LOCUS       NM_153308               1777 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit
            associated protein 1 (Grina), mRNA.
ACCESSION   NM_153308
VERSION     NM_153308.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Rojas-Rivera,D., Armisen,R., Colombo,A., Martinez,G.,
            Eguiguren,A.L., Diaz,A., Kiviluoto,S., Rodriguez,D., Patron,M.,
            Rizzuto,R., Bultynck,G., Concha,M.L., Sierralta,J., Stutzin,A. and
            Hetz,C.
  TITLE     TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene
            that controls apoptosis through the modulation of ER calcium
            homeostasis
  JOURNAL   Cell Death Differ 19 (6), 1013-1026 (2012)
   PUBMED   22240901
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Kumar,K.N., Tilakaratne,N., Johnson,P.S., Allen,A.E. and
            Michaelis,E.K.
  TITLE     Cloning of cDNA for the glutamate-binding subunit of an NMDA
            receptor complex
  JOURNAL   Nature 354 (6348), 70-73 (1991)
   PUBMED   1719427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 18, 2021 this sequence version replaced NM_153308.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062074.1, SRR22399484.1410598.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000007.1  109842870-109843032
            164-499             JAXUCZ010000007.1  109843973-109844308
            500-609             JAXUCZ010000007.1  109844390-109844499
            610-810             JAXUCZ010000007.1  109844581-109844781
            811-939             JAXUCZ010000007.1  109844902-109845030
            940-1083            JAXUCZ010000007.1  109845121-109845264
            1084-1777           JAXUCZ010000007.1  109845355-109846048
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1777
                     /gene="Grina"
                     /note="glutamate ionotropic receptor NMDA type subunit
                     associated protein 1"
                     /db_xref="GeneID:266668"
                     /db_xref="RGD:628873"
     exon            1..163
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
     exon            164..499
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1233
                     /gene="Grina"
                     /note="glutamate [NMDA] receptor-associated protein 1;
                     NMDA receptor glutamate-binding subunit; NMDA receptor
                     glutamate-binding chain; N-methyl-D-aspartate receptor
                     glutamate-binding chain; glutamate receptor, ionotropic,
                     N-methyl D-aspartate-associated protein 1 (glutamate
                     binding)"
                     /codon_start=1
                     /product="protein lifeguard 1"
                     /protein_id="NP_695220.4"
                     /db_xref="GeneID:266668"
                     /db_xref="RGD:628873"
                     /translation="MSHEKSFLVSGDSYPPPNPGYPVGPQAPMPPYVQPPYPGAPYPQ
                     AAFQPSPYGQPGYPHGPGPYPQGGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPPPFQD
                     PGSPQHGNYQEEGPPSYYDNQDFPSVNWDKSIRQAFIRKVFLVLTLQLSVTLSTVAIF
                     TFVGEVKGFVRANVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILTISLSYM
                     VGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAIL
                     CIFIRNRILEIVYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIIN
                     IFLYILTIIGRAKE"
     exon            500..609
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
     exon            610..810
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
     exon            811..939
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1083
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1777
                     /gene="Grina"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaggcccg cccagtcaca aggctcttct gcgtcttccc agccgcaggc gcaggcccaa
       61 gcaactcggc cgtccagcgg gtgcaggtgc ggacgcaccg gccatcaccg cgcgcggctg
      121 cgcagcgggc accgtagaca ccggtctctg gctccctaga gcggggcagc cacagaaccc
      181 gaggccatgt cccatgaaaa gagtttcttg gtgtctgggg acagctatcc tcccccaaac
      241 cctggctatc ctgtggggcc acaagcccct atgcctccct atgttcagcc tccctaccct
      301 ggggccccat acccacaggc cgctttccag ccctctccct atggtcaacc agggtatccc
      361 catggtcccg gtccctatcc acaaggtggt taccctcaag gaccctaccc tcaaggaggc
      421 tacccacagg ggccataccc acagagcccc ttccccccta acccctatgg acagccacca
      481 cccttccagg accctggctc acctcagcat gggaactacc aggaggaagg gcctccatcc
      541 tactatgaca accaggactt cccctcggtc aactgggaca agagcattcg ccaggccttc
      601 atccgaaagg tgttcctggt gctgaccctg cagctgtcgg taaccctgtc gactgtggcc
      661 attttcactt ttgtcgggga ggtgaagggc tttgtccggg ccaatgtctg gacctactat
      721 gtctcctacg ccatcttctt catctccctc attgtcctca gctgttgcgg ggacttccgg
      781 cgaaagcatc cctggaacct tgttgccctg tcgatcctga ccatcagttt gtcctacatg
      841 gtgggcatga tagccagttt ttacaacacg gaggcggtca tcatggccgt gggcatcacc
      901 acagctgtct gcttcacggt ggtcatcttc tccatgcaga cccgctacga cttcacctcg
      961 tgcatgggcg tgctcctggt gagcgtggtg gtgctcttca tcttcgccat actctgcatc
     1021 ttcatccgga accgcatcct ggagatcgtg tacgcctcgc tgggcgctct gctcttcacc
     1081 tgcttcctgg ctgtggacac ccagctgctc ctggggaaca agcaactgtc cctgagccca
     1141 gaagaatatg tgtttgcggc cctgaatctg tacacggaca tcatcaacat cttcctatac
     1201 attctcacca tcattggccg tgccaaggaa taggacaagc cccagctcag gtggcatggt
     1261 gggctcagac ccatgcccct ggcatgacat tgccatctgt gcttccccct ctctggtccc
     1321 caggcatggc ctggagcaga gggagcccct ctcgccctcg tgtatgtaca ctgcaaatac
     1381 ttaacgttcg gaccctctct ggccacagca tggccccctt tatccctttt gcccttgcca
     1441 aggggtgaca gggctgcatt tctgtgccac cttctgtcta ctcattgttg catgagccct
     1501 gtctgccagc ccatcccggg gtctgggatc aacaccaggt cccaggggag aaggatcata
     1561 ccaagaggtg agggtgcacg tcttccctcc tgtcccagct cccctggcat agagtcccca
     1621 tgtcccctcc tcaccctgcc ttctgagggg cttgcagggt ggggtctcgt tcttgttctg
     1681 ggccccgaga gcagagaggg tggcatgttt caggggagga ggctctcttg tgctgccatt
     1741 gttaaaatgc caataaaagg gtatcttctg ctctctg
//
