LOCUS       NM_032069               4527 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus glutamate receptor interacting protein 1 (Grip1),
            mRNA.
ACCESSION   NM_032069
VERSION     NM_032069.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4527)
  AUTHORS   Liang,J., Li,J.L., Han,Y., Luo,Y.X., Xue,Y.X., Zhang,Y., Zhang,Y.,
            Zhang,L.B., Chen,M.L., Lu,L. and Shi,J.
  TITLE     Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the
            Reconsolidation of Drug Reward Memory
  JOURNAL   J Neurosci 37 (37), 8938-8951 (2017)
   PUBMED   28821652
  REMARK    GeneRIF: Our findings indicate that calpain-GRIP signaling is
            essential for the restabilization process that is associated with
            drug cue memory and the inhibition of calpain activity may be a
            novel strategy for the prevention of drug relapse.
REFERENCE   2  (bases 1 to 4527)
  AUTHORS   Tan,H.L., Queenan,B.N. and Huganir,R.L.
  TITLE     GRIP1 is required for homeostatic regulation of AMPAR trafficking
  JOURNAL   Proc Natl Acad Sci U S A 112 (32), 10026-10031 (2015)
   PUBMED   26216979
  REMARK    GeneRIF: subcellular redistribution of GRIP1 and a change in the
            binding of GRIP1 to GluA2 during synaptic scaling, was observed.
REFERENCE   3  (bases 1 to 4527)
  AUTHORS   Bian,W.J., Miao,W.Y., He,S.J., Wan,Z.F., Luo,Z.G. and Yu,X.
  TITLE     A novel Wnt5a-Frizzled4 signaling pathway mediates
            activity-independent dendrite morphogenesis via the distal PDZ
            motif of Frizzled 4
  JOURNAL   Dev Neurobiol 75 (8), 805-822 (2015)
   PUBMED   25424568
REFERENCE   4  (bases 1 to 4527)
  AUTHORS   Gainey,M.A., Tatavarty,V., Nahmani,M., Lin,H. and Turrigiano,G.G.
  TITLE     Activity-dependent synaptic GRIP1 accumulation drives synaptic
            scaling up in response to action potential blockade
  JOURNAL   Proc Natl Acad Sci U S A 112 (27), E3590-E3599 (2015)
   PUBMED   26109571
  REMARK    GeneRIF: Data show that glutamate receptor-interacting protein-1
            (GRIP1) is recruited to synapses under conditions of hypoactivity.
REFERENCE   5  (bases 1 to 4527)
  AUTHORS   Jourdi,H. and Kabbaj,M.
  TITLE     Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1
            interactions: implications for sustained AMPA receptor expression
  JOURNAL   PLoS One 8 (2), e57124 (2013)
   PUBMED   23460828
  REMARK    GeneRIF: Acute BDNF treatment upregulates the interactions between
            AMPA receptor subunits (GluR1 and GluR2) with their scaffold
            proteins SAP97 and GRIP1, respectively.
REFERENCE   6  (bases 1 to 4527)
  AUTHORS   Bruckner,K., Pablo Labrador,J., Scheiffele,P., Herb,A.,
            Seeburg,P.H. and Klein,R.
  TITLE     EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft
            membrane microdomains
  JOURNAL   Neuron 22 (3), 511-524 (1999)
   PUBMED   10197531
REFERENCE   7  (bases 1 to 4527)
  AUTHORS   Srivastava,S., Osten,P., Vilim,F.S., Khatri,L., Inman,G.,
            States,B., Daly,C., DeSouza,S., Abagyan,R., Valtschanoff,J.G.,
            Weinberg,R.J. and Ziff,E.B.
  TITLE     Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA
            receptor-binding protein ABP
  JOURNAL   Neuron 21 (3), 581-591 (1998)
   PUBMED   9768844
REFERENCE   8  (bases 1 to 4527)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   9  (bases 1 to 4527)
  AUTHORS   Dong,H., O'Brien,R.J., Fung,E.T., Lanahan,A.A., Worley,P.F. and
            Huganir,R.L.
  TITLE     GRIP: a synaptic PDZ domain-containing protein that interacts with
            AMPA receptors
  JOURNAL   Nature 386 (6622), 279-284 (1997)
   PUBMED   9069286
REFERENCE   10 (bases 1 to 4527)
  AUTHORS   Johnson,M.N. and Okunade,A.O.
