggaactga agcgctatgg cggacccctg
     2101 ggtatcacca tctccggtac agaggaacct tttgacccca tcatcatctc tggtctcacc
     2161 aagcggggtc tggctgaaag gactggagcc atccatgttg gggaccgcat actggccatc
     2221 aacagcgtga gcctcaaggg ccggcccctg agtgaggcca ttcaccttct gcaggtggca
     2281 ggggagactg tcacactgaa gatcaagaag cagctggacc gtccccttct cccccgccag
     2341 tcaggcagcc tcagtgaggc cagtgatgtg gatgaggacc cccctgaggc cctcaaggga
     2401 ggcttgctga caacccactt ctcacctgct gtacccagcg tggacagtgc tgtggagtcc
     2461 tggggcagct ctgccacaga gggtggcttt gggggctcag gctcctacac tccgcaggtg
     2521 gcagtccgga gtgtgactcc tcaggagtgg cgttccagca gactgaagag tagcccccca
     2581 ccccttgagc cccggaggac gagctacaca ccgggcccca ctgacgaaag cttcccagag
     2641 gaggaagagg gggactggga gccaccaatg agcccagccc ctggccccgc ccgagaggag
     2701 ggcttctgga gagtgcttgg agaggccctt gaagacctgg agtcctgtgg tcagtctgaa
     2761 ctgctaaggg agctggaggc ttccatcatg acaggcactg tacagtcggt agctgtggat
     2821 ggcaggcctg gctctcggcc ctggcgccgg agccgggaag tcggaacatc cccggaagac
     2881 ctgcaggagc tgctgttgcc aacgcccctg gagatgcaca gggtgaccct gcacaaagac
     2941 ccggtgagga acgactttgg tttcagtgtc tcagatggcc tcctggagaa gggtgtctat
     3001 gtccacactg tgcgcattga tgggccagct cagcacggag gcctgcagcc ctttgaccgt
     3061 ctcctgcagg tcaaccatgt tcgcactcgg gacttcgatt gctgtctggc cgttccactc
     3121 ctggcagagg ctggggacat ccttgagctg gtggtcagcc gaaaccctct ggcacagagc
     3181 cgcaggacac caggagcacc gggccccagt agtccccaga tgatctgagg tcattatgta
     3241 agtcagctgg cggagtgccc ccagtcatcg acttatggcc tgcagatttc acatccggta
     3301 gagtggcatc ttcaagttgg gtcttcagga tgctcagaga accccacagg aaaggggtca
     3361 tccctgctgc tcagctagga gagcccagct ccctgtgcag tcatctcaga gcagcgaaca
     3421 gagtggggac ggcccagctc cgtgtggtaa ctggactgag ctgccagtat ttcccatcct
     3481 gggaagttaa taagctgtag gtcgacaatt ctgctctgtg gaaagaggca tttggcgacc
     3541 cagctgttca gatggtaccc agtgcacagg gaccctgcca ccgggaaaga tatggcacaa
     3601 gaacagtgtc ctcccttctc ccaaatggtg gtgttttgag agcctccagc acctagtgac
     3661 catactgagg aaccccaatt agggacaatc tagggtgcca gagaatgctt gccccttcct
     3721 ttgggttggt ctttcaatta tttcacgggt gattctgaac ctcagagcag aactgtggcc
     3781 atcaaccctc ctgtcccaca aaaccttagc ccaagtcctt gcccagagga gggcacagct
     3841 cgggtcaaac ggtccaggag catccacaca cctgccattc cagcacatat ggtaaacctt
     3901 gggaagagac tgagccacag ttctgcccct gaccccatca gaggaagaga ggaagaggaa
     3961 aggagctgac atggagggag gtcagctgaa ggatgagaga gtggctaact ggagcagtgt
     4021 ccaaggaggc tattcaagga ggtccccagc atcccttaac tctgggctcc tccatctctg
     4081 ctaagcagaa cccttccagc ttcaagcaag actcaagaca cttccttccc agcagtctga
     4141 gctgttctgg agactggctt catgtttgcc cagcttaagg tctcaaggac ctgcgggaag
     4201 cctccaaccc tgccctgtca cccctctgtg cccttgaagc tcactgctag aaagcactcc
     4261 ctgttcaaga ggacagatga ggtcccagaa gccattcttt ccccgttctc ttcttggctg
     4321 tataaccttg agtaaagctg aaaagacaca gggcgagctc cagctgccca ctaagacact
     4381 tcagctctct gcttttccta gcttccccca tatcctgccc ttcatgatgg cttccccagg
     4441 gacccttcag gcaacccagt gactctactt tcactgcccc agggtagaaa gatactaccc
     4501 acccatcatg ggcaccaaac aaagaccttc agcttcacta gcagagaagt gactcctagc
     4561 caccagctca cctgatcctg tgtgaccttg ggcagatggc tcagcctctg gatttctggt
     4621 gtgtggcata actgactgta ccctgaaggc ctcttagctt gggaaatctg tgttccactt
     4681 aatgactcca ggctctgaaa atgcaacccc tcgaccactg ccctcccctc gggctgaggc
     4741 tctcccatcc tcccagacgt atgcaactag gccaagcggg tggacctcct ggctgtggcc
     4801 tgaggccttc tcatatgcaa tatacccccc tggcttctca caggggtgtt tgccccacac
     4861 aacatcccta gcccccaccc cagtgagcat cctgcctgcc tatgcatttt gggtacctcc
     4921 cctgtgacac ccacccccag agctgtattt ttctctggct aagattagaa catattcctt
     4981 gtaaagtatt tttctatgcg ggttttctta gggctcccag gaagcaccca gcacacccat
     5041 ggccccactg tacaggttgt ttctggtctg tctggggccc acctataaat ctttgtccca
     5101 ccaggcatca cagtgactgg ggggaggttg agtgctattg gggtgatttt ttttaaataa
     5161 aattggttaa atgcacaaa
//