  TITLE     Roles that nurses in the community can play in nursing research
  JOURNAL   Int Nurs Rev 22 (5), 147-149 (1975)
   PUBMED   1041498
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U88572.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U88572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4527
                     /gene="Grip1"
                     /note="glutamate receptor interacting protein 1"
                     /db_xref="GeneID:84016"
                     /db_xref="RGD:621667"
     exon            1..241
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..3525
                     /gene="Grip1"
                     /note="AMPA receptor-interacting protein GRIP1; GRIP-1"
                     /codon_start=1
                     /product="glutamate receptor-interacting protein 1"
                     /protein_id="NP_114458.1"
                     /db_xref="GeneID:84016"
                     /db_xref="RGD:621667"
                     /translation="MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSI
                     PEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIK
                     AVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSIQGSSVMFRTVEVTLHKEGN
                     TFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAE
                     AMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSVCCNKQ
                     VIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP
                     HHQTRLALKGPDHVKIQRSDRQLPWDPWASSQCSVHTNHHHNPHHPDHCRVPALGFPK
                     ALTPNSPPAMVSSSSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSS
                     LSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEAD
                     SPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLLRDSSITSKVTLEIEFDVAESVIP
                     SSGTFHVKLPKKHSVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLA
                     IDNIRLDSCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPL
                     GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ
                     MAGETVTLKIKKQTDAQPASSPKKLPIPSHSSDLGDGEEDPSPIQRPGKLSDVYPSTV
                     PSVDSAVDSWDGSGIDARYGSQGTTFQTSGYNFNTYDWRSPKKRASLSPVPKPRSQTY
                     PDVGLSNEDWDRSTASGFAGASDSADAEQEENFWSQALEDLETCGQSGILRELEATIM
                     SGSTMSLNHEAPTARSQLGRQASFQERSNSRPHYSQTTRSNTLPSDVGRKSVTLRKMK
                     QEIKEIMSPTPVELHKVTLYKDSGMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLK
                     PYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIEQPALPSDWSE
                     QNSAFFQQPSHGGNLETREPTNTL"
     exon            242..322
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..458
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..604
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..688
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..764
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..910
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1058
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1228
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1384
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1537
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1724
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1870
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1951
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2021
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2167
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2312
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2452
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2647
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2804
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2916
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3150
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3297
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..4527
                     /gene="Grip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccacca gatgacatgt agcgcgcggg acctctgcat cagccaagag gaattaagct
       61 ttgtcactcc ccactgggac taccttcctc ctggtatgtg cgcaaggaat tcatatactg
      121 ctgctcgccg ccgcaggcac cagagcagag ccctgtgtgc actttggcag agatcaggga
      181 gcaagaatga tagctgtctc ttttaaatgc cgctgtcaga ttctaaggcg acttaccaaa
      241 gatgagagtc cctacactaa atctgccagc cagacaaagc cgcccgatgg agcattggct
      301 gtgaggagac agagcatccc agaggaattc aagggctcca ccgtggtgga gctgatgaag
      361 aaggagggaa ccactcttgg cctgacggta tcaggaggaa tcgataaaga tggaaagcca
      421 agagtgtcca acctgcggca gggagggatt gctgccagaa gtgaccagct ggatgtgggc
      481 gactacatca aagcggtgaa tgggatcaac ctggccaaat tccgccatga tgagatcatc
      541 agcctgctga aaaatgttgg ggaaagagtg gtcctggagg tcgagtatga gcttccaccg
      601 gtctctatcc aaggatcgag tgttatgttc cgaacagtgg aggtcacctt gcacaaagaa
      661 ggcaacacct ttggttttgt catccgaggg ggagcgcatg atgacagaaa taagtcccgt
      721 ccagttgtga taacctgtgt tcgtcctgga gggcctgctg acagagaggg caccatcaaa
      781 cctggagaca ggttgctcag tgtggatgga attcggcttc tgggaaccac ccatgctgag
      841 gccatgagca tccttaaaca gtgcggacaa gaagcaacgc tgctgataga atatgatgtc
      901 tccgtgatgg attctgtagc aacagcatcc gggccactac tagttgaagt tgccaaaact
      961 cccggtgcaa gccttggggt tgcactaact acctccgtgt gctgtaacaa acaagtcatc
     1021 gtcatagaca aaatcaaatc tgcaagcatt gcggacaggt gcggggcgct acatgtggga
     1081 gaccacatcc tctccatcga cggcacgagc atggagtact gtaccctcgc agaagcaacc
     1141 cagttcctgg ccaacaccac tgaccaggtc aagctggaga ttctcccaca ccatcagacc
     1201 cgcctggccc tgaagggacc tgaccatgtg aaaattcaga ggagcgacag acagcttccc
     1261 tgggatccct gggccagcag ccagtgcagc gttcatacca accatcacca taacccgcac
     1321 cacccagacc attgccgagt accagccctg ggttttccga aagcgcttac tccaaacagc
     1381 cctccggcta tggtgtcctc gtcctctcct acctctatga gtgcgtacag cctgagttcc
     1441 ctgaacatgg ggactttacc tcgaagcctc tactctacta gtccacgagg aaccatgatg
     1501 aggaggagac tgaaaaagaa ggacttcaaa agctcactgt ctttagcttc tagcactgtg
     1561 ggattggctg gacaggttgt tcacactgaa accacagagg ttgtgctgac ggctgatcct
     1621 gtcactggct ttggaatcca actgcagggc agcgtgtttg ccacagagac tctctcctcc
     1681 ccacctctga tttcctatat tgaagctgac agcccagcag agagatgtgg tgtgctgcag
     1741 attggagaca gagtcatggc cattaatgga atcccaacag aagacagcac ctttgaggaa
     1801 gccaatcagc tccttcgaga ctcttccatc acgagcaaag tcacactgga aatcgagttt
     1861 gatgttgcag aatctgtcat cccaagtagt ggaacatttc atgtaaaact gcctaagaag
     1921 cacagcgtgg agcttggaat aaccatcagt tcgccatcca gtagaaaacc aggggaccct
     1981 ctcgtcattt cagatatcaa gaaaggcagt gtggcacaca gaactggaac tctggaactt
     2041 ggagataaat tgctcgccat agataacatc cggttggaca gctgttccat ggaagatgca
     2101 gtccagatcc tccagcagtg tgaagacctg gtgaagctca aaatccgcaa agatgaagat
     2161 aactcagatg agcaagagag ttccggggcg attatttaca cggtggagct gaagcgctat
     2221 ggggggcccc ttggcatcac catttctgga acggaagagc cctttgatcc tattatcatc
     2281 tcgagcctca ctaaaggggg attagctgaa aggactggag cgatccacat cggagatcga
     2341 atcctagcca tcaatagcag tagcttgaag gggaagcctc tgagtgaagc catccacttg
     2401 ctacagatgg cgggagagac tgtcaccctg aaaattaaga agcagacaga tgctcaacct
     2461 gcctcaagtc ccaagaagct gcccatcccc agccactcaa gtgacctagg agatggtgag
     2521 gaggacccct ccccaataca aaggcctggc aagctctctg acgtgtaccc ctccacagta
     2581 cccagcgtgg acagtgctgt ggactcctgg gacggatctg gaatagatgc caggtatggg
     2641 agtcaaggca cgacttttca gacttcaggg tacaatttca acacctatga ctggaggagt
     2701 ccgaagaaaa gagccagcct gtccccggtc cccaagcctc gaagccagac atacccagat
     2761 gtgggcttga gtaatgaaga ctgggaccgg tccacagcca gtggcttcgc cggggcttct
     2821 gacagtgcag acgctgaaca agaggaaaac ttctggtctc aagcattgga ggacctggag
     2881 acctgcggcc agtcgggaat cctgagagag ctcgaggcaa caatcatgtc ggggagcact
     2941 atgagtttga atcatgaggc tccaacggct cgcagtcagc tggggcgaca ggccagcttc
     3001 caggaacgga gcaattcgag gccacactat agccaaacga ctcgcagcaa cactctgccc
     3061 tcggatgtgg gcagaaagtc tgtgaccctg cggaaaatga agcaagaaat caaggagatt
     3121 atgtccccaa ctcccgtgga gcttcacaag gtgaccttat acaaagactc tggcatggag
     3181 gactttgggt tcagtgtggc agatggcctg ctggagaaag gggtgtatgt caaaaatatc
     3241 cgcccagctg ggccaggtga tcttggaggc ttgaagcctt atgacaggct cttacaggtt
     3301 aaccacgtcc gaacgagaga cttcgactgc tgcctggtgg tgcccctcat agccgaatcc
     3361 ggtaacaagc tggacctggt tattagcaga aacccgctgg cctcccagaa gtcgatagaa
     3421 cagccggctc tgcccagtga ctggagcgaa cagaacagcg ctttcttcca gcagcccagc
     3481 cacggtggta acctagagac acgagaaccc actaacacat tatagcatta cttttataaa
     3541 gcaggacgaa agacgatatc tacatggtgc taaaacaaaa cagaacagaa cagaacagaa
     3601 cagaacagaa cagaacagaa cagaacagaa caacccttta agatttcttg tgacagcttg
     3661 aagcacagag aatcaccgtg gcattaattg caaagcacag gggtctttta aatctccctc
     3721 atagctcatg ttctcatccc ttcccaacta gaagaggttt cttttaggat gaccactctg
     3781 ttaactggcg ggtcctcctc tgccgggggt ggggaggccc cttcggtaga caataaagag
     3841 gaaggcagcc caccccttcc cccaccccaa tcaagatcag aggaaacttt ttacaattca
     3901 ccttactgtc acttttaaca gagagaaaca tccctttgaa aatattctct atggtaattt
     3961 cctgaatgga gtaagtttct tactataacg tcattagtgt aagaacacga tcaatatgga
     4021 tttacacata gctggccctg ctaggggagc taggatgggt gaatggctag gcctgccgcg
     4081 gtgggagggg cacaggtata acattaggtt ttcttaaaat atttcagcaa cagtgcacgt
     4141 tggagaccat aataggtggt ggtaaatgtt tcgcccaaat ataggaatga ttttaactaa
     4201 gatgtatgct attccctatg caacagatga tcaaacagga tatgtcttgt gacctgtttt
     4261 tttttttcct taaggacaca ttcttttttt tttttttaat agctgaaaaa aatctctggt
     4321 aatgaattag agtgtgtggt aacactgagc attagtgata tgaccctatt tttaaaatcc
     4381 aagactaaga atttaaggag tgaagagtct aatgaaatga gattcacttt ctgggtaggc
     4441 aaacagaact catgcagctc agaagtctgc agactgctac accgaggggt gcacagcaca
     4501 atgacttaag gacgacgacg atttggt
//
